JPS5995927A - Emulsified composition - Google Patents

Abstract

PURPOSE:To provide a stable emulsified compsn. which has uniform and fine emulsified particles by using the condensation product of L-leucine alkyl ester having an alkyl group of adequate number of carbon atoms and protein as an emulsifier and adding water soluble polyhydric alcohol and oil thereof. CONSTITUTION:Condensation product of L-leucine alkyl ester having 4-12C alkyl group and protein and/or the salt thereof, water soluble polyhydric alcohol having >=2 hydroxyl groups in a molecule and oil are incorporated, thereby an emulsion having high safety to human body, fine particle sizes and good stability is obtd. to form an emulsion compsn. usable for cosmetics, pharmaceuticals, etc. It is possible to prepare a stable oil in water type emulsified compsn. by mixing such compsn. and a suitable amt. of water. The above-mentioned L-leucine alkyl ester is obtd. by the ester bond of alcohol such as butanol or the like and L-leucine and soybean protein, etc. are usable as protein. Ethylene glycol, etc. are usable as water soluble polyhydric alcohol, and beef tallow, etc. are usable as the oil.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention uses a protein to which TJ-leucine alkyl ester is enzymatically introduced as an emulsifier for use in cosmetics and medicine. The purpose is to effectively utilize it for i-products, etc.

In recent years, much research has been carried out on emulsification, a large number of emulsifiers have been developed, and the progress of Meisan technology has been remarkable, resulting in extremely stable emulsions being widely used in all industries. However, most of them are non-imene surfactants containing polyogine ethylene chains, aniline surfactants such as fatty acid soaps, and cationic surfactants.
:Amphoteric surfactants are used as emulsifiers, and in particular, as a result of research, we have found that L-leucine alkyl esters and protein entanglements, which are considered for general consumption, can be effectively used as emulsifiers. It was discovered that if a condensate of gyl ester and protein was dissolved in polyhydric alcohol and an oil was added thereto, it was possible to produce a highly stable emulsion with a fine particle size, and the present invention was completed. I ended up doing it.

That is, the present invention provides an alkyl group having 4 to 4 carbon atoms.
- Leucine alkyl ester and protein condensate and/or
or a salt thereof, a water-soluble polyhydric alcohol having 2 or more -1- hydroxyl groups in the molecule, and an oil component, and this emulsion composition further contains water. A stable oil-in-water emulsion composition having uniform and fine milk IIS particles obtained by mixing with ij++ is provided.

The emulsion composition obtained according to the present invention is a transparent or translucent viscous liquid or gel, and further contains water to form an oil-in-water type lb emulsion composition, a milky white fine condensate of ester and protein, and/or a salt thereof. This is thought to be because it is effectively oriented at the polyhydric alcohol/oil interface and acts as a Japanese roof tile.

Next, the configuration of the present invention will be explained in detail.

The water-soluble polyhydric alcohol used in the present invention is a water-soluble polyhydric alcohol containing two or more hydroxyl groups in the molecule, such as ethylene glycol, propylene glycol, 1,3-butylene gelicol, ]]4-butylene glycol, Rangeliful dipropylene glycol, glycerin, and glycerin such as diglycerin, triglycerin, and detraglycerin, glucose, maltose, maltitol, H1: sugar, fructose, ginger), These include sorbitol, maltotriose, threitol, erythritol and starch-degrading sugar, and one or more of these may be used.

The blending amount is 2 to 95 weight J1% (hereinafter simply referred to as 7o) of the emulsion 1 composition consisting of a condensate of L-leucine alkyl nysterte protein and/or its salt, a polyhydric alcohol, and an oil phase. be.

(Margins below) The condensate of L-leucine alkylnisdel and protein used in the present invention has alkyl in the carboxyl group! I
(L-leucine with an ester bond is amide-condensed with a free carboxyl group of a protein via an amide group.The upper limit of argyl groups is a saturated, unsaturated, straight chain, or branched alkyl group having 4 to 12 carbon atoms. Specific examples include butyl, heptyl, heginyl, isohexyl, hexenyl, katyyl, dodecyl, isotogesyl, and the like.

