JPS59193811A - Solid preparation - Google Patents

Abstract

PURPOSE:To prepare a solid preparation containing pirimiphos-methyl (an insecticide) in combination with a solid component incompatible with pirimiphos-methyl, by coating the solid component with a molten water-soluble wax which is solid at normal temperature, thereby improving the stability of the pirmiphos- methyl. CONSTITUTION:A solid component incompatible with pirimiphos-methyl, e.g. insecticide such as cartap and/or methomyl is coated with molten water-soluble wax which is solid at normal temperature, e.g. polyethylene glycol, polyethylene ppolypropylene glycol, polyethylene nonylphenyl ether, etc., and the coated component is combined with pirimiphos-methyl to obtain the objective solid preparation. In spite of the presence of both components, the preparation is extremely stable for a long period under normal storage condition, and sufficiently exhibits the activity of each component, e.g. vermin controlling effect.

Description

[Detailed Description of the Invention] Kibatsu 19J is a solid compound containing pirimiphos methyl! It is a solid preparation that combines the ingredients and hirimihonumefl.

1. Substances with different effects and effects have been used in various ways in history, and can be used effectively alone or in combination, mixtures, and combinations. When these substances are combined in one combination, chemical changes, physical changes, pharmacological changes, etc. occur during IF'd, and when these substances are combined, chemical, physical, and pharmacological changes occur, However, this may result in an inconvenient condition, which is called a combination contraindication.The combination contraindication that occurs when two or more of these substances are combined is used in various technical fields, including agricultural chemicals and medicine. For example, many agricultural and horticultural insecticides and fungicides with special characteristics have been developed, and various mixed preparations have been developed by taking advantage of the characteristics of each. A number of S1gKL control systems have been put into practical use, and they can perform simultaneous control, greatly contributing to labor savings in control work.However, although they have very useful features,
If more than one ingredient is combined, it will be chemically extremely unstable (9), the original excellent control effect will be lost, and there will be many ingredients that are contraindicated in combination, making it unsuitable for practical use. Solid preparations for agriculture and horticulture containing contraindicated ingredients are not commercially available.

In view of the above circumstances, the present inventors have investigated Yuzuyu and found that in a combination of virimiphos-methyl and a solid component that is contraindicated for combination with virimiphos-methyl, when the solid component is melt-coated with a water-soluble wax that is solid at room temperature, At the same time, we discovered that each component had an unexpectedly specific stabilizing effect compared to the knowledge obtained with kneaded coatings, and at the same time found that each component had an outstanding and useful effect, such as a pest control effect of 7J<7. and completed the present invention.

That is, the invention relates to (1) a solid component that is incompatible with virimiphos-methyl and is melt-coated with a one-sided water-soluble wax at room temperature; and (2) a solid product containing hirimiphos-methyl.

In the present invention, ingredients that are incompatible with pirimihonumethyl are solid ingredients. -The solid component of the consecration is ■Yuzumada is 2 or more buildings. Such a solid component is prepared at room temperature (15
Substances (with a melting point of 35°C or higher, preferably 37 to 95°C) that are used in solid form in ~ao'c, Specific examples of combinations of virimiphos-methyl and solid components that are contraindicated for incorporation with pirimiphos-methyl include combinations of cartap and pirimiphos-methyl, cartap, methomyl, and virimifos-methyl, and methomyl and pirimiphos-methyl, etc. Ingredients in such combinations Although the individual content varies depending on the use, solid components, dosage form, etc., it is generally 0.2 to 75% by weight of the total amount of the solid preparation, and 0.5 to 50% by weight. The content of the solid preparation is 1 to 99% by weight, preferably 2 to 70% by weight.

Specifically, each of the insecticides, such as cartap and methomyl, is usually contained in an amount of 1 to 90% by weight, preferably 1 to 50% by weight, based on the entire solid preparation. The total amount of the ingredients is preferably 2 to 80% by weight of the solid preparation for agricultural chemicals, preferably 2 to 6%.
The content is 0% by weight.

In the present invention, a water-soluble wax that is solid at room temperature is used to melt and coat solid components that are incompatible with pirimihonumethyl. Solid at room temperature means solid at room temperature, and specifically has a melting point of a5'C or higher, preferably 37 to 9
A water-soluble wax having a temperature of 5°C is used. Such water-soluble fuchs has a melting capacity of 0.5 g or more, preferably 51 g or more, per 100 g of water, such as polyethylene glycol/I/types (e.g. PEG-400
0.

