JPS58202029A - Granulating and coating apparatus - Google Patents

Abstract

PURPOSE:To provide the titled apparatus capable of uniform granulation and coating, constituted by providing a rotary plate having a notch in the almost radial direction thereof to one or more place of a rotary plate provided to the center of a container along the bottom surface of the container. CONSTITUTION:A predetermined amount of a powdery stock material to be subjected to granulation and coating is thrown into a container 1 from the inlet 3 thereof. On the other hand, a rotary shaft 7 and a rotary plate 8 are rotated and centrifugal force is imparted to the powdery stock material (particulate material) 10 on the flat plate part 8a of the plate 8 in the container 1 to generate whirling flow motion. At the same time, uniform mixing and driving action is imparted to the particulate material 10 with the rotation of the plate 8. In this case, because the lower surface of the plate 8 and the bottom surface of the container 1 are set in approaching relation to each other and a notch part 11 is formed to the flat plate part 8b of the plate 8 in the radial direction thereof, the particulate material 10 got into the underside the plate 8 is scraped up onto the plate 8 from the notch part 11 to prevent the stay of the particulate material under the plate 8. In addition, because air is supplied between the under surface of the plate 8 and the bottom surface of the container 1 through an air supply passage 12 provided to the shaft 7, the particulate material 10 on the bottom surface of the container 1 is blown up by air to facilitate the scraping-up thereof onto the plate 8 through the notch part 11 and the stagnation of the particulate material 10 under the plate 8 is prevented more certainly.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a granulation and coating device for powder and granules.

In general, examples include manufacturing powders and granules used in pharmaceuticals such as tablets, fine granules, granules, and capsules, foods such as chocolate, powder metallurgy, catalysts, ferrites, ceramics, detergents, cosmetics, dyes, and hand sanitizers. Several types of mechanical devices are used for grain coating. Among them are
For example, a pan- or drum-type transfer granulation/coating machine, an agitation granulation machine with an agitation reducer, and furthermore, a powder or granule is fluidized and dispersed with air, and then a binding liquid or a coating machine is sprayed to produce the powder. There is a so-called flow machine that aggregates or coats particles; there are *grain Φ coating machines.

By the way, for example, in granulation and coating in fields centered on pharmaceuticals and foods, particles with a uniform particle size distribution and particles with good sphericity are used for fine powder, toughness with less agglomeration, smoothness, and x'iit properties. In addition, coating operations with no coating unevenness, less grain breakage, and less generation of adhering aggregates are required.

In response to these requirements, conventional transfer coaching machines use a cascade flow that utilizes gravity, so they do not apply a strong force to the local area, but due to their poor mixing properties. However, in granulation, only uneven grains with a wide particle size distribution are obtained, and in coating, agglomerates are likely to occur.However, in a stirring granulator, agitation caused by local force can cause granules to break. Since granulation is also permeable, granulation has the disadvantage that the particle size distribution becomes wide, and coating tends to result in incomplete coating.

In addition, although the fluidized granulation pot coating machine has a mixing and dispersing action for powder and granules, it does not have a rolling action, so it has the disadvantage that it is difficult to produce heavy grains.

The purpose of the present invention is to eliminate the drawbacks of the above-mentioned prior art and to provide an apparatus capable of performing yarn hulling and coating with good uniformity2.In order to achieve this purpose,
According to the invention, a rotary plate having a notch extending approximately in the radial direction beyond the center of the rotary shaft is provided along the bottom surface of the container.

That is, granulation and coating essentially involve applying as uniform a shear to the granule layer as possible to
It is essential to provide the particles with a uniform mixing action without stagnation and an appropriate rolling action. In order to satisfy these requirements, instead of the stirring element of the stirring granulator, a rounded flat II-shaped or dish-shaped rotating plate is installed along the bottom of the granulator to provide appropriate rolling motion to the powder layer. provided in a substantially horizontal direction. In order to reduce the centrifugal force required to generate a sufficient spiral flow action in the rotating plate aS powder layer, the rotating plate should be large enough to cover at least 1/2 of the container bottom (3). It is better. Furthermore, in order to reduce as much as possible the violet of powder particles that enter between the rotary plate and the bottom of the container, the rotary plate is preferably arranged along the bottom of the container so as to be as close to the bottom of the container as possible. Furthermore, the powder and granular material t-1Jll entered below the rotating plate! 1
In order to lift the rotary plate onto the rotary plate, it is preferable to cut out one or more parts of the rotary plate in the radial direction, and preferably the leading edge of the rotary plate in the direction of rotation at the notch is closer to the bottom surface of the container. With such a structure, as the rotary plate rotates, the powder and granular material under the rotary plate can be scooped up onto the rotary plate. In addition, by providing an air nozzle below the rotating plate to supply air between the rotating plate and the bottom of the container,
The powder and granular material under the rotating plate is blown up, and the powder and granular material tube under the rotating plate is easily scooped up by the front rut in the rotational direction of the rotating plate in the notch. As a result, the area where powder and granules accumulate under the rotary plate at the bottom of the container is eliminated. In addition, air nozzles are installed on the bottom wall of the container and the tosagi, and the centrifugal force caused by the rotation of the rotating plate causes the powder and granules that have reached the wall of container II to be flowed with air along the body. It is possible to float the powder while dispersing it and promote the swirling circulation mixing action of the powder and granules.

