JPS60129053A - Radiation pasturizing method - Google Patents
Radiation pasturizing methodInfo
- Publication number
- JPS60129053A JPS60129053A JP58236783A JP23678383A JPS60129053A JP S60129053 A JPS60129053 A JP S60129053A JP 58236783 A JP58236783 A JP 58236783A JP 23678383 A JP23678383 A JP 23678383A JP S60129053 A JPS60129053 A JP S60129053A
- Authority
- JP
- Japan
- Prior art keywords
- resin
- polyethylene
- ethylene
- radiation
- density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
本発明は、注射筒、注射針、点滴用器具等の医療器具の
包装体の放射線滅菌方法に関するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for radiation sterilization of packages for medical instruments such as syringe barrels, injection needles, and drip devices.
これらの包装体は、従来、紙とプラスチックフィルムの
間に挾み込むように包装されたもので、エチレンオキサ
イド等の殺菌性ガスを粗側から浸透させて滅菌していた
。これらの滅菌方法は殺菌剤が残留して安全性を損なう
という危険があることから、このような危険のないγ線
滅菌方法や電子線滅菌方法等の電離性放射線による物理
的滅菌方法が注目を集めており、実際一部実用化されて
いる。しかしながら、この電離性放射線による滅菌は、
包装材料に使用されているプラスチック累月を劣化さU
るという問題があった。ポリオレフィン樹脂はこのよう
な劣化が少く、実際に使用されているものであるが、こ
のポリオレフィン樹脂を用いた場合であっても、樹脂の
分解による低沸点物質の臭気が発生している。Conventionally, these packaging bodies are sandwiched between paper and plastic film, and are sterilized by infiltrating a sterilizing gas such as ethylene oxide from the rough side. These sterilization methods have the risk of sterilizing agents remaining and compromising safety, so physical sterilization methods that use ionizing radiation, such as gamma ray sterilization and electron beam sterilization, which do not have this risk, are attracting attention. We have been collecting them, and some of them have actually been put into practical use. However, sterilization using ionizing radiation
The plastic used in packaging materials has deteriorated over time.
There was a problem that Polyolefin resins are less prone to such deterioration and are actually used, but even when this polyolefin resin is used, the odor of low boiling point substances is generated due to the decomposition of the resin.
この臭気は、ガスクロマトグラフィにより測定したとこ
ろ、ボルムアルデヒドやアセトアルデヒド等の低沸点ア
ルデヒド物質及び酢酸、プロピオン酸等の低沸点カルボ
ン酸にj、るもので、その濃度が低いこともあって、内
容物の衛生性等に害を与えるものではないが、臭気自体
が不快感を与えることから問題とされている。As measured by gas chromatography, this odor is caused by low-boiling aldehyde substances such as formaldehyde and acetaldehyde, and low-boiling point carboxylic acids such as acetic acid and propionic acid. Although the odor does not harm the sanitary properties of other people, it is considered a problem because the odor itself causes discomfort.
ところで、本発明者等は、この臭気について検問したと
ころ、意外なことに、この臭気はポリオレフィン樹脂の
密度に密接な関係を持っており、密度0.930g/c
m以上で、分子溝造的に長鎖分岐の少ないポリエチレン
樹脂の放射線照射時に分解発生り−る臭気は、これ以下
の密度のポリオレフィン樹脂に照射した場合に比べて極
端に少ないことを梵見しノこ。By the way, the present inventors investigated this odor and surprisingly found that this odor is closely related to the density of polyolefin resin, with a density of 0.930 g/c.
It has been found that the odor that decomposes when irradiating polyethylene resin with a molecular density of more than 200 m and less long chain branching in terms of molecular structure is extremely less than when irradiating polyolefin resin with a density less than this. Noko.
本発明はこのような知見に基ずいてなされたもので、り
なわら、本発明は、熱可塑性樹脂フィルムからなる包装
袋に内容物を収容してなる包装体に電離放射線を照射し
てこれを殺菌づるに際し、包装袋の最内層が密度0.9
30o/cm以上のポリエチレン系樹脂であることを特
徴とする放射線滅菌方法である。The present invention has been made based on such knowledge, and specifically, the present invention involves irradiating ionizing radiation to a packaging body made of a packaging bag made of a thermoplastic resin film containing the contents. When sterilizing, the innermost layer of the packaging bag has a density of 0.9.
