JPS59170002A - Solid pharmaceutical preparation - Google Patents

Abstract

PURPOSE:In a combination of components wherein at least one is solid and their blending is inhibited, a solid pharmaceutical preparation having improved stabilization effect and improved effect of each component, obtained by coating the solid component with water-soluble wax solid at normal temperature in a molten state. CONSTITUTION:In a combination of components (e.g., acidic drug and alkali drug) wherein their blending is inhibited, a solid component is coated with water- soluble wax solid at normal temperature in a molten state, to give a solid pharmaceutical preparation. Wax having solubility of >=5g in 100g water is preferable as the water-soluble wax, and 0.5-3 times as much as polyethylene glycol 2,000-6,000, polyethylene glycol, polyethylene nonylphenol ether, etc. as the solid component by weight is used. A substance (e.g., phosphoric acid, or oxalic acid) to promote stability of the solid component of inhibited blending may be added to the water-soluble wax.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a solid preparation containing one or more combinations of mutually incompatible ingredients, at least one of which is solid.

On the other hand, substances with various actions and properties are used for various purposes and are used more effectively alone or in various combinations, mixtures, and formulations. When these substances are blended in various combinations, changes such as chemical, physical, or pharmacological changes may occur simultaneously or gradually upon blending, resulting in inconvenient or inconvenient conditions during use. It is called taboo. Contraindications that arise when two or more of these substances are combined include pesticides,
In various technical fields including medicine, it has become a barrier to the more effective or labor-saving use of substances. For example, many agricultural and horticultural insecticides and fungicides with special characteristics have now been developed, and by taking advantage of the characteristics of each, many various mixed preparations have been put into practical use, making simultaneous pest control possible and greatly contributing to labor savings in pest control work. ing.

However, although they have very useful features, when two or more components are combined, they become extremely chemically unstable and lose their original excellent pest control effect, making them unsuitable for practical use. However, there are still no solid preparations for agriculture and horticulture on the market that contain two or more ingredients that are contraindicated.

1 In view of the above circumstances, the present inventors have conducted various studies and found that
When at least one of the combined components that exhibits incompatibility is solid, melt-coating the solid component with a water-soluble wax that is solid at room temperature results in unexpected and specific bi-stabilization compared to the findings obtained with kneaded coating. At the same time as showing the effect,
The present invention was completed based on the findings that each component has outstanding useful effects, such as pesticides and the like, which exhibit pesticidal effects.

That is, in the present invention, at least one of the solid components that are incompatible with each other is a water-soluble wax that is solid at room temperature, and at least one of the solid components that are incompatible with each other is melted with a water-soluble wax that is solid at room temperature. The present invention relates to a coated solid preparation containing two or more incompatible solid ingredients.

In the present invention, at least one of the components that are incompatible with each other is a solid component. Each ingredient that is contraindicated for combination is 1 type or 2 types.
More than a species. The present invention also includes cases where two or more types of ingredients are incompatible with each other. In this case, the present invention may be applied to each combination, or all combinations may be applied together. Such ingredients, at least one of which is a solid component, are incompatible with each other, and ingredients that are incompatible with each other are used in combinations of liquids and solids, and solids and solids, which are known in various types of ingredients. Solid components include substances that are used as solids at room temperature (15 to 301°C (melting point: 35°C or higher, preferably 37 to 95°C) in various fields, such as solid agricultural chemicals, medicines, foods, or solid additives thereof). A substance that is contraindicated with other ingredients is used. For example, solid ingredients that are contraindicated with each other include not only one type of solid ingredient and one solid ingredient that is contraindicated with each other,
For example, one type of solid component and two or more types of solid components that are incompatible with each other are blended, or a combination of three or more types of solid components that are incompatible with each other is used. As an example of ingredients that are incompatible with each other in medicines, agricultural chemicals, etc., generally acidic drugs and alkaline drugs may be ingredients that are incompatible with each other. Such acidic medicines include, for example, heavy metal salts such as hydrangea, alum, vitamin D, alkaloid salts such as cocaine hydrochloride and codine phosphate, resins such as aloe and BefV-balsam, rhubarb,
These include herbal medicines such as seed coat, saccharin, Haruhi 2 Tarp 1 phenobarbital, antipyrine salicylate, sugar-containing pepsin, pyrogallol, evilenamine hydrochloride, and carbolic acid. On the other hand, examples of alkaline medicines include soap preparations such as soap camphor, alkaline salts such as borax, potassium sulfide, and sodium phosphate, aminopyrine, quinine ethyl carbonate, hexamine, theopromine sodium salicylate, and rhubarb syrup.