In this way, the present inventors have eliminated the poor mixability associated with transfer granulation coaching, prevented grain breakage due to localized excessive wm force seen in stirring granulators, and We succeeded in giving particles a rolling action that cannot be found in coatings.

Moreover, uninvented! ! In addition to the original advantages of granulation coaching, the coaching device also has Gyl P (G
ood Manufacturing Practical
e) has an impressive percentage value.

Specifically, devices that are seemingly similar to the present invention include a device in which a rotating disk is provided at the bottom of the fluidized bed to add a rolling action to the fluidized bed granulation coating, and a device in which a rotating disk is provided at the bottom of the fluidized bed, and a rotating disk is provided on the fluidized bed air dispersion plate. There is a device equipped with a disc, but in the former, powder and granules fall under the rotating disc, and the powder and granules get mixed into the nozzles that are subsequently processed, reducing quality and causing problems. This makes complete cleaning after a series of operations difficult, while the latter also poses the problem of particles getting into the gap between the rotating disk and the air dispersion plate. Therefore, both of the above-mentioned conventional iron weights include problems in terms of GMPO.

On the other hand, the uninvented TiIt, unlike the flow-type one made in the U. After discharging the powder and granules from the container, the rotary plate can be slightly lifted during cleaning to completely remove the gauze.Therefore, the device of the present invention has the function of arbor and coating. In addition to being dredged, it is also in very good condition from a GMPO perspective.

Another conventional technique has been used in which a rotating disk is provided along the bottom wall of the granulation tank, and the particles are rolled and flowed on the rotating disk for granulation. However, this conventional method has the problem that powder and granules get into the space between the bottom wall of the granulation tank and the rotating disk, forming an S retention zone, and is not completely free from GMP issues. .

On the other hand, the device of the present invention can be used by forming radial notches in the rotary plate, by venting air between the bottom of the container and the rotary plate, or by using these methods. By having wrinkles, it is possible to prevent the granular material from smearing between the bottom surface of the container and the rotary plate, and it is very good not only in terms of granulation effect #i but also in terms of GMP.

Hereinafter, the present invention will be explained according to the embodiments shown in the drawings! +Explain in detail.

FIG. 1 is a schematic cross-sectional view showing an example of a granulation and coating apparatus according to the present invention.

Real ai? In 1J, a container 1ri for granulation and coating has a circular shape on the horizontal side, and a cover 2 is provided on the top, and the cover 2 has a powder bed for supplying a fixed amount of raw material powder. A supply pipe 3, an exhaust pipe 4 for evacuating the inside of the container 1, a vacuum suction pipe 5 for making the inside of the container 1 a desired vacuum state, and a spray nozzle 6 for supplying liquid for granulation and coning are provided. .

On the other hand, at the center of the bottom of the container I, a rotating shaft 7 that is rotatably driven by a drive source (not shown) is vertically protruded. A disc-shaped rotating plate 8 horizontally arranged along the bottom wall surface of the container l is fixed to the upper end of this rotating @7 with bolts 9, and a truncated conical part 8a at the center of the rotating plate 8 is container l
A flat plate part 8 protrudes inward, and its outer periphery is along the valley (to) low surface.
b.

The rotating plate 8 provides a concealed rolling action to the powder and granular material IO by placing the powder and granular material 10 put into the container 1 on the flat plate sBb of the rotating plate 8 and rotating it. be. This rotation @ 8 is necessary to provide the necessary centrifugal force to generate a sufficient spiral flow action on the powder and granular material lO, so that the bottom #i</)l/2 or more of the container 1 must be thickened. It is preferable to have a hollow area.