This is a radiation sterilization method characterized by using a polyethylene resin of 30 o/cm or more.
本発明に用いるポリエチレン系樹脂の具体例どしては中
低圧法ポリエチレン、■ヂレンーアクリル酸共重合樹脂
、エチレン−メタアクリル酸共重合樹脂、ポリ1チレン
アイオノマー、エチレンー酢酸ビニル共重合樹脂等を上
げることができる。Specific examples of the polyethylene resin used in the present invention include medium-low pressure polyethylene, dylene-acrylic acid copolymer resin, ethylene-methacrylic acid copolymer resin, poly-1-ethylene ionomer, ethylene-vinyl acetate copolymer resin, etc. I can do it.
また、包装袋とする際には、ポリエチレン系樹脂フィル
ム単体、又は他のポリオレフィン、ポリエステルあるい
はポリノアミド等の他の熱可塑性樹脂フィルムどの積層
フィルムとして用いることができる。積層フィルムとし
て用いる場合には、ポリエチレン系樹脂フィルムが包装
袋の最内層となるようにこれを作成する必要がある。In addition, when making a packaging bag, it can be used as a single polyethylene resin film or as a laminated film of other thermoplastic resin films such as other polyolefins, polyesters, or polynoamides. When used as a laminated film, it is necessary to create the polyethylene resin film so that it becomes the innermost layer of the packaging bag.
また、照射づべき放射線としては、一般に電離性放射線
として知られる程度の高エネルギー線が用いられ、具体
的にはγ線、電子線が好しく用いられるが、これ以外に
もX線等も用いることができる。In addition, as the radiation that should be irradiated, high-energy rays known as ionizing radiation are generally used, and specifically gamma rays and electron beams are preferably used, but in addition to these, X-rays, etc. are also used. be able to.
以下、実施例及び比較例により本発明を説明する。The present invention will be explained below with reference to Examples and Comparative Examples.
〈実施例及び比較例〉
1)25μの厚さの汎用ポリエステルフィルムに低密度
ポリエチレン(密度0.919g/c♂、Ml5、O)
をダイ下樹脂温度310℃なる条件で厚さ70μになる
ように押し出しコーティングを行なって、積層フィルム
を作成した。この積層フィルムをポリエチレン層面を重
ね命わせ、内部空気量が350ccになるように四方シ
ールして、包装体を作成し、比較用包装体(1)とした
。<Examples and Comparative Examples> 1) Low-density polyethylene (density 0.919 g/c♂, Ml5, O) on a 25μ thick general-purpose polyester film
A laminated film was prepared by extrusion coating to a thickness of 70 μm at a resin temperature of 310° C. under the die. This laminated film was stacked with polyethylene layer surfaces and sealed on all sides so that the internal air amount was 350 cc to create a package, which was designated as Comparative Package (1).
2)低密度ポリエチレン(密度0.’919(+ 10
♂、Ml5.O)の代りに低密度ポリエチレン(密度0
.923(1/cm1、Ml3.7>を用い、1)と同
様に包装体を作成し、比較用包装体(2)とし1こ 。2) Low density polyethylene (density 0.'919 (+10
♂, Ml5. O) instead of low density polyethylene (density 0
.. 923 (1/cm1, Ml3.7>), a package was prepared in the same manner as in 1), and one package was used as comparison package (2).
3)低密度ポリエチレン(密度0.919g/cm’、
Mlり、O)の代りに高密度ポリ1チレン(密度0.9
44g/c♂、Ml9.O>を用いて、1)と同様に包
装体を作成し、本発明の包装体(3)とした。3) Low density polyethylene (density 0.919g/cm',
High-density polyethylene (density 0.9
44g/c♂, Ml9. A package was prepared in the same manner as in 1) using O>, and was designated as a package (3) of the present invention.
