JP2021029202A - Spreader for feed, and solid feed on which medicine is spread by the same - Google Patents

Abstract

To provide a spreader for feed equipped with high uniformity and high spreading power, and a solid feed on the surface of which medicine is spread by the spreader.SOLUTION: A spreader for feed has reduced starch syrup or starch syrup with a saccharide composition in which monosaccharide is 1 to 50 mass%, disaccharide is 6 to 55 mass%, trisaccharide is 7 to 25 mass%, tetrasaccharide is 1 to 10 mass% and pentasaccharide or higher saccharide is 1 to 82 mass% as an active ingredient. According to the present invention, medicine can be uniformly spread on feed. Therefore, in an animal group where the feed is supplied, the spreader can contribute to prevention of shortage/excess or equalization in medicine dosage.SELECTED DRAWING: Figure 1

Description

The present invention relates to a predetermined reduced starch syrup or a feed spreading agent containing starch syrup as an active ingredient, and a solid feed on which a drug is spread.

When administering a drug orally to an animal, compulsory administration is generally required to administer the drug in the form of tablets, powders or solutions as is. However, when simultaneous administration to a large number of animals is required for the purpose of prevention / treatment of infectious diseases, it is troublesome and impractical. Therefore, in such a case, a method of feeding a feed mixed with a drug or spread on the surface is adopted.

When spreading a drug on the surface of solid feed, a spreading agent is often used for the purpose of facilitating or strengthening the spreading. Conventionally, water-soluble pastes such as carboxymethyl cellulose (CMC), guar gum, sodium alginate, and sodium polyacrylate have been used as the spreading agent, and Patent Document 1 describes for animal feed containing carbon powder. Spreading agents are disclosed.

Japanese Unexamined Patent Publication No. 2006-340622

However, the conventional spreading agent has a problem that the drug cannot be uniformly spread on the feed, and some drugs are spread in a large amount and some are spread only in a small amount. That is, in the animal group fed with the feed, there was a concern that excess or deficiency of drug dose would occur between individuals. In addition, there is also a problem that the spreading power is insufficient and a large amount of drug loss (drugs used for the purpose of administration but not administered) occurs. In this regard, although it is described that the spreading agent for animal feed of Patent Document 1 does not elute the drug in water (Examples 1 and 2), whether or not the drug can be uniformly spread on the feed. Is unknown. That is, even in view of these prior arts, the feed spreading agent having both uniformity and spreading power is not sufficiently supplied.

The present invention has been made to solve such a problem, and provides a feed spreading agent having high uniformity and high spreading force, and a solid feed in which a drug is spread on the surface thereof. The purpose is to do.

As a result of diligent research, the present inventors have found that monosaccharides are 1 to 50% by mass, disaccharides are 6 to 55% by mass, trisaccharides are 7 to 25% by mass, tetrasaccharides are 1 to 10% by mass, and pentasaccharides or more. The reduced starch syrup or starch syrup having a sugar composition of 1 to 82% by mass, or the starch syrup having a dextrose equivalent of 14 or more and 70 or less, or the reduced starch syrup obtained by reducing the starch syrup can uniformly spread the drug on the feed. I found it. It has also been found that the reduced starch syrup or the starch syrup can spread a large amount of a drug on the feed. Furthermore, it has been found that the reduced starch syrup or the starch syrup can maintain excellent spreading power even in water and suppress the elution of the drug into water. Therefore, based on these findings, the following inventions have been completed.

(1) The first aspect of the feed spreading agent according to the present invention comprises a reduced starch syrup having the following sugar composition or a starch syrup having the following sugar composition as an active ingredient;
1 to 50% by mass of monosaccharides,
Disaccharide is 6-55% by mass,
7-25% by mass of trisaccharide,
1-10% by mass of tetrasaccharide,
1-82% by mass of pentasaccharide or more.

(2) In the second aspect of the feed spreading agent according to the present invention, a starch syrup having a dextrose equivalent of 14 or more and 70 or less or a reduced starch syrup obtained by reducing the starch syrup is used as an active ingredient.

(3) The active ingredient of the spreader for feed according to the present invention may be a reduced starch syrup or a liquid containing starch syrup at a solid content concentration of 50% by mass or more.

