JP3805453B2 - Powder processing apparatus and powder processing method using the same - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
TECHNICAL FIELD The present invention relates to a granular material processing apparatus and a granular material processing method using the same, and in particular, an efficient granular material capable of performing operations such as granulation coating and drying of the granular material in the same apparatus. The present invention relates to a processing apparatus and a technique that is effective when applied to a granulation method, a coating method, a drying method, or a processing method that combines these methods.
[0002]
[Prior art]
Conventionally, as an apparatus for spherical granulation, an apparatus as shown in FIG. 12 described in a dissertation by Toshiro University by Yoshio Funakoshi is well known. In this apparatus, a rotating disk 52 is arranged at the bottom of the processing container 51, and air is sent from a gap 54 between the rotating disk 52 and the inner wall 53 of the processing container 51 to centrifugally flow the object to be processed. Yes. Spherical granulation is performed by charging the core particles into the processing vessel 51 and supplying the powder and binder to adhere the powder onto the core particles.
[0003]
On the other hand, a centrifugal fluidized granulator (also referred to as a centrifugal tumbling granulator, hereinafter abbreviated as a CF device) as shown in FIG. 13 is known as an apparatus that can be used industrially by improving the apparatus of FIG. ing. Such an apparatus includes, for example, “CF-GRANULATOR” manufactured by Freund Corporation, and is widely used in the pharmaceutical industry and the like. Similarly to the apparatus of FIG. 12, the CF apparatus 55 is also provided with a rotating dish 57 below the processing container 56, and air is fed from a gap 59 between the rotating dish 57 and the inner wall 58 of the processing container 56. Then, the workpiece is centrifugally flowed.
[0004]
Recently, a method for producing spherical particles by combining powders without using core particles using the CF device 55 (Japanese Patent Laid-Open No. 5-229961) has been developed. Here, a mixed powder of a water-soluble substance and a water-insoluble substance is charged into the CF device 55, and while rotating the rotating plate 57 of the CF device 55, a liquid mainly composed of water is added to the mixed powder. Spray until the liquid content is 95-110% of the plastic limit and then dry. As a result, spherical particles useful as excipients for pharmaceuticals and foods can be obtained without using core particles. The CF device 55 is used not only for granulation but also for coating a drug or the like on spherical particles.
[0005]
Thus, the CF device is a useful device widely used in the pharmaceutical industry and the like. However, since the gas flowing through the device is only the gas passing through the gap 59 between the rotating plate 57 and the inner wall 58, the drying capacity is There is a disadvantage that it is scarce. In this case, if the gap 59 is widened in order to improve the drying capacity, the powder particles fall from the gap, which is not preferable. Therefore, if the amount of gas fed from the gap 59 is increased in order to prevent the powder particles from falling, the powder particles are blown up and are less susceptible to rolling operation on the rotating dish 57 or the inner wall surface of the processing container 56. . For this reason, the sphericity of the spherical particles is lowered, and there is a problem that the particles become light particles because they are not consolidated. Further, when the rotating tray 57 is provided with a ventilation portion, there are similar drawbacks, which are also not suitable for spherical granulation.
[0006]
Therefore, many proposals have been made for improvement in order to solve such problems related to the centrifugal flow device, and most of them have blown gas from the rotating plate in the horizontal direction, particularly in the radial direction, and powder particles on the rotating plate. It is intended to enhance the body rolling action. For example, Japanese Patent Application Laid-Open No. 61-165577 discloses an apparatus in which a fluidized bed is formed by a rotating dish 60 as shown in FIG. 14 in which a large number of blow holes 61 are opened in the same turning direction. Japanese Patent Laid-Open No. 59-49838 discloses a device for forming a swirling flow by blowing gas from the upper and lower gaps 63 of a large number of integrated concentric rotating annular plates 62 having different diameters as shown in FIG. Is disclosed. Further, as an improved version of this apparatus, an apparatus described in Japanese Patent Laid-Open No. 60-183030 has been proposed. In this apparatus, as shown in FIG. 16, the rotating plate 64 has a substantially planar shape, and the air circulation hole 65 is located on the rotating plate 64 at the center side of the lower surface with respect to the upper surface. It is formed to do. Then, air is blown out from the air circulation hole 65 toward the outer side of the rotating plate 64 so that the swirling flow of the powder particles is performed smoothly.
