JPS59128366A - ヒト白血病ウイルス関連ペプチド - Google Patents
ヒト白血病ウイルス関連ペプチドInfo
- Publication number
- JPS59128366A JPS59128366A JP58001495A JP149583A JPS59128366A JP S59128366 A JPS59128366 A JP S59128366A JP 58001495 A JP58001495 A JP 58001495A JP 149583 A JP149583 A JP 149583A JP S59128366 A JPS59128366 A JP S59128366A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- pro
- acid
- reaction
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 208000032839 leukemia Diseases 0.000 title claims description 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 38
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- 239000011347 resin Substances 0.000 abstract description 21
- 229920005989 resin Polymers 0.000 abstract description 21
- 125000006239 protecting group Chemical group 0.000 abstract description 13
- -1 amino-protected amino Chemical class 0.000 abstract description 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract description 10
- 239000002253 acid Substances 0.000 abstract description 8
- 238000005859 coupling reaction Methods 0.000 abstract description 6
- 238000010168 coupling process Methods 0.000 abstract description 5
- 201000010099 disease Diseases 0.000 abstract description 5
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- 208000000389 T-cell leukemia Diseases 0.000 abstract description 3
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 abstract description 3
- 238000006482 condensation reaction Methods 0.000 abstract description 3
- 238000003745 diagnosis Methods 0.000 abstract description 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 3
- 238000010647 peptide synthesis reaction Methods 0.000 abstract description 3
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract description 2
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- 201000006966 adult T-cell leukemia Diseases 0.000 abstract 1
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- 238000003786 synthesis reaction Methods 0.000 abstract 1
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- 241001465754 Metazoa Species 0.000 description 6
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- 102000005686 Serum Globulins Human genes 0.000 description 5
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 4
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- 238000000921 elemental analysis Methods 0.000 description 4
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- 239000004220 glutamic acid Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- DHBXNPKRAUYBTH-UHFFFAOYSA-N 1,1-ethanedithiol Chemical compound CC(S)S DHBXNPKRAUYBTH-UHFFFAOYSA-N 0.000 description 3
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- 241000283073 Equus caballus Species 0.000 description 3
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- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 3
- SBVPYBFMIGDIDX-SRVKXCTJSA-N Pro-Pro-Pro Chemical compound OC(=O)[C@@H]1CCCN1C(=O)[C@H]1N(C(=O)[C@H]2NCCC2)CCC1 SBVPYBFMIGDIDX-SRVKXCTJSA-N 0.000 description 3
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- 210000004027 cell Anatomy 0.000 description 3
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- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920005990 polystyrene resin Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108010077112 prolyl-proline Proteins 0.000 description 1
- 108010029020 prolylglycine Proteins 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000000941 radioactive substance Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 102220043690 rs1049562 Human genes 0.000 description 1
- 102220039198 rs7243081 Human genes 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- RUPAXCPQAAOIPB-UHFFFAOYSA-N tert-butyl formate Chemical group CC(C)(C)OC=O RUPAXCPQAAOIPB-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical group CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- IERBVBGUKBHALB-UHFFFAOYSA-K tripotassium;phosphate;dihydrate Chemical compound O.O.[K+].[K+].[K+].[O-]P([O-])([O-])=O IERBVBGUKBHALB-UHFFFAOYSA-K 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 238000004457 water analysis Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58001495A JPS59128366A (ja) | 1983-01-07 | 1983-01-07 | ヒト白血病ウイルス関連ペプチド |
| DE8383109481T DE3380564D1 (en) | 1982-09-30 | 1983-09-23 | Human leukemia virus-related peptides, antibodies of the peptides and a process for production of the antibodies |
| US06/535,115 US4525300A (en) | 1983-01-07 | 1983-09-23 | Human leukemia virus-related peptides, antibodies of the peptides and a process for production of the antibodies |
| CA000437427A CA1262014A (en) | 1983-01-07 | 1983-09-23 | Human leukemia virus-related peptides, antibodies of the peptides and a process for production of the antibodies |
| EP83109481A EP0107053B1 (en) | 1982-09-30 | 1983-09-23 | Human leukemia virus-related peptides, antibodies of the peptides and a process for production of the antibodies |
| US06/713,659 US4804746A (en) | 1983-01-07 | 1985-03-19 | Antibodies to human leukemia virus-related peptides and a process for production of the antibodies |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58001495A JPS59128366A (ja) | 1983-01-07 | 1983-01-07 | ヒト白血病ウイルス関連ペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59128366A true JPS59128366A (ja) | 1984-07-24 |
| JPH0350759B2 JPH0350759B2 (enrdf_load_stackoverflow) | 1991-08-02 |
Family
ID=11503033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58001495A Granted JPS59128366A (ja) | 1982-09-30 | 1983-01-07 | ヒト白血病ウイルス関連ペプチド |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59128366A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242174B1 (en) | 1989-03-02 | 2001-06-05 | Replico Medical Ab | Discrimination between antibodies against HTLV-I, HTLV-II or related retroviruses, new peptides, detection of antibodies and immunoassay kits |
-
1983
- 1983-01-07 JP JP58001495A patent/JPS59128366A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242174B1 (en) | 1989-03-02 | 2001-06-05 | Replico Medical Ab | Discrimination between antibodies against HTLV-I, HTLV-II or related retroviruses, new peptides, detection of antibodies and immunoassay kits |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0350759B2 (enrdf_load_stackoverflow) | 1991-08-02 |
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