4)厚さ25μの汎用ポリエステルフィルムにエチレン
−アクリル酸共重合樹脂(密度0.940Q/C♂、M
l7.’O)をダイ下樹脂温度280℃なる条件で70
μの厚さになるように押し出しコーティングして積層フ
ィルムを作成しlcoこの積層フィルムをエチレン−ア
クリル酸共重合樹脂層面を重ね会わせて四方シールして
包装体を作成し、本発明の包装体(4)とした。4) Ethylene-acrylic acid copolymer resin (density 0.940Q/C♂, M
l7. 'O) at 70°C under the condition that the resin temperature under the die is 280℃.
A laminated film is prepared by extrusion coating to a thickness of μ, and this laminated film is overlapping the ethylene-acrylic acid copolymer resin layer surfaces and sealed on all sides to create a package. (4).
5)これらの包装体(IL(2>(3)<4)のそれぞ
れに2.5Mradの線量でγ線を照射し、20時間後
に包装体内部で分解発生した臭気濃度即ちホルムアルデ
ヒド、アセトアルデヒド、酢酸の各m瓜をガスクロマト
グラフィー(呂律製作所(株)製GC−6AM装置、T
enaxGCカスクロ工業(株)製のカラムを装填)を
用い、それぞれ定量分析を行なった。その結果を第1表
に示す。5) Each of these packages (IL(2>(3)<4) was irradiated with γ-rays at a dose of 2.5 Mrad, and after 20 hours, the concentration of odors decomposed inside the package, i.e., formaldehyde, acetaldehyde, acetic acid) Each meter of melon was subjected to gas chromatography (GC-6AM device manufactured by Ro Ri Seisakusho Co., Ltd., T
Quantitative analysis was carried out using enaxGC (loaded with a column manufactured by Kasukuro Kogyo Co., Ltd.). The results are shown in Table 1.
なお、ホルムアルデヒド、アセトアルデヒド、酢酸の各
濃度は△STM D−1505法で測定した。また、こ
の各濃度の単位はrmil/IJであり、[< O,0
01J ハコ(f)6度がO,001m g/I以下で
あることを示す。In addition, each concentration of formaldehyde, acetaldehyde, and acetic acid was measured by the ΔSTM D-1505 method. Also, the unit of each concentration is rmil/IJ, [< O, 0
01J Box (f) indicates that 6 degrees is 0,001 mg/I or less.
(以下余白)(Margin below)
Claims (3)
収容してなる包装体に電離放射線を照射してこれを殺菌
するに際し、包装袋の最内層が密I褒0.930g/c
m以上のポリエチレン系樹脂であることを特徴とする放
射線滅菌方法。(1) When sterilizing a package consisting of a packaging bag made of a thermoplastic resin film containing the contents by irradiating it with ionizing radiation, the innermost layer of the packaging bag has a density of 0.930 g/c.
A radiation sterilization method characterized in that the polyethylene resin has a polyethylene resin of m or more.
ることを特徴とする特許請求の範囲第(1)項記載の放
射線滅菌方法。(2) The radiation sterilization method according to claim (1), wherein the polyethylene resin is medium-low pressure polyethylene.
合樹脂、エチレン−メタアクリル酸共重合樹脂、ポリエ
チレンアイオノマー、エチレン−酢酸ビニル共重合樹脂
のうちから選ばれる一種であることを特徴とする特許請
求の範囲第(1)項記載の放射線滅菌方法。(3) A patent claim characterized in that the polyethylene resin is one selected from ethylene-acrylic acid copolymer resin, ethylene-methacrylic acid copolymer resin, polyethylene ionomer, and ethylene-vinyl acetate copolymer resin. The radiation sterilization method described in scope item (1).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58236783A JPS60129053A (en) | 1983-12-15 | 1983-12-15 | Radiation pasturizing method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58236783A JPS60129053A (en) | 1983-12-15 | 1983-12-15 | Radiation pasturizing method |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS60129053A true JPS60129053A (en) | 1985-07-10 |
Family
ID=17005724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP58236783A Pending JPS60129053A (en) | 1983-12-15 | 1983-12-15 | Radiation pasturizing method |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS60129053A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04371157A (en) * | 1991-06-18 | 1992-12-24 | Hogi Medical:Kk | Method for processing silicone rubber tube with radiation |
-
1983
- 1983-12-15 JP JP58236783A patent/JPS60129053A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04371157A (en) * | 1991-06-18 | 1992-12-24 | Hogi Medical:Kk | Method for processing silicone rubber tube with radiation |
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