JPS5953406A - Cosmetics - Google Patents

Abstract

PURPOSE:To provide a stable cosmetic having antiphlogistic and tissue regenerating activities, by extracting TOKI (root of Angelica acutiloba) with a mixture of water and an organic solvent such as ethyl alcohol, storing the extract at a low temperature or a high temperature, removing the precipitated solid component from the liquid, and using the resultant TOKI extract as an active component. CONSTITUTION:TOKI is extracted with a mixture of water and an organic solvent miscible with water and capable of extracting oil-soluble components, e.g. ethyl alcohol, isopropyl alcohol, ethylene glycol, glycerol, etc. and the obtained crude extract is stored at a low temperature to promote the formation of sediments by the decrease of the solubility or stored at a high temperature to promote the formation of sediments by ripening effect. The precipitated solid component is removed from the liquid, and the obtained TOKI extract liquid is used as a component of the objective cosmetic. The weight ratio of water to the organic solvent used as the extractant is preferably (90:55):(10:45), especially (80- 60):(20-40).

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to cosmetics, and more particularly to stable cosmetics containing anti-inflammatory and tissue regenerating effects.

It is a 1U substance that belongs to the seri family and has an anti-inflammatory effect.

Because it has tissue Pj bioactivity, analgesic effect, hemostasis effect, etc., it has been widely used as a raw material for Chinese herbal medicine for external use (for example, Shiyun plaster, etc.) or for internal use. Research has been carried out on obtaining a chemical compound that has anti-inflammatory effects, 1 effect on tissue regeneration, and 4 effects on cosmetics by incorporating it into cosmetics.

Conventionally, in order to extract the essential components, it is common to extract with water alone, and in some cases extraction with VC oil is not performed, but in this case, belcabutene, which is one of the essential components, is extracted at the same time. There are problems such as a large amount of sludge being produced. - i.e. Belcabuten is commonly used in fragrances such as bergamot oil, angelica root oil,
It is a harmful substance that is present in bitter oil, cumin oil, verbena oil, roux oil, etc. For example, if you put a good perfume containing belcabuten on your skin and put it on your eyes and expose it to sunlight, it will cause bellock skin.
It is widely known that this can have negative effects, such as causing flames.In addition, when the extract is stored, extract components precipitate out, causing a so-called slag. It is unfavorable when used as a cosmetic product because it produces precipitates and is unstable in quality. Therefore, the present inventors conducted various studies in order to obtain an inexpensive cosmetic containing the extract. As a result of repeated efforts, we have completed the present invention.

In other words, one aspect of the present invention is to extract the extract obtained by extracting Toki with a mixed solvent of water and an organic solvent that can be mixed with water and extract oil-soluble components from the oil, and to store the obtained extract at a low temperature or (and) at a high temperature. This cosmetic is characterized by containing a toki extract from which the solid content precipitated has been removed. To provide cosmetics that are of the highest quality.

In the present invention, the extraction medium used to extract the oil-soluble components is an organic solvent that can be mixed with water (1) to efficiently extract the water-soluble components and oil-soluble components contained in the oil (1), which can be mixed with water (2), and (2) an organic solvent capable of extracting the oil-soluble components (2). A mixed solvent of -organic solvent) and water is used.Specific examples of organic solvents include -flJ, tif ethyl alcohol-isopropyl alcohol + n-propyl alcohol, ethylene glycol, diethylene glycol, polyethylene glycol-ethylene glycol monoethyl Ether, ethylene glycol monobutyl ether, diethylene glycol monoethyl ether, propylene glycol, propylene gelicol monoethyl ether-propylene glycol monoisopropyl ether-7,3
-butylene glycol-glycerin and the like.

The ratio of water and organic solvent in the water and ethyl alcohol mixed solvent can be arbitrarily selected. If the ratio is high, sludge will occur more often.Therefore, as an extraction solvent, water: organic solvent = 90 to 1 part by weight.
．． A mixed solvent with a ratio of t:lo~4J-σ is recommended (-especially water:organic solvent=g.

It is preferable to use a mixed solvent with a ratio of 0 to 0, and the extraction operation using the above-mentioned mixed solvent can be carried out by any method. For example, 2<7□ [171 minutes, 2o
Below C. Preferably trz. +c-/sCvC After cold immersion, stirring can be performed for extraction.In this case, the amount of solvent should be sufficient for proper immersion.After completing such an extraction operation, Separate the solid and liquid by any method, such as centrifugation, to obtain a crude extract.