(4) In the present invention, the reduced starch syrup or the sugar composition of starch syrup may be as follows;
1-10% by mass of monosaccharides,
6-12% by mass of disaccharide,
7-12% by mass of trisaccharide,
5-10% by mass of tetrasaccharide,
64-82% by mass of pentasaccharide or more.

(5) The solid feed according to the present invention is a solid feed in which a drug is spread on the surface by the feed spreading agent according to the present invention.

According to the present invention, the drug can be uniformly spread on the feed. Therefore, it is possible to contribute to the prevention or equalization of excess or deficiency of drug dose in the animal group to which the feed is fed. In addition, when the drug is spread on the feed, it can be spread in a relatively large amount. Further, according to the present invention, even when the feed on which the drug is spread is used in water or water, the elution of the spread drug can be suppressed. From these facts, it is possible to contribute to guaranteeing drug efficacy and reducing drug loss.

It is a photograph which shows the state of the drug spreading about the whole amount of the drug spreading feed. The spreading agent used in preparing the drug spreading feed is shown at the upper part of each photograph. It is a photograph which shows the state of the drug spreading about one grain arbitrarily extracted from the drug spreading feed. The spreading agent used in preparing the drug spreading feed is shown at the upper part of each photograph. The upper part is a photograph exemplifying the state of drug spread corresponding to each evaluation point. The lower part is a table explaining the state of drug spread corresponding to each evaluation point. It is a bar graph which shows the evaluation point which concerns the state of the spread of a drug about the drug spread feed. The horizontal axis shows the spreading agent used when preparing the drug spreading feed. It is a bar graph which shows the average value of the illuminance of a drug spread feed. The horizontal axis shows the spreading agent used when preparing the drug spreading feed. It is a scatter plot which shows the absorbance (Abs.445) of 445 nm in the water which put them about the drug spreading feed prepared using CMC or the highly saccharified reduced starch syrup as a spreading agent. It is a scatter plot which shows Abs.445 in the water which put them about the drug spreading feed prepared using CMC or the medium saccharification reduction starch syrup as a spreading agent. It is a scatter plot which shows Abs.445 in the water which put them about the drug spreading feed prepared using CMC or low saccharification reduction starch syrup as a spreading agent. It is a scatter plot which shows Abs.445 in the water which put them about the drug spreading feed prepared using CMC or low saccharified starch syrup as a spreading agent. It is a photograph which shows the state of the drug spreading about the whole amount of the drug spreading feed. The spreading agent used in preparing the drug spreading feed is shown on the left side of each photograph. It is a bar graph which shows the evaluation point which concerns the state of the spread of a drug about the drug spread feed. The horizontal axis shows the spreading agent used when preparing the drug spreading feed. It is a bar graph which shows the spreading rate about the drug spreading feed prepared using 70% liquid, 50% liquid and 35% liquid as a spreading agent. It is a photograph which shows the state of a plastic bag after taking out a drug spreading feed. The spreading agent used in preparing the drug spreading feed is shown on the left side of each photograph. It is a bar graph which shows the average value of the illuminance of a drug spread feed. The horizontal axis shows the spreading agent used when preparing the drug spreading feed. It is a scatter plot which shows Abs.445 in the water which put them about the drug spreading feed prepared using 70% liquid, 50% liquid and 35% liquid as a spreading agent.

Hereinafter, the present invention will be described in detail. The feed spreading agent according to the present invention contains the following reduced starch syrup or starch syrup as an active ingredient:
First embodiment: 1 to 50% by mass of monosaccharides, 6 to 55% by mass of disaccharides, 7 to 25% by mass of trisaccharides, 1 to 10% by mass of tetrasaccharides and 1 to 82% by mass of pentasaccharides or more. The reduced water candy having the sugar composition of, or the water candy having the sugar composition shown on the left.
Second aspect; starch syrup having a dextrose equivalent of 14 or more and 70 or less, or reduced starch syrup obtained by reducing the starch syrup shown on the left.

In the present invention, "the drug spreads on the feed" means that the drug adheres to the whole or a part of the surface of the feed.

