JPS6075415A - Dentifrice composition - Google Patents

Abstract

PURPOSE:To provide the titled dentifrice composition having improved shape- retainability, stringiness and feeling to the palate, by adding a water-soluble alkaline earth metal salt to a dentifrice composition containing a non-calcium abrasive and a carboxymethylcellulose alkali metal salt as a binder. CONSTITUTION:A dentifrice composition containing a non-calcium abrasive as an abrasive and a carboxymethylcellulose alkali metal salt as a binder, is compounded with preferably 0.01-5wt%, especially 0.1-2wt% water-soluble alkaline metal salt. The thickening effect of the dentifrice can be increased and the feeling to the palate can be improved by adding a water-soluble phosphate such as dipotassium phosphate, etc. to the water-soluble alkaline earth metal salt. The amount of the water-soluble phosphate is preferably 0.1-0.5%, and that of the abrasive is preferably 20-40% of the whole composition. The binder is preferably the one having a molecular weight of 30,000-80,000 and an etherification degree of 0.7-0.9.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a dentifrice composition using a non-calcium abrasive such as precipitated silica.
The present invention relates to a dentifrice composition with improved feeling of use.

Traditionally, calcium-based abrasives such as calcium carbonate and calcium hydrogen phosphate have often been used as abrasives in dentifrice compositions, but in response to the recent diversification of consumer needs for dentifrice compositions, non-calcium abrasives have been used. The use of calcium-based abrasives is attracting attention. For example, silica-based abrasives such as sedimentation abrasives are used as abrasives for transparent toothpastes, which have advantages in appearance, while polymer powders such as polymethyl methacrylate are suitable as abrasives for low-abrasive dental calendars. From the viewpoint of compatibility with the active ingredient, insoluble sodium metaphosphate and aluminum hydroxide are preferably used.

However, 1-1 When preparing a dentifrice composition using these non-calcium abrasives, the viscosity of the dentifrice will increase if ordinary carboxymethylcellulose sodium, which has been widely used in calcium-based abrasive toothpastes, is used as a binder. Insufficient coagulation and retention.

Since extrusion properties are poor, it is necessary to use carboxymethyl cellulose sodium with a higher molecular weight, that is, higher viscosity, or to increase the amount of carboxymethyl cellulose sodium to ensure shape retention and extrudability. However, if such a highly viscous material is used or added to the formulation t7, the viscosity of the toothpaste increases, the dispersibility of the toothpaste deteriorates, the feeling of use decreases, and the use of the toothpaste increases due to the strong stringiness. This creates a problem of inferiority.

In view of the above circumstances, the present inventors conducted intensive studies on the effective use of ordinary carboxymethylcellulose alkali metal salts in preparing all toothpaste compositions using non-calcium-based abrasives, and found that non-calcium-based abrasives Adding a water-soluble alkaline earth metal salt such as calcium chloride or magnesium chloride to a dentifrice composition containing all abrasives and carboxymethyl cellulose alkali metal salt binders ensures the shape retention of the dentifrice and also improves its stringability. As well as improving the feeling of use, it has been improved compared to the conventional calcium-based vfM.
The inventors have discovered that carboxymethylcellulose alkali metal salts, which have been used as a binder in toothpaste, can be suitably used, leading to the present invention.

The present invention will be explained in more detail below.

The dentifrice composition of the present invention contains a non-calcium abrasive as an abrasive, a carboxymethyl cellulose alkali metal salt as a binder, and a water-soluble alkaline earth metal salt.

Here, the non-calcium abrasives include titanium oxide,
Alumina, water-use alumina such as aluminum hydroxide, silica-based abrasives, aluminum silicate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, bentonite, zirconium silicate, polymethyl methacrylate, polystyrene, Examples include synthetic resins such as polycarbonate and polyethylene, and one or more of these may be used.

