JPS6075420A - Dentifrice composition - Google Patents

Abstract

PURPOSE:To obtain a dentifrice composition containing uniformly dispersed titanium dioxide, and having excellent appearance and stability, by using titanium dioxide in combination with a fatty acid ethanolamide. CONSTITUTION:A toothpaste having excellent smooth texture and containing uniformly and homogeneously dispersed titanium dioxide is produced by adding 0.005-1(wt)%, especially 0.01-0.1% titanium dioxide (having an average particle diameter of 0.1-0.5mu, especially 0.2-0.4mu) and 1-500pts.wt., especially 20- 100pts.wt., based on 1pt.wt. of titanium dioxide, of a fatty acid ethanolamide (e.g. lauric acid diethanolamide) to a dentifrice composition containing an abrasive, a binder and a thickener. The composition can be stored for a long period without causing syneresis, and has excellent stability. It may be compounded further with other surface active agent (e.g. water-soluble salt of a higher alkylsulfate).

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a dentifrice composition containing titanium dioxide, and more specifically to a dentifrice composition containing titanium dioxide with good dispersibility and excellent appearance and stability.

(1) It has been known that the whiteness of a dentifrice composition can be increased by adding titanium dioxide to the dentifrice composition. Furthermore, according to the findings of the present inventors, Food Red No. 106, 2
When titanium dioxide is added to a dentifrice composition colored with a light-resistant tar-based pigment such as No. This can effectively prevent the dentifrice composition from changing and discoloring.

However, according to the results of various studies conducted by the present inventors regarding the blending of titanium dioxide into toothbrushing compositions, it is surprisingly difficult to uniformly disperse and blend titanium dioxide into toothbrushing compositions. It has been found that if the dispersion is not sufficient, problems such as the formation of lumps), a decrease in the effect of increasing whiteness, and a decrease in the stability of the toothpaste may occur. In this case, it is possible to improve the dispersion of titanium dimodified to some extent by increasing the stirring efficiency or changing the blending method, but this is not sufficient.

For this reason, the present inventors conducted extensive research into blending titanium dioxide into toothpaste compositions with good dispersibility to improve the appearance and stability of toothpaste compositions. It has been found that the above object can be effectively achieved when blended with the above.

In other words, when titanium dioxide is blended into a toothpaste composition containing an abrasive, a binder, and a thickening agent, when fatty acid ethanolamide is used in combination, the titanium dioxide is reliably dispersed and blended uniformly, resulting in the formation of lumps, etc. It has been found that a toothpaste with a good appearance and a good skin appearance can be obtained, and that this toothpaste does not undergo liquid separation even when stored for a long period of time and has excellent stability. In this case, anionic activators such as sodium lauryl sulfate, sucrose fatty acid esters, lactol fatty acid esters, ? Even if lyoxyethylene fatty acid ester is used, the dispersion effect of titanium dioxide and the stabilizing effect of toothpaste cannot be sufficiently achieved, and fatty acid ethanolamide is extremely effective in achieving the two objects of the present invention. This discovery led to the present invention.

The present invention will be explained in more detail below.

The dentifrice composition of the present invention is made by using titanium dioxide in combination with fatty acid ethanolamide, and the titanium dioxide may be either anatase type or rutile type. Furthermore, titanium dioxide has an average particle size of 0.
, 1 to 0.5 μm, particularly 0.2 to 0.4 μm. By using titanium oxide having an average particle size within this range, dispersibility is more reliably improved. In addition, the amount of titanium dioxide blended is 0.005 to 1 of the total composition.
(% by weight, the same hereinafter), particularly preferably 0.01 to 0.1%.

In addition, fatty acid ethanolamide is a fatty acid whose carbon number is 1.
0 to 18 can be suitably used, and the fatty acid ethanolamide may be monoethanolamide or jetanolamide. Specific examples include lauric acid/jetanolamide, lauric acid monoethanolamide, stearic acid jetanolamide, and oleic acid jetanolamide. Acid jetanolamide is most preferably used.

In this case, the blending amount of fatty acid ethanolamide is 1 to 500 parts by weight, particularly 20 to 1 part by weight, per 1 part by weight of titanium dioxide.
It is preferable to set it as 00 parts by weight.