Specific examples of ingredients that are incompatible with each other in medicines and foods include vitamin B+, bicumin C, parbital, phenobarbicur, and a combination of @acid codin and alkali bicarbonate. In addition, in terms of pesticides, for example, Calkutube and Daedae are treated with acephate, methomyl-1-benomyl, pirimiphos-methyl, synthetic pyrethroid (MTI-
500, A, C-705, etc.), and the combination of methomyl and, for example, pirimiphos-methyl, etc., are incompatible with each other. More specifically, for example, force μtap and ace7j1, cartap and methomyl, cartap and benomyl, cartap and pirimiphos-methyl, cartap and methomyl and pirimiphos-methyl, methomyl and pirimiphos-methyl, cartap and acephate, methomyl and benomyl, cartap and H- Combinations such as 500 (manufactured by Mitsui Toatsu Co., Ltd.) and C-705 (manufactured by Cyamid Co., Ltd.) are used as ingredients that are incompatible with each other in the present invention. Preferred examples of the ingredients that are contraindicated for mixing with each other include, for example, Chikara μ Tap and Methomyl, Cartap and Acephate, Chikara μ Tap and MT Eny 00, Cartap and AC-705.
etc. are used. Although the contents of these mutually contraindicated ingredients vary depending on the use, solid ingredients, dosage form, etc., they are generally 02 to 75% by weight of the total amount of the solid preparation, preferably 0.
．． It is 5 to 50% by weight. Further, the content of all solid components that are prohibited from being mixed with each other is 1 to 99% by weight of the solid preparation, preferably 2 to 70% by weight. For example, specific examples of pesticides include Calcutub, Ortolan, Mesomi'/
Each of the insecticides such as L/
~90% by weight, preferably 1 to 50% by weight, each bactericidal agent such as Benomyl usually contains 1% by weight in the solid formulation.
The content is 90% by weight, preferably 1 to 50% by weight.

Then, the total amount of the solid components, which are prohibited from being mixed with each other, is contained in an amount of 2 to 80% by weight, preferably 2 to 60% by weight, of the solid preparation for agricultural chemicals.

In the present invention, a water-soluble wax that is solid at room temperature is used to melt and coat one of the above-mentioned solid components that are incompatible with each other. Solid at room temperature refers to a solid state at room temperature, specifically a melting point of 35° or higher, preferably 37-9
A water-soluble wax having a temperature of 5°C is used. Such a water-soluble wax is preferably 0.5 g or more, or 5 g or more of molten wax per 100 g of water, such as polyethylene wax! J: Z-lv (e.g. PEG-4000, PE
G-6000, PEG-10000, PEG-2000
0, etc.), polyethylene polypropylene glycols (e.g. Newpo 1vPE-68*, 78", 1vPE-68*, 78", 1
08*, etc.), polyethylene nonylphenol ethers (e.g. Nonipor/L'400*, L'400*, L'500*L'8
00”, 862*, etc.), polyoxyethylene high-grade aμ
(eg, Emulmin L-380'', etc.) are used (*manufactured by Sanyo Kasei grade).These may be used singly or optionally mixed as required.

