JPS6075428A - Remedial adhesive tape or sheet - Google Patents

Abstract

PURPOSE:The titled tape or sheet, obtained by using a base material prepared by bonding an extensible woven or knitted fabric to an extensible plastic film with a pressure-sensitive adhesive, capable of extending according to the movement of the skin with the tape or sheet applied thereto, and having airtightness. CONSTITUTION:A remedial adhesive tape or sheet obtained by using a base material prepared by bonding an extensible woven or knitted fabric 1 to an extensible plastic film 3 with a pressure-sensitive adhesive 2 and an adhesive layer 4 for application to the skin, positioned on the plastic film side of the above-mentioned base material, and containing a remedial agent. The above- mentioned woven or knitted fabric 1 has >=40% elongation in at least one of the longitudinal and lateral directions and <=200g/cm tension at 20% elongation. The adhesive in the above-mentioned adhesive layer 4 contains >=60wt% polymer of an alkyl acrylate, etc. The tape or sheet will not be peeled even by the movement of the skin nor deteriorating the extensibility by the application for a long term nor excessive stretching of the surface. Thus, a wound or KABURE (rash) is hardly caused.

Description

DETAILED DESCRIPTION OF THE INVENTION Technical Field: The present invention relates to a therapeutic adhesive tape or sheet that contains a therapeutic drug in a skin adhesive layer and is used by being applied to the skin. More specifically, the present invention relates to a therapeutic adhesive tape or sheet that can stretch according to the movement of the skin to which it is applied, has sufficient airtightness, and can exhibit excellent pharmacological effects.

Jumeishijutsu: Many therapeutic tapes or sheets are already known that can be applied to the skin and are expected to have medicinal effects on the whole body or locally. For example, 0% Publication No. 52-31405 discloses a tape for skin diseases having a pressure-sensitive adhesive coating consisting of an acrylic acid-acrylic acid copolymer and an anti-inflammatory steroid. JP-A-57-116011 discloses a skin patch containing insorbitol nitrate or pentaerythritol tetranitrate, which is effective for suppressing or preventing attacks of angina pectoris, in an adhesive layer with a glass transition point of 170°C to -10°C. is disclosed. Also, in Japanese Patent Application Laid-Open No. 54-138124, A
-A patch having a plaster layer consisting of a B-A type block combination, an oil or fat or higher fatty acid, and a drug is disclosed. The base materials used in all of these materials have poor extensibility. When applied to the skin, it cannot follow the expansion and contraction of the skin that actually occurs in daily life, and it peels off from the skin surface. If the adhesive force of the adhesive layer is increased in order to prevent it from peeling off from the skin, the base material has poor extensibility, which forces the skin to stretch, which causes the skin to be stretched, resulting in scars and rashes. occurs.

In order to prevent peeling from the skin and skin wounds/rashes, if a soft adhesive with weak cohesive force is used, or if a large amount of adhesive is used, the adhesive may be on the skin when removed from the skin. remain in place. A so-called "glue residue phenomenon" occurs. - As shown in the above-mentioned Japanese Patent Application Laid-Open No. 54-138124, when the base material is cloth or nonwoven fabric, a sufficient therapeutic effect cannot be obtained because the drug escapes to the back side from the weave or between the fibers. At the same time, due to the lack of airtightness,
Skin respiration is not suppressed and therefore sufficient OI) 1' Therapeutic effect cannot be obtained.

OBJECTS OF THE INVENTION: An object of the present invention is to provide a therapeutic adhesive tape or sheet that is difficult to peel off and does not cause skin disorders such as scratches or rashes even when applied to the human skin surface for a long time. A primary object of the present invention is to provide a therapeutic tape or sheet having an adhesive that exhibits an adhesive effect in an appropriate amount so that the adhesive does not remain on the skin when removed. A further object of the present invention is to provide a therapeutic tape or sheet that enhances the 01) T therapeutic effect due to its airtightness and prevents the drug from escaping from the back surface of the base material. Still another object of the present invention is to provide a therapeutic tape or sheet that has excellent extensibility, airtightness, deformation resistance, and adhesive surface smoothness.