In the present invention, the spreader for feed refers to a composition used as an intermediary in order to facilitate the adhesion of a drug to feed.

In the present invention, the drug is a compound having a therapeutic or preventive effect on an animal disease or pathological symptom (so-called veterinary drug), as well as maintaining the quality of feed and promoting effective utilization of nutritional components contained in the feed. It also contains compounds that have the effects of nutritional supplementation, appearance improvement, etc., and are additionally ingested in addition to feed. Specifically, antibiotics, hormones, oral vaccines, physiologically active substances, synthetic antibacterial agents, vitamins and amino acids, minerals, pigments such as astaxanthin, nutritional supplements, flavoring agents, flavoring agents, enzymes, viable bacteria agents , Organic acids, antioxidants, antifungal agents, binders, emulsifiers, modifiers and the like can be exemplified. The drug may consist of one type or a plurality of types. Examples of the form of the drug include powders and granules.

In the present invention, the feed refers to a product fed to an animal as food. The form of the feed may be any solid feed on which the drug can be spread, and the size, shape, and composition of the feed can be appropriately set according to the animal species to be fed, the age of the moon, and the like. Specific examples of the shape of the feed include powder, granules, crumbles, pellets, and flakes.

Here, the animal to be fed with the feed refers to any animal other than humans, and may be a domestic animal or a wild animal. In the case of domestic animals, the purpose of breeding is not limited, such as for food such as livestock and fisheries, for pets, for ornamental / exhibition, and for experiments. Specific examples of animal species include chordates, vertebrates, mollusks, and arthropods, and more specific examples include fish, amphibians, crustaceans, mammals, birds, and shellfish.

When the feed is a feed for aquatic animals such as fish, crustaceans, and seafood, the present invention states that even when the feed on which the drug is spread is used in water or water, the elution of the spread drug can be suppressed. Demonstrate a unique effect. That is, one preferred embodiment of the feed is a solid aquatic animal feed such as aquatic feed.

Syrup is a substance obtained by saccharifying starch with an acid or an enzyme, and is a mixture of monosaccharide (glucose) and polysaccharide (oligosaccharide, dextrin, etc.). Reduced starch syrup is a type of sugar alcohol obtained by reducing starch syrup. Therefore, reduced starch syrup is also a mixture containing two or more sugar alcohols among monosaccharide sugar alcohols and polysaccharide sugar alcohols (disaccharides, trisaccharides, tetrasaccharides or pentasaccharides or more).

In the present invention, the sugar composition refers to a percentage indicating the mass ratio of each sugar to the total mass of sugars. That is, it is the mass percentage of each sugar when the total mass of sugars is 100.

In the first aspect of the feed spreading agent according to the present invention, the sugar composition of the reduced water candy or water candy is 1 to 50% by mass of monosaccharide, 6 to 55% by mass of disaccharide, and 7 to 25% by mass of trisaccharide. %, Tetrasaccharide is 1 to 10% by mass, and pentasaccharide or more is 1 to 82% by mass. Among the sugar compositions, monosaccharides are 1 to 10 from the viewpoint of further improving the uniformity of drug spread in the feed, further improving the spread amount of the drug, or further suppressing the elution amount of the drug. Sugar composition of 6 to 55% by mass of disaccharide, 7 to 25% by mass of trisaccharide, 1 to 10% by mass of tetrasaccharide and 5 to 82% by mass of pentasaccharide or more, or 1 to 1 by mass of monosaccharide Sugar composition of 10% by mass, 6 to 21% by mass of disaccharide, 7 to 16% by mass of trisaccharide, 5 to 10% by mass of tetrasaccharide and 51 to 82% by mass of pentasaccharide or more, or 1 to 1 by monosaccharide. The sugar composition may be 10% by mass, 6 to 12% by mass of disaccharide, 7 to 12% by mass of trisaccharide, 5 to 10% by mass of tetrasaccharide, and 64 to 82% by mass of pentasaccharide or more.