In addition, as a silica-based abrasive, for example, Japanese Patent Application Laid-Open No. 49-9
No. 1994, JP-A-49-94712,! JP-A-50-64198, JP-A-50-65497, JP-A-51-928695, JP-A-51-
Those described in Japanese Patent Publication No. 136841, Japanese Patent Publication No. 54-4919, etc. are used. More specific examples include zeodent■, Zeo■, 5iden
Precipitated silica, silica xerogel, silica aerogel, etc. sold under the trademark t■, which have primary particles of 500 μm or less and secondary particles of 1 to 30 μm, can be used. In this case, precipitated silica is particularly preferably used;
0% or more, preferably 90% or more, alkali/alkaline earth metal oxide content O~5%, binding of metal oxides such as aluminum, magnesium, calcium, etc. to SiO2 1O-10%, preferably 0~5% , adhering moisture content (drying area i#) of 1 to 1°, average particle size of 0.5 to
30 μ, preferably 1 to 15 μ, specific surface area per 12 CBET method) 500 m” or less, more preferably 30
〇- or less, refractive index 1.44-1.47, liquid absorption 1086-
A material having a property of 1.3 CC/r is preferably used. Specifically, Zeo 49, Zeod from Huber, USA
ent 113, 5ylo from Grace, W-R, USA
id A L-1,63,74゜404, UK J,
Neoay by Crossfield & 5ons
lET, 5ident 3 from Degussa, Germany
, 20, etc.

In the present invention, the blending amount of the non-calcium abrasive is 15 to 50% (by weight, the same applies hereinafter) of the entire composition,
In particular, it is preferably 20 to 40%.

Furthermore, the composition of the present invention may optionally contain calcium-based abrasives such as dicalcium phosphate dihydrate and anhydride, dibasic calcium phosphate, dibasic calcium phosphate, calcium carbonate, calcium pyromonoate, and sulfuric acid. There is no problem even if all calcium etc. are combined.

Examples of the carboxymethylcellulose alkali metal salt used as a binder in the present invention include carboxymethylcellulose sodium or potassium, and in this case, the molecule t is 10,000 to 150,000, particularly 30,000 to 80,000.
10,000, the degree of mata etherification is 0.6 to 1.2, especially 0.7 to
It is preferable to use all those with t1.9. According to the present invention, in a dentifrice composition using a non-calcium abrasive,
Using a water-soluble alkaline earth metal ring in combination with a carboxymethyl cellulose alkali metal salt VC improves the shape retention, spinnability, and feel of #I calendar, and makes it a carboxymethyl cellulose alkaline earth metal salt metal with a relatively low molecular weight. can also be used effectively.

The amount of carboxymethyl cellulose alkali metal salt to be blended is preferably 0.5 to 2%, particularly 0.7 to 1.2%, based on the total composition. In addition to dicarboxymethylcellulose alkali metal salts, other binders such as methylcellulose, hydroxyethylcellulose, sodium carboxymethylhydroxyethylcellulose, carrageenan, alkali metal alginates such as sodium alginate, and propylene glycol alginate may be used in the present invention. Gums such as esters, xanthan gum, tragacanth gum, karaya gum, and gum arabic; synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, and polyvinylpyrrolidone; inorganic binders such as silica gel, aluminum silica gel, pea gum, and laponite. It is possible to combine one or more of the following.

In the present invention, a water-soluble alkaline earth metal salt is blended into the dentifrice composition containing the above-mentioned non-calcium abrasive and carboxymethyl cellulose alkali metal salt, which provides suitable shape retention and stringiness. Furthermore, it was possible to obtain a tooth M with good extrudability, excellent usability, and a good feeling of use. In this case, the water-soluble alkaline earth metal salt preferably has a solubility in water of IP/100ω or more, and particularly has a good taste and taste.
From the viewpoint of stability, magnesium salts and calcium salts are preferably used. Magnesium salts include magnesium acetate, magnesium chloride, magnesium potassium chloride,
Examples include magnesium sulfate, and examples of calcium salts include calcium acetate and calcium chloride.

In addition, in the present invention, one of these alkaline earth metal salts
A species may be used alone or two or more species may be used in combination.

The amount of water-soluble alkaline earth metal salt blended is not necessarily limited, but is 0.01 to 5%, particularly 0.1 to 2% of the total composition.
% is preferable. If the amount of alkaline earth metal salt blended is too small, the effect may not be fully exhibited, and if it is too large, a bitter taste may be produced and the feeling of use may be poor.

In the present invention, the effect of adding water-soluble phosphates such as disodium phosphate, sodium phosphate, dipotassium phosphate, etc. in addition to water-soluble alkaline earth metal salts can be further increased, and The use of it can make you feel better. The amount of water-soluble phosphate to be added is preferably 0.01 to 1%, particularly 0.1 to 0.5% of the total composition, and the above effects can be more reliably exhibited within this range. can.

