JPS5995462A - Chemical manipulator - Google Patents

Abstract

PURPOSE:To perform automatically procedures such as centrifugal separation of a sample, reagent injection, drying, temp. variation and mixing by a sequence controller by moving automatically a reaction vessel between a revolution table and a thermostat. CONSTITUTION:The reagent supplied from a reagent liquid delivery apparatus 21 injected in mul unit into the reaction vessel 3 under the state in which a reagent ejecting nozzle 7 is joined by descent of a holding plate 9 by operating an electromagnetic plunger 13. When a revlution driving motor 1a is operated to rotate a revolving table 4 and to position at the position corresponding to a sucking nozzle 8 for drying and the plunger 13 is operated, the plate 9 descends and the nozzle 8 is attached tightly to the vessel 3, and the liquid after the centrifugal separation is sucked by a vacuum pump 24 and a condensor 23. When an electromagnetic plunger 19 is operated to raise a holding plate 16, a thermostat 14 raises and the reagent enters the vessel. The sample is moved to the thermostats 32, 33, 34 by an automatic carrier 35 of reaction vessel and plural samples are treated in order.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a chemical manipulator, and in particular to a novel improvement for automating the analysis of liquids and analysis processes in units of μ.
The analysis process for ordered liquids is extremely complex, and most of it is done manually by researchers.

The purpose of this invention is to provide extremely effective means for quickly eliminating the above-mentioned drawbacks.
In particular, it is equipped with a centrifugal separator equipped with a rotary table with a freely rotatable reaction container, a nozzle up-and-down device that can move up and down the reagent discharge nozzle and drying suction nozzle, a constant temperature bath, and a mixer. It has a constant temperature chamber and a mixer vertical device that can be moved up and down, an automatic reaction container conveyance device, and a constant temperature chamber that is installed in a separate position from the distribution constant temperature chamber. It is configured so that it can be automatically moved in between.

Hereinafter, a preferred embodiment of the chemical manipulator according to the present invention will be described in detail with reference to the drawings.

In the drawings, the reference numeral 1 denotes a centrifugal separator, and a rotary table 4 having a plurality of reaction vessels 3 at its peripheral end is rotatably attached to the drive shaft 2 of this centrifugal separator R1. There is. A detection disk 5 is provided at approximately the center portion Kl of the drive shaft 2, and one end of the detection disk 5 is arranged so as to overlap with a rotational positioning sensor 6 having a U-shape as a whole. , the rotational position of the rotary table 4 can be detected.

A reagent discharge nozzle 7 is located at the upper part of the centrifugal separator 1.
This holding plate 9 has an integrally provided shaft 11 slidably attached to a holding cylinder 12, and is actuated by an electromagnetic plunger 13.
is configured to move up and down in the direction of arrow A.

Roughly speaking, a constant temperature bath 1 is installed at the bottom of the centrifugal separator 1.
4 and mixer 15 at its peripheral end.
A constant temperature bath mixer up/down device 17 is provided, and a shaft 18 integrally provided with this holding plate 16 is movable up and down in the direction of arrow B within a holding cylinder 20 having an electromagnetic plunger 19. By operating the electromagnetic plunger 19 which is provided, the retaining plate 16 moves in the direction of arrow B.
It is configured to be able to move up and down in the direction of. In addition, drive shaft 2
, axes 11 and 18 are located on the same center line.

The reagent sent from the reagent liquid feeding device 21 is discharged to the reagent discharge nozzle 7 in the order of μt, and the front 8e drying suction nozzle 8#'i, the cooling device 221C & the connected condenser 23 are connected as a source. , the output Fi of this capacitor 23 is connected to the vacuum pump 24.

On the other hand, thermostatic chambers 32, 33, and 3 each having a different control temperature are located close to the center separation device R1 and the reaction vessel automatic transfer device 35.
4S was distributed and M! E'kum@1. The output control signal from the sequence controller 26 is connected to a temperature control device 25 together with a to control the temperature at a constant temperature.
Electromagnetic plunger 19 of thermostat and mixer up/down device 17,
It is supplied to the reagent feeding device 21, the electromagnetic plunger 13 of the nozzle upper and lower limbs fi10, and the reaction container automatic transport device 35, and controls each of them.

In order to be able to heat and cool multiple samples at the same time at a constant temperature of
Reaction vessel holding plates 62α, 33α are provided with a plurality of reaction vessel insertion holes made of a material with a medium-L heating material.

34 (L) is provided.

