JPS60214864A - Nutritious supplementary food - Google Patents

Abstract

PURPOSE:To titled novel food, obtained by sealing a mixed liquid material prepared by dissolving delta-tocopherol, etc. and soybean lecithin in a liquid vegetable oil in a gelatin capsule, and having improved ability to reduce blood cholesterol. CONSTITUTION:A nutritious supplementary food obtained by sealing a mixed liquid material prepared by dissolving delta-tocopherol or a mixed tocopherol at composition ratio of the delta-tocopherol increased to >=50% and soybean lecithin preferably at 10pts.wt.: 1-100pts.wt. ratio between the former and the latter in a liquid vegetable oil, e.g. corn oil, in a gelatin capsule.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel nutritional supplement containing δ-tocopherol and soybean lecithin as active ingredients and having a cholesterol-lowering effect.

In recent years, there has been an increase in the nutritional balance brought about by a rich diet,
■Unbalanced eating and excessive intake caused by a diet that prioritizes preferences; ■Nutritional loss due to loss of balance in maintaining health, which is the key to exercise, rest, and nutrition; ■The necessity of supplementary nutrition to cope with an aging society. The demand for supplementary foods is rapidly increasing9, and nutritional supplements are being preferred, especially since there is a strong belief that adult diseases can be prevented by improving dietary habits.

The present invention was derived from such dietary needs.
4, and aims to provide a novel nutritional supplement that has a remarkable ability to lower blood cholesterol (D) through the synergistic effect of δ-tocopherol and soybean lecithin.

The present inventors previously discovered a new finding that δ-tocopherol has an extremely superior blood cholesterol-lowering effect even though its vitamin E activity is 1/I DO compared to α-tocopherol. This δ-tocopherol can be isolated and used, or mixed tocopherols (tocopherol homolog mixtures, i.e. α-1β-1γ-1δ) in which the composition ratio of δ-tocopherol is increased to 50% or more are used.
We have found that the effect of lowering blood cholesterol can be significantly improved by using a mixture of tocopherols (a mixture of tocopherols), and have applied for a patent. - Unexploited aAFie (Da-) Core Yellow KK Soybean lecithin has a synergistic effect that further improves the effect of lowering blood cholesterol levels.

That is, the present invention provides δ-tocopherol or δ-)
A mixture of Toko7erol and soybean lecithin with a higher composition ratio of Core Z-roll than 50tX in liquid vegetable oil! This is a nutritional supplement made by inserting a liquid mixture of # into a gelatin capsule.

The feature of Sei 1 in the present invention is that the tocopherol used is not the conventionally commonly used α-tocopherol or mixed tocopherol mainly composed of α-tocopherol, but isolated δ-tocopherol or δ-tocopherol. The use of mixed tocopherols having a tocopherol composition ratio of 50% or more and the use of δ-tocopherol significantly improved the effect of lowering fresterol in blood samples.

The δ-tocopherol used in the present invention is known to be contained in vegetable oils such as soybean oil, wheat germ oil, sesame oil, and rice bran oil, and can be produced using known manufacturing methods such as the above-mentioned deodorizing process of the vegetable oil. The deodorized distillate (so-called deodorized scum) obtained is subjected to molecular distillation and deodorization, or it is dissolved in an organic solvent and adsorbed on an ion exchange resin or adsorption chromatography, and then an organic solvent is used to extract each of the tocopherols. It can be obtained by a method of fractionating fractions, a synthesis method, etc., but its production method and origin are not particularly limited.

Note that the isolated δ-tocopherol is already commercially available for uses such as antioxidants, so it is also possible to use this commercially available product.

In addition, mixed tocopherols with the composition ratio of δ-tocopherol increased to 50% or more can be obtained by adding isolated δ-tocopherol to mixed tocopherols or selectively concentrating δ-tocopherol in mixed tocopherols. Even if it is used, the effects of the present invention can be obtained.

The second feature of the present invention is that δ-tocopheryl and soybean lecithin are used together, and the synergistic effect of this combination further improves the blood cholesterol lowering effect. It is.

The soybean lecithin used in Fudashi 8A is usually soybean phospholipid containing soybean oil (lvrm soybean lecithin) obtained by dehydrating and drying the gum that hardens during the soybean oil degumming process. /, lecithin purified or concentrated with alcohol etc. may be used;
It is also possible to use fractionated lecithins with a low arine content or a cephalin content.

Blending ratio of δ-tocopherol and soybean lecithin Fi#
KII4 Although not specified, in order to more effectively exhibit the effects of the present invention, it is preferable to mix about 1 to 100 parts by weight of soybean lecithin to 10 parts by weight of δ-tocopherol.

