JPS6063061A - Production of body fluid treating device - Google Patents
Production of body fluid treating deviceInfo
- Publication number
- JPS6063061A JPS6063061A JP10474784A JP10474784A JPS6063061A JP S6063061 A JPS6063061 A JP S6063061A JP 10474784 A JP10474784 A JP 10474784A JP 10474784 A JP10474784 A JP 10474784A JP S6063061 A JPS6063061 A JP S6063061A
- Authority
- JP
- Japan
- Prior art keywords
- hollow fiber
- body fluid
- production
- fiber bundle
- treating device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001124 body fluid Anatomy 0.000 title claims description 9
- 239000010839 body fluid Substances 0.000 title claims description 9
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 239000012510 hollow fiber Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 239000000243 solution Substances 0.000 description 6
- 239000000306 component Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 239000005022 packaging material Substances 0.000 description 3
- 239000002504 physiological saline solution Chemical group 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000000834 fixative Substances 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
本発明は体液処理器の製造方法に係り、特にこれまで特
に難しいとされてきたポリプロピレン中空＃ｌｌ維膜を
用いた体液処理器のオートクレーブ滅菌を支障なく行な
えるようにしたものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for manufacturing a body fluid treatment device, and in particular to a method for manufacturing a body fluid treatment device, in which autoclave sterilization of a body fluid treatment device using polypropylene hollow #ll membrane, which has been considered particularly difficult, can be carried out without any problems. This is what I did.
従来より、ポリプロピレン（以下ｐ、ｐと略す）の中空
繊維）１りを利用して血液を血漿成分と血球成分とに分
離するだめの血漿分離器が知られている。2. Description of the Related Art Conventionally, a plasma separator has been known that separates blood into plasma components and blood cell components using a single hollow fiber of polypropylene (hereinafter abbreviated as P, P).
しかし、このＰ、Ｐ中空繊維は疎水性であり、しかも湿
度を伴なった加熱では２〜６％収縮するという性質があ
る。このため、中空繊維束ヲそのままハウジングに入れ
、繊維固定剤で両端を固定し、オートクレーブ滅菌する
と、中空繊維が収縮して繊維の孔径が部分的に大きくな
り、血液成分が血漿成分側へ流出して血漿分離器として
の機能を果さなくなる。However, this P, P hollow fiber is hydrophobic and has the property of shrinking by 2 to 6% when heated with humidity. For this reason, if the hollow fiber bundle is placed in a housing as it is, fixed at both ends with a fiber fixative, and sterilized in an autoclave, the hollow fibers will shrink and the pore diameter of the fibers will partially increase, causing blood components to flow out to the plasma component side. It will no longer function as a plasma separator.
本発明はこのような現状に鑑みて提案されたものであり
、加熱に対して収縮性のある中空繊維束を用いた体液処
理器を製造するにあたって、従来困難もしくは不ロｆ能
とされていたオートクレーブ滅菌が支障なく行なえるよ
うな方法を提供しようとするものである。The present invention was proposed in view of the current situation, and it has conventionally been considered difficult or impossible to manufacture a body fluid treatment device using a hollow fiber bundle that shrinks when heated. The purpose is to provide a method that allows autoclave sterilization to be performed without any problems.
以下、本発明の具体的実施例につきＰ６Ｐ中空繊維膜を
用いた血漿分離器を製造する場合を例にとって説明する
。Hereinafter, a specific embodiment of the present invention will be described, taking as an example a case in which a plasma separator using a P6P hollow fiber membrane is manufactured.
まず、Ｐ、Ｐ中空ｍ維膜を通気性のある包装材で覆う。First, the P and P hollow fiber membranes are covered with an air-permeable packaging material.
この包装材はたとえば湿気を容易に通す紙などが用いら
れる。この包装材はあらかじめ袋状にしておくと便利で
ある。The packaging material used is, for example, paper that allows moisture to pass through easily. It is convenient to make this packaging material into a bag shape in advance.
次に、包装したＰ、Ｐ中空繊維膜を湿度２０％〜７０％
、温度５０℃〜１３０°Ｃの条件下で加熱処理を行なう
。この加熱処理はＰ、Ｐ中空繊維膜を約２％〜６％収縮
させるための前工程であり、前記処理条件はこの収縮率
を得るために適した条件である。Next, the packaged P, P hollow fiber membrane was heated at a humidity of 20% to 70%.
, heat treatment is performed at a temperature of 50°C to 130°C. This heat treatment is a preliminary step for shrinking the P,P hollow fiber membrane by about 2% to 6%, and the treatment conditions described above are conditions suitable for obtaining this shrinkage rate.