It is desirable that the lower surface of the rotary plate 8 be as close as possible to the screen 10 paper (3) to prevent the y# powder O from entering and accumulating between both surfaces as much as possible. scoops up the powder and granular material that enters between the lower surface of the rotary plate 8 and the bottom surface of the container IS1 onto the flat plate HBb of the rotary plate 8 to prevent the formation of a stagnation area of the powder and granular material below the rotary plate 8. Therefore, a notch 1111 in the radial direction is formed at one location on the flat plate portion 8b of the rotating plate 8. This notch 11 is formed in a shape that becomes slightly wider as it goes from the inner side to the outer side in the radial direction when viewed in plan, and has a cross-sectional shape ri as shown in FIG. It is cut diagonally toward the man's front edge, and (b) is configured to easily scoop up the granular material below the 1st 8 onto the rotary plate 8.

In addition, in this embodiment, the powder and granules that have entered between the bottom (3) of the rotary plate 8 and the bottom of the container 1 are blown up in the circumferential direction of the container 1 and scooped onto the rotary pot 8 by the notch 11. In order to make the upper part easier, an air supply passage 12 is provided through the instep of the rotating shaft 7 between the downward direction of the rotating shaft 7 and the bottom surface of the container 1 for blowing air outward in one direction.

The air ejection nozzle opening of this air supply path 12 may be formed in the radial direction of the rotating shaft 7, but if it is formed in the tangential direction of the rotation s7, a better effect of blowing up and removing powder particles can be obtained, and the nozzle opening The number of parks per garden is not limited to one. Further, a bearing 13 is provided around the upper portion of the rotation 1a7 at a position below the bottom wall of the container.

Further, in the lower part of the @ wall of the container 1 of this embodiment, that is, at a position corresponding to a position slightly above the flat part 8b of the rotary plate 8, the centrifugal force caused by the rotation of the rotary plate 8 is applied to the wall of the valley if. An air nozzle 14 is provided to disperse and float the powder 1O that has passed through the wall along the sales wall while dispersing it by the force of air, and to promote the swirl-like Shinano mixing action of the powder 1O. . The air nozzle 14 may be opened to introduce air in the radial direction of the container 1, but in order to better perform the mixing action of the powder and granular material 10, the air nozzle 14 should be opened so as to introduce air in the radial direction of the container 1. It is preferable to open in one direction. The number of air nozzles 14 is not limited to one at all, and one air nozzle may be provided, or may be provided on the bottom wall of the container l.

A baffle plate 15 is provided inside the wall of the valley 1 in this embodiment to assist in the mixing action of the powder and granular material IO. However, this baffle plate 15 may be omitted. In addition, at the lower side wall of the container 1, there is a ninth product discharge 11i for taking out the granulated or coated product to the outside of the IFi 61.
16 is formed and the pulp 17 is opened and closed. Furthermore, in this example, the powder to be granulated or coated is
A sensor 18 is installed inside the vessel, which is useful for sensing temperature, temperature, etc., and controlling the amount of donated body supplied from the spray nozzle 6 and the amount of hot air supplied from a hot air supply source (not shown). ing.

Next, the operation of this embodiment will be explained.

First, a large amount of powdered raw material of granulated and coating powder is charged into a container l through eight supply pipes 3 from a hopper (not shown).

On the other hand, the rotating shaft 7 and rotating plate 8 are driven by a drive source (not shown).
When rotated, the powder raw material in the container l receives a hawk center force on the flat plate ssb of the rotating plate 8, as shown as the powder lO in FIG. 10 receives uniform mixing action and rolling action as the rotating plate 8 rotates.

On the other hand, since the lower surface of the rotary plate 8 and the bottom surface of the container l are close to each other, and the flat plate portion 8b of the rotary plate 8 is formed with a radial notch 11, powder particles may have entered the lower side of the rotary plate 8. The particles are scooped up from the notch 11 onto the rotary plate 8, and the powder particles are prevented from accumulating below the rotary plate 8. Air is blown out between Tl of No. 8 and paper L of container 1, so that air is blown out between Tl of No. 8 and paper L of container No. # The paddy body is blown up by this air, and it is easier to scoop it onto the rotary plate 8 through the notch 11, and the accumulation of powder and granules below the rotary plate 8 is more
indeed prevented.

Furthermore, in this example, since the air nozzle 14 is provided at the bottom of the wall of the valley, the powder grains 1O are slowed to the side wall of the container by the centrifugal force caused by the rotation of the rotating plate 80 times. The air flows and disperses the particles and floats them up along the pot, promoting the swirling mixing action of the powder and granules.

Therefore, according to this example, the powder to be granulated and coated is subjected to not only a uniform fluid mixing action but also a moderate rolling action and further a spiral circulation mixing action.
As the coating is coated, it is possible to obtain powder with uniform particle size, and it is possible to produce grains that are heavy without agglomeration, and are less likely to be affected by local excessive shear forces in conventional agitator granulators. It is possible to prevent particle breakage and also to prevent accumulation of powder and granules.

