JPS60158059A - Package - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field] This invention relates to the packaging of small, independent objects.

[Conventional technology]

One type of well-known packaging widely used in the pharmaceutical industry is the so-called blister package or push-through package. This is based on a rigid raised sheet, usually made of a rigid transparent plastic such as PvC, containing the goods to be packaged in a blister, such as a rupturable rigid aluminum film or a peelable sheet to remove the packaged article. It is soled with a composite aluminum plastic film with manual means. Such blister package cards (also referred to as blister platforms) usually consist of parallel rows of blisters.

Recent advances in pharmaceutical and formulation research have made it possible to administer drugs that can be administered in extremely low daily doses, thus allowing for ideal dosing for individual patients requiring precise prescription. For example, a patient with relatively mild symptoms may
Furthermore, only one-half or one-fourth of the dose required for severely ill patients is required.

However, the realization of formulations that are suitable for such purposes has presented problems in the formulation and packaging of appropriate dosage forms. Various possibilities are possible, examples of which are as follows.

1) Preparations in various forms (eg tablets), each containing a different content of active ingredient.

2) A single form formulation containing the lowest dose of active ingredient.

3) A single form preparation containing the highest dose of active ingredient, provided with dividing means (e.g. score lines in the case of tablets).

The first, while offering a high degree of flexibility, requires separate formulation systems, packaging systems, label systems, etc., and requires authorities to list each form separately, adding to the confusion. It has many drawbacks, such as the possibility of

The second eliminates the need for separate manufacturing lines, but increases the cost of supplying enough unit dosage forms for all dosage regimens.

Additionally, they have the disadvantage of poor acceptability, especially in patients who need to take a large number of single dose forms to obtain the prescribed daily dose.

The third one does not have the disadvantages of the above two and is therefore the preferred formulation/packaging form.

One of the major remaining problems with this last method is to provide the patient with a means of storing, for example, tablet portions in a convenient and hygienic manner while minimizing the risk of misplacing them. This is particularly important when the dosage form is conveniently packaged for more or less long-term regular use (calendar packaging).

Two methods have been proposed to solve this problem.

a) Installation of "empty" blisters covered with a removable and replaceable adhesive strip.

b) Installation of a separate container (pill box) in a blister for subsequent removal use.

Method a) above means that during use, the stickiness of the strip is lost due to contact with dust or other particles, e.g. when placed in a pocket, handbag or in contact with a greasy object, e.g. an oily finger. It has its drawbacks.

Poor stability of the adhesive layer also shortens the shelf life of the package.

Method b) above can avoid such problems, but once the pill box is removed, it is placed separately (there is a risk of misplacing it, and there is a risk of misidentifying the content when found). , and its inclusion has the disadvantage of requiring extra material costs and extra manufacturing/mechanical components.

[Description of the invention]

In order to avoid such problems, the present invention provides that, for example, tablet portions can be stored in stable, reusable and hygienic enclosures using blister packaging cards, for example simply by stamping. This relates to a method that can be manufactured using existing machinery by changing the

The invention therefore provides a blister package card having closure means for at least one blister removably sealing said blister to form a containment cavity and integral with the card.

In a preferred form, the blister package card comprises a series of blisters, including at least one pair of blisters adapted to meet each other to form a sealed cavity.

A special configuration is one in which concave and convex blisters are formed adjacent to each other, with means for folding one blister back and meeting the other to seal the cavity. . The raised blister protrudes from the surface of the packaging card in the same direction as the blister containing the tablets. For example, the flange around a convex or concave blister can be configured to be separate and independent from the remaining three sides of the card by folding back along the side adjacent to the blister to be sealed at the appropriate perforation. . In this case, it is advantageous to provide this pair of blisters at the end of the package card, with a perforation on the third side of the flange. The flange between the concave and convex blisters may be provided with means to facilitate rearward bending, such as an I or more score line. Position the score line so that the flange around one blister extends beyond the flange around the mating blister when folded back to aid in reopening the sealed cavity. It is advantageous to be able to listen.

The means of association of the two blisters can take various forms. For example, when including concave and convex blisters, one of the two blisters is deeper than the other, and the diameter of the part touching the surface of the package card is larger than the other blister, and is equal to or smaller than the other blister. The ratio can be formed to decrease as the distance from the surface of the card increases. In this way, by folding backwards and pressing one blister against the other, it can be closed completely, as with a snap, leaving the necessary cavity. Blister package cards can be formed in a conventional manner using suitable drawing and punching dies in a forming machine with compressed air passed through the top.

The deeper of the two blisters is preferably formed over a convex stud on the punching die rather than being drawn into a recess. This increases the strength and resistance to repeated closures.

Card portions containing dosage forms (usually tablets) are also known, for example consisting of a row or two parallel rows of blisters sealed with aluminium, as described above.