The sugar composition can be confirmed using high performance liquid chromatography (HPLC). That is, a chromatogram is obtained by subjecting reduced starch syrup or starch syrup to HPLC as a sample. In the chromatogram, the total area of all peaks corresponds to "total mass of sugars" and the area of each peak corresponds to "mass of each sugar". Therefore, the mass percentage of each sugar in the sample can be calculated as the ratio of the area of each peak to the total area of all the detected peaks. The HPLC conditions can be appropriately set according to a conventional method, and the following conditions can be exemplified.
<< HPLC conditions >>
Column; MCI GEL CK04S (10mm ID x 200mm)
Eluent; high pure water flow rate; 0.4 mL / min injection volume; 20 μL
Column temperature; 65 ° C
Detection: Differential refractive index detector RI-10A (Shimadzu Corporation)

Dextrose equivalent (Dextrose Equivalent value; DE) is generally used as an index of the degree of saccharification of starch syrup. DE is the ratio (percentage) of the reducing sugar to the total solid content when the reducing sugar in the sample is measured as glucose. The maximum value of DE is 100, which means that all of the solids are glucose, and the smaller the DE, the more oligosaccharides and polysaccharides.

In the second aspect of the feed spreading agent according to the present invention, when the active ingredient is starch syrup, the DE of the starch syrup is 14 or more and 70 or less. Alternatively, when the active ingredient is reduced starch syrup, the reduced starch syrup is a reduced starch syrup obtained by reducing starch syrup having a DE of 14 or more and 70 or less. From the viewpoint of further improving the uniformity of drug spread in the feed, further improving the spread amount of the drug, or further suppressing the elution amount of the drug, the DE is 14 or more and 37 or less, 14 or more and 30 or less. Alternatively, starch syrup of 14 or more and 16 or less or a reduced product thereof may be used as an active ingredient.

The DE of starch syrup can be measured by the following method.
<< Measurement method of DE >>
Accurately weigh 2.5 g of the sample and dissolve in water to make 200 mL. Weigh 10 mL of this solution, add 10 mL of 1/25 mol / L iodine solution (Note 1) and 15 mL of 1/25 mol / L sodium hydroxide solution (Note 2), and leave it in the dark for 20 minutes. Next, 5 mL of 2 mol / L hydrochloric acid (Note 3) is added and mixed, and then titrated with a 1/25 mol / L sodium thiosulfate solution (Note 4). When the liquid turns slightly yellow near the end point of the titration, add 2 drops of starch indicator (Note 5) to continue the titration, and set the time point when the color of the liquid disappears as the end point of the titration. The blank value is obtained using water, and DE is obtained by the following equation 1.
(Note 1) 1/25 mol / L iodine solution: Put 20.4 g of potassium iodide and 10.2 g of iodine in a 2 L volumetric flask, dissolve in a small amount of water, and then add water up to the marked line.
(Note 2) 1/25 mol / L sodium hydroxide solution: Put 3.2 g of sodium hydroxide in a 2 L volumetric flask, dissolve in a small amount of water, and then add water up to the marked line.
(Note 3) 2 mol / L hydrochloric acid: Gradually add 150 mL of hydrochloric acid to 750 mL of water while stirring.
(Note 4) 1/25 mol / L sodium thiosulfate solution: Put 20 g of sodium thiosulfate in a 2 L volumetric flask, dissolve in a small amount of water, and then add water up to the marked line.
(Note 5) Starch indicator: Dissolve 5 g of soluble starch in 500 mL of water, and dissolve 100 g of sodium chloride in it.

The spreader for feed of the present invention may contain only reduced starch syrup or starch syrup, or may contain other components other than reduced starch syrup or starch syrup. Other components are not particularly limited as long as they do not impair the characteristics of the present invention, and are, for example, known spreading agents such as guar gum, CMC, sodium alginate, sodium polyacrylate, animal oils and vegetable oils. , Oils and fats such as petroleum-based synthetic oil (for example, liquid paraffin), solvents such as water and alcohol, and the like.

