JPS59110616A - Poultice - Google Patents

Abstract

PURPOSE:To provide a poultice free from the tendencies of sagging and strike- through, by acidifying the plaster to improve the stability of the active components, and crosslinking the constituent polyacrylic acid, etc. and other water- soluble polymer separately with different polyvalent metallic salts having different kind of metallic ions. CONSTITUTION:An acidic poultice containing a plaster of 3.5-6pH is prepared by crosslinking (A) polyacrylic acid and/or its salt and (B) a water-soluble polymer having functional group reactive with polyvalent metallic ion, e.g. gelatin, pectin, cellulose derivative, alginic acid, polyvinyl alcohol and/or methyl vinyl ether/maleic anhydride copolymer separately with (C) two kinds of metallic salts having different metallic ions, especially Ca or Mg salt and Al, Fe or Sn salt. The poultice is free of strike-through of the plaster to the substrate, has excellent shape retainability and water retainability, high pressure-sensitive adhesivity, excellent stability of the active components, and low irritation to the skin.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention has no oozing of the paste onto the support, excellent shape retention and water retention, high viscosity, and
This invention relates to an acidic poultice with excellent active ingredient stability and reduced skin irritation.

Conventional poultices are made by baking kaolin, ceratene, and chrycerin, adding other water-soluble polymers such as sodium polyacrylate, polyvinyl alcohol, etc., and kneading the mixture to form a paste. is applied to a support, and if left as is, the paste tends to shake due to heat and sweat, so it is cross-linked with a polyvalent metal image (
Particularly: 1 1973-15413, 1971-17113, Door, 154-26326, iEi 5 4-92618!
4) Adding urea to form a urea-gelatin combination (JP-A-45-5278, JP-A-45-12314)
etc.), No. 7 p- = e)' R, etc., which can be cross-linked and gelled with 7, i5 ingredients (special) -
1 Showa 51-91318, 16No 51-
101L19, 5 1 - 1 0 4 0 2
7,■]52. -143223, 54-14351
7), insolubilization by forming a polymer-polymer complex (Japanese Patent Laid-Open No. 52-38016), etc., to improve heat resistance and water resistance and prevent sagging.

However, conventional poultices have a pH of 6 or higher, usually 7 to 9.
Therefore, there are problems such as poor stability of active ingredients such as salicylic acid esters and skin irritation. For this reason, acidic plasters are desirable, but conventional poultices
Adding organic acids such as tartaric acid and citric acid or mineral acids such as hydrochloric acid to lower the pH and make it acidic in order to stabilize the active ingredient and alleviate skin irritation, etc. ) decreases significantly, causing sag and bleed. Therefore, in acidic poultices, it is necessary to thoroughly crosslink and glue to prevent sagging, but with conventional technology, when the pH is lower than 6, With noaldehyde denzone and urea, the reaction did not proceed, and with metal crosslinking, the crosslinking effect was small. It was extremely difficult to obtain a poultice.

In view of the above circumstances, the present inventors have developed an acidic plaster that does not bleed, has excellent water retention and shape retention, has strong adhesive strength, has high stability of active ingredients, and has reduced skin irritation. As a result of intensive research to obtain a poultice with a pH of 3.5 to 6 containing polyacrylic acid and/or polyac material,
In this poultice, the above objective is effectively achieved by using two or more lines of polyvalent metal salts with different metal ion types as crosslinking agents, and crosslinking each high fl separately. I found out. That is, for example, carboxymethel cellulone contains Cr, Ag, Fe""
10,3+ Pb2+, At5+, Ba2+, and Sn2+ ions cross-link and dull, but Ca2+, Mg2+, and Mn2+ do not cross-link and glugate, while sodium polyacrylate does not cross-link with Ca2+.
, which cross-links with Mg2+, and also A7"
, Ba2Fe2+13+ hacarpoxymethylcellulose and sodium acrylate are both crosslinked and dulled, but in the acidic region, the reaction with carboxymethyl heptylulose is overwhelmingly likely to occur, so for example in the carboxymethylcellulone-sodium polyacrylate mixed system. At3+ ions and Ca
When 2+ ions are added, only carboxymethyl cellulose participates in the crosslinking reaction with At5+ ions, sodium polyacrylate virtually does not react with At3+ ions, and sodium polyacrylate is crosslinked by Ca2+ ions. By combining two or more metal ions in this way, the present inventors achieved complete crosslinking of the blended polymeric material of the glaze, resulting in an excellent product that does not sag or crease even in acidic areas. It was discovered that a characteristic acidic poultice can be obtained, and this led to the present invention.

The present invention will be explained in more detail below.