The condensate of L-leucine argyl ester having 4 to 12 carbon atoms and protein according to the present invention can be obtained, for example, as follows.

mass, L-leucine alkyl ester, butyl,
Heptatool, hex/-ol, hexenol, octatool, dodecamer, isohexanol, isododecanol, etc. with 4 to 2 monovalent saturated, unsaturated, straight chain, branched alcohols and L-leucine and in an organic solvent such as carbon tetrachloride using ~-toluenesulfonic acid etc. as a catalyst,
Boil and reflux to form an ester bond.

Next, this L-leucine argyl ester and protein are combined 6X in an aqueous solution system, and a thiA-rubrotease such as papain, bromelain, or phicine is added as a catalyst, and the reaction is allowed to proceed at room temperature. At this time, the protein is hydrolyzed by the enzyme, but at the same time, L-leucine alkyl ester is bonded with an amide bond to the C-terminal carboxyl group of the hydrolyzed protein via the amino group, and the L-leucine alkyl ester is The protein condensate is converted into a protein molecule by changing the hydrolysis by the protease mentioned above and the reaction time of the amide bond and the type of enzyme.
etc. can be changed arbitrarily.

2. The protein constituting the condensate of L-leucine alkyl ester and protein of the present invention is a protein usually obtained from nature, such as soybean protein, wheat protein/glutelin, whey powder, soybean caseibun, soybean flour/ Fiya°loin, glucagon, fullergen, gelatin, elastin, egg white lysozyme, amylase, fibrinogen, myosin, enolase, chymotrypsinogen, histones, actin, keratin, hemoglobin, avidin, pepsin, gliadin, growth hormone, albumin, glupurin, myoglobin, casein , papain, beta-galactosidase, insulin, lysodeme, and catalase.

(Left space below) Substances that form salts when the condensate of L-leucine alkyl ester and protein is used as a salt include helithium ions, sodium ions, potassium ions, cesium ions and ammonium ions. Inorganic, organic bases and basic inorganic and organic salts, basic amino acids such as arginine, histidine, lysine, ornithine, and basic oligopeptides containing these as residues, monoethanolamine, jetanolamine, trieta/-
Basic amine hemorrhoid bases such as amines and amine sugars, and inorganic acids such as hydrochloric acid, sulfuric acid, nitric acid, and carbonic acid, ffj: e
, citric acid, maleic acid, organic acids such as Tuma/I/a, acidic amino acids such as glutamic acid, aspartic acid, and oligopeptides containing these as residues.

The salt may be reacted in advance to form a salt and then added, or may be added separately and reacted during the manufacturing process of the emulsion composition to form a salt. L-leucine alkyl ester h
eThe pH of the aqueous salt solution of the white matter complex may be any value, but it is preferable to avoid the isoelectric point of the protein if possible.

In the present invention, any one or two of the above-mentioned leucine alkyl ester, protein condensates and salts thereof may be used.
You can select and use more than one species.

The blending amount of the condensate of L-leucine alkyl ester and protein or its salt and the polyhydric alcohol is "r (j:l ratio 1 = 1 to 1.000.
/l/ (j) Formulation m If it is less than 1 with respect to the condensate of L-leucine alkyl ester and protein and/or its salt, the solubility of the condensate of L-leucine alkyl ester and protein and/or its salt will decrease. It got worse, 1.0
If it exceeds 00, emulsion stability will deteriorate.

The oils used in the present invention include animal and vegetable oils and fats and hydrocarbons such as beef tallow, squalane, olive oil and rice bran oil, liquid paraffin, mineral oils such as petrolatum, isopropyl myristate, pentaerythritol-tetra-2-ethylhexanoate, and vitamins. Cosmetics 1, such as ester oils such as A palmitate and vitamin E acetate, and silicone oils such as methylphenyl licone and dimethyl silicone.
It is an oil commonly used in the pharmaceutical, food, and other industries.