Summary of the Invention: The present invention provides that if the base material that is to serve as a carrier for the adhesive containing the drug has optical extensibility, it can be deformed freely along the movement of the skin surface. Even when applied, it does not peel off and does not cause scratches or rashes1.And if a stretchable plastic film is used as the base material, a therapeutic adhesive tape or sheet with high airtightness can be obtained. It was completed by the inventor's new knowledge. Therefore, the therapeutic adhesive tape or sheet of the present invention is:

A base material made by adhering a stretchable woven or knitted fabric and a stretchable plastic film with a pressure-sensitive adhesive, and a skin adhesive containing a therapeutic drug located on the plastic film side of the base material. It has an adhesive layer, thereby achieving the above object.

The therapeutic adhesive tape or sheet of the present invention is:

As shown in the figure, a stretchable woven or knitted fabric 1 and a stretchable plastic film 3 are bonded together via a pressure-sensitive adhesive layer 2 to constitute a base material. This substrate is therefore highly extensible. On the surface of this base plastic film 3 is an adhesive layer 4 containing a drug. A release paper 5 made of silicone resin or the like is further placed on the surface of the adhesive layer 4. The tape or sheet thus obtained is appropriately cut into a suitable size and used.

The woven or knitted fabric 1 has an elongation ratio of 404 or more in at least one direction, both vertically and horizontally. The tension of the vine when it is stretched to 20 degrees is 2.00 g/m.

Such a woven or knitted fabric 1 is a highly stretchable woven fabric in which extensible threads are used in at least one of the vertical and horizontal directions, or a knitted fabric made of highly stretchable threads or ordinary threads. Or knitted fabric. Extensible yarns include spandex yarns, spandex core yarns, spandex covered yarns, rubber core yarns, and high stretch processed yarns such as nylon, polyester, and acrylic. Spandex core yarn is preferred as a material that has high elongation and texture as well as deformation resistance.

The pressure-sensitive adhesive layer 2 needs to have sufficient adhesive force and cohesive force to bond the woven fabric 1 and the plastic film 3 together. As a guideline.

The adhesive force when this pressure-sensitive adhesive layer 2 is applied to a non-stretchable film such as cellophane to a thickness of 50 μrnH is:

Based on the test method of JIS Z1522, 400g/15 +w ~ 1200g/15 for stainless steel repair plate surface
It is in the range $ of yas. The adhesive used for the pressure-sensitive adhesive layer 2 is an acrylic ester polymer.

There are rubber adhesives containing acrylic adhesives such as copolymers of acrylic esters and methacrylic esters; and rubber or synthetic rubbers, Tackifier-0 plasticizers, and the like. In addition, vinyl adhesives made of a mixture of high and low polymerization polyalkyl vinyl ethers, polyurethane adhesives, and the like may also be used. These adhesives are applied to the woven fabric 1 and/or the plastic film 3 in the form of a solution by adding an organic solvent, a suspension by adding water, or a solvent-free hot melt.

After volatilizing the solvent if necessary, the adhesive is adhered to the corresponding plastic bare plastic 3 or woven or knitted fabric 1 to form a sandwich-like base layer. In addition to this, there is a transfer method. In this method 9 e.g.

Apply the above liquid adhesive onto a separately prepared release paper,
This is bonded to the back-woven knitted fabric 1 or plastic film 3 in which the solvent has been volatilized as required. Then, remove the release paper. By doing so, the adhesive layer is transferred to the woven or knitted fabric 1 or the plastic film 3. Then, this adhesive layer is adhered to a corresponding plastic film 3 or woven or knitted fabric 1 to obtain a base material layer.

The plastic film 3 functions to block the permeability and air permeability of the woven fabric layer 1 to the drug without inhibiting the extensibility of the layer 1. At the same time, it has the role of smoothing the surface and exhibiting deformation resistance of the entire base material layer by a mechanically combined effect with the woven or knitted fabric 1. Therefore, this plastic film 3 needs to be as thin as possible and have extensibility. At the same time, it is also necessary to have good adhesion with the pressure-sensitive adhesive. For that reason,
The thickness is preferably in the range of 10 μm to 100 μm. The higher the extensibility, the better. The elongation rate in at least one of the vertical and horizontal directions.

Usually, the tension is 100'1 or more, and the tension at 20 degrees of elongation is 200 g/z or less. The material of this plastic film 3 is 1, for example, polyethylene.

Various copolymers of ethylene and vinyl acetate, polyurethane, flexible polyvinyl chloride, polybutadiene.

There are vinylon etc.

