JPH0627061B2 - Toothpaste composition - Google Patents

Description

The present invention relates to a dentifrice composition containing titanium dioxide, and more specifically to a dentifrice composition containing titanium dioxide with good dispersibility and having excellent appearance and stability.

Conventionally, by adding titanium dioxide to a dentifrice composition,
It is known to increase the whiteness of dentifrice compositions. According to the knowledge of the present inventors, food red No. 106, 2
When titanium dioxide is added to a dentifrice composition colored with a light-resistant tar dye such as No. 4, Yellow No. 4 or the like, the light resistance is remarkably enhanced, and therefore, even if the dentifrice composition is housed in a transparent container, it does not absorb ultraviolet light. The discoloration of the dentifrice composition can be effectively prevented.

However, according to the results of various studies conducted by the present inventors on the incorporation of titanium dioxide into a dentifrice composition, it is surprisingly difficult to uniformly disperse and blend titanium dioxide in the dentifrice composition, and titanium dioxide It has been found that if the dispersion is not sufficient, problems such as the occurrence of lumps, a decrease in the effect of increasing the whiteness, and a decrease in the stability of toothpaste will occur. In this case, the dispersion of titanium dioxide can be increased to some extent by increasing the stirring efficiency or changing the blending method, but this is not sufficient.

For this reason, the present inventors have conducted intensive studies to improve the appearance and stability of the dentifrice composition by adding titanium dioxide to the dentifrice composition with good dispersibility, and as a result, added lauric acid diethanolamide. In that case, it has been found that the above objective is effectively achieved.

That is, when blending titanium dioxide into a dentifrice composition containing an abrasive, an adhesive, and a thickener, when fatty acid ethanolamide is used together, titanium dioxide is surely dispersed and uniformly blended, and skin without bumps etc. It has been found that a toothpaste having an excellent appearance can be obtained, and that this toothpaste is excellent in stability because liquid separation does not occur even after long-term storage. In this case, even if an anion activator such as sodium lauryl sulfate, a sucrose fatty acid ester, a lactol fatty acid ester, or a polyoxyethylene fatty acid ester is used, such a titanium dioxide dispersion effect and a toothpaste stabilization effect are not sufficiently achieved, The present inventors have found that lauric acid diethanolamide is extremely effective for achieving the above-mentioned object of the present invention, and have completed the present invention.

Hereinafter, the present invention will be described in more detail.

The dentifrice composition of the present invention comprises titanium dioxide in combination with lauric acid diethanolamide, and titanium dioxide may be either anatase type or rutile type. Further, it is preferable to use titanium dioxide having an average particle diameter of 0.1 to 0.5 μ, particularly 0.2 to 0.4 μ, and by using titanium oxide having an average particle diameter within this range, The reliability is improved more reliably. The amount of titanium dioxide added was 0.0
05-1% (wt%, the same applies hereinafter), especially 0.01-0.
It is preferably set to 1%.

In this case, the compounding amount of lauric acid diethanolamide is
1 to 500 parts by weight, especially 2
It is preferably from 0 to 100 parts by weight. If the amount of the fatty acid ethanolamide is too small, the effect will not be sufficiently exhibited, and if it is too large, bitterness may occur and the usability may deteriorate.

In the present invention, other surfactant may be added in addition to lauric acid diethanolamide.

