JPS60502100A - 黄体活性を示すステロイド - Google Patents
黄体活性を示すステロイドInfo
- Publication number
- JPS60502100A JPS60502100A JP59502899A JP50289984A JPS60502100A JP S60502100 A JPS60502100 A JP S60502100A JP 59502899 A JP59502899 A JP 59502899A JP 50289984 A JP50289984 A JP 50289984A JP S60502100 A JPS60502100 A JP S60502100A
- Authority
- JP
- Japan
- Prior art keywords
- steroid
- methyl
- group
- ethynyl
- dione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 238000000034 method Methods 0.000 claims description 50
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- 239000000203 mixture Substances 0.000 claims description 22
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
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- -1 1-cyclopentylcarbonyl Chemical group 0.000 claims description 13
- 229940011871 estrogen Drugs 0.000 claims description 12
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
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- 239000005556 hormone Substances 0.000 claims description 8
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 6
- 230000003054 hormonal effect Effects 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 5
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- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
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- 239000000186 progesterone Substances 0.000 description 47
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- 239000001257 hydrogen Substances 0.000 description 5
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- YYFLOYVXFFHZAY-UHFFFAOYSA-L O[Cr](O)(=O)=O.C1=CC=NC=C1.C1=CC=NC=C1.C1=CC=NC=C1.Cl Chemical compound O[Cr](O)(=O)=O.C1=CC=NC=C1.C1=CC=NC=C1.C1=CC=NC=C1.Cl YYFLOYVXFFHZAY-UHFFFAOYSA-L 0.000 description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
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- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 4
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- QUZMIAJIRIZFQN-UHFFFAOYSA-N (e)-diazo(dimethoxyphosphoryl)methane Chemical compound COP(=O)(OC)C=[N+]=[N-] QUZMIAJIRIZFQN-UHFFFAOYSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Electroluminescent Light Sources (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US517457 | 1983-07-26 | ||
| US06/517,457 US4512986A (en) | 1983-07-26 | 1983-07-26 | Progrestationally active steroids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60502100A true JPS60502100A (ja) | 1985-12-05 |
| JPH0469639B2 JPH0469639B2 (enExample) | 1992-11-06 |
Family
ID=24059873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59502899A Granted JPS60502100A (ja) | 1983-07-26 | 1984-07-26 | 黄体活性を示すステロイド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4512986A (enExample) |
| EP (1) | EP0152429B1 (enExample) |
| JP (1) | JPS60502100A (enExample) |
| AU (1) | AU583476B2 (enExample) |
| DE (1) | DE3480094D1 (enExample) |
| WO (1) | WO1985000609A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010529174A (ja) * | 2007-06-12 | 2010-08-26 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | １７β−シアノ−１９−アンドロスト−４−エン誘導体、その使用、及び前記誘導体を含んで成る薬剤 |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8517360D0 (en) * | 1985-07-09 | 1985-08-14 | Erba Farmitalia | Substituted androsta-1,4-diene-3,17-diones |
| US4963540A (en) * | 1986-04-16 | 1990-10-16 | Maxson Wayne S | Method for treatment of premenstrual syndrome |
| GB8801697D0 (en) * | 1988-01-26 | 1988-02-24 | Erba Farmitalia | Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione |
| FR2679236B1 (fr) * | 1991-07-18 | 1997-01-24 | Theramex | Nouveaux sterouides substitues en position 6, leurs procedes d'obtention et des compositions pharmaceutiques en renfermant. |
| US5661141A (en) * | 1995-03-27 | 1997-08-26 | Petrow; Vladimir | 19-oxygenated steroids as therapeutic agents |
| US6020328A (en) | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
| ATE473759T1 (de) | 1998-05-22 | 2010-07-15 | Univ Leland Stanford Junior | Bifunktionelle moleküle sowie darauf basierende therapien. |
| US6667050B1 (en) | 1999-04-06 | 2003-12-23 | Galen (Chemicals) Limited | Chewable oral contraceptive |
| US7459445B2 (en) * | 2000-03-10 | 2008-12-02 | Duramed Pharmaceuticals, Inc. | Estrogenic compounds and topical pharmaceutical formulations of the same |
