JPS59198990A - ペプチド性抗生物質ｋ５８２ｍ−ａ及びｋ５８２ｍ−ｂの分離方法 - Google Patents
ペプチド性抗生物質ｋ５８２ｍ−ａ及びｋ５８２ｍ−ｂの分離方法Info
- Publication number
- JPS59198990A JPS59198990A JP7432883A JP7432883A JPS59198990A JP S59198990 A JPS59198990 A JP S59198990A JP 7432883 A JP7432883 A JP 7432883A JP 7432883 A JP7432883 A JP 7432883A JP S59198990 A JPS59198990 A JP S59198990A
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- water
- peptide antibiotics
- ion exchange
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003910 polypeptide antibiotic agent Substances 0.000 title claims abstract description 7
- 238000000926 separation method Methods 0.000 title claims description 5
- WBVFBXZGHGWBRE-RZOMMOEVSA-N (2r)-2-[[(2s)-6-amino-2-[[(2r)-5-amino-2-[[(2s,3r)-2-[[(2r)-5-amino-2-[[(2s,4s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)-4-hydroxypentanoyl]amino]pentanoyl]amino]-3-hydroxybutanoyl]amino]pentanoyl]amino]hexa Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](C[C@H](O)CN=C(N)N)C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](CCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(O)=O)CC1=CC=C(O)C=C1 WBVFBXZGHGWBRE-RZOMMOEVSA-N 0.000 title abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000005342 ion exchange Methods 0.000 claims abstract description 6
- 239000002952 polymeric resin Substances 0.000 claims abstract description 6
- 229920003002 synthetic resin Polymers 0.000 claims abstract description 6
- 239000007864 aqueous solution Substances 0.000 abstract description 5
- 239000011347 resin Substances 0.000 abstract description 3
- 229920005989 resin Polymers 0.000 abstract description 3
- 239000003242 anti bacterial agent Substances 0.000 abstract description 2
- 229940088710 antibiotic agent Drugs 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 241000223250 Metarhizium anisopliae Species 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000010828 elution Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 101100313763 Arabidopsis thaliana TIM22-2 gene Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000005907 cancer growth Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000012156 elution solvent Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7432883A JPS59198990A (ja) | 1983-04-27 | 1983-04-27 | ペプチド性抗生物質ｋ５８２ｍ−ａ及びｋ５８２ｍ−ｂの分離方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7432883A JPS59198990A (ja) | 1983-04-27 | 1983-04-27 | ペプチド性抗生物質ｋ５８２ｍ−ａ及びｋ５８２ｍ−ｂの分離方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59198990A true JPS59198990A (ja) | 1984-11-10 |
| JPH0349557B2 JPH0349557B2 (enrdf_load_stackoverflow) | 1991-07-29 |
Family
ID=13543932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7432883A Granted JPS59198990A (ja) | 1983-04-27 | 1983-04-27 | ペプチド性抗生物質ｋ５８２ｍ−ａ及びｋ５８２ｍ−ｂの分離方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59198990A (enrdf_load_stackoverflow) |
-
1983
- 1983-04-27 JP JP7432883A patent/JPS59198990A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0349557B2 (enrdf_load_stackoverflow) | 1991-07-29 |
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