Examples of such a surfactant include water-soluble salts of higher alkyl sulfates having an alkyl group with 8 to 18 carbon atoms such as sodium lauryl sulfate and sodium myristyl sulfate, and water-soluble salts of hydrogenated coconut oil fatty acid monoglyceride monosulfate monosulfate. Higher fatty acid monoglyceride monosulfate, alkylaryl sulfonate such as sodium dodecylbenzene sulfonate, higher alkyl sulfonate,
Higher fatty acid ester of 1,2-dihydroxypropane sulfonate, N-lauroyl, N-myristoyl or N-
Anionic activators such as substantially saturated higher aliphatic acylamides of lower aliphatic aminocarboxylic acid compounds such as sodium, potassium or ethanolamine salts of palmitoylsarcosine, and fatty acid groups such as sucrose mono- and dilaurates having 12 carbon atoms. ~ 18 sucrose sugar fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene (10, 20, 40, 60, 8
(0,100 mol) hydrogenated castor oil, polymers of ethylene oxide and propylene oxide, and condensation products of polyethylene oxide such as polyoxyethylene polyoxypropylene monolauryl ester with fatty acids, fatty alcohols, polyhydric alcohols and polypropylene oxide. Nonionic active agents, amphoteric active agents such as betaine type and amino acid type are exemplified, and one or more kinds of these surfactants (combined both usually 0 to 7%, preferably 0.5 to 5).
%).

The dentifrice composition of the present invention further contains various commonly used components.

For example, as a polishing agent, dicalcium phosphate dihydrate and anhydride, monocalcium phosphate, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, calcium sulfate, alumina, hydrated alumina, precipitated silica and anhydrous alkali metal silicate. Compound one or more of silica-based abrasives such as complex salts, aluminum silicate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, magnesium triphosphate, magnesium carbonate, bentonite, zirconium silicate, synthetic resin, etc. To obtain (usually 20 to 50%, especially 25 to 40%).

In this case, in the present invention, it is preferable to use a silica-based abrasive as the abrasive, and by using the silica-based abrasive, the titanium dioxide particles are prevented from aggregating and the stability becomes better.

Here, as the silica-based abrasive, for example, JP-A-49-
91994, JP 49-94712, JP 50-641
98, JP-A-50-65497, JP-A-51-928
Those described in Japanese Patent No. 695, Japanese Patent Application Laid-Open No. 51-136841, Japanese Patent Publication No. 54-4919 and the like are used. For example, precipitable silica, silica xerogel, silica aerogel, etc., which are sold under the trade names of Zeodent, Zeo, and Sident, whose single particles are 500 mμ or less and whose secondary particles are 1 to 30 μm can be used. In this case, precipitable silica is particularly preferably used, having a SiO ₂ content of 70% or more, preferably 90% or more, an alkali or alkaline earth metal oxide content of 0 to 5%,
The amount of binding of oxides of metals such as aluminum, magnesium and calcium to SiO ₂ is 0 to 10%, preferably 0 to
5%, attached water content (loss on drying) of 1-10%,
Average particle size 0.5 to 30 μ, more preferably 1 to 15 μ,
A material having a specific surface area per 1 g (BET method) of 500 m ² or less, more preferably 300 m ² or less, a refractive index of 1.44 to 1.47 and a liquid absorption amount of 0.6 to 1.3 cc / g is preferably used. . Specifically, Zeo49, Zeodent1 from Huber, USA
13. Syloid AL-1, 63, 74, 4 from WRGrace, USA
04, Neosy1ET of J. Crossfield & Sons, UK, De, Germany
Examples include Sident 3, 20 manufactured by gussa.

Further, in the dentifrice composition of the present invention, carrageenan as a binder, sodium carboxymethyl cellulose, methyl cellulose, hydroxyethyl cellulose, carboxymethyl hydroxyethyl cellulose sodium, cellulose derivatives such as cellulose sulfate, alkali metal alginates such as sodium alginate, and propylene glycol alginate. , Gums such as xanthan gum, tragacanth gum, karaya gum, and gum arabic, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, synthetic binders such as polyvinylpyrrolidone, silica gel, aluminum silica gel, bee gum, inorganic binders such as laponite, etc. 1 type or 2 types or more (the compounding amount is usually 0.5 to 5%), and sorbit and glyce are further used as a viscous agent. Emissions, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, one or may be incorporated two or more (amount usually from 10 to 75%) such as Rakuchitto.