It is of course possible to concentrate this crude extract by an appropriate method, such as by heating under reduced pressure.

By storing the extract thus obtained at a low temperature, the solubility decreases and the formation of dregs is promoted, and by storing it at a high temperature, the formation of dregs is promoted by ripening. That is, the above crude extract is stored for a certain period of time at low temperature or (and) high temperature to precipitate unstable components that cause 2-sore.
After filtration, use any method to obtain a 71" extract.

In this case, low temperature means sufficiently lower than room temperature (resulting in a decrease in solubility).

A temperature that does not freeze the extract is preferably -10 to IC. Furthermore, the term "high temperature" refers to a temperature that is higher than the temperature (at which temperature is sufficient to ripen the slag and not much volatilization of the solvent occurs, and JO to jOC are preferred among them.

The storage time may be sufficient as long as it is sufficient for unstable components that cause sludge to precipitate.

For example, first store it at a high temperature for 1 c/week, then store it at a low temperature with λ
Save for a week. , Rirui is under high temperature and once a day under low temperature vc1
It is preferable to combine low-temperature storage and high-Y crystal storage, such as storing for several days per cycle and storing the final storage condition at low temperature for 7 weeks. In this case, either low-temperature storage or high-temperature storage may be performed first, but low-temperature storage is preferred as the final storage condition in order to sufficiently precipitate unstable components.

Here, specific examples of extraction using the extract used in the present invention are as follows.

■Toki 1M Layer - Ethyl Alcohol/. 4-fold section - water 4
．． 2 parts by weight in the same container, cooled at 20C for 7 hours, cooled at -10C for 7 hours, centrifuged [↓] Separate the N solution and obtain the crude extract. get. Next, this crude extract was stored for <toC7-VC-7 weeks, and then filtered for 1-1 hours using diatomaceous earth as a super-assistant.
) was obtained.

■ Return' M fit part - Ethyl alcohol 2 weight -
3 parts by weight of water was charged in the same container. After stirring for 10 hours at /jc, the solid and liquid were separated using a centrifuge to obtain a crude extract. Next, this crude extract was heated under reduced pressure to concentrate the total amount to / and stored under -OC for 22 days, and then filtered using a perlite filter aid to obtain a home extract (B).

■Kawabe type 7, ethyl alcohol”N amount flu
and water in the same container, cooled for 5 hours in an IOC, stirred for -10 CVC for J hours, and separated solid and liquid using a centrifuge to obtain a crude extract. Next, this crude extract was stored under IOC for 2 days, stored under -sC [/day] in a cycle of 1 cycle, and then stored under -IC for 2 days, after which the mixture of diatomaceous earth and cellulose was filtered. An extract (C) was obtained by using the filtrate as an auxiliary agent.

■Toki/parts by weight, propylene glycol 3. Weight part -
Pour g and t parts of water into the same container, and use lIC to make IJ.
The mixture is stirred for several hours, and solid and liquid are separated using a centrifuge to obtain a crude extract. Next, this crude extract was heated to 30C for 3 days.
After storage for 012 days as 1 cycle, and after further storage for VcJ' days under VCO'Q, the extract was filtered using cellulose as a filter aid.
I admire D).

■ Parts by weight - Ethylene glycol monobutyl ether J - 3 parts by weight - 10s of water were placed in the same container, stirred at -0C for 1 hour, and then cooled at 1U OC for 70 hours? T theory: Separate the solid and liquid using a centrifugal separator to obtain a crude extract. Next, store the crude extract lrk under 0'c for 1 day, J-[under 7 days as 1 cycle, 8
-1-cycle storage - After further storage for 2 days under KJC, the mixture of diatomaceous earth and perlite was subjected to an output 1-1 filtration using f-1 filter to obtain a filter extract (E).

The extract extracted as described above showed no deterioration such as putrefaction, and the bergapten goldstone was about 0-3~/-, -
l) The amount of Pm was extremely small, and when compared with the extract lf separated by N' without the above preservation treatment, there were no significant changes in the amount of Equine, pH1 refractive index, specific gravity, color tone, etc. Also, when comparing the stability, the extraction/fi that is not subjected to the above preservation treatment produces scum within a week and the amount increases over time, whereas the extract that has been subjected to the above preservation treatment. It remained stable even after -/'g months (no deposits were observed and it was stable.