In the present invention, one or two or more of these are selected and used. ・Total ratio of polyhydric alcohol, L-leucine, alkyl nystelte protein condensate and/or its salt. It is desirable to adjust so that it is equal to or higher than Nod%.

In addition to the above-mentioned essential ingredients, the emulsified composition according to the present invention may contain a nonionic surfactant, an anionic surfactant, a carionic surfactant, an amphoteric surfactant, a drug, and an ultraviolet absorber depending on the purpose of use. , preservatives, antioxidants, etc. may be mixed and added. Furthermore, alcohol, fatty acids, other water-soluble polymers, etc. may be added for the purpose of homogeneity stabilization and viscosity adjustment.

The emulsion composition of the present invention can be obtained by dissolving a condensate of L-leucine alkyl ester and protein and/or a salt thereof in a polyhydric alcohol or an aqueous solution thereof, and adding an oil component while stirring. In this case, it is preferable to perform a homomixer treatment, but a good emulsified composition can also be obtained even with a weak stirring force such as by hand stirring.

(The following is a margin) The emulsified composition obtained here is a uniform, transparent or translucent gel or viscous liquid, so it can be used for example in skin care jelly, beauty serum, and edible jelly. It can be used in a variety of fields, including medicated jelly, massage jelly, lubricating oil, cosmetics, medicine, and feed.

The in-water 7111 type named composition according to the present invention can be obtained by mixing the above-described emulsified composition and water.

In this case, it is desirable to perform homomixer treatment.
The oil-in-water emulsion composition obtained here has extremely excellent stability.

In water, wetting agents, water-soluble vitamins, water-soluble preservatives, water-soluble drugs, water-soluble polymers, etc., which are commonly used in the cosmetics, pharmaceutical, and food industries, are included in water. It can also be added.

The quantitative relationship between the emulsified composition and tap water can be selected from a very wide range, but it is normal! The proportion of water is 995 to 20 parts per 05 to 80 parts of the oxidizing composition.

The oil-in-water emulsion composition obtained here is a milky white viscous or low viscosity liquid in which uniform fine particles are dispersed, so that it can be used in cosmetics such as emulsions, creams, creams, undaeinyong, etc. It can be suitably used in all fields such as toiletry products such as conditioners, pharmaceuticals such as urea cream and acne cream, and foods such as mayonnaise. Furthermore, there is no problem in adding other water-soluble polymers, drugs, surfactants, powders, etc. in order to stabilize homogeneity, adjust viscosity, or provide synergy.

Hereinafter, the present invention will be roughly explained in detail using Examples and Comparative Examples. The present invention is not limited thereby.

Examples 1 to 8/Comparative Examples 1 to 3 Salt of condensate of L-loin alkyl ester and protein,
Polyhydric alcohol, ice cubes, and oil were blended in the composition and amounts shown in Table 1, treated with a 70″C Pomo mixer,
An emulsified composition was made. Further, 10 times the amount of water was added to this emulsified composition while stirring at room temperature to prepare an oil-in-water emulsified composition. The state of the emulsified composition and oil-in-water emulsified composition was observed, the characteristic values were measured, and the results are shown in the table.

It was shown to. Note that the numbers for each component are weight %.

(The following is a blank space) Table 1 (g) The condition of the oil-in-water emulsion composition was judged based on the following criteria after being left in the lEl.

◎ Emulsified particle size 1 μ or less ○ 1 to 5 μ △ 5 to 10 μ × 10 μ or more (blank below) Comparative Example 1) and a composition containing no polyhydric alcohol and using water as an external phase (Comparative Example 2) did not provide stable emulsified compositions. Further, even if a salt of a condensate of L-leucine alkyl ester and a protein, a polyhydric alcohol, and an oil were included, a stable emulsified composition could not be obtained if the polyhydric alcohol was relatively small (Comparative Example 3). On the other hand, in Examples 1 to 8 according to the present invention, very good transparent or translucent viscous liquids or gels were obtained at all levels, and furthermore, they were obtained by adding water. The oil-in-water emulsion composition was a stable emulsion with very fine particles dispersed therein.

