JPS5980646A - ヒトγ型インタ−フェロンの精製法 - Google Patents
ヒトγ型インタ−フェロンの精製法Info
- Publication number
- JPS5980646A JPS5980646A JP58176091A JP17609183A JPS5980646A JP S5980646 A JPS5980646 A JP S5980646A JP 58176091 A JP58176091 A JP 58176091A JP 17609183 A JP17609183 A JP 17609183A JP S5980646 A JPS5980646 A JP S5980646A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- formula
- arg
- ala
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 108090000790 Enzymes Proteins 0.000 claims abstract description 20
- 125000000539 amino acid group Chemical group 0.000 claims abstract description 18
- 108010078791 Carrier Proteins Proteins 0.000 claims abstract description 12
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- 125000003277 amino group Chemical group 0.000 claims abstract description 3
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- CLNSYANKYVMZNM-UWVGGRQHSA-N Gly-Lys-Arg Chemical compound NCCCC[C@H](NC(=O)CN)C(=O)N[C@H](C(O)=O)CCCN=C(N)N CLNSYANKYVMZNM-UWVGGRQHSA-N 0.000 claims description 3
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- NPBGTPKLVJEOBE-IUCAKERBSA-N Lys-Arg Chemical group NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=N NPBGTPKLVJEOBE-IUCAKERBSA-N 0.000 claims description 2
- 108010026333 seryl-proline Proteins 0.000 claims description 2
- HXNNRBHASOSVPG-GUBZILKMSA-N Ala-Glu-Leu Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O HXNNRBHASOSVPG-GUBZILKMSA-N 0.000 claims 8
- CNPNWGHRMBQHBZ-ZKWXMUAHSA-N Ile-Gln Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O CNPNWGHRMBQHBZ-ZKWXMUAHSA-N 0.000 claims 6
- JHNOXVASMSXSNB-WEDXCCLWSA-N Lys-Thr-Gly Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(O)=O JHNOXVASMSXSNB-WEDXCCLWSA-N 0.000 claims 5
- ADJDNJCSPNFFPI-FXQIFTODSA-N Ser-Pro-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO ADJDNJCSPNFFPI-FXQIFTODSA-N 0.000 claims 5
- GIVATXIGCXFQQA-FXQIFTODSA-N Arg-Ala-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCN=C(N)N GIVATXIGCXFQQA-FXQIFTODSA-N 0.000 claims 2
- RVLOMLVNNBWRSR-KNIFDHDWSA-N (2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O RVLOMLVNNBWRSR-KNIFDHDWSA-N 0.000 claims 1
- OINVDEKBKBCPLX-JXUBOQSCSA-N Ala-Lys-Thr Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O OINVDEKBKBCPLX-JXUBOQSCSA-N 0.000 claims 1
- IKAIKUBBJHFNBZ-LURJTMIESA-N Gly-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)CN IKAIKUBBJHFNBZ-LURJTMIESA-N 0.000 claims 1
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- 238000006243 chemical reaction Methods 0.000 description 46
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1982/000381 WO1984001149A1 (fr) | 1982-09-22 | 1982-09-22 | Nouveau polypeptide et son utilisation |
| MC82/00444 | 1982-11-22 | ||
| MC83/00174 | 1983-05-31 | ||
| MC82/00381 | 1983-09-22 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59052244A Division JPS6034994A (ja) | 1982-09-22 | 1984-03-21 | 新規ポリペプチドおよびその用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5980646A true JPS5980646A (ja) | 1984-05-10 |
| JPS6234760B2 JPS6234760B2 (enExample) | 1987-07-28 |
Family
ID=13762331
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58176091A Granted JPS5980646A (ja) | 1982-09-22 | 1983-09-22 | ヒトγ型インタ−フェロンの精製法 |
| JP59052244A Pending JPS6034994A (ja) | 1982-09-22 | 1984-03-21 | 新規ポリペプチドおよびその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59052244A Pending JPS6034994A (ja) | 1982-09-22 | 1984-03-21 | 新規ポリペプチドおよびその用途 |
Country Status (3)
| Country | Link |
|---|---|
| JP (2) | JPS5980646A (enExample) |
| WO (1) | WO1984001149A1 (enExample) |
| ZA (1) | ZA837058B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985004420A1 (fr) * | 1984-03-29 | 1985-10-10 | Takeda Chemical Industries, Ltd. | Nouvel adn et son utilisation |
| JPS6167481A (ja) * | 1984-09-11 | 1986-04-07 | Takeda Chem Ind Ltd | 新規ハイブリドーマおよびその製造法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5779897A (en) * | 1980-07-01 | 1982-05-19 | Hoffmann La Roche | Polypeptide containing amino acid arrangement of aged human corpuscle interferone |
-
1982
- 1982-09-22 WO PCT/JP1982/000381 patent/WO1984001149A1/ja not_active Ceased
-
1983
- 1983-09-22 JP JP58176091A patent/JPS5980646A/ja active Granted
- 1983-09-22 ZA ZA837058A patent/ZA837058B/xx unknown
-
1984
- 1984-03-21 JP JP59052244A patent/JPS6034994A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5779897A (en) * | 1980-07-01 | 1982-05-19 | Hoffmann La Roche | Polypeptide containing amino acid arrangement of aged human corpuscle interferone |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985004420A1 (fr) * | 1984-03-29 | 1985-10-10 | Takeda Chemical Industries, Ltd. | Nouvel adn et son utilisation |
| JPS6167481A (ja) * | 1984-09-11 | 1986-04-07 | Takeda Chem Ind Ltd | 新規ハイブリドーマおよびその製造法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6234760B2 (enExample) | 1987-07-28 |
| WO1984001149A1 (fr) | 1984-03-29 |
| ZA837058B (en) | 1984-04-25 |
| JPS6034994A (ja) | 1985-02-22 |
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