PEG-6000, PEG-10000, PEG-20
000 Temple), polyethylene polypropylene glycols (for example, New Ball PE-68**, New Ball PE-68**, New Ball PE-68**, New Ball PE-68**, New Ball PE-68**, New Ball PE-68*, New Ball PE-68*, etc.), polyethylene nonylphenol ethers (such as Noni Ball 400*,
500*, 800", 862*), polyethylene ethylene higher alcohols (for example, Emulmin L-8)
80*, etc.) tickets are used (*Sanyo Chemical KKf[). These can be purchased separately as needed! (You may also use them in any combination.

Among them, for example, PEG (polyethylene glycol)-2000, PEG-4000, pp:a-6000
Polyethylene such as PEG-2000 to 6000 polyethylene Daliko/I/Class, Newbo/L/PE-68, Newpo/I/PE-78 polyethylene/polypropylene glyco/L/Kawa, Nonipou/Shi 400, etc. Nonylphenol ethers or mixtures thereof are preferred water-soluble hooks. The amount of such water-soluble wax to be used is preferably 0.5 to 5 times the solid component to be melt-coated, because if it is too small, self-coating will be contraindicated, and if it is too large, it will be inconvenient during use. is 0
．． Use 5 to 3 times (weight ratio). In addition, if the resulting solid preparation has appropriate water solubility and is to be used as an irrigation agent, use an appropriate amount of water-soluble wax, paying attention to the fact that if too much water-soluble wax is used, the water-solubility will deteriorate. For this purpose, it is desirable to use 0.5 to 2.5 times (weight ratio) to the solid component to be melted and coated (particularly good results can be obtained by using 0.7 to 2 times). ). Substances that promote the stability of solid components that are incompatible with pirimiphos-methyl are added to such water-soluble waxes, such as phosphoric acid, oxalic acid, PAP (isoglobil acid phos-7a), and IAl (1 part by weight of water-soluble wax). 0.1 to 1 part by weight, preferably 0.2 to 8M For example, clays such as bentonite and acid clay, powdered surfactants, and the like may be appropriately blended.

In the solid preparation of the present invention, pirimiphos-methyl and solid components that are incompatible with each other are fused with water and 8-based wax that are solid at room temperature. For example, in the Dt series of 161 type IJ history and virimiphos methyl, which is contraindicated for combination with virimifos-methyl, only the solid component of the former's 1-vl or all of the 1-form component of 2 or more buildings are separately added. Alternatively, they may be appropriately melt-coated together. The melting humidity is higher than the melting point of the water-soluble wax and higher than the melting point of the solid components to be mixed with virimiphos-methyl, and is generally 40-100%.
'C is desirably 50-85°C. Other melt coating conditions, methods, etc. can be carried out according to known means.

The lr'=I type control agent of the present invention comprises virimihonumethyl and IQ
! The solid components of the Apocalypse treated with a water-soluble wax that is solid at room temperature and virimiphos-methyl may be used as they are as a thI-form preparation according to a conventional method, or they may be combined with a suitable solid carrier (for example, a diluent, (filling agents, etc.) or adsorbed thereto, and furthermore, penetrants, wetting agents, mucilage agents, etc.

By adding a stabilizer and the like, it may be used in a suitable solid dosage form, such as an aqueous solution, two powder tablets, one m-granule tablet, etc., according to a conventional method.