If the amount of fatty acid ethanolamide blended is too small, its effect will not be sufficiently exhibited, and if it is too large, a bitter taste may be produced and the feeling of use may be poor.

In addition, in the present invention, other surfactants may be blended in addition to fatty acid ethanolamide.

Examples of such surfactants include water-soluble salts of higher alkyl sulfates whose alkyl group has 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate, and hydrogenated coconut oil fatty acid monodaliceride monosodium sulfate. Water-soluble higher fatty acid monoglyceride monosulfates such as
Alkylaryl sulfonates such as sodium dodecylbenzenesulfonate, higher alkyl sulfonates, 1,
Higher fatty acid esters of 2-dihydroxyzolopanesulfonate, N-lauroyl, N-myristoyl (5) and lower aliphatic aminocaldenic acid compounds such as thorium, potassium or ethanolamine salts of 1tN-noyalmitoylsarcosine anionic surfactants such as saturated higher aliphatic acylamides, sucrose fatty acid esters in which the fatty acid group has 12 to 18 carbon atoms such as sucrose mono- and dilaurate, lactose fatty acid esters, lactitol fatty acid esters, maltitol fatty acid esters, Stearic acid monodaliseride, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene (io.

20.40, 60.80, 100 mol) hydrogenated castor oil,
Nonionic surfactants such as polymers of ethylene oxide and propylene oxide and condensation products of polyethylene oxide such as polyoxyethylene polyoxyzolopylene monolauryl ester with fatty acids, fatty alcohols, polyhydric alcohols and hyperpolypropylene oxide, betaine type, Ampholytic active agents such as amino acid types are exemplified;
food or two or more surfactants (compounding amount usually 0 to 7 (6
), preferably 0.5 to 5%).

The dentifrice composition of the present invention further contains various commonly used components.

For example, as abrasives, dibasic calcium phosphate dihydrate and anhydride, dibasic calcium phosphate, dicalcium phosphate, calcium carbonate, -calcium diphosphate, calcium sulfate, alumina, water-containing alumina, precipitated silica, and anhydrous alkali metal silicate Contains one or more of silica-based abrasives such as complex salts, aluminum silicate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, bentonite, zirconium silicate, synthetic resin, etc. (The blending amount is usually 20 to 50 inches, especially 25 to 40 inches).

In this case, in the present invention, it is preferable to use a silica-based abrasive as the abrasive, and by using a silica-based abrasive, agglomeration of titanium oxide particles can be prevented, resulting in better stability.

Here, as the silica-based abrasive, for example, JP-A-49-
91994, JP-A-49-94712, %
Publication No. 50-64198, Japanese Patent Application Publication No. 50-65497
No. 1, JP-A-51-928695, JP-A-51-Sho.
Those described in Japanese Patent Publication No. 136841, Japanese Patent Publication No. 54-4919, etc. are used. For example, z6(+
dHt■.

Precipitated silica, silica xerodal, silica knee, etc. sold under the trademarks Zso■ and 5ldent■, which have primary particles of 500 μm or less and secondary particles of 1 to 30 μm, can be used. In this case, precipitated silica is particularly preferably used, with an S10□ content of 170 s or more, preferably 90 qb or more, an alkali/alkaline earth metal oxide content of 0 to 5%,
5102, the binding amount of oxides of metals such as aluminum, magnesium, calcium, etc. is 0 to 10 cm, preferably 0 to 5 cm, the attached moisture content (loss on drying) is 1 to 10%, and the average particle size is 0.5 to 10%. 30μ, preferably 1 to 15
μ, specific surface area per 1 g (BET method) 500 or less, more preferably 300 m2 or less, refractive index 1.44 to 1.
47, those having properties of liquid absorption of 0.6 to 1.3 ac/f/ are preferably used. Specifically, Ze049, Zeodent l 13 from Huber, USA, W, R from USA
, Grace's 5yLoidAL-1, 63, 74,
404, Neosyl BT% manufactured by J-Croasfield & Song, UK, and S ID 3.20 manufactured by Degussa, Germany.