Among them, for example, PEG (polyethylene glycol)
-2000, PEG-4000, PEG-6000 and other polyethylene glycols of PEG-2000 to 6000, New Ho/1/PE-68, New Ho/L/
Preferred water-soluble waxes include polyethylene/polypropylene glycols such as PE-78, polyethylene nonylphenol ethers such as Nonipor/1/400, and mixtures thereof. If the amount of water-soluble wax used is too small, it will be contraindicated, and if it is too large, it will be inconvenient to use.The amount of water-soluble wax used is preferably 0.5 to 5 times the solid component to be melt-coated. .5 to 3 times (weight ratio) is used. In addition, if the resulting solid preparation has appropriate water solubility and is used as an aquarium, etc., use an appropriate amount of water-soluble wax, taking into account that too much water-soluble wax will result in poor water solubility. It is necessary to use
For this purpose, 0.5~
It is desirable to use 25 times (weight ratio) (especially 0.7 to 2
Good results can be obtained by using twice the amount.) To such water-soluble waxes, a small amount (0.00% per 1 part by weight of water-soluble wax) of substances that promote the stability of solid components that are prohibited from being mixed with each other, such as phosphoric acid, oxalic acid, and PAP (isopropyl acid phosphate), are added. 1 to 1 part by weight, preferably 0.2 to 0.8 parts by weight), and silicas such as diatomaceous earth and powdered silicic acid, bentonite, acid clay, etc. can also be added as grinding aids and anti-caking agents. It is also possible to appropriately blend clays such as, powdered surfactants, etc.

In the solid preparation of the present invention, at least one of the contained solid components that are incompatible with each other is melt-coated with a water-soluble wax that is solid at room temperature. There is no limit to the number of solid components that can be melt-coated unless there is a contraindication to their incorporation. For example, only one or both of two types of solid components that are contraindicated with each other may be separately melt-coated, and in the case of blending one solid component with two or more solid components that are contraindicated with each other, the former Only one type of solid component, all or both of the latter two or more solid components may be melt-coated separately, and if two or more combinations of solid components that are incompatible with each other are included, each One of the solid components of each combination may be melt coated separately or together, and the other solid component of each combination may also be melt coated separately or together as appropriate. The melting temperature is higher than the melting point of the water-soluble wax and lower than the melting point of the solid components that are incompatible with each other, and is generally 40 to 100°C, preferably 50 to 85°C. Other melt coating conditions, methods, etc. can be carried out according to known means.

In the solid preparation of the present invention, at least one solid component of the ingredients that are incompatible with each other is melt-coated with water-soluble wax, which is solid at room temperature, and solidified as is by a conventional method. It may be used as a formulation, or mixed with or adsorbed onto a suitable solid carrier (e.g. diluent, filler, etc.) and further supplemented with e.g. penetrants, wetting agents, mucilage agents, stabilizers, etc. It may be added and used in a suitable solid dosage form, such as an aqueous solution, 9 powder tablets, or 9 fine granule tablets, according to a conventional method.

When manufacturing solid formulations for agricultural chemicals, solid carriers such as diluents and bulking agents may be, for example, vegetable powders (e.g., rice bran, soybean flour, tobacco flour, wheat flour, wood flour, etc.), minerals, etc. Unprocessed rice (for example, clays such as kaolin, bentonite, calcium phosphate, and acid clay, talcs such as talcum powder and waxite powder, and silicas such as diatomaceous earth and mica powder), as well as alumina, sulfur powder, and activated carbon are also used. , these contain one or more kinds (5 in the preparation)
~90%, preferably 10-80%) may be used in combination. In addition, if necessary, for example, soaps, sulfuric esters of higher alcohols, alkyl sulfonic acids, alkylaryl sulfonic acids, quaternary ammonium salts, oxyalkylamines, fatty F esters, polyalkylene oxides, anhydrosorbic acid) /V type surfactants can also be generally included in the formulation in an amount of about 0.2 to 10%. In addition, casein, gelatin,
Starch, alginic acid, agar, CMC, polyvinyl alcohol, bentonite, cresol soap, etc. may also be used. In addition, other types of fungicides (e.g., organochlorine fungicides, organophosphorus fungicides, benzimidazole fungicides, copper fungicides, organic sulfur fungicides, phenol/l fungicides, etc.) may be used as necessary.
/ type fungicides, antibiotics, etc.), insecticides (natural insecticides, carbamate insecticides, organophosphorus insecticides, etc.), other acaricides, nematicides, herbicides, plant growth regulators, stabilizers , synergist, attractant, repellent, fragrance, plant nutrient, fertilizer,
Various amino acids, low-molecular or high-molecular phosphates, etc. may be mixed as appropriate, for example, when melt-coating solid components that are prohibited in combination with water-soluble wax, or when forming solid preparations after melt-coating. Furthermore, metal salts may be added for the purpose of enhancing efficacy. For example, when producing a wettable powder, the melt-coated solid component may be pulverized by a general method, and then other solid components and carriers may be added thereto.