In the feed spreading agent according to the present invention, the solid content concentration of the reduced starch syrup or starch syrup can be appropriately set according to the form of the feed, the form and the dose of the drug, and the like. On the other hand, from the viewpoint of further improving the uniformity of drug spread in the feed, further improving the yield of the drug, further improving the spread amount of the drug, or further suppressing the elution amount of the drug, 35 Mass% or more, 35 mass% or more, 40 mass% or more, 40 mass% or more, 43 mass% or more, 43 mass% or more, 45 mass% or more, 45 mass% or more, 48 mass% or more, 48 mass% or more, 50 Mass% or more, 50 mass% or more, 53 mass% or more, 53 mass% or more, 55 mass% or more, 55 mass% or more, 58 mass% or more, 58 mass% or more, 60 mass% or more, 60 mass% or more, 63 Examples can be made of solid content concentrations of mass% or more, 63 mass% or more, 65 mass% or more, 65 mass% or more, 80 mass% or less, 75 mass% or less, or 70 mass% or less. The solid content concentration of the reduced starch syrup or starch syrup in the liquid can be measured with a refractometer (sugar content meter).

In the present invention, as the reduced starch syrup or starch syrup, commercially available starch syrup may be used as it is, or may be manufactured and used according to a method known to those skilled in the art.

As a known method for producing reduced starch syrup, a reduction reaction in which hydrogen is added to starch syrup (raw sugar) as a raw material can be mentioned. In the reduction reaction by hydrogenation, for example, 40 to 75% by mass of a raw sugar aqueous solution is charged into a high-pressure reactor together with a reduction catalyst, the hydrogen pressure in the reactor is 4.9 to 19.6 MPa, and the reaction liquid temperature is The reaction may be carried out at 70 to 180 ° C. while mixing and stirring until hydrogen absorption is no longer observed. After that, the reduction catalyst is separated, decolorized and desalted by ion exchange resin treatment, if necessary, activated carbon treatment, etc., and then concentrated to a predetermined concentration to produce a high-concentration reduced starch syrup.

The spreader for feed can be used by a method known to those skilled in the art. Such methods include, for example, (i) applying a spreader for feed to the feed and then sprinkling the drug, or (i) mixing the spreader for feed and the drug, and then using this and the feed. (Iii), a spreader for feed, a method of mixing feed and drugs all at once or sequentially, and the like can be exemplified. The mixing may be performed by hand or by a machine such as a stirrer. By this method, a solid feed in which a drug is spread on the surface according to the present invention can be obtained.

Hereinafter, the present invention will be described based on each embodiment. The technical scope of the present invention is not limited to the features shown in these examples. In this embodiment, the percentage (%) indicates mass% unless otherwise specified.

<Sample>
As the spreading agent, commercially available reduced starch syrup, starch syrup, guar gum and CMC shown in Table 1 were used. Guar gum and CMC have traditionally been commonly used as spreading agents for marine feed. The reduced starch syrup and starch syrup (both product forms are liquids with a solid content concentration of 70% or 80%) remain as they are, and guar gum and CMC (both product forms are powders) are dissolved in water to a concentration of 1% to form an aqueous solution. Used in. In Table 1, the DE of the reduced starch syrup is the DE of the raw sugar.

The drug used was riboflavin (form: powder, color: orange-yellow, also known as vitamin B ₂ ) (Tokyo Kasei). Dextrin "Paindex # 100" (form: powder, color: white) (Matsutani Chemical Industry Co., Ltd.) was used as a drug doubling agent (an excipient that dilutes the drug to a certain magnification). The feed is "Hamachi EP Tough d12" (Shape: Extruder pellets, 1 grain size: φ10 mm x 10 mm, Color: Dark brown, Composition: Animal feed 51%, Grains 16%, Vegetable oil residue 14%, Other 19%) (Feed One) was used. Hereinafter, in this embodiment, this feed may be referred to as "pellet".

<Example 1> Examination of active ingredient (1) Preparation of drug-spreading feed Riboflavin was mixed in a proportion of 1 part by weight and dextrin in a ratio of 4 parts by weight, and this was prepared as a powder mixture. Put 7.5 g of the powder mixture, 300 g of pellets, and 3 g of each spreading agent in Table 1 in a plastic bag, and mix them in the plastic bag for 1 minute while being careful not to crack or chip the pellets. The drug was spread. The feed on which the drug was spread by the method was used as the drug spread feed.