When producing the solid preparation of the present invention, solid carriers such as diluents and fillers may be, for example, vegetable powders (e.g., rice bran, soybean flour, tobacco powder, wheat flour, wood flour, etc.), physical powders, etc. (For example, clays such as kaolin, bentonite, calcium phosphate, and acid clay, talc powders such as talcum powder and waxite powder, and silicas such as diatomaceous earth and mica powder) In addition, alumina, sulfur powder, and activated carbon are also used. , these contain one or more types (5 or more in the formulation).
~90%, preferably 10-80%) may be used in combination. In addition, if necessary, for example, soap cheeks, sulfuric esters of higher alcohols, alkyl sulfonic acids, etc. Surfactants such as lekylarylnuphonic acid, quaternary ammonium salts, oxyalkylamines, fatty acid esters, polyalkylene oxides, anhydrosorbitol, etc.
In general, it can be contained in the formulation in an amount of about 0.2 to 10%. Furthermore, if necessary, casein, gelatin, starch, alginic acid, agar, CMC, polyvinyl alcohol, bentonite, cresol soap, etc. may be used. In addition, other fungicides (e.g., organochlorine fungicides, organic phosphorous thread fungicides, benzimidazole-μ fungicides, steel fungicides, monosulfur fungicides, phenolic fungicides, antibiotics, etc.) may be used as needed. substances, etc.), insecticides (natural insecticides, carbamate thread insecticides, organosun insecticides, etc.), other acaricides, nematicides, herbicides, plant growth II1+D moderation agents, stabilizers, synergistic agents , attractants, repellents, fragrances, plant nutrients, fertilizers, various amino acids, low molecular or commercial molecule phosphates, etc., as appropriate.For example, solid components of virimihonumethyl and =a mixed repellent are melted with water-soluble wax. It may be mixed when coating or when forming a solid d/ll after melting and breaking the can, and gold i'4 salt neck may be added for the purpose of enhancing the potency. For example, when producing water-coated solid components, the melt-coated solid component may be pulverized by a general method, and then pirimiphos-methyl and a carrier may be added. li'J type AIJ is extremely stable for long periods of time under normal storage conditions, even though it contains a solid component that is contraindicated for combination with (livirimiphos-methyl). By using the ingredients according to their conventional usage methods, the ingredients can be used satisfactorily for their respective purposes.As a specific example, in the case of an insecticidal and sterilizing solid preparation consisting of a combination of the insecticide pirimiphos-methyl and a fungicide, for example, Paddy rice,
Seedling box treatment has an outstanding insecticidal effect against a wide range of pests such as vegetable and fruit tree pests (spraying on foliage of one crop, spraying the body of young adult insects, applying in water to rice fields, or treating soil). The insecticidal and sterilizing solid formulation of the invention has strong antibacterial activity against a wide range of plant pathogenic bacteria, especially the phytopathogens, such as insect pests. For example, when applied as a bactericide for rice fields, it simply kills rice fever pathogens. It not only kills, but also has a strong double-killing power against bacteria causing sheath blight, micrococcal rot, and sesame leaf blight.In addition, it not only kills pathogenic bacteria of rice, but also many other pathogens such as vegetable crops. It has strong antibacterial activity against pathogenic bacteria that cause diseases in crops.For example, it has antibacterial activity against pathogenic bacteria such as cucumber Gray Phytophthora and rapeseed Phytophthora 9th place. No.beta preparations should be applied to plants that are already diseased and have the curative ability to prevent their spread, but should be applied to uninfected plants.
CJ Niji also has the preventive ability to prevent infection with pathogenic bacteria and protect the plant body. Furthermore, as a treatment method, not only the usual spraying treatment on the stems and leaves of the plant body, but also the treatment on the roots of the plant body. Due to its strong osmotic properties, it is absorbed into the plant body, moves through the body, and is widely distributed. It has the ability to maintain the a degree necessary to protect uneven objects. Therefore, such insecticidal and sterilizing solid preparations are suitable for use against lepidopteran pests, such as the five-podhoptera 1ittur, which easily damage agricultural and horticultural useful objects.
a, ), CnaphFLlocr
ocis medinalis)
Parna, ra guttata), diamondback moth (P
luttelam+cuH, penni+3), Pierisrapa, e cruci
vora), Chil.

puppreq8FLlie), tobacco moth (Be'
J, 1coverpa.

assu], ta) + fall armyworm (Leucania)
5eparata)j Armyworm (Momestra)
brasFIicae), Kokakumon Hamaki (Ado
xophyes orana), Kinmonhosoga (L
ithocclletis ringonialla)
Cnaphalocrocis m
edinalis) + potato moth (Phthor
imaea operculella) and other larvae,
Coleoptera pests such as the lady beetle (Ep.
ilachna vigintioctopuncta
ta), Au1acophora fe
moralis), phyllomorph beetle (Phyllo
treta 5tiolata,), rice water weevil (Li5sorhoptrus oryzaphil)
us).

Rice weevil (Echinocnemus squam)
eus) s Rice black stink bug (Oulema ory
zae); young adult insects such as Serial order pests such as the locust locust (Locυ-5ta migratoria); and Hemiptera pests such as the rice black stink bug (Locυ-5ta migratoria).
cotinophara 1uri-da), Nasigunbai (5tophanitis nashi).

