JPS6348309B2 - - Google Patents
Info
- Publication number
- JPS6348309B2 JPS6348309B2 JP56183384A JP18338481A JPS6348309B2 JP S6348309 B2 JPS6348309 B2 JP S6348309B2 JP 56183384 A JP56183384 A JP 56183384A JP 18338481 A JP18338481 A JP 18338481A JP S6348309 B2 JPS6348309 B2 JP S6348309B2
- Authority
- JP
- Japan
- Prior art keywords
- collection tube
- liquid collection
- diameter pipe
- blood
- pass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000012528 membrane Substances 0.000 claims description 19
- 239000000126 substance Substances 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 10
- 239000002184 metal Substances 0.000 claims description 7
- 239000010409 thin film Substances 0.000 claims description 7
- 102000009123 Fibrin Human genes 0.000 claims description 6
- 108010073385 Fibrin Proteins 0.000 claims description 6
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 6
- 102000008946 Fibrinogen Human genes 0.000 claims description 6
- 108010049003 Fibrinogen Proteins 0.000 claims description 6
- 229950003499 fibrin Drugs 0.000 claims description 6
- 229940012952 fibrinogen Drugs 0.000 claims description 6
- 102000009027 Albumins Human genes 0.000 claims description 5
- 108010088751 Albumins Proteins 0.000 claims description 5
- 210000001772 blood platelet Anatomy 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 230000035699 permeability Effects 0.000 claims description 3
- 210000003743 erythrocyte Anatomy 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 230000014759 maintenance of location Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 210000004204 blood vessel Anatomy 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 6
- 239000010839 body fluid Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 238000004159 blood analysis Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 238000005259 measurement Methods 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Sampling And Sample Adjustment (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
【発明の詳細な説明】
本発明は、血液の分析などに使用する液採取
管に関するものである。体液、血液には血球、血
小板、リンパ球、各種タンパク質、ホルモン、脂
質、糖類、アミノ酸、ビタミン、塩類等数多くの
物質が含まれる。しかし、一般に血液分析で測定
する血中物質はこの中のごく一部についてであ
り、それ以外は殆ど無用であるばかりでなく、多
くの場合には逆に測定の妨害になる。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a liquid collection tube used for blood analysis and the like. Body fluids and blood contain many substances such as blood cells, platelets, lymphocytes, various proteins, hormones, lipids, sugars, amino acids, vitamins, and salts. However, blood substances that are generally measured in blood analysis are only a small portion of these substances, and the rest are not only of little use but, in many cases, actually interfere with the measurement.
そこで従来は血液分析の場合には、採取した体
液、血液から、遠心分離、過、血清分離、除タ
ンパク質等の操作によつて測定の妨害となる物質
を予め除去したうえで、測定を行なつていたが、
大へん繁雑であり、多くの費用と労力がかかると
いう欠点があつた。 Conventionally, in the case of blood analysis, substances that would interfere with the measurement were removed from the collected body fluids or blood by centrifugation, filtration, serum separation, protein removal, etc. before the measurement was performed. was, but
The drawback was that it was very complicated and required a lot of cost and effort.
そこで、発明者等は上記欠点を克服すべく鋭意
研究を重ねたところ、先端開口部に選択透過性を
有する膜を備えた細径パイプを血管等へ留置する
ことによつて容易に必要な液を採取できること
を突きとめた。 Therefore, the inventors conducted intensive research to overcome the above-mentioned drawbacks, and found that by placing a small-diameter pipe equipped with a selectively permeable membrane at the tip opening into a blood vessel, etc., it is possible to easily obtain the necessary fluid. It was discovered that it is possible to collect
したがつて本発明の一般的な目的は、生体から
直接、余分な有形成分を含まない体液、血液の
液を容易に採取する手段を提供することにある。 Accordingly, a general object of the present invention is to provide a means for easily collecting body fluids and blood, which do not contain any extraneous substances, directly from a living body.