The dentifrice composition of the present invention also contains carabinan, carabinan, and carabiner as binders. Sodium oxymethylcellulose, methylcellulose, hydroxyethylcellulose, Cal? Sodium dimethylhydroxyethyl cellulose, 4 ittr
Cellulose derivatives such as lk cellulose, alkali metal alginates such as sodium alginate, propylene glycol alginate, xanthan gum, gums such as tiger canth gum, karaya gum, and gum arabic, polyvinyl alcohol, sodium polyacrylate,
Carboxyvinyl polymer, synthetic binders such as polyvinylpyrrolidone, silica dull, aluminum silica gel,
One or more types of inorganic viscosity (9) such as Veegum and Laponite, binders, etc. should be blended in the amount usually 0.5
~5ch), and also sorbitol, glycerin, as a thickening agent.
Ethylene glycol, propylene glycol, 1.3-
One or more types of butylene glycol, polyethylene glycol, polyzolopylene glycol, xylit, maltite, laftite, etc. may be blended (the amount of blending is usually 1
0-75%).

The dentifrice composition of the present invention further includes saccharin sodium,
Stevioside, neohesberidyl dihydrochalcone,
Glycyrrhizin, perilartin, thaumatin, Asuno 9
Sweetening agents (0-1%, preferably 0
, 01 to 0.5%), and further p-hydroxymethyl benzoic acid, p-hydroxyethyl benzoic acid, p-hydroxypropyl benzoic acid, p-hydroxybutyl benzoic acid, sodium benzoate, lower fatty acids as necessary. Preservatives such as monoglyceride, fragrances such as wintergreen oil, spearmint oil, peppermint oil, tussafras oil, clove oil, eucalyptus oil, gelatin, peptone, arginine hydrochloride, albumin, casein, silicone, pigments, etc. In addition, enzymes such as allantoins, epsilon aminocaproic acid, tranexamic acid, dextranase, amylase, protease, mutanase, lysozyme, bath fungus enzyme, and Lytec enzyme, sodium monofluorophosphate, monofluoroline Alkali metal monofluorophosphates such as potassium chloride, fluorides such as sodium fluoride, ammonium fluoride, and stannous fluoride, chlorhexidine salts, dihydrocholesterol, clycyrrhetinic salts, glycyrrhetinic acid, glycerophosphate, chlorophyll, Kalope f made, water-soluble Contains one or two active ingredients such as inorganic phosphoric acid compounds, vitamins, tartar inhibitors, antibacterial agents, and plaque inhibitors.
Two seed plates can be combined.

The dentifrice composition of the present invention can be produced by kneading titanium dioxide, fatty acid ethanolamide, and other necessary ingredients with water, but in this case, it is preferable to add and stir titanium dioxide and fatty acid ethanolamide at the same time. However, fatty acid ethanolamide may be added after titanium dioxide is dispersed.

According to the present invention, by using fatty acid ethanolamide in combination with titanium dioxide, titanium dioxide is evenly dispersed and blended, so that the whitening effect of titanium dioxide or food red No. 106, No. 2, Yellow No. 4, etc. When toothpaste is colored with light-fast tar-based pigments, the effect of improving light resistance is more effectively exhibited.

A dentifrice composition that is colored with such a tar-based pigment and whose light resistance is significantly increased by incorporating titanium dioxide can be suitably stored and used in a container that is at least partially transparent.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

[Experiment example]

A toothpaste having the following formulation was prepared using the surfactant shown in the first coating.

Toothpaste formulation Precipitated silica (Zeo49) 25.0% polyethylene glycol 4.0 Glycerin 24.0 Sorbitto 21.0 Sodium Calgaxymethylcellulose 0.9 Sodium saccharin 0.1 Methyl laben 0.1 Fragrance 1. 〇Titanium dioxide 0.1 Surfactant Amount shown in Table 1 100.0% Next, the dispersibility and stability of these toothpastes were evaluated based on the following evaluation criteria. The results are shown in Table 1.

(1.3) Evaluation Criteria Dispersibility ○: Sufficient dispersion, high whiteness, and good skin.