Example 9 Water-based cosmetic oil (wt%) (A)
L=leucine dodecyl ester gelatin condensate arginine salt 2.0 maltitol (70% aqueous solution)
'30.01.3-Butylene glycol 10.0 Sodium chondroitin sulfate 05(B) Liquid paraffin
300 olive oil
20.8 Glyceryl Tristearate 5.0 Vitamin E Acetate 05 Vitamin A Palmitate 05 Preservatives. 5 Flavors
0.2 (A) phase was thoroughly stirred at 70"C.
Phase B) was dissolved at '70'C and added to phase (A) with stirring. Process this with a homo' mixer.
The mixture was stirred and cooled to obtain an aqueous cosmetic oil. This cosmetic oil has a viscous, slightly fluid, transparent gel-like appearance, and has a skin II... It is an emulsion that is highly safe and has excellent stability over time.It spreads very well when applied to the skin, and has the ability to be used over a wide range of applications with a small amount.

Example 1O (% by weight) (A) Pharmacopoeia glycerin
20.01.3-Butylene glycol
5゜L-leucine hexyl ester elastin condensate zOL-leucine decyl ester milk protein condensate 1.
.

Sodium hydroxide 01
(B) Liquid paraffin
10.0 olive oil
5.0 Pentaerythritol-tetra-2-
Ethylhexanoate 50 Vaseline
50 Ethinylestradiol 01 Preservative
O24 fragrance
0.3(C) Purified water 45.
5 Sodium alginate 0
1 xanthine gum 0
．． 1 Kizuna extract
01 Aspergillus japonica extract
01 According to the manufacturing method of Example 9, an emulsion composition was obtained from the (Δ) phase and the (B) phase, and the temperature was adjusted to 70°C and the temperature was adjusted separately to 70″C.
The mixture was diluted and dispersed in an aqueous thickener solution (phase C) kept at 100 mL, and then cooled to obtain a nutritional milky lotion in the form of an oil-in-water emulsion. The viscosity of this emulsion was 30''C, 42 BOep, and the emulsion had a stable emulsion particle size of about 1 to 3 microns, and had a smooth and smooth texture.

Example U Zancare Cream (% by weight) (A) Diglycerin
200n Lubitol (70% aqueous solution)
aO glucose (50% aqueous solution) 40 L-leucine decyl ester milk protein condensate hydrochloride
20L-leucine 2-ethyl xyl ester albumin condensate o-5 (13) liquid paraffin
2αO Isopropyl Myristate 100 Vaseline
5.0 Stearyl Alcohol 5.0PA
BA' 2
．． 0 preservatives 0.5 fragrances
03(C) Purified water 08. .

Hydroxyethylcellulose 02
(D) Mixed powder 1. .

Titanium dioxide 2
-O One dollar a cream was obtained according to the manufacturing method of Example 10. At this time, the (C) phase was used as a diluted phase after the (D) phase was treated with a 70'' Cζ trowel dispersion homomixer.

This Zancare cream has a hardness of Co-7 at 25°C, is slightly transparent, and has a highly stable oil-in-water emulsion composition with an emulsion particle size of about 1 to 3 μm, so it can withstand sunlight. It was suitable for use.

patent applicant Hi Seido Co., Ltd.

Claims (1)

[Claims] (1) A composite of an L-loydialkyl ester with an alkyl group having 4 to 4 carbon atoms and a protein and/or a salt thereof.
An emulsified composition characterized by containing a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule and an oil component. (L-leucine alkyl ester with an alkyl group having 4 to 12 carbon atoms, a protein condensate and/or its salt, and a water bath with two or more hydroxyl groups in the molecule 1fJ: Multi-411i alcohol, oil content An oil-in-water emulsion composition comprising an emulsion composition comprising: and water.