本発明の主たる目的は、両端開口した一方の開
口部を選択透過性を有する薄膜で覆つた細径パイ
プと、該細径パイプよりも長い二分割金属針と、
該二分割金属針を一体に保持するためのプラスチ
ツク製さやとを備えた液採取管を提供すること
にある。 The main objects of the present invention are: a small diameter pipe having both ends open and one opening covered with a thin film having selective perms; a two-part metal needle longer than the narrow diameter pipe;
The object of the present invention is to provide a liquid collection tube with a plastic sheath for holding the two-part metal needle together.
なお、選択透過性を有する薄膜が赤血球、白血
球、血小板を透過させず、それ以下の大きさの物
質の透過が可能なものであれば、円滑に血液中か
ら血漿成分のみを採取することができて好適であ
る。 In addition, if the thin membrane with selective permeability does not allow red blood cells, white blood cells, and platelets to pass through, but allows substances of a smaller size to pass through, only plasma components can be smoothly collected from blood. It is suitable.
また、選択透過性を有する薄膜がフイブリン、
フイブリノーゲンは透過させず、フイブリン、フ
イブリノーゲンより分子量の小さな物質の透過可
能なものであれば、フイブリン、フイブリノーゲ
ンを含有しない血清サンプルを採取することがで
きて好適である。 In addition, thin films with permselectivity are fibrin,
It is preferable to use a material that does not allow fibrinogen to pass through, but allows a substance with a molecular weight smaller than that of fibrin and fibrinogen to pass through, since it is possible to collect a serum sample that does not contain fibrin or fibrinogen.
選択透過膜がアルブミンは透過させず、アルブ
ミンより分子量の小さな物質の透過可能なもので
あれば、タンパク質を含有しない血清サンプルを
採取することができて好適である。 It is preferable that the selectively permeable membrane does not allow albumin to pass therethrough, but allows a substance with a molecular weight smaller than albumin to pass therethrough, since a protein-free serum sample can be collected.
次に、本発明に係る液採取管の実施例につき
添付図面を参照し、詳細な説明を行なう。先端開
口部に選択透過性を有する薄膜1を備えた本発明
に係る細径パイプ2の実施例を第1図に示す。こ
の選択透過膜は体液、血液中の不必要な有形成分
をふるい分けるためのものであり、その物質透過
能は、膜の物理化学的な材質によつて決定される
が、ポアーサイズによつても一応の基準とするこ
とができる。たとえば、血漿成分のみを採取する
場合には、血球、血小板を透過させない膜のポア
ーサイズは0.1〜1.0μmが有効であり、またフイブ
リン、フイブリノーゲンを含まない血清サンプル
を必要とする場合にはポアーサイズが0.05〜
0.2μm、アルブミンを透過させない膜のポアーサ
イズは30nÅ以下のものがそれぞれ有効である。
液を採取するには、この膜の付いた先端側を血
管内、あるいは皮下に留置し、一方の開口端5に
ポンプ等によつて陰圧をかければ、圧力差によつ
て、液が膜を通して血管から採取管内へにじみ
出てくる。 Next, an embodiment of the liquid collection tube according to the present invention will be described in detail with reference to the accompanying drawings. FIG. 1 shows an embodiment of a small-diameter pipe 2 according to the present invention, which has a thin film 1 having permselectivity at its tip opening. This selectively permeable membrane is used to screen out unnecessary organic components in body fluids and blood, and its substance permeability is determined by the physicochemical material of the membrane, but it also depends on the pore size. can also be used as a standard. For example, when collecting only plasma components, a pore size of 0.1 to 1.0 μm is effective for a membrane that does not allow blood cells and platelets to pass through, and when a serum sample that does not contain fibrin or fibrinogen is required, a pore size of 0.05 is effective. ~
A pore size of 0.2 μm and a membrane that does not allow albumin to pass through have a pore size of 30 nÅ or less, respectively.