(2) Evaluation of uniformity With respect to the drug spreading feed of (1) prepared using each spreading agent, the state of drug spreading was visually evaluated. A photograph of the total amount of feed is shown in FIG. 1, and a photograph of one randomly selected feed is shown in FIG. In addition, 10 grains were randomly sampled from each feed, and it was judged which of the evaluation points 0 to 4 shown in FIG. 3 was applicable, and the score was given. The scoring results (mean value of 10 grains) are shown in the bar graph of FIG.

As shown in FIGS. 1 and 2, when CMC and guar gum were used as the spreading agent, most of them were pale orange-yellow, and dark orange-yellow spots were present in the spots. That is, it was clarified that a small amount of drug was spread on most of the pellets, and a relatively large number of pellets spread on a large amount of drug were present in the pellets.

On the other hand, when high saccharified reduced starch syrup, medium saccharified reduced starch syrup (SE 57, SE 58), low saccharified reduced starch syrup (SE 30, SE 100) and low saccharified starch syrup were used as spreading agents, most of them were used. It was moderately dark orange-yellow, and there were very few dark orange-yellow spots in it. In particular, when medium saccharified reduced starch syrup, low saccharified reduced starch syrup and low saccharified starch syrup were used, the shade of orange-yellow was small, and when low saccharified reduced starch syrup was used, the shade of orange-yellow was extremely small. That is, it was revealed that although there were only a few pellets in which a large amount of drug was spread, a moderate amount of drug was spread in most of the pellets.

Further, as shown in FIG. 4, the evaluation points were higher saccharified reduced starch syrup, medium saccharified reduced starch syrup (SE 57, SE 58), and lower saccharified reduced starch syrup (SE 30, SE 100) than when CMC and guar gum were used. ) And low saccharified starch syrup were higher. In particular, the evaluation points of the medium saccharified reduced starch syrup and the low saccharified starch syrup were high, and the evaluation points of the low saccharified reduced starch syrup were remarkably high. That is, when the reduced starch syrup or starch syrup was used, there were fewer sites where the drug was not spread on the pellets than when CMC or guar gum was used, and the uniformity of spreading was higher. In addition, the uniformity of the spread was particularly high in the medium saccharified reduced starch syrup or the low saccharified starch syrup, and was remarkably high in the low saccharified reduced starch syrup.

From the above results, it was clarified that the reduced starch syrup and starch syrup can spread the drug on the feed more uniformly than the commercially available feed spreading agent.

(3) Evaluation of spreading amount Ten grains were randomly extracted from the drug spreading feed of (1) prepared using each spreading agent, and photographs were taken. Using the image analysis software "Adobe Photoshop CC 2017" (Adobe Systems), select the feed in the photographic image one by one with the Nagenawa tool, obtain the histogram of the color channel, and calculate the average value (average value of illuminance). The average value of 10 tablets was calculated for each spreading agent used. The result is shown in the bar graph of FIG. Here, since the pellets are dark brown and the drug is orange-yellow, it is considered that the larger the spread amount of the drug, the higher the illuminance of the feed in the photographic image. That is, the average value of the illuminance in the feed is an index of the spread amount of the drug.

As shown in FIG. 5, the average illuminance values are higher saccharified reduced starch syrup, medium saccharified reduced starch syrup (SE 57, SE 58), and lower saccharified reduced starch syrup (SE 30, SE 100) than when CMC and guar gum are used. ) And low saccharified starch syrup were higher. In particular, the illuminance of the medium saccharified reduced starch syrup and the low saccharified starch syrup was high, and the illuminance of the low saccharified reduced starch syrup was remarkably high. That is, the amount of drug spread in the feed was larger when reduced starch syrup or starch syrup was used than when CMC or guar gum was used. The spread amount was particularly large in the medium saccharified reduced starch syrup or the low saccharified starch syrup, and was remarkably large in the low saccharified reduced starch syrup.

From this result, it was clarified that the reduced starch syrup and starch syrup can spread the drug on the feed in a larger amount than the commercially available feed spreading agent. That is, it was clarified that reduced starch syrup and starch syrup have high spreading power.

