JPS6024422B2 - Automatic sample analyzer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an automatic sample analyzer such as an automatic urine test apparatus.

Conventionally, this type of automatic sample analyzer collects a sample from a sample container with a syringe, drops the sample onto a test paper pre-soaked with a reagent, and performs a color reaction between specific components of the sample and the reagent. This is then irradiated with light of a specific wavelength, and the amount of reflected light is detected as an electrical amount by a photoelectric conversion element.

However, when dropping the above sample onto the test paper, if the absolute amount of the sample is insufficient, the viscosity of the sample is high, or the syringe itself is broken and the sample cannot be collected, the required amount may be dropped onto the test paper. The amount of specimen was not dropped, and therefore the color reaction described above was not performed satisfactorily. For example, a test result that should be positive may be incorrectly determined to be negative due to insufficient magenta reaction. The present invention eliminates the above-mentioned drawbacks of the conventional type, and will be described below based on an embodiment shown in the drawings.

Reference numeral 1 denotes a light source made of a light emitting diode or the like, and the light from this light source is irradiated onto the test paper A, and the reflected light is received by a photoelectric conversion section 2 including a photoelectric conversion element such as a phototransistor and converted into an electrical signal. Configure it as follows.

An A/D conversion circuit 3 is connected to the output side of the photoelectric conversion section 2 in order to convert the input analog signal into a required digital signal, and one output side of this A/D conversion circuit 3 is connected to a storage device 4. , the other output side is connected to an arithmetic circuit 5 for performing logical operations with the output of the storage device 4, and the output side of this arithmetic circuit 5 is connected to the output side of the above-mentioned sample, for example, to obtain a required measurement result. A setting circuit 6 that determines a criterion for determining the quantitative suitability of dropping, and a judgment circuit 7 that compares and judges the signal from the arithmetic circuit 5 and the reference value from the setting circuit 6 are provided. A display section 8 such as a pudding display device is provided. next,
The operation of the above embodiment will be explained.

First, on the test paper A, place the test area B onto which the sample has been dropped.
In addition to this, a sample-free area C is formed in which no sample is dropped at all. This test paper A is transported directly below the photoelectric conversion section 2 by a feeding device (not shown), and first, only the non-sample area C of the test paper A, that is, the color tone of the test paper A is measured. This measured value is converted into a digital signal by the A/○ conversion circuit 3 and recorded in the storage circuit 4 as a base value for measurement. Note that the storage circuit 4 is controlled so that only the data value of the non-analyte portion C, that is, the base value is recorded. Next, the color tone of the test area B of the test paper A is measured and similarly converted into a digital signal by the A/D converter circuit 3, and then is stored together with the data of the non-sample area C recorded in the storage circuit 4. The signal is introduced into the arithmetic circuit 5 and subjected to arithmetic processing.

This calculation process, for example, subtracts the measured value of the inspection point B from the data value of the non-analyte section C, divides this subtracted value by the data value of the no-analyte section C, and divides the result into the measurement value of the inspection point B. It is applied to the determination circuit 7 as a required data value. On the other hand, the setting circuit 6 records setting values for determining the appropriateness of the amount of sample to be dropped, and the judgment circuit 7 compares and calculates the data value of the inspection point B with the setting value to determine the required amount. A determination is made and the result is sent to the display section 8 and displayed. In this judgment circuit 7, it is judged whether or not the amount of the specimen to be dropped onto the test paper is appropriate. ,
The rate of change in the data value of the measured value changes at a rate of 15% or more, assuming that the data value of the non-sample area C is 100%.

Therefore, the rate of change of the measured value at the inspection point B is the non-analyte section C.
Since the data value changes only at a rate of 7 to 8%, assuming that the data value is 100%, it should be determined that the amount of sample dropped is insufficient.The required setting value is set in the setting circuit 6. In this case, even if the amount of sample dropped on the test paper is insufficient, or even if the sample is not dropped at all, it is determined that the amount of sample dropped is insufficient and is processed. This is especially true in urine tests, etc., where the purpose is to detect the enteric nature of the specimen using a color reaction, so when there is no specimen dripping or the amount of specimen dripped is small, changes in the reflected light from the specimen may occur. The rate of change in the G rate of the reflected light is smaller than that of the reflected light from the non-sample area C, and as a result, it is determined to be negative, so in order to perform the test accurately, the G rate of the reflected light must be less than the set value. If the measured value becomes 100%, it will be treated as an insufficient amount of sample dropped, and a retest will be performed. As explained above, when measuring a required specimen, the present invention determines whether the measurement data of the specimen is equal to or higher than a reference value, and if it is equal to or lower than the reference value, the amount of the specimen dropped is insufficient. Although it is processed as
This makes it possible to eliminate erroneous test results due to an insufficient amount of sample to be dropped, thereby increasing the reliability of the test.

[Brief explanation of the drawing]

FIG. 1 is a block diagram of essential parts of an embodiment of an automatic sample analyzer according to the present invention, and FIG. 2 is a plan view of a test strip. In the figure, 1 is a light source, 2 is a photoelectric conversion section, 3 is an A/D conversion circuit, 4 is a storage circuit, 5 is an arithmetic circuit, a shading setting circuit, 7 is a determination circuit, and 8 is a display section. Figure 1 Figure 2

Claims (1)

[Claims] 1. In an automatic sample analyzer that collects a sample from a container, drops the sample onto a test paper, causes a color reaction, and performs the required measurements using a photoelectric conversion element, etc. A storage device that measures the color tone of the test paper that has not been dropped and records this measured value as a base value for sample measurement, a setting circuit that sets a value for determining whether or not the sample has been dropped, and a sample. An automatic analyte analyzer, comprising: a determination circuit for determining whether the measured value of is within a required setting range with respect to the base value.