To collect the fluid, place the distal end with this membrane in the blood vessel or subcutaneously, and apply negative pressure to one open end 5 with a pump or the like, and the pressure difference will cause the fluid to flow through the membrane. It oozes out from the blood vessel into the collection tube.
留置する部位によるが、留置される細径パイプ
の外径はφ2mm以下であることが望ましい。第1
図に示すように生体に留置する部分のみ細くし、
反対側の吸引口は太くても構わない。 Although it depends on the site where it is placed, it is desirable that the outer diameter of the small diameter pipe to be placed is φ2 mm or less. 1st
As shown in the figure, only the part to be placed in the living body is made thinner,
It doesn't matter if the suction port on the opposite side is thicker.
第2図は、細径パイプを生体の血管あるいは皮
下等に穿刺留置する場合に使用する本発明に係る
助具の一実施例の分解図である。細径パイプ2の
外周部に該パイプより長い二分割金属針6,6′
があり、その外周部に該二分割金属針を一体に保
持するためのプラスチツク製のさや7,7′を備
えている。第3図は第2図の採取管セツトを一体
にした状態で脈管9に穿刺した状態を示す。穿刺
後、プラスチツク製のさやのつまみ8,8′を外
側に各々引つぱり抜くとさや7,7′はとつに引
き裂くことができる。金属針6,6′を二分割す
ることによつて引き抜くと、第4図の如く、内側
の細径パイプ2のみが脈管内に残る。この方法に
よれば、穿刺時、細径パイプ先端の膜部に圧力が
かからないので、膜は破れない。 FIG. 2 is an exploded view of one embodiment of the aid according to the present invention, which is used when puncturing and indwelling a small-diameter pipe into a blood vessel or subcutaneously in a living body. Two split metal needles 6, 6' longer than the pipe are attached to the outer periphery of the small diameter pipe 2.
It has plastic sheaths 7, 7' on its outer periphery for holding the two-part metal needle together. FIG. 3 shows a state in which the collection tube set of FIG. 2 is integrated and punctured into the blood vessel 9. After puncturing, the sheaths 7, 7' can be torn into pieces by pulling the plastic sheath tabs 8, 8' outward, respectively. When the metal needles 6, 6' are divided into two parts and pulled out, only the inner small-diameter pipe 2 remains in the vessel, as shown in FIG. According to this method, no pressure is applied to the membrane at the tip of the small-diameter pipe during puncturing, so the membrane does not tear.
本発明で用いる選択透過性薄膜で、細径パイプ
開口部をふさぐ方法に特に限定はない。細径パイ
プの外側もしくは外側から膜を接着する方法、O
リング等によりはさみ込む方法、パイプと膜を同
じ材質により一体に成型し、その先端に所望の径
の穴をあける方法等が可能である。 There is no particular limitation on the method of blocking the opening of a small diameter pipe with the permselective thin film used in the present invention. A method of adhering a membrane from the outside or from the outside of a small diameter pipe, O
Possible methods include sandwiching the tube between rings or the like, or molding the pipe and membrane integrally from the same material and drilling a hole of a desired diameter at the tip.
膜の取付位置は細径パイプの出来るだけ先端が
好ましい。膜の外側に体液の滞留部が出来ると膜
が目詰りを起して過性能が低下するので膜の外
側表面を脈管中の体液の流れで洗われる構造が好
ましい。 The membrane is preferably installed at the tip of the small diameter pipe as much as possible. If a body fluid stagnates on the outside of the membrane, the membrane will become clogged and performance will be reduced, so a structure in which the outside surface of the membrane is washed by the flow of body fluid in the blood vessels is preferable.
細径パイプの材質は、血液凝固が生じにくい材
質が好ましく、例えば、ポリエチレン、ポリプロ
ピレン、ポリスルフオン、テフロン、シリコーン
等が良い。 The material of the small diameter pipe is preferably a material that does not easily cause blood coagulation, such as polyethylene, polypropylene, polysulfone, Teflon, silicone, etc.