The adhesive that seizes the drug-containing adhesive layer 4 includes:

Good adhesion to the skin; Low toxicity and skin irritation; 1. The drug does not change in quality and the adhesive itself does not age easily; Adhesive strength is appropriate and does not pull the skin or leave adhesive on the skin when removed. No, something is used. Preferred examples of such adhesives include those whose main component is a polymer of acrylic ester, a copolymer of acrylic ester and methacrylic ester, or the like. The adhesive contains these polymers in a proportion of 60% or more by weight. And the structure
Copolymers such as vinyl acetate, diacetone acrylamide, vinyl pyrrolidone, dimethyl acrylamide, acrylic acid, oleic anhydride, hydroxyalkyl acrylic acid ester, hydroxyalkyl methacrylic acid ester, etc. are incorporated as f1li components, depending on the drug to be added. can be used.

The drug contained in the adhesive layer 4 is not particularly limited. However, it is appropriate to use a drug that is absorbed through the skin surface when applied to the skin for a long period of time, such as 4 hours or more, and that continues to exhibit its medicinal efficacy at a predetermined level. Such drugs include one example.

Anti-inflammatory agents, anti-inflammatory analgesics, coronary vasodilators, blood circulation promoters, skin disease treatments, keratin softeners/removal agents, asthma medications.

Sedatives/Stabilizers 1 Local anesthetics, antihypertensive agents, etc.

The therapeutic adhesive tape or sheet of the present invention can be obtained by mixing such a drug and an adhesive in an appropriate ratio and applying the mixture onto the plastic film 3 as a base material.

Example-: The present invention will be described below with reference to Examples.

Example 1 (~) A woven fabric (trade name: ESPA) having elasticity in the horizontal direction and using nylon thread for the warp and spandex core yarn for the weft was used as the fabric.

The elongation height of this cloth in the transverse direction is 80%, and the tension when elongated by 20 degrees is 70 g/m.

('B) As the plastic film, an elastic film made of polyurethane material was used. The elongation rate of the film is over 300 modulus, and the tension when elongated by 20 yen is 25
g/cIn.

(C) Photosensitive adhesive A composition consisting of 74 parts by weight of 2-ethylhexyl acrylate, 20 parts by weight of 2-ethylhexyl methacrylate, and 6% by weight of methacrylic acid was polymerized in ethyl acetate using benzoyl peroxide as a catalyst. A polymer having a weight average molecular weight of about 220,000 was obtained. To this was added 20 g of an adduct of butylene glycol and hexamethylene diisocyanate (molecular weight per equivalent of about 215 + trade name: Duraney L) to prepare a 28% ethyl acetate solution.

(To) Preparation of base material: The pressure-sensitive adhesive solution was applied onto a silicone release paper and dried to form a pressure-sensitive adhesive layer having a residual solid content of 15 g per 100 mm. Next, the cloth of item (A) was passed between two rubber rollers while applying a slight tension to the surface of the pressure-sensitive adhesive layer on the release paper, and was adhered while applying an E force.

The completed intermediate sheet was rolled up. When the release paper was removed while unwinding the intermediate sheet, the adhesive layer was transferred onto the fabric. A polyurethane film was placed on top of the adhesive layer and passed between two rubber rollers to bond it under pressure.

2) Adhesive for drug inclusion (for skin application): Methacrylic acid 2
-20 parts by weight of ethylhexyl, 70 parts by weight of butyl acrylate, 10 parts by weight of N-vinyl-2L pyrrolidone, and 1
- A composition consisting of 0.03 parts by weight of 6-hexane gelicol dimethacrylate was polymerized in ethyl acetate using lauroyl peroxide as a polymerization catalyst to obtain a copolymer solution having a weight average molecular weight of about 290,000.

(F) Preparation of drug mixing part and therapeutic adhesive sheet; Insorbitoni dinitrate (coronary vasodilator) was used as the drug. This was dissolved in an amount of 10 parts of the above adhesive solution in terms of solid content to prepare a solution with a concentration of 25 parts. This drug-mixed adhesive solution was applied onto a silicone release paper so that the solid content after drying was 0.6 g per 100 cII and dried. Then, overlap the plastic film side of the base material prepared earlier on the dry adhesive side of the release paper.

This was passed between two rubber rollers while being strongly pressed. This was cut into an appropriate size to obtain the desired therapeutic adhesive sheet. This sheet is effective in suppressing or preventing attacks such as angina pectoris and myocardial infarction if the release paper is removed from the sheet and applied to the skin at or near the affected area. The therapeutic adhesive sheet thus produced (10 cIn x 10 crn
) was applied to the skin for 24 hours. As a result, I didn't experience any irritation or pain from my skin tightening.

