JPS59228828A - Fluorescent amount measuring apparatus of eye body - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention measures the amount of fluorescence in the vitreous body of a subject's eye,
The present invention relates to a device for diagnosing the function, medical condition, etc. of a subject.

Recently, there have been devices that diagnose the medical condition of a subject, such as diabetes or hypertension, by injecting a fluorescent dye into the subject and measuring the amount of fluorescence in the vitreous body of the subject's eye. has been developed.

Figure 1 shows the principle of the above-mentioned device, in which light is projected from a light source (not shown) onto the subject's plate 1, and the amount of fluorescence in the vitreous body of the subject's plate 1 is extracted as an optical signal. This is amplified by a photomultiplier tube 2, the output thereof is given to a photometer 3, and recorded by an XY recorder 4, and the recorded characteristic waveform is used for diagnosis of a medical condition.

FIG. 2 shows a specific example of the device, in which 5 is a light source lamp section;
6 is a support member thereof; 7 is a slit lamp microscope for applying the light from the light source lamp section 6 to the printing plate and extracting the amount of fluorescence in the printing plate as an optical signal; 8 is a light guide member for the optical signal; 9 is a photomultiplier incorporating a photomultiplier tube for amplifying the optical signal; 10 is a photometer; 11 is a plywood board; 12 is an adjustment section.

By the way, in the above device, the photomultiplier generates a considerable amount of heat during operation, and the built-in photomultiplier tube and control circuit become hot, making it difficult to operate normally, and the output signal is disturbed, making diagnosis difficult. was causing problems.

To solve this problem, we added a fan device,
A means to air-cool the photoelectron multiplier has also been considered, but
It was not practical because it did not provide effective cooling and was still noisy. It is also conceivable to install this device to cool the entire room, but normal cooling is not effective, the cooling device becomes large, and it is not preferable from a cost standpoint.

The present invention has been made in consideration of the above-mentioned conventional problems, and an object of the present invention is to provide an apparatus for measuring the fluorescence amount of a printing plate, which uses small equipment, can effectively cool a photomultiplier, and can perform accurate measurements.

In order to achieve the above object, the present invention provides a plate fluorescence measuring device that extracts the fluorescence of a plate of a subject as an optical signal and amplifies it with a photomultiplier, in which the photomultiplier is installed in a cooling case. The photoelectron multiplier operates stably and contributes to diagnosis by obtaining accurate measurement results.

An embodiment of the present invention will be described below with reference to FIGS. 3 and 4.

In the figure, 13 is a plywood board, 14 is a light source lamp section, 16 is a slit lamp microscope, and 16 is a photoelectron multiplier that receives an optical signal from the slit lamp microscope 15 through a light guide member 17 and amplifies this optical signal. , 18 is a cooling case containing the photoelectron multiplier 17, and 19 is a photometer having an amplification function. The cooling case 18 has a small shape similar to that seen in an ordinary ice box for keeping items cold, and the outer case 2
0, an inner case 21 made of aluminum or the like,
It is composed of a heat insulating material 22 filled between both cases 20 and 21, a storage chamber 23 formed by the heat insulating material 22, and a heat insulating lid 24. A thermoelectric cooling element 25 that absorbs and radiates heat by passing a direct current is arranged in the lower part of the inner case 21. A heat dissipation fin 27 is provided on the heat dissipation surface side. A fan 29 is provided in a space 28 at the bottom of the inner case 21, and a ventilation hole 30 communicating with the space 28 is provided in the outer case 2°.

The light guiding member 1 and the output lead 31 connected to the photoelectron multiplier 16 installed in the storage chamber 23 are led out through a small hole in the heat insulating lid 24 and a small hole provided in the side of the cooling case 18. Connected to required components.

Although not shown, the output signal is processed by an X-Y recorder and recorded as a waveform.

In the apparatus for measuring the amount of fluorescence of a plate having the above structure, the photoelectron multiplier is particularly installed in a small cooling case, and is sufficiently cooled by the cooling effect of the electronic cooling element. In the above example, the temperature was about 2'C, the photomultiplier worked normally, and accurate measurement waveforms were obtained in the X-Y recorder.

In the above embodiments, the shape, arrangement, etc. of each component may be arbitrarily changed, and the photometer may be omitted, and the present invention is not limited to the configuration shown in the drawings.

As is clear from the description of the embodiments above, the apparatus for measuring the fluorescence amount of plates according to the present invention is provided with a cooling case, and the photoelectron multiplier is installed in the cooling case, so that the photoelectron multiplier can be effectively cooled. , the amount of fluorescence in the printing plate can be accurately measured. Since the cooling case only needs to be large enough to house the photoelectron multiplier, it is small and can be combined compactly, and the cost of the cooling device can be reduced. Furthermore, unlike refrigeration cycles, the cooling case does not require a compression pump, etc., and uses an electronic cooling element, so the configuration is simple, and since the operation is static, there is no adverse effect from vibration, and power consumption is low. Therefore, the value of the present invention is great.

[Brief explanation of the drawing]

Fig. 1 is a principle diagram of a device for measuring the amount of fluorescence of a plate, Fig. 2 is a perspective view of a conventional device for measuring the amount of fluorescence of a plate, and Fig. 3 is a device for measuring the amount of fluorescence of a plate according to an embodiment of the present invention. FIG. 4 is a sectional view of the cooling case portion of the device. 14...Light source lamp part, 16...Slit lamp microscope, 16...Photoelectron multiplier, 18...;
... Cooling case, 26 ... Electronic cooling element. Patent applicant Fumi Kayazawa

Claims (1)

[Claims] (1) A slit lamp microscope, a means for extracting the amount of fluorescence of the plate as an optical signal through the slit lamp microscope, a photomultiplier for increasing the optical signal, and a photomultiplier for increasing the output of the photomultiplier. An apparatus for measuring the amount of fluorescence of a printing plate, comprising a processing means and the photoelectron multiplier housed in a cooling case. (Takumi) The apparatus for measuring the amount of fluorescence of a printing plate according to claim 1, wherein the cooling case has an electronic cooling element as a cooling means.