JPH0794383B2 - Patch agent - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of use] The present invention relates to a poultice used for anti-inflammatory and analgesia such as bone fracture, bruise, and sprain.

[Conventional technology]

A poultice that is applied to the affected area at the time of bone fracture, bruise, or sprain to exert hardening of anti-inflammatory analgesia is usually prepared by applying a hydrous gel plaster containing a medicinal agent and other required substances to a support surface such as a nonwoven fabric and spreading it. The coated surface is peeled off and covered with a sex film to protect it. When used, this peelable film is peeled off and applied to the affected area.

Such a poultice has conventionally used polyacrylic acid such as polyacrylic acid or sodium polyacrylate as a component for forming the gel plaster.

The above-mentioned polyacrylic acid and polyacrylic acid salt are excellent in water retention as a poultice, and have many advantages in adhesion to skin during use, peelability after use, etc. It is known that when the cross-linking of polyacrylic acid or polyacrylic acid salt is weak, exudation or sagging of the gel plaster on the support occurs.

[Problems to be solved by the invention]

In order to improve such a drawback of polyacrylic acid or polyacrylic acid salt, for example, a crosslinking agent is added to strengthen the crosslinking, or another water-soluble polymer substance is added. .

However, in this case, the viscosity increase at the time of kneading becomes remarkable, and it is impossible to perform suitable spreading when the prepared gel plaster is spread on the support, which hinders the spreading work. At the same time, the gel plaster becomes hard, and various problems such as a decrease in adhesiveness to the skin occur.

In order to solve this problem, a method of adding a substance having poor solubility such as aluminum hydroxide or synthetic aluminum silicate is also known, but the workability at the time of preparing the gel plaster is tentatively good. There is a problem that the adhesive state and the state of the gel plaster itself change with the passage of time, the exudation of the gel to the back surface of the support and the adhesiveness deteriorate, and it is not a fundamental solution.

[Means for solving problems]

As a result of earnest research in view of the present situation, the present invention produces a crosslinked insoluble salt at an appropriate speed when an acrylic compound is allowed to act with a water-soluble polyvalent metal compound and a sparingly soluble polyvalent metal compound. It was discovered that an excellent gel plaster for poultices was obtained, and the workability during the production of poultices was good, and there was no oozing of the gel plaster on the back surface of the support or sagging during use. This is a completed poultice.

That is, the present invention is a poultice which is characterized in that a crosslinked acrylic compound obtained by crosslinking an acrylic compound with a water-soluble polyvalent metal compound and a sparingly soluble polyvalent metal compound is used as a gel plaster component. Is.

In the present invention, the gel plaster is a water-containing gel-like substance obtained by kneading a medicinal component that exerts an action of directly suppressing inflammation and pain on the affected area, a powder base, a wetting agent, other modifiers, water and the like. A substance that has been prepared before being applied to a support.

The acrylic compound for constituting such a gel plaster component is, specifically, [A] a copolymer of acrylic acid and allyl acid salt, [B] the above acrylic acid and acrylic acid salt. There are a mixture of a copolymer and polyacrylic acid, and a mixture of [C] polyacrylic acid and a polyacrylic acid salt.

In the copolymer [A] of acrylic acid and acrylate, examples of the acrylate include sodium acrylate, potassium acrylate, alkanolamine acrylate, and the like.

The acrylic acid salt may be an acrylic acid-containing acrylic acid salt obtained by adding an alkali metal compound or amines to acrylic acid to form a part of the acrylic acid salt, and copolymerizing this with acrylic acid. The copolymer thus obtained can also be used.

The ratio of acrylic acid and acrylate used in such a copolymer is not particularly limited, and a specific commercially available product is Aronbis AH (manufactured by Nippon Pure Chemical Co., Ltd.).

In the mixture of [A] acrylic acid-acrylic acid salt copolymer and polyacrylic acid, the polyacrylic acid to be mixed with the copolymer is not particularly limited and may be a straight chain,
Both branched and crosslinked types and various molecular weights can be used.

The preferable amount of this polyacrylic acid used in the gel plaster is generally 20% (wt%; the same applies hereinafter) or less, especially 1 to 8%.
Is preferred, and specific commercial products include Jurimer AC-10H, Jurimer AC-10SH, Junron PW-110, and Junron PW-111 (all manufactured by Nippon Pure Chemical Co., Ltd.).

In the mixture of the polyacrylic acid and the polyacrylic acid salt of the above [C], any salt can be used as the polyacrylic acid salt. However, by adding an alkali metal compound or amines to the polyacrylic acid, A polyacrylic acid-containing polyacrylic acid salt, a part of which is a polyacrylic acid salt, can also be used, and particularly, sodium polyacrylate, potassium polyacrylate, and alkanolamine polyacrylate can be preferably used.