Example 2 A base material and an adhesive solution were prepared in the same manner as in Example 1. Indomethacin (an anti-inflammatory drug) was used as the drug.

This drug was dissolved in an amount of 8% based on the solid content of the adhesive in the adhesive solution, and a therapeutic adhesive sheet was produced in the same manner as in Example 1. This sheet can be used as an anti-inflammatory patch.
By applying it to the skin for a long time, it was able to exhibit high medicinal efficacy along with the ODT effect.

Example 3 (A) A knitted fabric made of nylon stretch yarn was used as the fabric. Its transverse elongation rate is 60 mm and the tension when stretched to 20 inches is 75 g/cm.

(8) As the plastic film, an ethylene/vinyl acetate copolymer resin film C (thickness: 40 μm) was used. Its expansion rate is 190'1. The tension at 20 tension is 45 g/cm.

(qPressure sensitive adhesive: Styrene/Isoprene/Styrene block polymer (Product name: Cariflex TR-110
7) 80 parts by weight, 20 parts by weight of polyisoprene rubber, 15 parts by weight of polyterpene resin (softening point 100°C), 80 parts by weight of squalene, and 1.0 parts by weight of zinc dithiocarbamate.
Parts by weight of the composition were added to 890 parts by weight of cyclohexane to prepare a pressure-sensitive adhesive solution.

(Preparation of 11 base material: The weight of the pressure-sensitive adhesive layer after drying is 1
A base material was produced in the same manner as in Example 1 except that the coating was applied at a rate of 1.3 g per 00 cd.

(E) Adhesive for drug inclusion: A composition consisting of 25 parts by weight of butyl methacrylate, 65 parts by weight of butyl acrylate, 20 parts by weight of diacetone acrylamide, and 0.04 part by weight of 1,6-hexane gelicol dimethacrylate. was polymerized in ethyl acetate using a lauroyl peroxide catalyst to obtain 1
A copolymer solution having a weight average molecular weight of about 310,000 was obtained.

(F) Mixing of drugs and production of adhesive sheet: An anti-inflammatory and analgesic drug was used as the drug. This drug contains 10 parts by weight of monoglycol salicylate, 3 parts by weight of methyl salicylate, 3 parts by weight of nomenthol, 2 parts by weight of d-nocamphor, 0.5 parts by weight of thymol and 0.5 parts by weight of diphenhydramine hydrochloride.
It has a composition of 5 parts by weight. This drug was dissolved in a ratio of 2011 to the solid content in the adhesive solution to prepare a solution with a concentration of 35 parts. This drug-containing pressure-sensitive adhesive solution was applied so that the coating weight after drying was 1.0 g per 100 clI, and a sheet was prepared in the same manner as in Example 1. This sheet could be applied to areas such as the shoulders and back for a long time to maintain its medicinal effects (anti-inflammatory and analgesic effects). This treatment sheet expands and contracts according to the expansion and contraction of the skin, so it does not peel off or stretch the skin, causing damage or rashes.Also, the drug does not escape from the back, so 100% of the drug can be used for treatment. .

and 1 Todoroki ↓ (^ As the fabric, we used a bidirectional stretch woven fabric with polyester high stretch yarn in the warp and polyester stretch yarn in the weft.The elongation rate in the vertical direction was 50
%, a transverse elongation rate of 30%, and a tension of 110 g/m when elongated by 20 inches in the longitudinal direction.

(To) A highly plasticized polyvinyl chloride resin film (thickness: 70 μm) was used as the plastic film. Its elongation rate is 230 and the tension at 20 is 64 g/m.
It is.

(q Pressure-sensitive adhesive: 10 parts by weight of uroyl methacrylate, 50 parts by weight of 2-ethylhexyl acrylate, N-
15 parts by weight of vinyl-2-pyrrolidone, 25 parts by weight of diacetone acrylamide, and 1.・A composition consisting of 0.02 parts by weight of 6-hexane gelicol dimethacrylate is polymerized in ethyl acetate using azobisisobutyronidine (IJ) as a catalyst to obtain an ethyl acetate solution of a copolymer having a weight average molecular weight of approximately 280,000. I got it.

0 Preparation of base material: The weight of the film after drying of the pressure-sensitive adhesive is 1
A base material was prepared in the same manner as in Example 1 except that the coating was applied at a rate of 1.2 g per 00 cd.

