JPH0520303B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field] This invention relates to the packaging of tablets, which are small independent objects.

[Conventional technology]

One type of well-known packaging widely used in the pharmaceutical industry is the so-called blister or push-through package. It is based on a rigid raised sheet, usually made of a rigid transparent plastic such as PVC, containing the goods to be packaged in a blister, such as a rupturable rigid aluminum film or peelable to remove the packaged goods. It is sealed with a composite aluminum plastic film with available means. Such blister package cards (also referred to as blister platforms) usually consist of parallel rows of blisters.

Recent advances in pharmaceutical and formulation research have made it possible to administer drugs that can be administered in extremely low daily doses, thus making dosing ideal for individual patients requiring precise prescription. for example,
Patients with relatively mild symptoms require only one-half or one-fourth the dose required by those with more severe disease.

However, the realization of a formulation suitable for such purposes has presented problems in the formulation and packaging of appropriate dosage forms. Various possibilities are possible, examples of which are as follows.

(1) each containing different amounts of active ingredients;
Preparations in various forms (e.g. tablets).

(2) A single-form preparation containing the lowest dose of active ingredient.

(3) A single-form preparation containing the highest dose of active ingredient, provided with a means of division (e.g., a score line in the case of tablets).

The first, while offering a high degree of flexibility, requires separate formulation systems, packaging systems, labeling systems, etc., and requires authorities to list each dosage form separately, adding to the confusion. There is a risk of
It has a number of drawbacks.

The second eliminates the need for separate manufacturing lines, but increases the cost of supplying enough unit dosage forms for all dosage regimens.
Furthermore, they also have the disadvantage of poor acceptability, especially in patients who need to take a large number of single dose forms to obtain the prescribed daily dose.

The third one does not have the disadvantages of the above two and is therefore the preferred formulation/packaging form.

One of the major remaining problems with this last method is to provide the patient with a means of conveniently and hygienically storing, for example, tablet portions while minimizing the risk of misplacing them. This is particularly important when the dosage form is packaged to be convenient for more or less long-term regular use (calendar packaging).

Two methods have been proposed to solve this problem.

(a) Installation of "empty" blisters covered with a removable and replaceable adhesive strip.

(b) Placement of a separate container (pill box) in a blister on the card for subsequent removal use.

Method (a) above prevents the strip from becoming sticky due to contact with dust or other particles during use, such as when placed in a pocket, handbag or when touched with a resinous object such as an oily finger. It has the disadvantage of being lost. Poor stability of the adhesive layer also shortens the shelf life of the package.

Method (b) above can avoid such problems, but once the pill box is removed, it is placed separately (there is a risk of misplacing it, and there is a risk of misidentifying the content when it is found). , and its inclusion has the disadvantage of requiring extra material costs and extra manufacturing/mechanical components.

[Description of the invention]

In order to avoid such problems, the present invention provides that, for example, tablet fractions can be stored in stable, reusable and hygienic enclosures using blister package cards, for example simply by stamping. This relates to a method that can be manufactured using existing machinery by changing the

Accordingly, the present invention provides a blister package card comprising a receptacle having a plurality of blisters each for accommodating tablets and capable of accommodating tablet fragments, the receptacle comprising at least one receptacle in a first part of the card. at least one sealing blister in a second portion adjacent to and hingedly connected to the first portion of the card;
The first and second portions are located on one side edge of the card, and the second portion of the card is separably coupled to the remainder of the card along the one side edge, and the sealing blister is attached to the storage blister. The cavity mouth of the storage blister is slightly larger than the base of the sealing blister, with the base projecting from the same plane as the card face containing the cavity, so that the base of the sealing blister is a friction fit with the mouth of the storage blister. the second portion of the card is separable from the remainder of the card along one side edge and foldable over the first portion in a flap-like manner about the hinge joint;
The base of the sealing blister then meets the cavity of the storage blister to provide a blister package card that provides a removable seal for the storage blister.

Specifically, concave and convex blisters are formed adjacent to each other.
Some include means for folding one blister back and meeting the other blister to seal the cavity. The raised blister projects from the surface of the package card in the same direction as the blister containing the tablets. For example, the flange around a convex or concave blister can be configured to be separate and independent from the remaining three sides of the card by folding back along the side adjacent to the blister to be sealed at a suitable perforation. . in this case,
Conveniently, this pair of blisters is provided at the end of the package card, with a perforation on the third side of the flange. The flange between the concave and convex blisters may be provided with means to facilitate rearward bending, such as one or more score lines. Position the score line so that when the circumferential flange of one blister is folded back it extends beyond the circumferential flange of the mating blister, creating an ear to aid in reopening the sealed cavity. It is advantageous to be able to do so.

The means of association of the two blisters can take various forms. For example, in the case of concave and convex blisters, one of the two blisters is deeper than the other, and the diameter of the part touching the surface of the package card is larger than the other blister, equal to or smaller than the other blister. The ratio can be formed to decrease as the distance from the surface of the card increases. In this way, by folding backwards and pressing one blister against the other, it can be completely closed, as when snapping, leaving the necessary cavity. The blister package card can be formed in a conventional manner using suitable drawing and punching dies in a forming machine with compressed air passing through the top.

The deeper of the two blisters is preferably formed over a convex stud on the punching die rather than being drawn into a recess. This increases the strength and resistance to repeated closures. Card portions containing dosage forms (usually tablets) are also known, for example consisting of a row or two parallel rows of blisters sealed with aluminium, as described above. The sealing film may extend over the cavity forming the blister, but it is preferred not to extend that far.