The solid preparation thus obtained contains two ingredients that are incompatible with each other.
Despite containing more than one species, it is extremely stable for a long period of time under normal storage conditions, and can be used satisfactorily for various purposes by using it in accordance with conventional methods for using solid components.

As a specific example, regarding solid formulations for agricultural chemicals, for example, in the case of an insecticidal and sterilizing solid formulation consisting of a combination of an insecticide and a fungicide, which are mutually prohibited ingredients, it is effective against a wide range of pests such as paddy rice, vegetable, and fruit tree pests. It has an outstanding insecticidal effect when spraying on the leaves of 9 crops treated with seedling boxes, spraying the body of young adult insects, applying in water to rice fields, and treating soil.
Moreover, the insecticidal and sterilizing solid preparation of the present invention has strong antibacterial activity against not only insect pests but also a wide range of plant pathogenic bacteria, especially common pathogens. It not only kills bacteria 9, but also has strong double-killing power against sheath blight, micrococcal root blight, and sesame leaf blight. Furthermore, it has strong antibacterial activity not only against pathogenic bacteria of rice but also against pathogenic bacteria that cause disease in many crops such as cane vegetables. For example, it has antibacterial activity against cucumber gray Phytophthora, vegetable rot, and strawberry gray mold. In addition, the insecticidal and sterilizing solid preparation of the present invention can be applied to already diseased plants.
Not only does it have the therapeutic ability to inhibit its extension;
By treating unaffected plants, it also has the preventive ability to prevent pathogen infection and protect the plants. Furthermore, as a treatment method, in addition to the usual spraying treatment on the stems and leaves of the plant, it is also possible to treat the roots of the plant due to its strong osmotic properties, which allow it to be absorbed into the plant, move through the body, and be distributed widely. It has the ability to maintain the concentration necessary for plant protection. Therefore, such insecticidal and sterilizing solid preparations are suitable for use against lepidopteran pests, such as Spodoptera, which chew and damage useful agricultural and horticultural plants.
1ittura), Cna-p
halocrocia medinalis), Inet beetle (Parnara guttata)
, diamondback moth (Plutella maculipenni)
s), the cabbage butterfly (Pierisrapae)
crucivora), Chil.

5uppressalis), Tapaco moth (He1i
coverpaassulta), Awayoto'r7
(Leucania sgparata), armyworm (
Momestra brassicae), Adoxophyes orana
, Lithocolletia ri
ngoniala), Cottontail moth (Cnaph)
alcrocis medinalis), potato moth (Phthorimaea opercule)
lla), and coleopteran pests such as the lady beetle (Epilachna lla).
ioctopunctata), auricular beetle (Au
Phyllotreta 5tiola), Phyllotreta 5tiola
ta), rice weevil (Li5sorhoptr)
us oryzaphilus).

Rice weevil (Echinocnemus aquam)
eua), Oulema or
yzae), orthoptera pests such as the locust locust (Locu-ata migratoria).
), hemiptera pests such as the rice black turtle (5cotinophala 1uri-da)
, Nasigunbai (5tophanitis nash)
i).

Laodelphax 5tiate
).

Japanese brown planthopper (Ni1oparuata lugen)
s), Nephotettix
cincticeps),
Unaspis yannonensis).