The amount of this polyacrylic acid salt used for the gel plaster is 1 to
20%, especially 4 to 15% is preferable.

The copolymer of [A] and the mixture of [B] and [C] are used in the range of 3 to 30% with respect to the total amount of the gel plaster, and preferably in the range of 5 to 15%. The pH of the gel plaster can be freely adjusted within the range of 2.5 to 8.5 depending on the mixing ratio.

When the amount of the compound of [A] to [C] used is less than 3% with respect to the total amount of the gel plaster, the viscosity is so low that it does not solidify into a gel and sags when spread on a support. Easy,
If the amount used exceeds 30%, the tendency to become insoluble in water increases and a hard gel plaster is formed, resulting in poor workability.

The polyvalent metal compound added to the acrylic compound is a water-soluble polyvalent metal compound and a sparingly soluble polyvalent metal compound. Examples of the water-soluble polyvalent metal compound include aluminum chloride and aluminum sulfate. , Calcium chloride,
There are potassium alum, magnesium chloride, iron alum, ferric sulfate, ammonium alum, etc., and one or more of these water-soluble polyvalent metal compounds are used.

Examples of the sparingly soluble polyvalent metal compound include, for example, aluminum hydroxide, aluminum silicate, aluminum phosphate, iron citrate, magnesium oxide, calcium oxide, and the like. One of these sparingly soluble polyvalent metal compounds or Two or more types are used.

The amount of such polyvalent metal compound used (total amount of water-soluble or sparingly soluble polyvalent metal compound) is preferably in the range of 0.01 to 1.0 equivalent, particularly preferably 0.03 to 0.4, relative to the acrylic compound. It is in the equivalent range.

Further, the preferable ratio of use of the water-soluble polyvalent metal compound and the sparingly soluble polyvalent metal compound is in the range of 9/1 to 3/7 (weight ratio) as the water-soluble polyvalent metal compound / slightly soluble polyvalent metal compound. .

When the amount of the water-soluble polyvalent metal compound exceeds the above range and the crosslinking reaction proceeds rapidly, the gel plaster tends to solidify, and when the amount of the sparingly soluble polyvalent metal compound becomes excessive, the crosslinking reaction slows. It becomes a gel plaster with a lot of sagging.

The poultice of the present invention comprises the above-mentioned acrylic compound, a water-soluble and sparingly soluble polyvalent metal compound, and other medicinal components and other kaolin, bentonite, zinc oxide that exert an effect of directly suppressing inflammation and analgesia on the affected area. With a powder base such as the above, a wetting agent such as glycerin, propylene glycol, polyethylene glycol and the like, and a desired component such as water, these are kneaded to prepare a paste to form a gel plaster.

The gel plaster thus obtained is applied, for example, to a cloth such as flannel or a non-woven fabric obtained by binding fibrous nylon, rayon, polyester, polyolefin, etc. with a binder, and if necessary, It is put on the market as a poultice by protecting the coated surface with a polyethylene film or the like, and when applied, the protective film is peeled off and attached to the affected area.

[Action]

The poultice of this invention is a mixture of [A] the copolymer of acrylic acid and acrylic acid salt, [B] the copolymer of acrylic acid and acrylic acid salt, and polyacrylic acid, or [ Both the water-soluble polyvalent metal compound and the sparingly soluble polyvalent metal compound are allowed to act on the acrylic compound consisting of a mixture of polyacrylic acid and polyacrylic acid salt of C]. When a water-soluble polyvalent metal compound and a sparingly soluble polyvalent metal compound are allowed to act on a compound, a crosslinked insoluble salt is produced at an appropriate speed, which is an excellent insoluble crosslinked acrylic system as a gel plaster for poultices. The compound is obtained.

The gel plaster thus obtained retains a reasonable softness for kneading and spreading of the gel plaster for a while (at least a few minutes) after preparation, and as time passes thereafter. It has a hardness suitable for sticking to the affected part of the human body due to the progress of crosslinking.

Therefore, the workability at the time of kneading the gel plaster and the application of the support is excellent, and there is no sagging of the gel plaster after the application and no bleeding on the back surface of the support, and a comfortable feeling of use is obtained.

This state is, of course, the gel plaster obtained without adding the water-soluble or sparingly soluble polyvalent metal compound, which is overwhelming compared with the gel plaster obtained by adding only one of them. It is possible to obtain a poultice that is excellent in adhesiveness and maintains a suitable tackiness.

〔Example〕

Hereinafter, the present invention will be described more specifically with reference to Examples and Comparative Examples.

Example 1 and Comparative Example 1 The poultice of Example 1 and the poultice of Comparative Example 1 were produced according to the formulations shown in Table 1 below.

The operating procedure in manufacturing is as follows.