Furthermore, since the granulation and coating apparatus of this embodiment does not have an air dispersion plate, the powder IO is completely retained in the container 1, and when the container is cleaned after the powder IO is discharged from the container 1. , complete cleaning can be carried out by simply lifting the rotor 18 slightly from the rotary shaft 7, making it extremely superior from a GMP standpoint.

FIG. 4 is a partial sectional view showing another embodiment of the cutout portion of the rotating plate according to the present invention. In this embodiment, the cutout portion 11 of the flat plate portion 8b of the rotary plate 8 is a front rut 111 in the rotational direction of the rotary plate 8.
1b is bent in the stacking direction of V tjr 1, that is, in the downward direction, and its tip is in close contact with the bottom surface of the container. Therefore, in this case, as the rotating plate rotates 80 times, the powder and granules on the bottom of the container curve as the leading edge i! 1ll
lb, it is scooped up more easily and reliably and returned to the flat plate s8b of the rotary plate 8.

igs diagram and FIG. 6 are plan views showing other embodiments of the rotary plate in the present invention. That is, in the embodiment shown in FIG. 5, the notches 5till in the flat plate portion 8b of the rotary plate 8 are formed at two locations 1801f and l@ in the diametrical direction. In the example of Fig. 6 and Fig. 6, the notches @vSll are 120
A total of 31,161 VCs are formed at each position. Note that the notch &1llll is not limited to this, for example, 4
When a plurality of notches 11 are formed, the effect in scooping powder and granules becomes more severe than when only one notch 11 is formed. Fig. 7 shows granulation according to the present invention. FIG. 3 is a sectional view showing another embodiment of the coaching device. In this example, h unit 1
The 111119th part of a is formed into a curved shape, and the diameter becomes smaller toward the upper end. Such a container 1a
In this case, there is an advantage that the circulation mixing effect of the powder and granules in each container becomes better. In addition, in the fourth M1 example, the kill baffle plate is omitted because it is provided on 11+1 of the side walls of the nidifier, or the baffle plate (!- may be provided).

FIG. 8 is a sectional view of a further embodiment of the present invention. In this embodiment, in addition to the 1IIll wall portion of the container 1a, +
h? R+ is also formed into a curved nozzle shape, and the flat plate portion of the rotating plate 8 is also formed as a dish-shaped curved plate a8c that curves along this curved bottom wall. action and circulation mixing action can be obtained.

Note that the present invention is not limited to the above embodiments,
Various other waveforms are possible.

As mentioned above, according to the present invention, it is possible to granulate and coat powder with uniform particle size without causing lE1 failure due to locally excessive shearing force, and to generate aggregates. It is possible to make heavy grains without any problems, and prevents the powder from entering between the bottom of the container and the rotating plate.
Excellent effects can also be obtained in terms of MP.

[Brief explanation of the drawing]

FIG. 1 is a sectional view showing one embodiment of the granulation and coating apparatus according to the present invention, FIG. 2 is a half plan view of a rotary plate, and FIG.
Figure 4 is a partial sectional view showing other embodiments of the notch of the rotating plate, and Figures 5 and 6 are respectively showing other embodiments of the rotating plate. Plan view shown, No. 7
The figure is a cross-sectional view showing another embodiment of the granulation and coating apparatus of the present invention, and FIG. 8 is a cross-sectional view showing still another embodiment of the apparatus of the present invention. 1.11... Container, 2... Cover, 3... Powder supply pipe, 6... Spray nozzle, 7... Rotating shaft , 8・
... Rotating plate, 8a ... truncated conical part,
8b... Flat & part, 8C... Curved plate part,
lO... Powder, 11... Notch,
ll&lTo......front edge in rotational direction,
12... Air supply path, 14.
...Air nozzle, 16...Chute, 1
7...Valve. I# Eaves - Person Representative of Freund Zaka Co., Ltd. Patent attorney Daiwa Tsutsui

Claims (4)

[Claims] (1) A rotary plate having a substantially radial notch at one or more places is attached to a rotary shaft provided at the center of a container whose horizontal section (8) is substantially circular so as to run along the bottom surface of the container. A granulation and coating device characterized in that it is provided with: (2) The granulation and coating apparatus according to claim 1, characterized in that the spinning edge in the rotary print rotation direction of the notch of the rotary plate is brought close to the bottom surface of the container.
. (3) Claim 1 characterized in that it has a means for introducing air between the front NC rotor 61 turning plate and the bottom surface of the container.
Granulation and coating equipment as described in Section 2 or Section 2. (4) The granulation according to claim 1 or 2, characterized in that a means for introducing air is provided in at least one part of either or both of the side wall and the bottom wall of the container; Coaching equipment.