JPS60176659A - Radiation pasturizing method - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for radiation sterilization of packages of medical equipment such as syringes, needles, and drip devices.

Ko♂9. Conventionally, these packages are sandwiched between paper and plastic film, and are sterilized by penetrating a sterilizing gas such as ethylene oxide from the paper side.
Was. Since the sterilization method of Kone et al. has the risk of the island-killing agent remaining and compromising safety, physical methods using ionizing radiation, such as R-ray sterilization method and electron beam sterilization method, which do not have this danger, are recommended. Sterile method or two 1-mouth 41 people V)
De pine tree ψ1 light -) r [(q! 怀 + ll / chipped iiru.

However, sterilization using ionizing radiation has the problem of degrading the plastic material used for the packaging material 1. Polyolefin resins are less susceptible to such deterioration and are actually used, but even when polyolefin resins are used, the odor of low-boiling substances is generated due to the decomposition of the resin.

This odor is 1l-1,1
1) It was determined that this is due to low-boiling altehyde substances such as formaldehyde and acetaldehyde, and low-boiling point carboxylic acids such as acetic acid and propionic acid, and because their concentrations are low, they do not harm the amphibious nature of the contents. However, it is considered a problem because the odor itself is unpleasant.

The present invention provides a radiation sterilization method that does not generate such an odor, and includes a package V, which is formed by storing contents and gas absorption in a packaging bag whose innermost layer is made of polyolefin resin, and sealing the bag. , a radiation sterilization method characterized by sterilization by irradiation with ionizing radiation.8- The packaging bag according to the present invention has an innermost layer made of a polyolefin resin, and is a film of a single layer of polyolefin resin, Alternatively, a film in which another thermoplastic resin film such as polyester or polyamide is laminated on the outside can be used. This polyolene may be of any type, such as low-density polyethylene, medium-high density polyethylene, ethylene-
Acrylic acid copolymer resin, ethylene-methacrylic acid copolymer resin, polyethylene ionomer, ethylene-vinyl acetate copolymer resin, etc. can be used.

Gas adsorption has the ability to adsorb the above-mentioned low-boiling aldehyde substances and low-boiling carboxylic acids, and includes activated carbon, activated alumina, Norica gel, activated clay, fluorite (zeolite, molecular sieve), sulfonated carbon, and ion exchange resins can be used.

This gas adsorption agent can be stored in a small bag made of paper, polyolefin non-woven fabric, or porous polyolefin, and housed inside the packaging bag, or it can be coated with binder resin on a support such as paper or polyolefin resin in the innermost layer of the packaging bag. It can be coated or printed with VC and housed inside the packaging bag.

The present invention is as described above, and the contents contained in the packaging bag may be arbitrary, but when the contents are medical devices such as syringe barrels, injection needles, and drip devices, the present invention The special feature is the fresh fish, especially the raw fish.

The present invention will be explained below using Example VC.

<Example 1> (It) 12μ thick polyester film (Toyobo ■
low-density polyethylene (Mitsui Polychemicals (Kikusei Mirason i6P melt index 67, density 0.9)
23) was extrusion coated to a thickness of 30 μm at a resin temperature under the die of 51° C. to obtain a laminated film for packaging bags.

(2) A non-woven fabric made by laminating polyester and polyglopyrene (manufactured by Teijin ■) was used as a sachet III material, and 5 g of powdered activated carbon (Rarecol made by Kuraray Chemical ■) was put therein. Created.

(3) Using the laminated film of (1) above, with the low density polyethylene side facing inside, the internal air volume is 10011
Seal 1A' and Naruyo Ij K on all sides, 150. X
A package (B) of 1'40 mrh was created.

(4) Using the laminated film of (1) above, store the small outfit) and seal it on all sides so that the internal air volume is 100 m, e. It was created.

(5) These packaging bags (T3), (q vc 2. s
After 20 hours of irradiation with 2' rays at the R amount, the packaging bag (13) and the odor concentration (formaltehyde, acetaltehyde) in which decomposition occurred for Y<II in the tC1 were measured by gas chromatography. (Shimadzu Corporation (1'1.
) G C6A M device) and column (Gas Kuro Kogyo (
4'JJ'A i, "en ax G (:) was identified and measured. The results are as shown in the first section below.

Table 1 Also, when packages (13) and (C) were opened and smelled, package (I3) had a strong odor, but package (C) had no odor at all. Ta.

<Example 2> (1) Low-density polyethylene (Mitsui Polychemicals (Milanon 16p made by Kikyo)) was placed on a 12μ thick polyester film (Toyobo (Kiyoshi Lumi Y-P-11)) at a resin temperature of 310°C. Then, it was extrusion coated to a thickness of 60 μm to obtain a laminated film for packaging bags.

(2) The polyethylene surface of this @ scrap film (l) was coated with ink of the following composition by gravure printing in an amount of 5137.
It was applied partially so that it became m. Note that the area that was not coated was the seal area when making the packaging bag, and the entire surface was coated except for this area.

Ink composition: Ethylene-vinyl acetate co-merger 25fflLitiN3
(Mitsui Polychemical Co., Ltd. Evan Lenox Co., Ltd.) Powdered activated carbon 20 l'i quantity (Kuraray Chemical Meat J Manufactured by Raleyeur) Toluene 50
Part by weight (3) A second coat of the laminated film thus coated [with the side facing inside and soles on all sides so that the internal air volume is 100 ml, a package σ of 150 x 140 + Il] was prepared.

(4) This package (I)) was prepared in the same manner as in Example 1 (5). Identification and measurement were performed 24 hours after irradiation.

The results are shown in Table 2.

Table 2 Also, open jy1 and see the odor! When I was there, there was no odor at all.

Claims (1)

[Claims] 1) A packaging body made by housing an inner pot and a gas adsorbent in a packaging bag whose innermost layer is made of polyolene yarn resin, and sealing the bag.
To sterilize by irradiating with ionizing radiation