Laodel, phax 5tiat
ellus).

Japanese brown planthopper (Ni1oparuata lugen)
sl, Nephotettix c
incticeps), Una
epis yannoneneis) + soybean aphid (Aphis glycineB) j Young adult insects such as the cotton aphid (Aphis yannoneneis), and two-spotted spider mites (Tetra, ycbus)
urti-eae) *Orange spider mite (Panon
gchus citri).

Applefin = (Fanonychus ulmi)
nematodes that parasitize the roots of plants, such as Meloidogyne ha
Pla) and other agricultural and horticultural pests, and grain-eating insect pests such as Tri-bolum castan (5ito-phj, lu8 zeamais) and Tri-bolum castan (Tri-bolum castan).
eum), as well as bur moths ('l'nea pellione-11) that feed on wool, leather, paper, etc.
a) *Attagenus
piceus), Yamatonmi (Ctenolepism)
Culex pipien, which directly and indirectly harms domestic pests such as A villosa
s), Nippon Yamabuyu (Simulium na
cojapi) *Housefly (Muscado+ne
stica) Lucil,ia cae
sar) y black cockroach (Periplaneta)
fuiigjnosa), German cockroach (Bla
ttala germanica) s Yamato Magni (
Hygiene 0 such as Ixodes japonensis)
It is highly effective against insects in the house. Moreover, it has low susceptibility to warm-blooded animals, has little impact on the environment such as susceptibility to fish, and shows no toxicity to damaged animals. Furthermore, it is equally effective against insects and mites that are resistant to many existing insecticides.

The application of the above-mentioned insecticidal and sterilizing solid preparation of the present invention can be carried out based on, for example, the growth stage of the target plant, the growth situation, the type of disease, the state of disease onset,
Although it varies depending on various conditions such as the time of application or the method of application, in general, the amount of each active ingredient per 10 ares,
It may be adjusted to about 10 to 3001. In addition, if the solid preparation is an aquarium, it may be diluted so that the concentration of each active ingredient is in the range of 10 to 1000 ppm, and the method of use is as follows:
The crop may be sprayed, dusted, irrigated or seed coated;
As long as it is used safely and effectively on crops, no limitations are imposed on the present invention, regardless of the amount, concentration, or method of use.

The insecticidal and sterilizing solid preparation (toshiwake irrigation agent) of the present invention is safe, simple, and inexpensive with very few side effects.

Moreover, it is extremely useful in the art because it can accurately exhibit excellent actions and effects even after long-term medical treatment.

The method and effects of the present invention will be explained in detail with reference to Examples below.

Note that all parts and % in the examples indicate parts by weight and weight h (%).

Example 1 1.5 parts of PEG-20000 and 0.01 part of phosphoric acid were mixed with 3 parts of Cartap, melted at 80°C, cooled and pulverized, and 3 parts of virimiphos-methyl and 95 parts of clay were added and mixed uniformly. A powder that is despised.

Hyakikari IN2゜Kalutara 110 Miyako ni New Ball lL/P E-682
5 parts and 0.05 part of phosphoric acid were mixed and melted at 70°C,
An irrigation agent obtained by cooling, pulverizing, adding 5 methomils and 2 virimiphos methyl and mixing uniformly.

Example 8 Add Noniball 40071S to Methomil 10 and heat at 60°C.
An irrigation agent obtained by melting, cooling, pulverizing, adding 3 parts of biliminus methyl and 10 parts of clay, and uniformly mixing.

Accidental example 1. (Stability test of active ingredients) Examples 1 to 3
The improved agricultural and horticultural hard-carving formulation according to the present invention shown in Figure 1 was packaged in an aluminum foil bag and stored in a 40°C thermostat for 60 days, after which the residual rate of active ingredient content was measured and changes in appearance over time were measured. was measured and the results are shown in Table 12 and Table 2.

Control formulations that do not belong to the invention are shown below.

Control formulation: 3 parts Caltag, 3 parts Viliminous Methyl and Clay 95
Powder obtained by adding Miyako and mixing uniformly.

Table-1 Residual rate of active ingredients Table-2 Changes in appearance of preparations 8

Claims (1)

[Scope of Claims] (L) It is characterized by comprising (contains virimihonumethyl) a single-forming molecule 'crystal' that is incompatible with virimihonumethyl and is melted and coated with an Irkl-like water-activated wax when wet. Same shape AIJ.