Soybean aphid (Aphis glycines)
, cotton aphid (Aphis gossypii)
), spider mites such as the two-spotted spider mite (Tet
raychus urti-cae), orange spider mite (Panongchua citri).

F'a, nonychus ulmi
), and nematodes that parasitize the roots of plants, such as Meloidogyne
Agricultural and horticultural pests such as S. hapla) and brown elephants (Sito-philus zeamais) that damage grains
, Tri-bolum casta
neum), as well as the bur moth (Tinea pellionella), which damages wool, leather, paper, etc.
, Attagenus pice
us).

Ctenolepisma villos
Culex pipiens, which directly and indirectly harms domestic pests such as a), =
- Simulium nacojap
i), the house fly (Muscadomes ti)
ca ), Lucilia caesar
).

Black cockroach (Periplaneta fuligi)
nosa), German cockroach (j31attala)
germanica), Yamato tick (Enxod
It is highly effective against sanitary and domestic pests such as Es japonensis. Moreover, it has low toxicity to warm-blooded animals.
It has little effect on the environment, such as toxicity to fish, and shows no phytotoxicity to plants. Furthermore, it is equally effective against insects and mites that are resistant to many existing insecticides.

The application of the above-mentioned insecticidal and sterilizing solid preparation of the present invention can be carried out based on, for example, the growth stage of the target plant, the growth situation, the type of disease, the state of disease onset,
Although it varies depending on various conditions such as the time of application or the method of application of the drug, in general, the amount of each active ingredient per 107-μ,
The weight may be adjusted to about 10-300 g. In addition, when the solid preparation is a wettable powder, the concentration used may be diluted so that each active ingredient is in the range of 10 to 11,000 pp, and the usage method is as follows:
Crops may be sprayed, dusted, oiled or seed coated;
As long as it is used safely and effectively on crops, no limitations are imposed on the present invention, regardless of the amount, concentration, or method of use.

The insecticidal and sterilizing solid preparation (toshiwake irrigation agent) of the present invention is safe, simple, and inexpensive with very few side effects.

Moreover, it is extremely useful in this industry because it can accurately exhibit excellent actions and effects even after long-term storage.

The method and effects of the present invention will be explained in detail below with reference to Examples.

Note that all parts and % in the examples indicate parts by weight and % by weight.

Example / Irrigation agent obtained by mixing 10 parts of KPEG-6000020 parts of yvp'', yp, melting at 65°C, cooling, crushing, adding 10 parts of acephate and 3 parts of diatomaceous earth and mixing uniformly. .

Example 2 Mix 10 parts of VP Whelk, 20 parts of KPEG-60000, and 01 part of phosphoric acid, melt 6 parts at 5°C, cool, crush, add 10 parts of Mesomi/L/1, and 5 parts of diatomaceous earth, and mix uniformly. Irrigation agent obtained by

Example 3 An irrigation agent obtained by adding 5 parts of PEG-40000 and 10 parts of clay to 10 parts of Cartap and mixing them uniformly.

Example 3 parts of Gukartap were mixed with 1.5 parts of PEG-20000 and 0.01 part of phosphoric acid, melted at 80°C, cooled and ground, and 3 parts of pirimiphosmethyl/L/1 and 95 parts of clay were added and mixed uniformly. A powder obtained by

Example 5 10 parts of Cartap were mixed with 10 parts of Newport/l/PE-6825 parts and 0.05 parts of lost≧methic acid, melted at 70'C, cooled, pulverized, and mixed with 5 parts of methomyl and pirimiphos methic acid/L/2.
An irrigation agent obtained by adding the following ingredients and mixing them uniformly.

Example 10 parts of PEG-60000 were added to 10 parts of Otsu Caltap, and 10 parts of PEG-6000 were added to Mesomi/L'IO part, melted separately at 65°C, cooled, and crushed. To these were added 5 parts of powdered silicic acid and Hymer/L'2004A (manufactured by Matsumoto Yushi)
Wettable powder obtained by adding 2 parts and mixing uniformly.