In the above configuration, when the chemical manipulator according to the present invention is operated, the electromagnetic plunger 13 is actuated to lower the holding plate 9 and the reagent discharge nozzle 7 reacts with the reagent sent from the reagent feeding device 21. Inject μ into the reaction container 6 while connected to the container 6?
Further, when injecting a reagent into another reaction container 3 provided on the rotary table 4, the rotation drive motor 1α is rotated by a predetermined angle by a control signal from the sequence controller 26, and the other reaction container 3 is injected. When the electromagnetic plunger 13 is operated again in this state, the holding plate 9 is lowered, and the same operation as described above causes the reaction container 5K to be removed from the reagent discharge nozzle 7.
The reagent at position tttN is injected.

Furthermore, when removing moisture in the reaction vessel 6,
When the rotary drive motor 1cL is activated to rotate the rotary table 4, the reaction container 3 is positioned at a position corresponding to the drying suction nozzle 8, and the electromagnetic plunger 13 is activated, the holding plate 9 is lowered and the drying suction nozzle 8 is activated. The nozzle 8 comes into close contact with the reaction vessel 3, and at the same time the liquid dIc in the reaction vessel 6 after centrifugation is sucked by the empty water pump 24 and the condenser 23, air is supplied from the air filter 8a and the air supply pipe 8b to the second
Since the liquid enters as shown in the figure, unnecessary liquid scatters and is suctioned from the drying suction nozzle 8 in a short time.

In addition, when the temperature of the sample in the reaction vessel 6 is to be rapidly raised or lowered, the electromagnetic plunger 19 is actuated to raise the holding plate 16, which causes the thermostatic chamber 14 to rise and the reaction vessel 3 to move inside the thermostatic chamber 14. □ On the other hand, the temperature inside the reaction vessel 3 that has entered the tear tank 14 is changed within a certain period of time while the temperature inside the reaction vessel 3 is set at the constant temperature bath 14. VC can hold the reaction container 3 for a certain period of time until the reaction is completed, but if other samples are to be processed such as centrifugation or mixing during that time, the reaction container 3 is transferred to the thermostatic chamber 32 or By moving the constant temperature bath 33 or the constant temperature bath 34Vc, it is possible to sequentially process samples of different numbers of eggs.

Therefore, according to this embodiment, operations such as centrifugation of the sample in the reaction container 3, reagent injection, drying, temperature change, and mixing can be performed extremely easily, accurately, and automatically by the sequence controller without any manual intervention. The effect of making it possible to quickly carry out the difficult work that has traditionally been done by many researchers is extremely beneficial.

In particular, constant temperature bath 52.35. '54 is provided separately from the thermostatic chamber 14, and the automatic reaction vessel conveyance device 35 is connected between each to allow for the conveyance of 3F of reaction vessels. It is possible to proceed at the same time, and the effect of being able to perform the IF-order reaction on a large number of samples is tremendous.

[Brief explanation of the drawing]

FIG. 1 is an overall configuration diagram showing the chemical manipulator according to the present invention, and FIG. 2 is a configuration diagram showing the main parts of Fi. 1. Centrifugal separator 3. Reaction container 4. Rotating table 6. Rotation position sensor 7. Reagent discharge nozzle 8. Drying suction nozzle 9. Holding plate 10. Nozzle earthwork device 14
, 32.33.54 ... Constant temperature bath 15 ... Mixer
16...Holding plate 17...Thermostatic chamber and mixer up/down device 21...Reagent liquid feeding device 22...Cooling device-23...Condenser 24...Vacuum pump 25...Temperature control device 26...Sequence controller 50... Reagent supply pipe body 35...Reaction container automatic transport device 52α, 35α, 34α...Reaction container holding plate. Applicants: Agent Hachidaini Kaikosha Co., Ltd. Patent Attorney Mogami

Claims (1)

[Claims] A centrifugal separator having a rotary table that has a plurality of reaction vessels and is rotatably provided; a rotation position detection section for detecting the rotational position of the rotary table; It has a constant temperature bath (/kl) and a mixer and is movable in the direction of its spindle. and a nozzle holder having the above-mentioned constant temperature bath (A).
A thermostatic chamber (Bl) is installed in a separate location from the thermostatic chamber (Bl), an automatic reaction container conveying device for transporting the reaction container to the thermostatic chamber (Bl) is installed in a separate position, the sample filling discharge nozzle, a suction nozzle for drying, and a centrifugal chamber. It is equipped with a sequence controller for controlling a separation device, a constant temperature bath (All, (B), a mixer up-and-down device, and a transfer device), and the reaction process on the pre-delivery core separation device is controlled by the reaction container automatic transfer device. It is configured to allow reactions of multiple samples to occur simultaneously by transporting the reaction containers in progress to a constant temperature bath set at the pre-distribution position, heating and cooling them, and holding them for a certain period of time. A chemical manipulator that indicates f% of what has been done,