In the poultice of the present invention, the plaster is acidic with p) 13.5 to 6, and the acrylic acid and/or polyacrylate and the other water-soluble polymer a are different from each other. It is characterized by being crosslinked with a polyvalent metal salt having metal ion species.

In this case, the type of polyacrylic acid is not particularly limited in the present invention, and polyacrylic acids of linear, branched, or crosslinked types with various molecular weights can be used.

Specifically, as a commercially available product, Di-Limer AC-10H%AC
-10SH, Jinron PW-110, 111 (all manufactured by Nippon Tsumugi Pharmaceutical Co., Ltd.), Aron A-10H (manufactured by Toagosei Co., Ltd.), and the like are preferably used. 1. Any salt can be used as the polyacrylate, but sodium polyacrylate, potassium polyacrylate, alkanolamine polyacrylate, etc. are particularly preferably used, and commercially available products include Alonbinu SX SS, GLXM ( Nippon Tsumugi Pharmaceutical Co., Ltd.), Binukome) P-480, F-480, F-460 (Showa Denko Co., Ltd.), Aron A-20P, A-20PG.

A-20PH (manufactured by Toagosei Co., Ltd.) etc. can be used.

In addition, the blending portion of polyacrylic acid and noryacrylate is 0.5 to 20 parts (by weight, the same applies hereinafter) of the entire compress side plaster.
In particular, it is preferable to set the ratio to 1 to 10. If it is less than 0.5, sufficient viscosity will not be obtained and the shape retention will decrease, causing sagging. If it is more than 20%, the viscosity will increase. Workability such as rinsing, kneading, and coating may be reduced. In addition, when polyacrylic acid and polyacrylate are used together, it is preferable that the blending ratio (weight ratio) is 9:1 to 3. If the polyacrylate is too small, the pH will be 3. If the amount is too high, the pH may become higher than 6.

One or more selected from cutin, sodium alginate, carboxymethyl cellulose, vinyl alcohol, methyl vinyl ether/maleic anhydride copolymer, etc. are preferably used.

In this case, it is preferable that the amount of the water-soluble polymer substance is 1 to 15 parts, especially 1 to 10 parts, of the entire poultice.If it is less than 1 part, the viscosity will be insufficient and the shape retention will be cannot be maintained, 1
When the amount is more than 5, the viscosity becomes high and workability during kneading and coating may decrease.

The present invention provides a poultice containing the above-mentioned water-soluble polymeric substance, which includes a polyvalent metal salt for crosslinking polyacrylic acid and/or polyacrylate as a crosslinking agent, and a combination of this polyvalent metal salt and a metal ion. 1 or 2 or more polyvalent metal salts are used in combination to crosslink water-soluble polymer substances (carboxymethyl cellulose, gelatin, etc.) other than the polyacrylic acid and polyacrylate, and In this case, the former is Ca salt, Mg@, etc., and the latter is At field, Fe salt (Fe2+, Fe5 +), Sn salt (Sn4
+, Sn2+), etc. are particularly preferably used. Note that these polyvalent metal salts may be soluble, slightly soluble, or ile-soluble in water, and specifically include calcium chloride, magnesium chloride, aluminum chloride, potash light bread, ammonium light bread, ironmon bread, Soluble salts such as aluminum sulfate, ferric sulfate, magnesium sulfate, EDTA-calcium, EDTA-aluminum, EDTA-magnesium, stannous chloride, stannic chloride, calcium hydroxide, dibasic hydroxide
Iron, aluminum hydroxide, calcium carbonate, magnesium carbonate, calcium phosphate, magnesium stearate, aluminum nateate, quench, calcium phosphate,
A combination of two or more selected from slightly soluble or sparingly soluble salts such as barium sulfate, barium hydroxide, aluminum allantoinate, aluminum acetate, aluminum dalicinal, stannous hydroxide, orstannic acid, α-stannic acid, etc. can. It's 1.
The total blending amount is preferably 5 to 10 parts, particularly 0.01 to 5 parts, O, OO of the entire poultice, and 0.00 parts.
If it is less than 5%, a sufficient crosslinking effect cannot be obtained, resulting in sag,
If the amount is more than 10 tsumu, the paste becomes too hard, resulting in poor adhesion to the skin and sometimes causing water separation.