| US6660726B2 (en) * | 2000-03-10 | 2003-12-09 | Endeavor Pharmaceuticals | Estrogenic compounds, pharmaceutical compositions thereof, and methods of using same |
| US6855703B1 (en) | 2000-03-10 | 2005-02-15 | Endeavor Pharmaceuticals | Pharmaceutical compositions of conjugated estrogens and methods of analyzing mixtures containing estrogenic compounds |
| US7989436B2 (en) | 2003-07-23 | 2011-08-02 | Duramed Pharmaceuticals, Inc. | Estrogenic compounds and pharmaceutical formulations comprising the same |
| MXPA05002561A (es) * | 2002-10-25 | 2005-05-05 | Pfizer Prod Inc | Nuevas formulaciones de liberacion prolongada inyectables. |
| US6992075B2 (en) * | 2003-04-04 | 2006-01-31 | Barr Laboratories, Inc. | C(14) estrogenic compounds |
| WO2004091535A2 (en) * | 2003-04-11 | 2004-10-28 | Barr Laboratories, Inc. | Methods of administering estrogens and progestins |
| US7556150B2 (en) * | 2004-06-07 | 2009-07-07 | Duramed Pharmaceuticals, Inc. | Dispenser for progestin used for acute and maintenance treatment of DUB |
| EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
| US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
| DE102007027637A1 (de) * | 2007-06-12 | 2008-12-18 | Bayer Schering Pharma Aktiengesellschaft | 17ß-Cyano-19-nor-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel |
| DK3395372T3 (da) | 2009-02-20 | 2022-04-19 | Enhanx Biopharm Inc | System til afgivelse af glutathion-baseret medikament |
| CN110075069A (zh) | 2009-05-06 | 2019-08-02 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用 |
| RU2649757C1 (ru) * | 2016-12-16 | 2018-04-04 | Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" | Пероральная форма бигормональной композиции для регуляции половой охоты у мелких домашних животных (варианты) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4002746A (en) * | 1959-09-25 | 1977-01-11 | Herchel Smith | Synthesis of gon-4-enes |
| US3361744A (en) * | 1962-07-18 | 1968-01-02 | American Cyanamid Co | Novel 17-hydrocarbon substituted progesterones, intermediates and methods of preparing the same |
| US3846456A (en) * | 1965-04-07 | 1974-11-05 | Upjohn Co | Organic compounds |
| GB1159434A (en) * | 1965-08-16 | 1969-07-23 | Glaxo Lab Ltd | 11beta&;-Fluoro-19-nor-Steroids |
| GB1235285A (en) * | 1967-07-28 | 1971-06-09 | Organon Labor Ltd | Substituted methylene steroids and their preparation |
| US3705179A (en) * | 1971-03-15 | 1972-12-05 | American Home Prod | Antiandrogenic steroids |
| US4239681A (en) * | 1974-04-15 | 1980-12-16 | Richardson-Merrell Inc. | Androst-4-en-19-ols |
| US4139617A (en) * | 1974-05-13 | 1979-02-13 | Richardson-Merrell Inc. | 19-Oxygenated-androst-5-enes for the enhancement of libido |
| GB1527161A (en) * | 1976-02-19 | 1978-10-04 | Leo A | Enol esters of steroids |
| DE2645104C2 (de) * | 1976-10-04 | 1986-04-24 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11β-Hydroxy-1,4,8-pregnatrien-3,20-dion-Derivate und Verfahren zu ihrer Herstellung |
| US4278668A (en) * | 1977-11-25 | 1981-07-14 | Nicolas Gueritee | Pure 17 alpha-ethynyl(5 alpha), androst-2-ene,17 beta-cl, process for its preparation and therapeutical applications of the same |
| US4265815A (en) * | 1980-03-31 | 1981-05-05 | E. R. Squibb & Sons, Inc. | 17-(Substituted thio)androst-4-ene[16,17,-b]-[1,4]benzodioxin-3-ones |
-
1983
- 1983-07-26 US US06/517,457 patent/US4512986A/en not_active Expired - Lifetime
-
1984
- 1984-07-26 EP EP84903014A patent/EP0152429B1/en not_active Expired
- 1984-07-26 WO PCT/US1984/001173 patent/WO1985000609A1/en not_active Ceased
- 1984-07-26 AU AU31582/84A patent/AU583476B2/en not_active Ceased
- 1984-07-26 DE DE8484903014T patent/DE3480094D1/de not_active Expired
- 1984-07-26 JP JP59502899A patent/JPS60502100A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010529174A (ja) * | 2007-06-12 | 2010-08-26 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | １７β−シアノ−１９−アンドロスト−４−エン誘導体、その使用、及び前記誘導体を含んで成る薬剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU583476B2 (en) | 1989-05-04 |
| US4512986A (en) | 1985-04-23 |
| DE3480094D1 (en) | 1989-11-16 |
| EP0152429A1 (en) | 1985-08-28 |
| JPH0469639B2 (enExample) | 1992-11-06 |
| WO1985000609A1 (en) | 1985-02-14 |
| EP0152429A4 (en) | 1985-12-05 |
| AU3158284A (en) | 1985-03-04 |
| EP0152429B1 (en) | 1989-10-11 |
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