Example Z Add 7 parts of Nonipor/Iz400 to 10 parts of methomyl and prepare 6
Melt to 0°C, cool, grind, pirimihomethi/L/3
An irrigation agent obtained by uniformly mixing 10 parts of clay and 10 parts of clay.

In the example, 10 parts of Newport/L/PE-780 was added to 20 parts of Caltap, and PEG-60007 was added to 10 parts of acephate.
10 parts of Benomi/L, 5 parts of Meso-Mil, 3 parts of Hi-q-/L/2004C (manufactured by Matsumoto Yushi), and separately melted at 65°C, cooled, and crushed. An irrigation agent obtained by adding 10 parts of clay and mixing uniformly.

Example 40 parts of ppG-6ooo and 0.5 part of oxalic acid were mixed with 20 parts of Takal Tap, melted to 65 ml, cooled, and pulverized.
An irrigation agent obtained by adding 20 parts of acephate and 5 parts of diatomaceous earth and mixing them uniformly.

Example 10 Mix 120 parts of PEG-1000030 parts of PEG-100000, 10 parts of Nonipou) lz400, and 0.2 parts of phosphoric acid to make 6
Melt at 5°C, cool, crush, Mesomi/l/20 parts,
A hydrating agent obtained by adding 7 parts of diatomaceous earth and mixing uniformly.

Example/Z 65C by mixing 2 parts of Cartap with 3 parts of PEG-6000
0.5 part of synthetic pyrethroid MT Knee 500 (Mitsui Toatsu Co., Ltd.) was melted, cooled and crushed.

A powder obtained by adding 2 parts of white carbon and 92.5 parts of clay and mixing them uniformly.

Example/2 Mix 20 parts of Cartap and 30 parts of KPEG-60000 to create 6
Melt to 5°C, cool, grind, synthetic pyrethroid AC
-705 (Siamid Co., Ltd.) 5 parts, Heimer/l/20
20 An irrigation agent obtained by adding 3 parts (Matsumoto Oil) and 5 parts of diatomaceous earth and mixing them uniformly.

Experimental Example/(Stability test of active ingredients) The improved agricultural and horticultural solid preparations according to the present invention shown in Examples/-12 were packaged in aluminum foil bags and stored in a 40tE thermostat for 60 days. We measured the residual rate of the component content and measured the change in appearance over time, and the results are shown in Table 12 Table 2
It was shown to.

Control formulations that do not belong to the invention are shown below.

Control formulation-1 10 parts of cartap, 10 parts of acephene, 3 parts of diatomaceous earth
1 part and 20 parts of clay and mix uniformly.

Control Preparation-2 Irrigation agent obtained by adding 10 parts of Mesomi 1v, 0.1 part of phosphoric acid, and 5 parts of diatomaceous earth to 10 parts of Cartap and uniformly mixing the mixture.

Control formulation-3 Irrigation agent obtained by adding 10 parts of Benomyl and 10 parts of clay to 10 parts of Cartap and mixing uniformly.

Control formulation-4 A powder obtained by adding 3 parts of pirimiphosmethi/L' and 95 parts of clay to 3 parts of Cartap and uniformly mixing the mixture.

Table-1 Remaining rate of active ingredient Table-2 Change in appearance of preparation Example Place a potted cabbage on a rotating table Example 1.2.
8, 9. Add the irrigation agent obtained in 10 to 6 Contents of the amendment (1) Correct "Used." on page 4, line 6 of the specification to "Used. J."

(2) Correct the following from page 5, line 13 of the circular to page 6, line 1.

[Cefniet, methomyl, benomyl, synthetic pyrethroids (MTI-500, AC-705, etc.), etc. are contraindicated in combination with each other. Specifically, for example, cartap and acephate, cartap and methomyl,
Cartap and Benomyr, Cartap and A±” (3) From the 4th line of the 19th member of the same book to the last line of page 25,
Correct as follows.

