JPS6012939A - Spreading drug composition and drug administration using it - Google Patents

Abstract

PURPOSE:To enable formation of a uniform, stable gel film on the surface of solid feed in a wet state, and to keep a drug effectively, by blending the drug with inexpensive starch and dextrin to give a spreading drug composition. CONSTITUTION:A spreading drug composition consisting of 30-100wt% spreading composition in a dry state comprising 100pts.wt. starch having preferably >=80wt% galatinization degree and 15-100pts.wt. dextrin having 3-15DE, and the rest of a drug is sprinkled on a solid feed having a wet surface immediately before feeding, and fed. Consequently, a uniform, stable gel film is formed on the surface of a solid feed in a wet state, and the drug is effectively kept. Since gel strength is further increased, water-soluble gum such as xanthan gum, etc. may be added to the drug composition, but an amount of it is preferably <=3wt% based on the drug composition. All the drug composition components (raw materials used) are used in dried powder.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides a strong and inexpensive spreadable drug composition for spreading (also referred to as adhering or adhering) drugs etc. on the surface of a solid feed whose surface is in a wet state. The present invention relates to a product and a method of administering a drug to aquatic feed using the same.

As a spreader for feed, it is desired that the following conditions be met. That is, ■ Spread the drug on the surface of the (bait).

■ An effective amount of the spread drug is retained until it enters the fish's mouth.

■ Spreading agent has high biological safety.

■ Low price.

■ Easy to work with, resistant to slipping, and easy to wash afterwards.

Conventionally, as this type of spreading agent, wheat flour, α-starch, dextrin, which becomes viscous upon hydration, water Rje gum, and synthetic thickening agents have been used singly or as a mixture.
A formulation that satisfies the above conditions has not yet been provided. - For example, when administering a drug for yellowtail culture feed, the drug is mixed with 1. After spreading and spreading the drug on the surface of raw sardines, etc., which is the feed, the human father uses a feeding machine to administer the drug. thrown into the sea. What is important here is that the drug fixed on the bait does not fall off during the bait casting operation or in the water after feeding, and is reliably retained in the bait until it is eaten by the cultured fish.

However, when the conventionally used wheat flour or α-starch is used alone, there is a problem that the bait sticks uniformly during spraying and is likely to separate from the bait during the operation. For this reason, these days, natural gums such as xanthan gum and sodium alginate,
Synthetic glues such as CMC are increasingly being used. However, as a result of detailed striding and observation by the present inventors, we found that when using a gum-based spreading agent that is strong against stiffness, although the adhesive strength of the R-crab spreading agent itself is excellent, there are unexpected results. Particularly eye 11
It has become clear that there is a serious drawback in that the drug, which is a liquid, is eluted in water, and as a result, only the spreading agent is stuck. In addition, these gum-based spreaders are more than 10 times more expensive than α-starch, wheat flour, etc., and if they stick to the floor, equipment, equipment, etc. of a work place, they become slimy and slippery, reducing safety and making cleaning difficult. There are also problems with ease of handling, such as creating significant difficulties.

In view of the current situation, the present invention combines inexpensive α-starch and dextrin to form a uniform and stable gel film on the wet solid surface and effectively retain the target substance. , which solves the above drawbacks.

That is, the present invention provides a spreader composition containing 30% by weight or more and less than 100 parts by weight of a dry spreading agent composition consisting of 100 parts by weight of alpha starch, 15 to 200 parts by weight of textrin, and the remainder being a drug. The present invention includes a drug composition and a method for administering drugs to aquatic feed, which is characterized in that immediately before feeding, the spreadable drug composition is sprinkled onto a solid feed having a wet surface and cast.

In the spreading agent composition of the present invention, the ratio of α-starch to dextrin varies depending on the purpose and conditions of use;
A uniform and good gel coating can be obtained within the range of 5 to 200 weight ii. When a drug is blended, 30% by weight or more of 100% by weight in the final blended spreadable drug composition.
It is desirable that the spreading agent composition accounts for less than % by weight. The spreading agent itself plays the role of a diluent when mixing the drug. Further, it is desirable that the proportion of dextrin in the pharmaceutical composition is 9% by weight or more and 50% by weight or less. In addition, in order to further strengthen the gel strength, it is possible to incorporate a water-soluble gum such as xanthan gum, but it is preferable to use less than 3% of the pharmaceutical composition, and if it exceeds this amount, the water-soluble gum will Another negative effect appears.

The α-starch of the present invention is not limited to the type of raw material, but the degree of α-starch is 80%.
% or more is desirable. Dextrin is D lη3~
As long as it is within the range of 15, the raw materials and the manufacturing method do not matter.

All pharmaceutical composition components (use pressure) are used in dry powder form. The powder may contain moisture to the extent that the powder does not lose its properties of fixation and flow.

The drug used in the present invention can be either water-soluble or water-insoluble as long as it is in powder form. Furthermore, even aqueous solutions and oils can be suitably used as long as they exhibit the properties of a dry powder in appearance due to microencapsulation, clathration, etc.

The particle size of raw materials and drugs is approximately 50% of their respective particle size distributions.
It is desirable that the particle size is such that the two overlap. This is to prevent raw materials from being classified and non-uniform due to vibration during transportation and use.

Regarding the administration method during feeding, the spreadable pharmaceutical composition of the present invention is used in solid feed. Solid baits include round corners, cut fish,
Either moist pellets or water-absorbed pellets may be used; matshu or minced pellets are not applicable.