The dentifrice composition of the present invention further comprises saccharin sodium,
Stevioside, neohesperidyl dihydrochalcone,
Glycyrrhizin, perillartine, thaumatin, asparatyl phenylalanine methyl ester, p-methoxycinnamic aldehyde, sucrose, lactose, fructose, sweeteners such as sodium cyclamate (0 to 1%, preferably 0.01 to 0.5%) If necessary, preservatives such as p-hydroxymethyl benzoic acid, p-hydroxyethyl benzoic acid, p-hydroxypropyl benzoic acid, p-hydroxybutyl benzoic acid, sodium benzoate, and lower fatty acid monoglyceride, winter green Oils, spearmint oil, peppermint oil, sassafras oil, clove oil, eucalyptus oil, and other flavors, gelatin, peptone, arginine hydrochloride, albumin, casein, silicone, pigments, and other ingredients may be added. Allantoins, epsilon aminocaproic acid, tranexamic acid, dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme, enzymes such as litec enzyme, sodium monofluorophosphate, potassium monofluorophosphate, alkali metal monofluorophosphate, fluorine Sodium iodide,
Ammonium fluoride, fluorides such as stannous fluoride, chlorhexidine salts, dihydrocholesterol, glycyrrhetinic salts, glycyrrhetinic acid, glycerophosphate, chlorophyll, caropeptide, water-soluble inorganic phosphate compounds, vitamins, anticalculus agents, antibacterial agents, One or more active ingredients such as a plaque inhibitor may be blended.

The dentifrice composition of the present invention can be produced by kneading titanium dioxide, lauric acid diethanolamide and other necessary ingredients with water. In this case, titanium dioxide and lauric acid diethanolamide should be charged and stirred at the same time. However, lauric acid diethanolamide may be added after the titanium dioxide is dispersed.

According to the present invention, titanium dioxide is evenly dispersed and blended by using lauric acid diethanolamide in combination with titanium dioxide. Therefore, the whitening effect of titanium dioxide or food red No. 106, red No. 2, yellow No. 4, etc. When the toothpaste is colored with the lightfast tar-based dye, the lightfastness improving effect and the like are more effectively exhibited.

A toothpaste having the following formulation using the surfactant shown in Table 1 was prepared.

Next, the dispersibility and stability of these toothpastes were evaluated based on the following evaluation criteria. The results are shown in Table 1.

Evaluation Criteria Dispersibility ◯: Well dispersed, whiteness is high, and skin is good.

Δ: The whiteness is slightly reduced, and there are small bumps.

X: The whiteness is reduced and many small lumps are present.

Stability (after storing toothpaste at 40 ° C. for 1 month) ◯: Good with no liquid separation or rough skin.

Δ: Roughness of liquid separation is observed.

X: Liquid separation and rough skin are observed.

From the results in Table 1, toothpaste containing titanium dioxide mixed with lauric acid diethanolamide has good dispersibility and stability, high whiteness, and liquid separation and rough skin even after storage at 40 ° C for 1 month. It is found that there is no.

[Example 1] [Example 2] [Example 3] [Example 4] Each of the toothpastes of Examples 1 to 4 had good dispersibility of titanium dioxide, no rough skin of the toothpaste, and good stability.

Continuation of the front page (56) Reference JP 58-118506 (JP, A) JP 58-118507 (JP, A) JP 56-39008 (JP, A) JP 56-95110 (JP , A) Japanese Patent Publication No. 52-24106 (JP, B2)

Claims (3)

[Claims] 1. A dentifrice composition comprising a dentifrice composition containing titanium dioxide and lauric acid diethanolamide as a dispersion stabilizer of the titanium dioxide. 2. The dentifrice composition according to claim 1, wherein the mixing ratio of titanium dioxide and lauric acid diethanolamide is 1: 1 to 500 by weight. 3. The dentifrice composition according to claim 1 or 2, which contains a silica-based abrasive as an abrasive.