JPS5944096B2 - Method for producing gelatin capsules filled with hydrophilic substances - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for producing gelatin capsules in which the filling is made of a hydrophilic substance.

Capsules using an oil-based filling material and a water-soluble coating material can be manufactured using conventional capsule manufacturing equipment.

However, when the filling material is not oily but hydrophilic, there are considerable limitations in obtaining gelatin capsules of this type with conventional capsule manufacturing equipment.

Because both the filling material and the coating material are hydrophilic, for example, if both liquids were simultaneously pushed into cooling oil through a double orifice using the conventional drip method, the osmotic pressure of the filling material would Because of the phenomenon that the filling material migrates into the coating material, it was unavoidable to use the rotary method or manual techniques to fill the coating with a hydrophilic material containing a small amount of water.

Furthermore, if both the filling material and the coating material are hydrophilic and the liquid nature of the filling material is acidic, it will be difficult to encapsulate the gelatin because the acid will destroy the gelatin. I had to limit it.

As described above, in the conventional method, the filler that can be encapsulated is limited, and it is extremely impractical, and it is impossible to obtain beautifully shaped capsules with a diameter of 4 lines or less as in the case of the dropping method. First, there were drawbacks such as the fact that continuous mass production was not possible at all when the particle size was small.

The present invention has been made in view of such circumstances, and includes:
The coating material is a water-soluble gelatin material, the filling material is a hydrophilic material, and even if the filling material is acidic, continuous mass production is possible by the dropping method, and this type of capsule can be produced quickly and efficiently. This makes it possible to produce beautifully shaped capsules.

In the case where both the coating material and the filling material are hydrophilic, the inventors added tannic acid to water-soluble gelatin, which is the coating material, when the filling material is not acidic; It has been found that when this is the case, by adding an enteric coating material, the penetration of the filling material into the coating material is weakened and the interface between the two is maintained, thereby preventing the migration of the filling material into the coating material. .

In this case, depending on the liquid nature of the filling material, if it is not acidic, that is, alkaline or neutral, tannic acid may be used to suppress the penetration of the filling material and weaken gelatin's solubility in hydrophilic substances. (A film can be formed and maintained.)

However, when the filling material is acidic, the reaction between gelatin, which is a coating material, and the acid in the filling material causes the Ge/4 degree of the gelatin to be extremely reduced, resulting in a further increase in permeability.

Therefore, by adding an enteric coating agent such as methyl acrylate, methacrylic acid, or methyl methacrylate copolymer, which does not dissolve in acids, to the coating instead of the tannic acid, it is possible to suppress the decrease in the gel strength of gelatin and to prevent the coating from decreasing. It is possible to prevent the filling material from migrating into the material and to maintain the formation of a film.

Therefore, by extruding and molding the coating material and the filling material into cooling oil through a double orifice based on the combination according to the liquid properties of the filling material, gelatin containing a wide range of hydrophilic substances as filling materials can be produced. Capsules can be manufactured rapidly.

Examples of the present invention are listed below.

Example ■ This example is a so-called coffee capsule filled with a neutral substance, and gelatin is used as the coating material. dextrose
60 gtannic acid
1g water
Using a sol solution consisting of 60g and heated to 70°, reduced malt starch syrup and 100g of reduced malt starch syrup were used as the filling material. Coffee extract powder 11' water
Use 10g of this mixture heated to 70°.

Both liquids are extruded into cooled vegetable oil flowing down-flow through dual orifices.

In this case, the granulation size of the capsules can be freely controlled by adjusting the flow rate of the vegetable oil to rapidly and continuously mass-produce the capsules.

In this example, concentrated coffee capsules with a granulation diameter of 4 mm were obtained.

Example (2) This example is a so-called milk capsule filled with a neutral substance, and the coating material is the same as in Example (2) above.

The filling used was condensed milk heated to 700℃.

Same as Example ① (extrusion molding into cooled vegetable oil descending from a double orifice yields concentrated milk capsules with a granulation size of 4 squares).

These capsules have a water-soluble gelatin coating that easily dissolves during the day.

In addition, since the filling material is hydrophilic, it has good taste.
You can enjoy the fresh flavor.

Example 1 This example is a tangerine juice capsule containing an acidic filling.

Gelatin as coating material 15 g D-sorbitol 60 g Methyl acrylate, methacrylic acid, ■, 5 cu methyl methacrylate copolymer Sodium carbonate 1.8 g Water
65 The coating solution is prepared as follows.

First, make Solution A by mixing 1.82 g of sodium carbonate, 15 g of water, and 1.52 g of methyl acrylate, methacrylic acid, and methyl methacrylate copolymer, then separately add 15 g of gelatin, 60 g of D-sorbitol, and 50 g of water. Mix and heat to 70°, and use this as liquid B.

This B solution and the former A solution are combined and heated to 70°, and this is used as a coating solution.

Next, let's talk about the filling material in this example: Mandarin orange juice 95I? 5 grams of anhydrous citric acid, a small amount of fragrance Mix these together and heat to 70°.

The coating solution and fill solution as described above are extruded into cooled vegetable oil flowing downwardly through a dual orifice.

In this example, the granulation size of the capsules was controlled by adjusting the flow rate of the vegetable oil to obtain mandarin orange juice capsules with a granulation size of 4 mm.

Example (2) In this example, the coating material was the same as in Example (2), and the filling material was a highly acidic marine extract capsule as shown below.

Honey 80g Plum extract 10g Water
Mix 10 grams of these and heat to 70°.

Similarly, by controlling the granulation size of the capsule by adjusting the flow rate of the vegetable oil and extruding both liquids into the cooled vegetable oil flowing downward from the double orifice, highly acidic plum meat with a granulation size of 4 lines is produced. Extract capsules were obtained.

In this way, gelatin capsules filled with hydrophilic substances can be rapidly and continuously mass-produced using conventional equipment.

Therefore, the water content of the filler is low and limited to non-acidic materials as in the case of conventional methods, and the particle size is 4r.
The drawback that it is impossible to obtain an IL of less than 7 rL has been eliminated, and the range of liquid properties of the filler that can be encapsulated by the present invention is wider (and particle size 0.5
It has also become possible to mold minicapsules of ~4 mm.

This will further enhance the advantages of the capsule dosage form, and will expand its range of use to various other fields such as luxury foods, foods and drugs, and cosmetics.

Claims (1)

[Claims] 1. When the filling material is a hydrophilic material and the coating material is a water-soluble substance composed of gelatin and sugar alcohols or sugars such as glucose, if the filling material is not acidic, tannic acid is added to the coating material. In addition, if the filling material is acidic, an enteric coating agent may be added to the coating material, and both the filling material and coating material made of such a combination may be separately jetted into the cooling oil through a double orifice. A method for producing gelatin capsules filled with a hydrophilic substance, characterized by extrusion molding in a flowing stream.