The poultice of the present invention is prepared by thoroughly kneading each of the above components with other appropriate ingredients to form a beinet-like poultice. It is used by applying it to a support (backing) such as a tech film, and covering it with a facing such as a polyethylene film if necessary. As other components of the present invention, any commonly used appropriate components may be used. For example, propylene glycol, polyethylene glycol, glycerin, sorbitol, etc.
Seeds or two or more polyhydric alcohols (composition 14°, usually 5 to 60 parts of the entire plaster. If it is less than 5 parts, the moisturizing effect will be insufficient, and the upper limit will especially include night, montmorillonite, zinc oxide, titanium oxide, anhydrous silicon. Inorganic powder containing one or more types of acids, etc. (compounding amount is usually 0 to 30%. If the amount is more than 30%, the paste becomes too hard and the fit and adhesion to the skin are low),
Water (compounding amount usually 10 to 80 parts. Methyl decaate, glycol salicylate, indomethacin, t-menthol,)
Tsuka oil, eucalyptus oil, dt-camphor, capsicum quince, nonylic acid vanillylamide, vitamin E1, diphenhydramine, chlorpheniramine maleate, thymol, etc. or 2 or more active ingredients (compounding amount usually 0 to 20
), and the physical properties of the paste (flexibility, adhesiveness, shape retention, etc.)
[As agents, guar gum, xanthan gum, gum arabic,
Starch derivatives, polybutene, latex, vinyl acetate emulsicone, y-ri-IJ-le-M fat emulsions and other molecular substances and active ingredients are appropriately blended according to the need for stable blending.

Therefore, the present invention provides that the plaster is acidic with a pH of 3.5 to 6, and that polyacrylic acid and/or polyacrylate and other water-soluble polymeric substances are mixed with different metal ions. It is characterized by being cross-linked with a polyvalent metal salt having seeds, and as a result, it does not cause blurring or bleeding even in the acidic range of 35 to 6. If it is stably blended, it will have low skin irritation, and if it is blended with polyacrylic acid and/or 1d polyacrylate, it will have high adhesion to the skin.

Next, the present invention will be specifically explained by showing Examples and Comparative Examples.

[Example 1. Comparative example 1] A poultice having the following formulation was prepared according to the following manufacturing method.

[Prescription]

Example 1 Comparative Example 1 (1) Gelatin 20
% 2.0 section (3), j′? Liacrylic acid sodium (
Aronbis SS) 2.0 2.0 (4
) Carboxymethyl cellulose (Daicel 1350)
2.0 2.0(5) Polyvinylpyrrolidone (K
-90) 2.0 2.0(6) Glycerin 20.0 20.0(7
) Kaolin 10
10(8) Active ingredient Glycol salicylate
1.0 1. Ot-Menthol 05
05dt-camphor 0.5
Q,5 Vitamin E O,5Q,5
(9) Activator Polysorbate) 80'0
．． 5 0.5 (10 Calcium hydroxide
0.2-Old) Ammonium light bread 10% aqueous solution 3.0 5.0 Total 100.0
100.0% [Production method] Dissolve (1) in (12) by heating, and add (2) (7) to this.
(8) Add (9) and knead to disperse well. Next, to this K (6) (3) (4) (5) QQ (1
A well-dispersed mixture of 1) was added and kneaded uniformly to obtain a poultice in the form of 4 to 7 sheets. This was applied to non-woven soil and quasing with polyethylene film was applied.

The poultice of Example 1 has excellent adhesion (n1?-Rutanok A;10), and when folded, the poultice has an excellent adhesive strength (ρI-1&, :f4)
．． The active ingredients such as glycol salicylate were extremely stable.

[Example 2. Comparison f! 12] I applied the following prescription poultice according to the lower C52 method and used iE4!
[Prescription] Example 2 Ratio example 2 (1) Polyacrylic acid 10 aqueous solution 30.0
Section 300 (Zirimar-ACIO3H)
(Solid content 3%) (2) Polyaxono 9 wave soda (Aronbis 88) 1.6 1.6 (3) Carboxymethylcellulose (Daicel 1350) 3
．． 0 30 (4) Algi 2j Soda
0.5 0.5 (5) Karayagam 1.0 1.
0(6) Glycerin 13.0
], 3.0 (7) 70% sorbitol
10.0], 0.0(8) Kaolin
10.0 10.0
(9) Active ingredient salicylic acid-recall 10
]]OL-Menthol 1.0 1.
0dl-Power/Nfur 10 10 Vitamin E O, 30, 311 () Activator Polysorbate) 80 0.5 0.5
111) Calcium hydroxide 0.2-
(Lv aluminum stearate 20
25 Password j 100.0% 1
00.0% [Manufacturing method] (1) (7) (8) (9) Oo) f13) are mixed and stirred well to ensure uniform dispersion. Next, add (6) to (2) (3) (4) (5) (+
1) (Add 121 dispersed and mix well,
K ~ Obtain a sticky poultice. This was applied onto a nonwoven fabric, and a facing of polyethylene film was applied.

The poultice of Example 2 has strong adhesive strength, has a pH of around 4.6, has excellent stability of the active ingredient, and does not require any heating during the manufacturing process, so the volatile active ingredient (1 −
It was extremely useful in blending menthol, dt-camphor) [Example 3. Comparative Example 3] A poultice having the following formulation was prepared according to the following manufacturing method.