(4) Evaluation of elution amount Put 1500 g of deionized water in a beaker with a capacity of 2 L, and use a stirrer "Three One Motor BL300" (Shinto Kagaku) and a stirrer blade (anchor blade) to create a water flow at 60 rpm. Generated. Here, the total amount (about 310.5 g) of the drug spreading feed (1) (only commercially available feed spreading agents using CMC) was added. 0.95 mL of water was collected from the beaker 10 seconds, 20 seconds, 30 seconds, 60 seconds, 120 seconds and 180 seconds after the addition, and this was used as sample water. 100 μL of sample water was subjected to a microplate reader “SpectraMax M2” (Molecular divice), and the absorbance (Abs.445) at 445 nm was measured. The results are shown in FIGS. 6-9. Since riboflavin has an absorption spectrum peak at a wavelength of 440 to 450 nm, Abs.445 is an index of riboflavin concentration in sample water. That is, it is considered that the larger the value of Abs.445, the larger the amount of the drug eluted from the drug spreading feed.

As shown in FIGS. 6 and 7, Abs.445 when the highly saccharified reduced starch syrup and the medium saccharified reduced starch syrup (SE 57) were used was equivalent to that when CMC was used. That is, when a highly reduced starch syrup or a medium-reduced starch syrup having a predetermined sugar composition was used, the amount of drug eluted was suppressed to the same amount as when a commercially available feed spreading agent was used.

On the other hand, as shown in FIGS. 7, 8 and 9, Abs.445 in the case of using medium saccharified reduced starch syrup (SE 58), low saccharified reduced starch syrup (SE 30, SE 100) and low saccharified starch syrup is CMC. Was smaller than when was used. In particular, Abs.445 of low-saccharified reduced starch syrup (SE100) was remarkably small. That is, the amount of the drug eluted was smaller when the medium-reduced starch syrup, the low-saccharified reduced starch syrup, or the low-saccharified starch syrup having a predetermined sugar composition was used than when CMC or guar gum was used. The elution amount of the drug was remarkably small in the low-saccharified reduced starch syrup having a predetermined sugar composition.

From these results, it was clarified that the reduced starch syrup and starch syrup retain excellent spreading power even in water and can suppress the elution of the drug into water. It was clarified that the elution inhibitory effect of the drug was high in the low saccharified reduced starch syrup, the low saccharified starch syrup and the medium saccharified reduced starch syrup having a predetermined sugar composition, and remarkably high in the low saccharified reduced starch syrup having a predetermined sugar composition.

<Example 2> Examination of concentration (1) Preparation of drug spreading feed As a spreading agent, a stock solution (solid content concentration 70%) of the low saccharified reduced starch syrup (SE30) shown in Table 1 was diluted with deionized water. Then, one having a solid content concentration of 50% and one having a solid content concentration of 35% were prepared, and were used as a 70% solution, a 50% solution and a 35% solution, respectively. Riboflavin was mixed with 1 part by weight and dextrin at a ratio of 4 parts by weight to prepare a powder mixture. Approximately 7.5 g of powder mixture, approximately 300 g of pellets, and approximately 3 g of each spreading agent are placed in a plastic bag and mixed in the plastic bag for 1 minute while being careful not to crack or chip the pellets. The drug was spread to prepare a drug spreading feed.

(2) Evaluation of uniformity With respect to the drug spreading feed of (1), the state of drug spreading was visually evaluated. A photograph of the total amount of feed is shown in FIG. In addition, 10 grains were randomly sampled from each feed, and it was judged which of the evaluation points 0 to 4 shown in FIG. 3 was applicable, and the score was given. The scoring result (average value of 10 grains) is shown in the bar graph of FIG.

As shown in FIG. 10, the difference in shades of orange-yellow was the smallest when the 70% solution was used, followed by the 50% solution and the largest when the 35% solution was used. Further, as shown in FIG. 11, the evaluation points were highest in the 70% solution, followed by the 50% solution and the lowest in the 35% solution. That is, when a spreading agent containing low-saccharified reduced starch syrup at a solid content concentration of 50% or 70% was used, the uniformity of drug spreading was remarkably high. From this result, it was clarified that the drug can be spread on the feed with higher uniformity by setting the solid content concentration of the reduced starch syrup or starch syrup in the spreading agent to 50% or more.