The bait itself may be raw, steamed, dried, or frozen, but if it is frozen fish, it must be surface-thawed (no ice crystals on the surface), and if it is dried, it must be watered once. It is necessary to moisten the surface. In addition, if the surface of cut fish is significantly contaminated with internal organs or blood, it is best to simply wash it with water to make the surface fresh.

A spreadable drug composition obtained by pre-mixing a spreader and a drug is sprinkled onto the raw rice cake. The powdered drug composition absorbs moisture on the surface of the raw rice cake, turns into a gel, and spreads, so it can be poured into water immediately after being sprayed.

When the spreadable drug composition of the present invention is sprayed onto the surface of a wet object, it almost instantaneously absorbs surface free water and forms a gel film. This is mainly due to the effect of dextrin, which coats and fixes the drug and α-starch placed at the same time. Next, the α-starch begins to absorb water and swell, further strengthening and stabilizing the gel film (~increasing its adhesion. The time required for this process is approximately 30 seconds or less. In this case, the drug is water-soluble and the dissolution rate is fast. In the case of dextrin, it naturally dissolves in free water, but as the above-mentioned dextrin absorbs water at the same time as IJ, it is naturally absorbed as water inside the gel and is retained within the film, so it can be easily added to water. It will not elute.

On the other hand, α-starch, especially gum-like starch, takes time to absorb water and swell. It takes 1 to 2 minutes for the former to complete water absorption and swelling, and about 30 minutes for the latter. As a result, it is known that when looking at a single α-starch or gummy powder particle microscopically, the particle does not swell all at once, but gradually hydrates due to surface forces. actually has a weak viscosity and thus loses its effectiveness as a spreading agent. In fact, when a mixture of xanthan gum powder and pigment powder is sprinkled on the surface of sardines and immersed in water in a beaker, only the surface of the xanthan gum particles is dyed, and this surface phase is easily dyed with water. It is observed that the core is washed out, and as a result, only the undyed core (which has not yet completed water absorption and swelling) remains. That is, the rate of dissolution to the outside is faster than the rate of water absorption to the inside. On the other hand, when a similar test was conducted with dextrin, it was found that even if a large amount of powder was sprinkled on the dextrin and it was dropped into water while the dry powder was still clinging, a gel layer was immediately formed. No leaching of the dye was observed, and effects such as tanning were observed.

EXAMPLES The present invention will be described below with reference to Examples, but the present invention is not limited thereto.

Example, Kari Teru Example 201Cgf frozen in two blocks, average body length 17
cm) -11 Japanese carp l'U were cut off with a toothed roller to obtain cut live bait with an average length of about 6 cm. Sprinkle seawater on the surface and thaw it, then divide it into 2 (l kq each) and spread on each f'L at a blending ratio not shown in Table 1. Add 1 drug and 1% food red No. 2 dye as a tracer to F'L. 100 da of the added material was sprayed (after -1 lO minutes, 100 beta of seawater was put into a drum), and the scogs were dropped vertically from a height of 2 m four times at 51 J viscosity each.

The bait will sink, so feed it slowly or slowly so that it doesn't go up.
After stirring, take a sample of the water and add IJ Ding-T with hydrochloric acid.4. Q, the absorption wavelength of the tracer is 5 after precipitating blood-related proteins etc.
The absorbance at 7Qmμ was measured. The results were as shown in Table 1.

Table 1 *Drug Example 1.4, Control Example 2: L-ascorbic acid 99m,
1 part riboflavin Example 2.3, Control example 3.4: L ascorbin a6o
i, 15 parts of α-α tocopherol nitrate, 15 parts of 4-amine nitrate, 46 parts of D-pantothenic acid, 1.5 parts of riboflavin, 0.0 parts of pyridoxine hydrochloride.
Part 8 Hero η5: Sulfadimethoxine sodium control example 1
: Gizanthan gum control example 5: L ascorbine ill 00m patent applicant Kanekabuchi Chemical Industry Co., Ltd.

Claims (1)

[Claims] 1 15 to 2 parts of dextrin per 100 parts by weight of αm powder
30% by weight of a dry spreading agent composition consisting of 00 parts by weight
A spreadable drug composition containing less than 100% by weight, with the remainder consisting of a drug. 2. The composition according to claim 1, wherein the IJ content is 9 to 50% by weight. 3. The composition according to claim 1, wherein both the IJ powder and the drug are dry powders. 4. The composition according to claim 1, which contains 3% by weight or less of a water-soluble gummy substance. 5. The composition according to claim 1, wherein the degree of gelatinization of α-stagnant powder is 80% or more. 6. The composition according to claim 1, having an IJ value of DE3 to DE3-15. 7. 15 to 15 parts of dextrin per 100 parts by weight of α-starch
30% by weight or more of a spreading agent composition consisting of 200 parts by weight1
Spreading a spreadable drug composition containing less than 0.00% by weight with the remainder consisting of a drug onto a solid feed having a wet surface immediately before feeding,
8. The method according to claim 7, wherein the IJ content is 9 to 50% by weight. 8. The method according to claim 7, wherein the 941M iR, dex) phosphorus and the drug are both dry powders. 10. The method according to claim 7, wherein the spreadable drug composition contains 3% by weight or less of a water bath 11-gummy substance. 11.Special ffl”a in which the degree of gelatinization of α-starch is 80% or more
The method described in item 7 of the scope of E-requisition. 12 Dextrins are DlΣ3-15. The method according to claim 7.