[Prescription]

Example 3 Comparative Example 3 (2) f! ! J 7 ri'J xfQ (Shi z on P
W-110) 2.0 2.0 (3) Sodium polyacrylate (Aronbis SS) 2.0
2.0 (4) Carboximenal cellulose (Daicel 2200) 2.0 2.0 (7) Active ingredient Methyl salicylate 1.0 1. Ot
-Menthol 1.0 ], 0 Nonylic acid vanillylamide 0.05 0.05
(8) Activator Polysorbate 80 0.
5 0.5(9) Magnesium stearate
20 - (10) Stannous chloride 5-containing aqueous solution 4,0 10.0 (11) EDT
A-2 Sodium 0.15
0.37 total 100.0
1000 [Manufacturing method] (1) <2) (6) (7) (8) α2) are mixed and stirred to uniformly disperse. Next, add (5
), add (3), (4), and (9) dispersed therein and mix well to form a paste.

A solution prepared by dissolving (11) in (10) is added under the pillow bed and kneaded into 9) to obtain a paste-like poultice. This was applied onto a nonwoven fabric, and a polyethylene film facing was applied.

The poultice of Example 3 had a pH of around 48, and had excellent properties similar to those of Example 1.2.

[Example 4] A poultice having the following formulation was prepared according to the following manufacturing process.

[Prescription]

(1) Gelatin
20%) (3) Hori 7 Ri) klp (Shuyan PW-110
) 1.0 (4) Sodium polyacrylate (Alonbis SS) 1.5 (5) Carboxymethel cellulone (Daicel CMC1350)
3.0 (6) Kaori 7
10.0(7) Glycerin
20.0(8) Active ingredient Glycol salicylate]]Ot-menthol
10dt-camphor
10(9) Activator Polysorbate 80
05 (11 Magnesium stearate
O5 (1υ dihydroxyaluminum allantoinate o2 (1,2+ 5% potassium bright pan solution 1° (13) water
Remaining amount
Word 1 100.0 [
Manufacturing method] (1) (2) (3) (6) (8) (9) (1
31 is stirred and mixed to form a uniform dispersion. Next, a stock solution containing (4) and (5) α0 (11) α-thin dispersed in (7) is added to the kernel dispersion and kneaded to obtain a poultice-like paste. A poultice was obtained in the same manner as in Examples 1 to 3.

This poultice also had excellent properties similar to Examples 1 to 3.

[Comparative Example 4] A conventional poultice having the following formulation was prepared according to the following manufacturing method.

[Manufacturing method]

(1) is heated and dissolved in α0. Add (5), (6), and (7) into this aqueous gelatin solution and disperse uniformly.

Next, a pre-dispersed mixture of (4), (2), and (3) is added to this mixture and kneaded uniformly. Finally, in (9) (
8) was added and further kneaded to form a paste, which was applied onto a nonwoven fabric, and the surface was coated with polyethylene film. What is the surface of this thing?
H was about 8.5.

Next, using the poultices of Examples 1 to 3, Comparative Examples 1 to 3, and the conventional poultice of Comparative Example 4, their subsequent exudation and stability of active ingredients were investigated. In this case, to remove the ooze, place the sample with the polyethylene film-covered side facing up, apply a pressure of 10 ff/Qn, and leave it in room mud for a week, and remove the plaster or its composition from the back of the support. A sensory evaluation was performed to determine whether or not a part of the ingredient oozed out, and the stability of the active ingredient was determined by storing the sample at 80°C for 3 days and determining the residual rate of salicylic acid ester after storage.The results are shown in the table. The evaluation criteria for back seepage and active ingredient stability are as follows.

Front * Back seepage evaluation criteria ○: No seepage at all It has been found that an excellent acidic poultice is obtained.

Applicant Lion Corporation Agent: Patent Attorney Takashi Kojima 122

Claims (1)

[Scope of Claims] 1. The plaster is acidic with a pH of 3.5 to 6, and the polyacrylic acid and/or polyacrylate and other water-soluble polymer substances are made of different metals. A poultice made by cross-linking with polyvalent metal salts having ionic properties. 2 Sen's water-soluble polymer substances include gelatin, pectin, cellulose 6 conductor, alginate, polyvinyl alcohol,
Patent gt that is 1 ai or 2 or more selected from methyl vinyl ether/maleic anhydride copolymer
The death of f, the poultice as described in the first section of the box 03, the combination of Tatsukuda 1 metal salts each having a tough ionic glaze of rA, Ca1fi and p, salt, Ca salt and Fej3
, Mg salt and Fe salt, Ca salt and Sn salt, Mg salt and Sn salt, or Mg salt and At salt, claim 1 or 2.
A poultice written by Yu.