こうしたＰ、Ｐ中空繊維膜束は、次いで血液、出口、血
漿出１」を有するハウジング内に収納され、ポリウレタ
ン等の固定剤により、通常の方法でＰ、Ｐ中空繊維膜束
の両端部が同ハウジング内に固定される。These P, P hollow fiber membrane bundles are then housed in a housing having blood, outlet and plasma outlets, and both ends of the P, P hollow fiber membrane bundles are fixed in the same manner using a fixative such as polyurethane in a conventional manner. fixed within the housing.
その後、前記ハウジング内に血漿出口等からエタノール
液を充填し、Ｐ、Ｐ中空繊維膜にエタノール液を含浸さ
せた後、蒸留水または生理食塩水で置換する。この蒸留
水または生理食塩水はエタノール溶液と相溶性が良いた
め、Ｐ。Thereafter, an ethanol solution is filled into the housing from the plasma outlet or the like to impregnate the P and P hollow fiber membranes with the ethanol solution, and then replaced with distilled water or physiological saline. This distilled water or physiological saline has good compatibility with the ethanol solution, so P.
Ｐ中空繊維膜に含浸したエタノール溶液に溶は込み、結
果的に中空繊維膜を親水化させる。It is dissolved in the ethanol solution impregnated into the P hollow fiber membrane, thereby making the hollow fiber membrane hydrophilic.
なお、本発明ではエタノール溶液に代えて他の親水性溶
液を用いてもよい。Note that in the present invention, other hydrophilic solutions may be used instead of the ethanol solution.
こうして後、ハウジング内に蒸留水、生理食塩水等の充
填液を充填し、８０°Ｃ〜１３０°Ｃの範囲の温度でオ
ートクレーブ滅菌を行なうものである。Thereafter, the housing is filled with a filling liquid such as distilled water or physiological saline, and sterilized in an autoclave at a temperature in the range of 80°C to 130°C.
上記した実施例は、中空繊維束としてＰ、Ｐ中空繊維束
を例にとって説明したが、本発明は、これ以外にも加熱
に対して収縮性のある合成膜を用いた体液処理器にも適
用することができる。The above-mentioned embodiments have been explained using P and P hollow fiber bundles as examples of the hollow fiber bundles, but the present invention is also applicable to body fluid treatment devices using synthetic membranes that are shrinkable when heated. can do.
以上説明した本発明によれば、体液処理器の処理１模と
してＰ、Ｐ中空ｍ維ＩＩり等加熱に対して収縮性のある
中空繊維膜を使用した場合において、従来不可能もしく
は困難とされてきたオートクレーブの前にあらかじめＰ
、Ｐ中空糸繊維膜束を収縮させておくため、オートクレ
ーブ滅菌を行なっても膜の孔径は所定の大きさに保持さ
せておくことができる、なとの効果が得られる。According to the present invention as described above, when a hollow fiber membrane having shrinkage property when heated, such as P or P hollow m fiber II, is used as a first model of treatment in a body fluid treatment device, it is possible to perform a treatment that was conventionally impossible or difficult. P in advance before the autoclave
Since the P hollow fiber membrane bundle is contracted, the pore diameter of the membrane can be maintained at a predetermined size even after autoclave sterilization.
Claims (1)
器の製造方法であって、前記中空繊維束をあらかじめ湿
度を伴なった雰囲気中で加熱した後、該中空繊維束をハ
ウジング内に収納して中空繊維束の端部を固定剤により
固定することを特徴とする体液処理器の製造方法。A method for manufacturing a body fluid treatment device using a hollow fiber bundle that is shrinkable when heated, the method comprising heating the hollow fiber bundle in advance in an atmosphere with humidity, and then placing the hollow fiber bundle in a housing. A method for manufacturing a body fluid treatment device, which comprises storing the hollow fiber bundle and fixing the ends of the hollow fiber bundle with a fixing agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10474784A JPS6063061A (en) | 1984-05-25 | 1984-05-25 | Production of body fluid treating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10474784A JPS6063061A (en) | 1984-05-25 | 1984-05-25 | Production of body fluid treating device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6063061A true JPS6063061A (en) | 1985-04-11 |
| JPH0362431B2 JPH0362431B2 (en) | 1991-09-25 |
Family
ID=14389083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10474784A Granted JPS6063061A (en) | 1984-05-25 | 1984-05-25 | Production of body fluid treating device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6063061A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010090174A1 (en) | 2009-02-04 | 2010-08-12 | 東洋紡績株式会社 | Hollow-fiber membrane, process for producing same, and blood purification module |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6063062A (en) * | 1983-05-13 | 1985-04-11 | 川澄化学工業株式会社 | Production of body fluid treating device |
-
1984
- 1984-05-25 JP JP10474784A patent/JPS6063061A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6063062A (en) * | 1983-05-13 | 1985-04-11 | 川澄化学工業株式会社 | Production of body fluid treating device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0362431B2 (en) | 1991-09-25 |
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