The sealing film may extend over the cavity forming the blister, but it is preferred not to do so.

Perforations can be placed between individual blisters, but calendar packages usually do not.

Alternatively, a raised storage blister is formed adjacent the end of the package card. These two parts can be separated by a score line which facilitates folding back the end covering the blister.

The end region covering the blister is substantially planar.

In this case, one or more snaps, similar to the blister arrangement, for example, are used as closure means, the convex and concave integral parts of which are located at the ends (folded parts), and the storage blisters are respectively (or (Similarly vice versa) It has a part (uneven part) that meets the folded part when it is folded back.

The remaining parts of the blister package card are again known.

As mentioned above, a preferred method of completing the closure means is to form it together with the tablet-containing blister, for example from a single sheet of plastic. Furthermore, in embodiments in which the closure means is associated with a blister,
These can be independent of the cavity for holding the tablet fractions, and can themselves form cavities, as described below with reference to Figures 4.5 and L2 and 3, respectively. can.

Are the attached drawings an embodiment of this invention? I will explain from here.

FIG. 1 is a generally full-scale perspective view of an initially formed package card.

FIG. 2 is a generally full-scale perspective view from below of a card with two adjacent blisters meeting each other.

FIG. 3 is a sectional view taken from the side of the enclosed cavity unit taken along line B--B in the upper part of FIG.

Corner A is marked to indicate the relative position from two directions.

The card is made of a rigid transparent plastic sheet made, for example, from PVC (polyvinyl chloride) and has a series of raised blisters 2 formed to receive tablets (not shown for convenience). and a recessed blister 4 are made to form a sealed cavity unit 5. The card also has two score lines 6, a perforation 8
A separation part 7 is provided to facilitate separation of the parts. Perforation 8
Stretch the card across from one end to the dividing line 6.

The blister containing the tablets 2 is sealed, for example with an aluminum film 9. A blister 4 with a concave diameter over the entire portion 10 (cylindrical in the figure) in contact with the surface of the card.
The convex blister 3 is formed so that it is larger than the above.

The blister 3 tapers away over its 11 sections (which are truncated in the figure) to an end diameter equal to or slightly smaller than the diameter of the blister 4, yielding a cavity 14 when closed.

A score line 6 is provided so that when the concave and convex blisters 3 and 4 meet, the ear I3 goes beyond the edge of the card.

In use, the line of perforation 8 is separated and the flange I2 containing the blister 4 is folded along the score line 6. The card is then turned over and the tablet aliquots to be stored are placed inside the blister 3. Next, turn the blister 4 over 180 degrees, push it into the blister 3, engage it, and seal! A
form 14.

To remove the tablet portions again, the blister 4 is pulled off by lifting the flange 5 at the ear 13.

A more special example will be explained with reference to FIGS. 4 and 5.

FIG. 4 is a substantially full-scale perspective view of the card from the underside.

FIG. 5 is a sectional view taken from the side along line CD.

The non-shaded portion of the card is provided with a convex blister 15 separated from a folded flap-like end 20 by a score line 16. In the folded part there are two concave integral parts 17 in a snap arrangement, a convex integral part 18 located corresponding to the card part with raised blisters 15.

The shaded portions of the package card are the same as those described in FIGS. 1 to 3.

In use, the folded portion 20 is folded back along the dividing line 16 in the direction of arrow I9. The tablet aliquots to be stored are placed in the blister 15 and the folded portion 20 is folded back 180°. Align the concave integral part 17 with the convex integral part and press it in to form a sealed cavity (2 on top of +5).
0). To remove the tablet portion again, peel off the flap.

[Brief explanation of drawings]

FIG. 1 is a generally full-scale perspective view of an initially formed package card. FIG. 2 is a generally full-scale perspective view from below of a card with two adjacent blisters meeting each other. FIG. 3 is a sectional view taken from the side of the enclosed cavity unit taken along line B--B in the upper part of FIG. FIG. 4 is a substantially full-scale perspective view of the card from the underside. FIG. 5 is a sectional view taken from the side along line CD. Patent Applicant Sand Akchengesellschaft Patent Attorney Aoyama Hao et al. FIG, 2 R FIG, 3 FIG, 5

Claims (5)

[Claims] (1) A blister package card having, for at least one blister, a closure means for releasably sealing said blister to form a containment cavity and integral with the card. (2) A blister package card consisting of a series of blisters, including at least one pair of blisters adapted to meet each other as a closure means to form a sealed cavity. (3) The blister package card according to claim 2, wherein the blisters that meet each other are themselves characterized by cavities. (4) A blister package card according to any one of claims 1.2 and 3, made from a single sheet of selected material. (5) Blister package card 7, which is substantially based on the drawings.