本発明による液採取管によれば、血液等か
ら、血液分析に必要な成分のみを簡易に採取する
ことができる。 According to the liquid collection tube according to the present invention, only the components necessary for blood analysis can be easily collected from blood or the like.
本液採取管は血中物質測定のためだけのみな
らず、他に様々な用途が考えられる。例えば、献
血時本液採取管を用いれば、血漿のみ採取する
献血も可能となるであろう。 This liquid collection tube can be used not only for measuring blood substances, but also for various other purposes. For example, if a main fluid collection tube is used during blood donation, it will become possible to donate blood in which only plasma is collected.
第1図は本発明の一実施例で細径パイプの断面
図を示す。第2図は生体への穿刺用補助具と採取
管本体の一実施例を示す。第3図は液採取管を
生体へ穿刺した状態を示す。第4図は穿刺後、穿
刺用補助具を取り除いた状態を示す。
1……選択透過性薄膜、2……細径パイプ、9
……脈管。
FIG. 1 shows a sectional view of a small diameter pipe according to an embodiment of the present invention. FIG. 2 shows an embodiment of an auxiliary device for puncturing a living body and a collection tube main body. FIG. 3 shows a state in which the liquid collection tube is punctured into a living body. FIG. 4 shows a state in which the puncturing aid is removed after puncturing. 1...Selective permselective thin film, 2...Small diameter pipe, 9
...vascular vessels.
Claims (1)
する薄膜で覆つた細径パイプと、該細径パイプよ
りも長い二分割金属針と、該二分割金属針を一体
に保持するためのプラスチツク製さやとを備えた
ことを特徴とする液採取管。 2 選択透過性を有する薄膜が赤血球、白血球、
血小板を透過させず、それ以下の大きさの物質の
透過が可能なものである第1項記載の液採取
管。 3 選択透過性を有する薄膜がフイブリン、フイ
ブリノーゲンは透過させず、フイブリン、フイブ
リノーゲンより分子量の小さな物質の透過可能な
ものである第1項記載の液採取管。 4 選択透過性を有する薄膜がアルブミンは透過
させず、アルブミンより分子量の小さな物質の透
過可能なものである第1項記載の液採取管。[Scope of Claims] 1. A small-diameter pipe with both ends open and one opening covered with a permselective thin film, a two-part metal needle longer than the small-diameter pipe, and the two-part metal needle integrated into one body. A liquid collection tube characterized in that it has a plastic sheath for retention. 2. A thin film with selective permeability is used for red blood cells, white blood cells,
2. The liquid collection tube according to item 1, which does not allow passage of platelets but allows passage of substances of a smaller size. 3. The liquid collection tube according to item 1, wherein the permselective thin membrane does not allow fibrin or fibrinogen to pass through, but allows a substance with a molecular weight smaller than fibrin or fibrinogen to pass through. 4. The liquid collection tube according to item 1, wherein the thin membrane having permselectivity does not allow albumin to pass therethrough, but allows a substance with a molecular weight smaller than albumin to pass therethrough.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56183384A JPS5885161A (en) | 1981-11-16 | 1981-11-16 | Filtered liquid collecting tube |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56183384A JPS5885161A (en) | 1981-11-16 | 1981-11-16 | Filtered liquid collecting tube |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5885161A JPS5885161A (en) | 1983-05-21 |
JPS6348309B2 true JPS6348309B2 (en) | 1988-09-28 |
Family
ID=16134822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56183384A Granted JPS5885161A (en) | 1981-11-16 | 1981-11-16 | Filtered liquid collecting tube |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5885161A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990012611A1 (en) * | 1989-04-21 | 1990-11-01 | Ash Medical Systems, Inc. | Non-intravascular infusion access device |
-
1981
- 1981-11-16 JP JP56183384A patent/JPS5885161A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS5885161A (en) | 1983-05-21 |
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