△: Whiteness is slightly decreased and there are small bumps.

×: Whiteness is low and there are many small bumps.

Stability (after storing the toothpaste at 40°C for 1 month) ○: Good with no liquid separation or rough skin.

Δ: Slight roughness of the skin is observed.

×: Liquid separation and rough skin are observed.

(14) According to the results in Table 1, the toothpaste containing titanium oxide combined with lauric acid jetanolamide has good dispersibility and stability, and has high whiteness, even after being stored at 40°C for one month. It is found that there is no liquid separation or rough skin.

[Example 1] Precipitated silica 25.0% Polyethylene glycol 3.0 Glycerin 24.0 Sorbit 20.0 Sodium carboxymethylcellulose 1.0 Titanium dioxide 0.01 Lauric acid diethanolamide 0.3 Sodium lauryl sulfate 1.5 Tranexam Acid 0.1 Flavor 1.0 Saccharin 0.1 Methylnoya Lapen 0.05 Total 100.0% [Example 2] Aluminum hydroxide 40.0% Polyethylene glycol 2.5 Sorbit 30.0 Sodium alginate 0.6 Dioxide Titanium 0.1 Lauric acid diethanolamide 1.0 Sodium lauryl sulfate 1.5 Dextranase 0.5 Fragrance 1.0 Satucharin 0.1 Methylparaben 0.1 (17) [Example 3] Dibasic calcium phosphate dihydrate Materials 45.0% polyethylene glycol 3.0 Rubit 25.0 Sodium carboxymethyl cellulose 0.8 Titanium dioxide o, i Lauric acid monoethanolamide 0.5 Sodium lauryl sulfate 1.3 Tranexamic acid 0.05 Fragrance 1.0 Saccharin 0 .1 Methylparaben 0.1 (18) [Example 4] Precipitated silica 24.0% Polyethylene glycol 4.0 Glycerin 25.0 Fulvit 23.0 Cal? Sodium oxymethylcellulose 0.9 Titanium dioxide o, i Stearic acid jetanolamide 1.0 Sodium lauryl sulfate 1.3 Fragrance 1.0 Satucharin 0.1 Methylparaben 0.1 Total 100.0% [Example 5] Precipitated silica 24.0% Polyethylene glycol 4.0 Glycerin 25.0 Sorbit 23.0 Sodium carboxymethyl cellulose 1.0 Titanium dioxide 0.02 Oleic acid diethanolamide 1.0 Sodium lauryl sulfate 1.1 Kabetsu 1.0 Satucharin 0.1 Methylparaben 0.1 Total 100.0 (19) [Example 6] Aluminum hydroxide 40.0 Polyethylene glycol 2.5 Sorbit 35. O Cal H? Sodium oxymethylcellulose 0.8 Titanium dioxide 0.1 Lauric acid diethanolamide 1.5 Sodium lauryl sulfate 1.0 Fragrance 1.0 Satucharin 0.1 Methylparaben 0.1 (21) (20) [Example 7] Dibasic calcium phosphate・Dihydrate 40.0% ethylene glycol 2.5 Sorbit 30.0 Caldexymethylcellulose sodium 0.7 Titanium dioxide 0.1 Lauric acid diethanolamide 3.0 Sodium lauryl sulfate 1.0 Fragrance 1.0 Saccharin 0 , 1 methyl no 9 lapen 0.1 (22) The toothpastes of Examples 1 to 7 all had good dispersibility of titanium dioxide, no roughening of the toothpaste, and good stability.

Applicant Lion Corporation Agent: Patent attorney Takashi Kojima (23) -19ri-

Claims (1)

[Claims] 1. A toothpaste composition characterized by using titanium dioxide in combination with fatty acid ethanolamide. 2. The dentifrice composition according to claim 1, wherein the fatty acid ethanolamide is lauric acid jetanolamide. 3. The dentifrice composition according to claim 1 or 2, wherein the blending ratio of titanium dioxide and fatty acid ethanolamide is 1:1 to 500 by weight. 4. The dentifrice composition according to any one of claims 1 to 3, which contains a silica-based abrasive as an abrasive.