In the present invention, an appropriate amount of the extract obtained as described above is used as a raw material for various cosmetics such as lotion, emulsion, cream, hair tonic, cologne, baby powder, etc. It is added in the process of obtaining the product from the ingredients to achieve the desired stable cosmetic composition. Furthermore, in this case, fragrances, bactericides, dyes, preservatives, solubilizing agents, etc. may be added as required.

The cosmetic composition of the present invention has one anti-inflammatory effect, one tissue regeneration effect, and is stable over a long period of time, with no turbidity or precipitation.
Since it does not cause any deterioration such as separation, it is extremely excellent as a cosmetic.

Next, examples of the present invention will be shown, but the present invention is not limited to these examples.

1] Add 2 parts of purified water, 4 parts by weight of the extract (A) obtained in the above-mentioned extraction example (■), and 1 part by weight of J-butyrenoglycol! After dissolving 2 parts by weight and 2 parts by weight of glycerin, 1 part by weight of ethanol and 2 parts by weight of polyoxyethylene lauryl ether (, 2°E, o, )/+ methyl oxybenzoate) were added in sequence, and the mixture was stirred and dissolved to make it homogeneous. A stable lotion was obtained after f1.

Example 2 Extract solution (B) prepared in 19.6 parts by weight of purified water in the above-mentioned extraction example ①.
'M quantity part, water turns) lium. 9 parts by weight were added 111 times and dissolved by heating to prepare an aqueous layer.

On the other hand, Stearin [10! Iti:gt+-71 parts by weight of cetyl alcohol, parts by weight of monostearin + t&glycerin-perfume (Janumin T-1?Otsu/-'?%e manufactured by Fragrance Industry Co., Ltd.) IN parts by weight and application of oxidation prevention 411
(Butyl hydroxyanisole) was sequentially added and dissolved by heating.The oil layer was added to the above water layer, stirred and mixed, and then cooled to form a stable solution.

Example: In the above-mentioned specific example of extraction,
After adsorbing 2 tM parts of incense, k [(Lemon Knee 901 - Takasago International Co., Ltd.) into 7 parts by weight of light anhydrous silicic acid - 9 parts by weight of talc, 2 parts by weight of incense, k Mixed uniformly and produced stable baby powder.

Example 4 Add 7 parts by weight of 7,3-butylene glycol, part NM, and 7 parts by weight of potassium hydroxide to the extract (D) in the above-mentioned specific example of extraction (1) to 7 parts of purified water. Add and heat to dissolve to prepare an aqueous layer.

On the other hand - parts for stearic acid λN - cetanol, 2 parts by weight -
Squalane, 2.3NM: parts - liquid paraffin 1.2N
■Partially polyoxoethylene monooleate (
/ OE-0,) 2 parts by weight - fragrance (Rose T-qO/
0 (manufactured by Takasago Fragrance and Fragrance Industry Co., Ltd.), -tit amount part- and an appropriate amount of oxidation prevention A11 (butyl hydroxyanineol) were sequentially added and dissolved by heating, and the oil layer was added to the above water layer. After stirring and mixing - cooling to obtain a milky lotion Example 5 3 parts by weight - 0.7 parts by weight of glycyrrhizin - 0.3 parts by weight of salicylic acid, 4 parts by weight of chili pepper tincture 0.6'Tf -! -Menthol 0. / Chonggangbu - Incense Xl [Bouquet T-g
9-Sasa Fragrance Industry-I(J) o-,? Heavy
part, refined water 10-j Ill [+ next addition (1゛])
I took out the stirring bath and applied a hair tonic.

Claims (2)

[Claims] (1) The extract obtained by extracting Toki with a mixed solvent of water and an organic solvent that can be mixed with water and can extract the oil-bathed components is stored at low temperature or (and) high temperature and precipitated. 1. A cosmetic product characterized by containing an extract from which the solid content has been removed. (2) The cosmetic according to claim 7, wherein the mixed solvent is a mixed solvent of water and an organic solvent, in which 1 part by weight of water:organic solvent=90 to 90 s: /o to 3.