Liquid vegetable oils for dissolving soybean lecithin and mixed tocopherols having a composition ratio of 5ON or more of δ-tocopherol or δ-tocopherol include germ oils such as wheat germ oil, rice oil, and corn oil, soybean oil, rapeseed oil, All liquid oils commonly used for human consumption can be used, such as cottonseed oil, sunflower oil, safflower oil, seed oil such as peanut oil, etc. These liquid vegetable oils can be extracted from 11III81 seeds by known methods. Use one made of N.

In particular, germ oil is suitable as a nutritional supplement of the present invention because it contains a large amount of tocopherols, linoleic acid, etc. and has a cholesterol-lowering effect.

δ~tospherol t+1dJ-) A mixed liquid product obtained by dissolving mixed tocopherols and soybean lecithin in which the composition ratio of cofurol is 50% or more in a liquid vegetable oil is as follows:
Seal it in a gelatin tube according to the usual method.

One example of this method is to insert a liquid mixture into gelatin,
After melting glycerin and ice, a predetermined amount is injected into an injection-molded gelatin capsule, and then the injection port is heated and tightly pierced to produce the nutritional supplement of the present invention.

The shape of the Seratin cuff cell can be spherical or rough pole.

The nutritional supplement of the present invention obtained by preparing ζγ has a remarkable effect on lowering blood cholesterol, and has been found to be effective in reducing arteriosclerosis, high blood pressure, and other diseases that have been increasing in recent years.
It can be said to be extremely effective in preventing adult diseases such as blood clots, angina pectoris, stroke, myocardial infarction, etc.

Next, an experimental example will be given to further clarify the effects of the present invention.

Experimental Example A test to confirm the effect of lowering plasma cholesterol and triglyceride in rats by administration of α-tocopherol, -tophenyl and soybean lecithin.

4-week-old 8D male rats were divided into 3 groups of 6 rats per group and tested for V%.

Feed hacholestyrol 0.5%, sodium cholate 0
．． Easily develops hypercholesterolemia when loaded with 25N
d~α-t=z7
Erol o, 5%, (ld-δ-tocophero-xo, 5
N, (1) Soybean lecithin 0.5% and (2) d-δ-tocopherol 0.25% soybean lecithin 0.25X were added together to make 5 m.

These feeds were given to rats with a feed intake of 1B1f.
Rats in each group were reared for two weeks while being fed an i.i.

The results are shown in the table below.

(?J’) The arteriosclerosis index in the table is HD L cholesterol It is expressed as

As can be seen from the results in the table above, plasma dark cholesterol, which is considered to be lower, was the most suppressed in the upper row by the combination of δ-tocopherol and soy lecithin, 11! + HDL cholesterol, which is said to be good cholesterol and the higher the value is, is α-
There was no significant difference between the three groups: tocopherol group, δ-tocopherol group, and δ-tocopherol and soy lecithin combination group, but regarding the arteriosclerosis index, δ-tocopherol a-
The combination group with lecithin and soybean lecithin showed the lowest value, indicating a synergistic effect.

Furthermore, triglycerides, which are considered to have lower values, were significantly reduced in the δ-tocopherol and soybean lecithin combination group.

From the above results, the combination and addition of 0.25% δ-tocopherol and 0.25% soybean lecithin is more effective than adding 0.5% δ-tocopherol alone, even though the amount of δ-tocopherol added is scary. It has been found to have a significant effect on lowering blood cholesterol.

Next, examples of the present invention will be shown.

Example 1 δ-tocopherol concentrate (manufactured by Eisai Koshiki, Emix D, δ-tocopherol content: 94.8% by weight) 2
0 parts by weight, 3[]lti parts of soybean lecithin, 5 parts of wheat germ oil
0 parts by weight, heated to about 60°C and stirred to dissolve uniformly.

Separately, 60 parts by weight of gelatin, 30 parts by weight of glycerin, and 10 parts by weight of water were uniformly mixed, formed into a film, and then injection molded into a capsule having a capacitance of 300 mF to produce a gelatin container.

The above-mentioned liquid mixture was poured into this container, and then the injection port was heated and sealed to obtain the nutritional supplement of the present invention.

Claims (1)

[Claims] (1) δ-tocopherolmataha δ-):=+7x. A nutritional supplement in which a liquid mixture obtained by dissolving mixed tocopherol and soybean lecithin in a liquid vegetable oil in which the composition ratio of tocopherol is increased to 50% or more is inserted into a gelatin capsule.