(3) Evaluation of spreading amount [3-1] Spreading rate The drug spreading feed of (1) was taken out of the plastic bag and weighed. In addition, the total weight of the pellets, spreading agent and powder mixture used to prepare the drug spreading feed was calculated and used as the charging amount. The value obtained by subtracting the weight of the drug spread feed from the charged amount was calculated, and this was taken as the lost amount. The lost amount is the weight of the spreading agent and powder mixture used that are not spread on the pellets. Subsequently, the spread rate was calculated by the following formula 2. The spreading rate indicates the ratio of the amount spread on the pellets among the spreading agent and powder mixture used (that is, the yield of the spreading agent and powder mixture, or the yield of the drug). The calculation results of the spread rate are shown in Table 2 and the bar graph of FIG. In addition, the state of the plastic bag after taking out the drug spreading feed was observed and a photograph was taken. The result is shown in FIG.
Equation 2: Spreading rate (%) = {(spreading agent (g) + powder mixture (g))-lost amount (g) / (spreading agent (g) + powder mixture (g))} × 100

As shown in Table 2 and FIG. 12, the spreading rate was highest when the 70% solution was used, followed by the 50% solution and the 35% solution. Further, as shown in FIG. 13, the amount of the drug adhering to the plastic bag after taking out the drug spreading feed was the smallest when the 70% solution was used, followed by the case where the 50% solution was used. The most common case was the use of a 35% solution.

That is, when a spreading agent containing low-saccharified reduced starch syrup at a solid content concentration of 50% or 70% was used, the amount of the drug spread on the pellet was remarkably large, and the amount of the drug that did not adhere (the amount of the drug). Loss) was significantly less. From this result, it was clarified that the drug can be spread on the feed with a higher yield by setting the solid content concentration of the reduced starch syrup or starch syrup in the spreading agent to 50% or more.

[3-2] 10 grains were randomly extracted from the drug spreading feed having the illuminance (1), and photographs were taken, and the average value of the illuminance was determined by the method described in Example 1 (3). The result is shown in the bar graph of FIG.

As shown in FIG. 14, the average value of the illuminance was highest when the 70% solution was used, followed by the 50% solution and the lowest value when the 35% solution was used. That is, when a spreading agent containing low-saccharified reduced starch syrup at a solid content concentration of 50% or 70% was used, the amount of the drug spread on the pellets was remarkably large. From this result, it was clarified that a larger amount of drug can be spread on the feed by setting the solid content concentration of the reduced starch syrup or starch syrup in the spreading agent to 50% or more.

(4) Evaluation of Elution Amount The absorbance (Abs.445) of the drug-spread feed of (1) was measured by the method described in Example 1 (4). The result is shown in FIG.

As shown in FIG. 15, Abs.445 was the smallest when the 70% solution was used, followed by the 50% solution and the largest when the 35% solution was used. That is, when a spreading agent containing low-saccharified reduced starch syrup at a solid content concentration of 50% or 70% was used, the amount of drug eluted was remarkably small. From this result, it was clarified that the elution of the drug into water can be further suppressed by setting the solid content concentration of the reduced starch syrup or starch syrup in the spreading agent to 50% or more.

Claims (5)

A feed spreading agent containing a reduced starch syrup having the following sugar composition or a starch syrup having the following sugar composition as an active ingredient;
1 to 50% by mass of monosaccharides,
Disaccharide is 6-55% by mass,
7-25% by mass of trisaccharide,
1-10% by mass of tetrasaccharide,
1-82% by mass of pentasaccharide or more. A spreader for feed containing starch syrup having a dextrose equivalent of 14 or more and 70 or less or reduced starch syrup obtained by reducing the starch syrup as an active ingredient. The feed spreading agent according to claim 1 or 2, wherein the active ingredient is a liquid containing the starch syrup or the reduced starch syrup at a solid content concentration of 50% by mass or more. The feed spreading agent according to any one of claims 1 to 3, wherein the starch syrup or the reduced starch syrup has the following sugar composition.
1-10% by mass of monosaccharides,
6-12% by mass of disaccharide,
7-12% by mass of trisaccharide,
5-10% by mass of tetrasaccharide,
64-82% by mass of pentasaccharide or more. A solid feed in which a drug is spread on the surface by the feed spreading agent according to any one of claims 1 to 4.