JPS5885161A - Filtered liquid collecting tube - Google Patents

Abstract

PURPOSE:To obtain a specimen collecting tube that is capable of collecting only a required constituent by constituting the tube with a plastic sheath that holds as one body a small diameter pipe at the open end of which a film of selective permeability is installed and a metallic needle that is longer than the pipe and divided into two parts. CONSTITUTION:In a small diameter pipe 2 with the outer diameter less than 2mm., the open end part of which stays in a living body is made smaller, is provided with a selective permeability film 1 that has different pore sizes in accordance with constituents to be collected. For example, when only blood plasma is collected the film 1 is provided with 0.1-1.0mum pore size. Metallic needles 6 and 6' that are longer than the pipe and divided into two are placed round the outer periphery of this pipe 2 and a plastic sheaths 7 and 7' hold the needles 6 and 6'. The sheaths are provided with stems 8 and 8' that can be pulled out by pulling. After a collecting tube is inserted into a blood vessel 9, the stems 8 and 8' are pulled out, and at the same time the needle 6 and 6' are pulled out, and only blood plasma is collected in the small tube 2 through the film 1.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an F fluid collection tube used for blood analysis and the like. Body fluids, blood include blood cells, platelets, lymphocytes, various proteins, hormones, lipids, sugars, amino acids,
Contains many substances such as vitamins and salts. However, blood substances that are generally measured in blood analysis are only a small portion of these substances, and the rest are not only of little use but, in many cases, actually interfere with the measurement.

Conventionally, in the case of blood analysis, substances that would interfere with the measurement were removed from the collected body fluids or blood by centrifugation, purification, serum separation, protein removal, etc. before the measurement was performed. However, it has the disadvantage that it is very complicated and requires a lot of cost and labor.

Therefore, the inventors conducted extensive research to overcome the above drawbacks and found that by placing a small-diameter vibrator equipped with a selectively permeable membrane at the tip opening into a blood vessel, etc., the necessary p liquid can be easily obtained. I found out that it can be harvested.

Therefore, a general object of the present invention is to provide a means for easily collecting P fluid of blood, which is a body fluid containing no extraneous material components, directly from a living body.

The main object of the present invention is to integrate a small-diameter pipe with both ends open and one opening covered with a permselective thin film, a two-part metal needle that is longer than the small-diameter pipe, and the two-part metal needle into one body. An object of the present invention is to provide an r-liquid collection tube with a plastic sheath for holding.

In addition, if the thin membrane with selective permeability does not allow red blood cells, white blood cells, and platelets to pass through, but allows substances of a smaller size to pass through, only plasma components can be smoothly collected from blood. It is suitable.

In addition, if the thin membrane with selective permeability does not allow iprin and fibrinogen to pass through, but allows substances with a lower molecular weight than fibrin and fibrinogen to pass through, a serum sample that does not contain fibrin or fibrinogen should be collected. It is suitable because it can be done.

If the selectively permeable membrane does not allow albumin to pass through, but allows substances with a molecular weight smaller than albumin to pass through, it is suitable because a serum sample that does not contain proteins can be collected. An embodiment of the liquid collection tube will be described in detail with reference to the accompanying drawings.

FIG. 1 shows an embodiment of a small-diameter pipe according to the present invention, which is equipped with a permselective thin film at the tip opening. This selectively permeable membrane is used to screen out unnecessary organic components in body fluids and blood, and its substance permeability is determined by the physicochemical material of the membrane, but it also depends on the bore size. It can be used as a standard. For example, when collecting only plasma components, the pore size of the membrane that does not allow blood cells and platelets to pass through is 0. /~/, 0! 1 m is effective, and if a serum sample free of fibrin and fibrinogen is required, the bore size force o
It is effective to use a membrane that does not allow albumin to permeate with a pore size of 30 nA or less. To collect the P fluid, place the distal end with this membrane in the canal or subcutaneously, and apply negative pressure to the dividing mouth end J with a pump or the like, and the pressure difference will cause the P fluid to pass through the membrane. It oozes out from the blood vessel into the collection tube.

Although it depends on the site where the tube is placed, it is desirable that the outer diameter of the small diameter pipe to be placed is less than or equal to φ. As shown in FIG. 1, only the part to be indwelled in the living body may be thin, and the suction port on the opposite side may be thick.

FIG. 2 is an exploded view of one embodiment of the aid according to the present invention, which is used when puncturing and indwelling a small-diameter pipe into a blood vessel or subcutaneously in a living body. There is a two-part metal needle 6,6' longer than the vibrator on the outer periphery of the small-diameter vipco, and a plastic sheath 7,7' is provided on the outer periphery to hold the two-part metal needle together. . FIG. 3 shows a state in which the collection tube set of FIG. 1 is assembled and punctured into a blood vessel. After puncturing, the sheaths 7 and 71 can be torn into pieces by pulling out the tabs r and r' of the plastic sheaths, respectively. When the metal needle 6.61 is divided into two parts and withdrawn, only the inner small diameter pipe 2 remains in the vessel, as shown in the figure. According to this method, during puncturing, no pressure is applied to the lumbar region from the tip of the small-diameter vibrator, so the membrane does not tear.

There is no particular limitation on the method of closing the small-diameter vibrator opening with the permselective thin film used in the present invention.

A method of adhering a membrane from the outside or from the outside of a small diameter pipe,
Possible methods include sandwiching the vibrator with an O-ring or the like, or molding the vibrator and membrane integrally from the same material and drilling a hole of a desired diameter at the tip.

The membrane is preferably installed at the tip of the small diameter pipe as much as possible. If a body fluid stagnates on the outside of the membrane, the membrane will become clogged and the transmissibility will deteriorate, so a structure in which the outside surface of the membrane is washed by the flow of body fluid in the blood vessels is preferable.

The material of the small diameter pipe is preferably a material that does not easily coagulate the fn liquid, such as polyethylene, polypropylene, polysulfone, Teflon, silicone, etc.

According to the F liquid collection tube according to the present invention, only the components necessary for blood analysis can be easily collected from blood or the like.

This P fluid collection tube can be used not only for measuring blood substances, but also for various other purposes. For example, if a blood donation P fluid collection tube is used, it will be possible to donate blood in which only plasma is collected.

[Brief explanation of the drawing]

FIG. 1 shows a sectional view of a small diameter pipe according to an embodiment of the present invention. FIG. 2 shows an embodiment of an auxiliary device for puncturing a living body and a collection tube main body. FIG. 3 shows the state in which the p-liquid collection tube is punctured into a living body. Figure 3 shows the puncturing aid removed after puncturing. / IIJF Permeable Thin Film Thin Diameter Pipe Vascular Patent Applicant Nikkiso Co., Ltd.

Claims (1)

[Claims] (1) A small-diameter pipe with both ends open and one opening covered with a permselective thin film, a two-part metal needle longer than the small-diameter pipe, and a device for holding the two-part metal needle together. P characterized by having a plastic sheath
Fluid collection tube. tW The p-liquid collection tube described in paragraph (1), in which the thin membrane with selective permselectivity does not allow red blood cells, white blood cells, or platelets to pass through, but allows the passage of substances with a smaller size (J) The thin film having the above-mentioned properties does not allow the permeation of iprin and fibrinogen, but allows the permeation of substances with a smaller molecular weight than iprin and fibrinogen.
The f-liquid collection tube according to item f11, which is permeable to a substance having a smaller molecular weight than the P-liquid collection rubumin described in item f11.