In addition to the above-mentioned components, the dentifrice composition of the present invention may contain other components commonly used in the preparation of dentifrices. For example, as a thickening agent, Nruvit, glycerin,
Ethylene glycol, propylene glycol, J, 3-
One or more types of butylene glycol, polyethylene glycol, polypropylene glycol, xylit, maltite, lufftite, etc. may be blended (the amount of blending is usually 10
~70%), sodium lauryl sulfate, myristyl sulfate), etc., where the alkyl group has 8 to 1 carbon atoms
Water-soluble salts of higher alkyl sulfates such as No. 8, water-soluble higher fatty acid monoglyceride monosulfates such as hydrogenated coconut oil fatty acid monoglyceride sodium monosulfate, alkylaryl sulfonates such as sodium dodecylbenzenesulfonate, higher alkyl sulfonic acids salt, higher fatty acid ester of 1,2-dihydroxypropanesulfonate,
anionic activators such as substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds such as the sodium, potassium or ethanolamine salts of N-lauroyl, N-myristoyl or 1dN-balmitoylsarcosine; sucrose; Sucrose fatty acid esters in which the fatty acid group has 12 to 18 carbon atoms such as mono- and dilaurates, lactose fatty acid esters, lactitol fatty acid esters, maltitol fatty acid esters, stearic acid monoglyceride, polyoxyethylene rubitan monolaurate, polyoxyethylene and polyethylene oxide such as polyoxyethylene (10, 20, 40, 60° 80.100 mol), hydrogenated castor oil, polymers of ethylene oxide and propylene oxide, and polyoxyethylene polyoxypropylene monolauryl ester. One or more surfactants (formulation 1, usually 0
~7%, preferably 0.5-5%). Furthermore, sweeteners (0 to 1 %, preferably from 0.01 to (J, 5%)
, p-hydroxymethylbenzoic acid, p-hydroxyethylbenzoic acid, p-hydroxypropylbenzoic acid, p-hydroxybutylbenzoic acid, sodium benzoate, dehydroacetic acid, potassium sorbate, lower fatty acid monoglyceride, etc. agents, fragrances such as wintergreen oil, spearmint oil, peppermint oil, satsafras oil, clove oil, eucalyptus oil, whitening agents such as gelatin, peptone, arginine hydrochloride, albumin, casein, titanium dioxide, silicones, pigments, etc. For example, in the case of a toothpaste, it can be prepared by mixing the above-mentioned desired ingredients with water.

Furthermore, in the dentifrice composition of the present invention, enzymes such as allantoins, epsilonamitsukagulonic acid, tranexamic acid, textlanase, amylase, protease, mutanase, lysozyme, bacteriolytic enzyme, litetsuque enzyme, sodium monofluorophosphate, monofluorophosphate, etc. Alkali metal monofluorophosphates such as potassium fluorophosphate, sodium fluoride, ammonium fluoride, fluoro(1116)
8 fluoride, chlorhexidine salts, dihydrocholesterol, clycyrrhetinic salts, glycyrrhetinic acid, glycerophosphate, chlorophyll, calopeptide,
Active ingredients such as vitamins, tartar inhibitors, antibacterial agents, and plaque inhibitors may be incorporated.

Next, an experimental example will be shown to specifically explain all the effects of the present invention.

[Experimental Example 1] All suspensions having the following composition were prepared, and were stirred and defoamed in a vacuum to obtain a uniform suspension sample.

After preparation and stabilization for 6 hours, the viscosity of the suspension sample was measured at 25° C. using a BH viscometer. The results are shown in Table 1.

Propylene glycol 3% Sodium carboxymethylcellulose 1.585 Tiglycerin 25 Calcium chloride Ca Ck O~] Disodium phosphate Na2HPO40~1 Precipitated silica (Zeodent 113) 2 (1 purified ice Remaining 1) From the results in Table 1, It has been found that a significant thickening effect can be obtained by adding calcium chloride to a system containing non-calcium abrasive (precipitated silica) and carboxymethylcellulose sodium. By using a small amount of IJium (dissulfate phosphate),
Furthermore, it was found that the thickening effect could be completely improved.

[Example 2] Toothpastes with formulations A to E shown in Table 2 were prepared, and their viscosity was measured in the same manner as in Experimental Example], and the shape retention, stringiness, storage stability, Feeling of use? Sensory evaluation was performed according to the following criteria. The results are also listed in Table 2.