[Example 4] 10 parts of PEG-6000 was added to 10 parts of Caltap, and 10 parts of Methomil and 10 parts of KPEG-6000 were separately melted at 65°C, cooled, and pulverized. (Manufactured by Matsumoto Yushi) 2 parts are added and mixed uniformly to obtain an irrigation agent.

Example 5 To 20 parts of Caltap, =-z-ho*p E-781
Add 0 parts of PEG-600 to 10 parts of acephate.
07 parts were added, separately melted at 65°C, cooled, and pulverized. To these were added 10 parts of Benomyl, 115 parts of Mesomi/3 parts of Heimaru 2004C (manufactured by Matsumoto Yushi) and 10 parts of clay and mixed uniformly. Irrigation agent obtained by

Example 6 20 parts of Cartap, 40 parts of PEG-600, and 0 parts of oxalic acid
．． A wettable powder obtained by mixing 5 parts of acephate, melting it at 65°C, cooling it, pulverizing it, adding 20 parts of acephate and 5 parts of diatomaceous powder, and mixing uniformly.

Example 7 20 parts of Cartap, 80 parts of KPEG-1000, 10 parts of Nonipol 400 and 0.2 parts of phosphoric acid were mixed and heated at 65°C.
An irrigation agent obtained by melting, cooling, pulverizing, adding 20 parts of methomyl and ±7 parts of diatomaceous powder, and mixing uniformly.

Example 8 Mix 2 parts of Caltap with 8 parts of PEG-6000 and mix at 65°
CK melted, cooled, crushed, synthetic pyrethroid MTI
-500 (Mitsui Toatsusha) 0.5 part.

A powder obtained by adding 2 parts of white carbon and 92.5 parts of clay and mixing them uniformly.

Example 9 Mix 20 parts of Caltap with 30 parts of PEG-600,
Melt to 5°C, cool, grind, synthetic pyrethroid AC
-705 (Siamid Co., Ltd.) 5 copies, Heimer/I/20
20 An irrigation agent obtained by adding 3 parts (Matsumoto oil and fat) and 5 parts of diatom and mixing them uniformly.

Experimental example 1. (Stability test of active ingredients) The improved solid preparations for agriculture and horticulture according to the present invention shown in Examples 1 to 9 were packaged in aluminum foil bags and incubated in a 40°C thermostat for 6 hours.
After storage for 0 days, the residual rate of active ingredient content and the change in appearance over time were measured, and the results are shown in Table 11 and Table 2.

Control formulations that do not belong to the invention are shown below.

Control formulation-1 10 parts of cartap, 10 parts of acephate, 3 parts of diatomaceous
1 part and 20 parts of clay and mix uniformly.

Control Preparation-2 Irrigation agent obtained by adding Methomyl I (1, 0.1 part of phosphoric acid, and 5 parts of diatomaceous acid) to 10 parts of Cartap and mixing uniformly.

Control Formulation-3 A wettable powder obtained by adding 10 parts of Benomyl and 1θ part of Clay to 10s of Cartap and uniformly mixing the mixture.

(Hereinafter referred to as "White") Table 1: Remaining rate of active ingredient Table 2: Change in appearance of preparation Example 1.2.
The irrigation agent obtained in steps 5, 6, and 7 was diluted 1,000 times with water, and 8,000 times Dyne ■ (spreading agent manufactured by Takeda Pharmaceutical Co., Ltd.) was added to the prepared chemical solution, which was then sprayed with 30xl of a needle tip. After 2 hours, remove 9 leaves
Seven leaves were taken and placed in a chalet, and the 3rd instar larvae of the diamondback moth and armyworm were transferred to separate leaves. Two days later, the number of dead bunches was investigated, and the results are shown in Table 3.

Table-3 Insecticidal power test (mortality rate %)

Claims (1)

[Claims] A solid preparation containing one or more solid components that are incompatible with each other, wherein at least one of the solid components is melt-coated with a water-soluble wax that is solid at room temperature.