Although perforations can be made between individual blisters, this is usually not the case with calendered package cages.

Alternatively, a raised storage blister is formed adjacent the end of the package card. These two parts can be separated by a score line which facilitates folding back the end covering the blister. The end region covering the blister is substantially planar.
In this case, one or more snaps, similar to the blister arrangement, for example, are used as closure means, the convex and concave integers of which are located at the ends (folded parts), and the storage blisters are respectively (or (Similarly vice versa) It has a part (uneven part) that meets the folded part when it is folded back.

The remaining parts of the blister package card are also known.

As mentioned above, a preferred method of completing the closure means is to form it together with the tablet-containing blister, for example from a single sheet of plastic. Furthermore, in embodiments in which the closure means are associated with a blister, these may include cavities for holding tablet portions, as described below with reference to Figures 4, 5 and 1, 2 and 3, respectively. They can be independent from each other and can form cavities themselves.

Embodiments of the invention will be described with reference to the accompanying drawings.

FIG. 1 is a generally full-scale perspective view of an initially formed package card.

FIG. 2 is a generally full-scale perspective view from below of a card with two adjacent blisters meeting each other.

FIG. 3 is a cross-sectional view of the enclosed cavity unit taken along line B--B in FIG. 2 from the side.

Corner A is marked to indicate the relative position from two directions.

The card consists of a rigid transparent plastic sheet made, for example, from PVC (polyvinyl chloride) 1, in which a series of raised blisters 2 are formed to receive tablets (not shown for convenience). Furthermore, a convex blister 3 and a concave blister 4 are made to form a sealed cavity unit 5.
A cut-off part 7 is provided to facilitate separation of the card, two dividing lines 6, and perforations 8. Perforation 8
The blister containing the tablets 2 is sealed with, for example, an aluminum film 9, which is extended to one end or the score line 6 to cross the card. The convex lister 3 is formed so that the diameter thereof is larger than that of the concave blister 4 over the entire portion 10 (cylindrical in the figure) in contact with the surface of the card.

The blister 3 tapers away over its 11 sections (in the figure frustoconically shaped) towards an end diameter equal to or slightly smaller than the diameter of the blister 4, yielding a cavity 14 when closed.

The score line 6 is placed so that the ear 13 goes over the edge of the card when the concave and convex blisters 3 and 4 meet.
Attach.

In use, the perforation line 8 is separated and the flange 12 containing the blister 4 is folded along the score line 6. The card is then turned over and the tablet aliquots to be stored are placed inside the blister 3. The blister 4 is then turned over 180° and pushed into the blister 3 into engagement, forming a sealed cavity 14. To remove the tablet portions again, the blister 4 is pulled off by lifting the flange 5 at the ear 13.

A more specific example will be explained with reference to FIGS. 4 and 5.

FIG. 4 is a substantially full-scale perspective view of the card from the underside.

FIG. 5 is a sectional view taken from the side along line CD.

The part of the card that is not diagonally lined is the dividing line 16.
It is provided with a convex blister 15 which is separated from a folded flap-like end 20 by a fold-back flap. The folded part has two concave integral parts 1 with snap arrangement.
7. There is an integral part 18 located corresponding to the card part with the raised blister 15.

The diagonally shaded part of the package card is the 1st to 3rd part.
It is the same as the description in the figure.

In use, the folded portion 20 is folded back along the dividing line 16 in the direction of the arrow 19. The tablet aliquots to be stored are placed in the blister 15 and the folded portion 20 is folded back 180°. Concave integral part 1
Align and press 7 into the convex integral part to form a sealed cavity (20 on top of 15). To remove the tablet portion again, peel off the flap.

[Brief explanation of the drawing]

FIG. 1 is a generally full-scale perspective view of an initially formed package card. FIG. 2 is a generally full-scale perspective view from below of a card with two adjacent blisters meeting each other. Figure 3 shows the second
It is a sectional view taken from the side of the enclosed cavity unit along the line BB in the upper part of the figure. FIG. 4 is a substantially full-scale perspective view of the card from the underside. Figure 5 shows C-
It is a sectional view seen from the side along the D line.

Claims (1)

[Scope of Claims] 1. A blister package card comprising a plurality of blisters each containing a tablet and a receptacle capable of storing tablet fragments, the receptacle comprising at least one receptacle in a first part of the card. a storage blister on one side of the card, and at least one sealing blister on a second portion adjacent to and hingedly connected to the first portion of the card; the second portion of the card is separably coupled to the rest of the card along one side edge, and the sealing blister has a base projecting from the same plane as the card surface containing the cavity of the storage blister. The cavity opening of the storage blister is slightly larger than the base of the sealing blister.
As a result, the base of the sealing blister is a friction fit in the mouth of the storage blister, and the second part of the card is separable from the rest of the card along one side edge and has a flap-like second part around the hinge joint. 1. A blister package card which can be folded back over one section, with the base of the sealing blister meeting the cavity of the storage blister to provide a removable seal to the storage blister. 2. The blister package card according to claim 1, wherein the cavity of the storage blister is tapered inward from the cavity opening to prevent the base of the sealing blister from entering too deeply into the storage blister. 3. A blister package card according to claim 1, wherein the hinged connection between the first and second parts is provided by a score groove in the card. 4. The blister package card according to claim 1, wherein the second portion of the card projects outward and serves as a handle tab.