First, a 20% aqueous solution of polyacrylic acid in water (Jurimer AC-
10H) was dissolved, and kaolin, titanium oxide, methyl salicylate, l-menthol, dl-camphor, peppermint oil as a medicinal component, and polysorbate 80 (Japanese Pharmacopoeia) as an activator were added and well dispersed.

Meanwhile, Alonbis AH (manufactured by Nippon Pure Chemical Co., Ltd.) as an acrylic acid-sodium acrylate copolymer, 10% aqueous solution of aluminum sulfate and dry aluminum hydroxide gel (Japanese Pharmacopoeia) were added to glycerin and well dispersed.

These two dispersions are mixed and kneaded uniformly to obtain a paste-like gel plaster for a poultice, which is applied and spread on a non-woven fabric, and the surface is protected with a polyethylene film to give a poultice. Obtained.

Example 2 and Comparative Example 2 The poultice of Example 2 and the poultice of Comparative Example 2 were produced according to the formulations shown in Table 2 below.

The operating procedure in manufacturing is as follows.

First, a 10% aqueous solution of polyacrylic acid in water (JULIMER AC-
10SH; Nihon Pure Chemical Co., Ltd.) was dissolved, and kaolin,
Methyl salicylate, l-menthol, dl-
Camphor and peppermint oil, polysorbate 80 as activator
Was added and well dispersed.

On the other hand, glycerin and sodium polyacrylate (Aronbis
SS; manufactured by Nippon Pure Chemical Co., Ltd., 20% calcium chloride aqueous solution,
A 10% aqueous solution of potassium alum and magnesium hydroxide were added and well dispersed.

These two dispersions were mixed and uniformly kneaded to form a paste-like gel plaster for poultice, which was spread on a non-woven fabric and the surface was protected with a polyethylene film to obtain a poultice. .

Each of the poultices of Examples 1 and 2 and Comparative Examples 1 and 2 was examined for workability during production, exudation to the back surface of the support after application, and adhesion to the skin.

In this case, workability was evaluated based on workability during kneading and coating, bleeding on the back surface was evaluated for presence or absence of back surface bleeding up to 1 week after production, and tackiness was evaluated 1 month after production.

The results are shown in Table 3.

In the above table, ⊚, ○ and × have the following meanings.

[Workability evaluation criteria]

◎: Very easy ○: Very good ×: Difficult [Evaluation criteria for bleeding] ◎: No bleeding at all ○: Bleed out ×: Remarkably large amount of bleeding [Adhesion evaluation criteria] ◎: Strong adhesion ○ : Adhesive x: Non-adhesive [Effect of the invention] The poultice of the present invention is a copolymer of acrylic acid and acrylic acid salt, or a mixture of the polymer and polyacrylic acid, or polyacrylic acid and polyacrylic acid. By cross-linking an acrylic compound consisting of any of a mixture with an acrylate salt with at least one or more water-soluble polyvalent metal compound and sparingly soluble polyvalent metal compound, an alkaline compound is formed at an appropriate speed. There is a gel plaster obtained by producing an insoluble salt to obtain a crosslinked acrylic compound and mixing the crosslinked acrylic compound with a medicinal component.

Therefore, when the obtained gel plaster is applied to a support such as a non-woven fabric, the workability is extremely good because it has an appropriate viscosity, so that the production efficiency at the time of producing a poultice can be dramatically improved. it can.

In addition, when the obtained gel plaster is applied to a support, the gel plaster has an appropriate viscosity, so that the gel plaster does not exude to the back surface of the support at all, and the gel plaster does not drip during use. It has excellent adhesiveness to the affected area and provides a comfortable feeling of use because it retains excellent adhesiveness due to proper water retention and appropriate elasticity and flexibility Is to have.

Claims (6)

[Claims] 1. A poultice according to claim 1, wherein a crosslinked acrylic compound obtained by crosslinking an acrylic compound with a sparingly soluble polyvalent metal compound of a water-soluble polyvalent metal compound is used as a gel plaster component. 2. The poultice according to claim 1, wherein the acrylic compound is a copolymer of acrylic acid and an acrylic acid salt. 3. The poultice according to claim 1, wherein the acrylic compound is a mixture of a copolymer of acrylic acid and an acrylic acid salt and polyacrylic acid. 4. The poultice according to claim 1, wherein the acrylic compound comprises a mixture of polyacrylic acid and polyacrylic acid salt. 5. The water-soluble polyvalent metal compound is one or two selected from aluminum chloride, aluminum sulfate, calcium chloride, potassium alum, magnesium chloride, iron alum, ferric sulfate, and ammonium alum. The poultice according to claim 1, which is the above compound. 6. The sparingly soluble polyvalent metal compound is one or more compounds selected from aluminum hydroxide, aluminum silicate, aluminum phosphate, iron citrate, magnesium oxide, and calcium oxide. The poultice according to claim 1, characterized in that it is present.