JPS59148722A - アロマタ−ゼ阻害性ピリミジン誘導体 - Google Patents

アロマタ−ゼ阻害性ピリミジン誘導体

Info

Publication number
JPS59148722A
JPS59148722A JP59017630A JP1763084A JPS59148722A JP S59148722 A JPS59148722 A JP S59148722A JP 59017630 A JP59017630 A JP 59017630A JP 1763084 A JP1763084 A JP 1763084A JP S59148722 A JPS59148722 A JP S59148722A
Authority
JP
Japan
Prior art keywords
compound
methyl
fluoro
chloro
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59017630A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0521893B2 (enExample
Inventor
ケネス・エス・ヒルシュ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS59148722A publication Critical patent/JPS59148722A/ja
Publication of JPH0521893B2 publication Critical patent/JPH0521893B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP59017630A 1983-02-02 1984-01-31 アロマタ−ゼ阻害性ピリミジン誘導体 Granted JPS59148722A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46308683A 1983-02-02 1983-02-02
US463086 1983-02-02

Publications (2)

Publication Number Publication Date
JPS59148722A true JPS59148722A (ja) 1984-08-25
JPH0521893B2 JPH0521893B2 (enExample) 1993-03-25

Family

ID=23838802

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59017630A Granted JPS59148722A (ja) 1983-02-02 1984-01-31 アロマタ−ゼ阻害性ピリミジン誘導体

Country Status (11)

Country Link
EP (1) EP0116431B1 (enExample)
JP (1) JPS59148722A (enExample)
AU (1) AU562413B2 (enExample)
CA (1) CA1211050A (enExample)
DE (1) DE3464120D1 (enExample)
GB (1) GB2134388B (enExample)
IE (1) IE56813B1 (enExample)
IL (1) IL70809A (enExample)
NZ (1) NZ206968A (enExample)
PH (1) PH23364A (enExample)
ZA (1) ZA84652B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
US4755526A (en) * 1984-06-18 1988-07-05 Eli Lilly And Company Method of inhibiting aromatase
US4933339A (en) * 1985-08-21 1990-06-12 Rohm And Haas Company (2-cyano-2-arylethyl)pyridine compounds useful in controlling fungicidal activity
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4769378A (en) * 1986-03-31 1988-09-06 Eli Lilly And Company Indenopyrimidine aromatase inhibitors
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds
GB8818561D0 (en) * 1988-08-04 1988-09-07 Ici Plc Diphenylethane derivatives
TW210334B (enExample) * 1990-12-12 1993-08-01 Ciba Geigy Ag

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3818009A (en) * 1969-12-29 1974-06-18 Lilly Co Eli Alpha, alpha-disubstituted-5-pyrimidinemethanes
US3868244A (en) * 1972-03-13 1975-02-25 Lilly Co Eli Plant growth regulation
US3869456A (en) * 1972-03-13 1975-03-04 Lilly Co Eli Synthesis of 5-pyrimidinecarbinols
US3887708A (en) * 1972-03-13 1975-06-03 Lilly Co Eli Alpha, alpha-disubstituted-5-pyrimidinemethanes used as fungicides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL179581C (nl) * 1972-09-05 1986-10-01 Lilly Co Eli Werkwijze voor het selectief dehalogeneren vanpyrimidylverbindingen, en werkwijze voor het bereiden van fungicide preparaten die de verkregen verbindingen bevatten.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3818009A (en) * 1969-12-29 1974-06-18 Lilly Co Eli Alpha, alpha-disubstituted-5-pyrimidinemethanes
US3868244A (en) * 1972-03-13 1975-02-25 Lilly Co Eli Plant growth regulation
US3869456A (en) * 1972-03-13 1975-03-04 Lilly Co Eli Synthesis of 5-pyrimidinecarbinols
US3887708A (en) * 1972-03-13 1975-06-03 Lilly Co Eli Alpha, alpha-disubstituted-5-pyrimidinemethanes used as fungicides

Also Published As

Publication number Publication date
AU2392884A (en) 1984-08-09
DE3464120D1 (en) 1987-07-16
IL70809A (en) 1987-01-30
PH23364A (en) 1989-07-14
IE840231L (en) 1984-08-02
ZA84652B (en) 1985-09-25
IL70809A0 (en) 1984-04-30
NZ206968A (en) 1986-06-11
EP0116431B1 (en) 1987-06-10
AU562413B2 (en) 1987-06-11
IE56813B1 (en) 1991-12-18
CA1211050A (en) 1986-09-09
EP0116431A1 (en) 1984-08-22
GB2134388A (en) 1984-08-15
JPH0521893B2 (enExample) 1993-03-25
GB8402344D0 (en) 1984-02-29
GB2134388B (en) 1986-07-02

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