Shape retention ○: It rides well on a toothbrush and does not lose its shape.

△: Slight deformation occurs.

×: The toothbrush flows out.

Thread quality ◎: No stringiness and good kneading.

○: Slight stringiness is observed.

Δ: Stringing was observed, and the finish was slightly poor.

×: Significant stringiness was observed, and the finish was poor.

○: Good condition with no liquid separation or rough skin observed.

△: Slight liquid separation is observed, but the skin is not rough.

×: There is liquid separation and rough skin.

Usability ◯: Good dispersibility, good foaming, and good feel when used.

62 Slightly poor dispersibility and foaming.

×: Poor dispersibility and sticky feel.

Table 2 From the results shown in Table 2, it was found that the addition of calcium chloride can improve the shape retention, threadability, and feel of the toothpaste, resulting in a toothpaste with excellent storage stability.

Note that similar results were obtained when magnesium chloride was used in place of calcium chloride.

Examples are shown below.

[Example 1] Toothpaste precipitated silica 30.0% Propylene glycol 3.0 Glycerin 30.0 Sodium carboxymethylcellulose 1.0 Sodium lauryl sulfate 2.0 Lauric acid diethalamide 0.5 Fragrance 1.0 Calin sodium 0.15 Sodium monofluorophosphate 0.76CaCLm
1.0 Methylparaben 0.05 Purified water Remaining 10.

[Example 2] Toothpaste precipitated silica 25.0% Sodium carboxymethyl cellulose 1.0 Polyethylene glycol 400 3.0 Glycerin 15.0 Lubitol 20.0 Sodium lauryl sulfate 1.5 Lauric acid diethalamide 1.0 Fragrance 1.0 Satucharin sodium 0.1 Sodium monofluorophosphate 0.76CaC2z
],0 NazHP04 0.2 Methylparaben 0.05 100.0% [Example 3] Toothpaste aluminum hydroxide 40.0% Sodium carboxymethyl cellulose 1.0 Carrageenan 0.5 Gelatin 0.5 Propylene gelyl 3.0 Nlubitol 35゜0 Sodium lauryl sulfate 1.5 Lauric acid diethalamide 1.5 Fragrance 1.0 Satucharin sodium U, ] Textlanase 0.5 MgC1z 0.75 Methylparaben 0.05 100.0% [Example 4 ]Toothpaste Aluminum hydroxide 35.0% Titanium dioxide 0.05 Sodium carboxymethyl cellulose 0.75 Sodium alginate 0.5 Polyethylene glycol 400 4.0 Glycerin 2
0.0 Rubitol 15.0 α-olefin (C10,) sulfone) 1.5 Flavor 1.0 Satucharin sodium 0. ] Tranequinic acid sail 1 CaC420.5 Methylparaben 0.1 100.0% [Example 5] Toothpaste precipitated silica ]5.0% Sodium carboxymethyl cellulose ], U Sodium alginate 0.3 Polyethylene glycol 400 5.0 Rubitol
50.0 α-olefin (C,] 4 ) sulfonate 1.5
Lauric acid diethalamide 0.5 Flavoring 1.2 Satucalin sodium 0.07 Tranexamic acid 0. l CaC4z O,5 Mg Ct2 0.5 Na2HPO< 0.3 Methylparaben 0.05 100.0% [Example 6] Toothpaste precipitated silica 5.0% Methyl methacrylate) 15.0 Titanium oxide (1 ,2 Sodium carboxymethyl cellulose 0.75 Carrageenan 0.75 Zoropylene glycol 3.0 Glycerin 15.0 Rubitol J5.0 Sodium lauryl sulfate 1.5 Fragrance 1.2 Sodium satucalin 0.1 CaCt2]-5 Methylparaben 0.05 1U0.0% Examples] - 6 toothpastes all had good shape retention, low stringiness, and excellent storage stability.

Applicant Lion Corporation Agent: Patent attorney Takashi Shima

Claims (1)

[Claims] 1. Totally containing non-calcium abrasive as an abrasive 1-1
A dentifrice composition comprising a water-soluble alkaline earth gold bullion salt added to a dentifrice composition containing all carboxymethyl cellulose alkali metal salts as a binder. 2. The total amount of water-soluble alkaline earth metal salt is 0.
The dentifrice composition according to claim 1, which has a weight ratio of 01 to 5.