(E) As an adhesive for drug inclusion, a combination consisting of 40 parts by weight of teuroyl methacrylate, 40 parts by weight of 2-ethylhexyl acrylate, 20 parts by weight of butyl acrylate, and 0.01 part by weight of 1,6-hexane gelicoldimethacrylate. The product was polymerized in an ethyl acetate solvent using a T/bisisobutyronitrile catalyst to obtain a polymer solution having a weight average molecular weight of about 230,000.

(G) Preparation of a pressure-sensitive adhesive sheet for mixing and pasting drugs: The solid component is 10% of the ethyl acetate solution of 25% of the pressure-sensitive adhesive solution.
A drug containing 3,00 parts by weight of chili pepper extract and 0.07 parts by weight of nonylic acid vanylamide per 0 parts by weight was dissolved to obtain a drug-containing adhesive solution.

This solution was applied so that the weight after drying was 0.8 g per 10 octIi, and the same method as in Example 1 was performed. This adhesive sheet is effective as a temperature-sensitive anti-inflammatory analgesic. When applied to the back, lumbar region, etc., it conforms well to the bending of the skin, does not peel off, and provides excellent anti-inflammatory and analgesic properties for a long period of over 6 hours.

Effect of the invention: According to the therapeutic tape or sheet of the present invention.

In this way, a stretchable woven or knitted fabric and a highly stretchable plastic film are bonded to each other with a soft pressure-sensitive adhesive layer to form a base material. Therefore, each layer does not cancel each other's extensibility, and moreover, a mechanical effect occurs due to their merging. Furthermore, since the plastic film layer is smooth, there are few irregularities on the surface of the adhesive, and it has good adhesion to the skin. Therefore, it can be used for a long time without peeling or wrinkling due to movement of the skin to which it is applied. Since it can be applied to the skin for a long period of time, the therapeutic effect can be increased accordingly.

Furthermore, even if the tape is applied for a long time, the extensibility of the base material is not impaired, so there is no unreasonable tension on the skin surface, and it does not cause scratches or rashes. Furthermore, since the base material has a high degree of airtightness due to the plastic film layer, the base material strength (Ql) can be effectively used without escaping from the back surface.
The T therapeutic effect is fully demonstrated.

[Brief explanation of the drawing]

The figure is a partial front sectional view of one embodiment of the therapeutic tape or sheet of the present invention. 1... Woven fabric or knitted fabric, 2... Pressure sensitive adhesive layer. 3...Plastic film, 4...Adhesive layer, 5
... Peeling line. -5-5 Procedural amendments stamped) 1. Indication of the case Patent Application No. 183267 of 1983 2. Name of the invention Medical adhesive tape or sheet 3. Person making the amendment Relationship to the case Patent applicant postal code 530 Address: 2-4-4 Nishitemma, Kita-ku, Osaka, Tokyo Patent Department (03) 434-95524, Subject of amendment (1) Detailed explanation of the invention in the specification column 5, Contents of amendment + l) Description , on the 4th line from the bottom of page 6, the text ``Knitted fabric'' has been corrected to ``Knitted fabric''. (2) Delete "medication" in the 5th line from the bottom of page 8. (3) In the 7th line from the bottom of page 11, the text "photosensitive adhesive" has been corrected to "pressure sensitive adhesive." (4) On page 12, line 5, correct the text r l 5 gJ to rl, 5gj. that's all

Claims (1)

[Claims] 1. A base material made by bonding a stretchable woven or knitted fabric and a stretchable plastic film with a rice-sensitive adhesive, and a therapeutic agent located on the plastic film side of the base material. A therapeutic adhesive tape or sheet having an adhesive layer for adhering to the skin. 2. The tape or sheet according to claim 1, wherein the elongation ratio of the woven fabric or knitted fabric and the plastic film in at least one of the vertical and horizontal directions is 40 modulus or more and 100 modulus or more, respectively. 3. The tape or sheet according to claim 1, wherein the woven fabric or knitted fabric and the plastic film each have a tension of 200 g/cm or less when stretched. 4. The adhesive contained in the adhesive layer is a polymer of acrylic acid alkyl ester or a copolymer of acrylic acid alkyl ester and methacrylic acid alkyl ester.
Weight 4 Claim 1 containing the proportion above J2J
Tape or sheet as described in section. 5. The therapeutic drug is an anti-inflammatory agent or an anti-inflammatory analgesic. The tape or sheet according to claim 1, which is a coronary vasodilator, a skin disease treatment agent, a sedative stabilizer, an antihypertensive agent, an asthma drug, or a keratin softener.