[0007]
In addition, JP-A-62-68535 and JP-A-62-68536 disclose a predetermined interval 66 as shown in FIG. 2 of JP-A-62-68535, for example. An apparatus is disclosed in which gas is blown out from the gaps 66 of a plurality of rotating plates 67 supported in a multilayer shape (FIG. 17). Furthermore, in Japanese Patent Laid-Open No. 8-24617, as shown in FIG. 18, a raised portion 69 is projected on the center upper surface of the rotating disk 68, and an outer portion is provided between the raised portion 69 and the upper surface of the rotating disk 68. An apparatus in which a jet port 70 is provided toward the radial side has been proposed. Furthermore, as a device in which the gas blowing direction is the circumferential direction, there is a device as shown in FIG. 19 described in Japanese Patent Laid-Open No. 60-255134. Ascending slopes 72 that incline upward in a direction opposite to the direction are formed radially, and a large number of pores 74 are arranged in the rear end wall 73.
[0008]
[Problems to be solved by the invention]
Thus, despite the fact that many apparatuses for spherical particle granulation have been proposed, the CF apparatus is still used for granulating spherical particles. The present inventors have investigated the reason, and in the various devices described above, depending on the gas blown from the rotating disk or the rotating plate, the granular material on the rotating disk or the inner wall of the container It turned out that the effect | action which strengthens the use for rolling is insufficient. In addition, it has been clarified that the granular material is blown up by the gas blown from the rotating disk or the like, and the inside of the processing vessel becomes an inappropriate environment for the granulation of spherical particles. For this reason, at present, no device has been developed that can efficiently produce spherical particles and dry the produced spherical particles in the same device, and the spherical particles granulated by the CF device are fluidized bed dried. The method of drying with a machine was common.
[0009]
However, in order to configure such a process, it is necessary to install both a CF apparatus and a fluidized bed dryer, which causes a problem that the installation cost increases and the installation place is widely occupied. In addition, it takes time and effort to discharge, transport, and recharge the granulated spherical particles to the next process such as coating and drying, and the spherical particles may be contaminated during these operations. is there. For this reason, development of the apparatus which can perform granulation and drying continuously in the same apparatus was desired.
[0010]
In addition, when coating spherical particles obtained using such an apparatus or spherical particles prepared in advance, it is desirable to perform coating in the same apparatus as described above, but there is an apparatus that can achieve this. It was not developed.
[0011]
An object of the present invention is to provide an efficient granular material processing apparatus capable of performing operations such as granulation coating and drying of granular material in the same apparatus, and granulation of granular material using such an apparatus. The object is to provide a method, a coating method, a drying method, or a treatment method combining these methods.
[0012]
The above and other objects and novel features of the present invention will be apparent from the description of this specification and the accompanying drawings.
[0013]
[Means for Solving the Problems]
Of the inventions disclosed in this application, the outline of typical ones will be briefly described as follows.
[0014]
That is, the granular material processing apparatus of the present invention has a processing container in which the horizontal cross section of the powder contact portion is circular, and the bottom of the processing container is horizontally mounted by a rotation driving means about a vertical line passing through the center of the powder contact portion. A rotating plate having a ventilation part through which gas can flow from the lower surface side to the upper surface side thereof, and a moving position vertically above the rotating plate so as to be concentric with the rotating plate. And a rotating lid that covers at least a part of the ventilation part of the rotating dish.
[0015]
On the other hand, the granular material processing method of the present invention accommodates the granular material in the granular material processing apparatus, sets the rotating lid to the lowered position, and rotates at least one of the rotating dish and the rotating lid. The binder liquid or the binder liquid and the powder are supplied while being granulated by combining the powder particles or the powder particles with the supplied powder.
[0016]
In addition, the granular material is accommodated in the above-described granular material processing apparatus, the rotary lid is set at the lowered position, and at least one of the rotary dish and the rotary lid is rotated, and the coating liquid or the coating liquid and the powder are rotated. It is also characterized by forming a coating layer on the powder particles.
[0017]
Furthermore, the granular material is accommodated in the above-mentioned granular material processing apparatus, the rotary lid is set to its raised position, and the rotary dish is formed from the gap generated between the rotary dish and the rotary lid by the rising of the rotary lid. It is also characterized in that gas is fed into the processing container through the ventilation part and the granular material is dried.
[0018]
In this case, the granular material is accommodated in the granular material processing apparatus, the rotary lid is set at the lowered position, and the binder liquid or the binder liquid is rotated while rotating at least one of the rotary dish and the rotary lid. After the powder is supplied and granulated by combining the powder particles or the powder and the supplied powder, the rotating lid is set to its rising position, and the rotating lid is raised to rotate the rotating dish. It is also possible to dry the granulated product by feeding gas into the processing container through the ventilation part of the rotating dish from the gap formed between the rotating lid and the rotating lid.
[0019]
In addition, the granular material is accommodated in the above-described granular material processing apparatus, the rotary lid is set at the lowered position, and at least one of the rotary dish and the rotary lid is rotated, and the coating liquid or the coating liquid and the powder are rotated. After forming the coating layer on the powder particles, the rotary lid is set at its raised position, and the gap formed between the rotary dish and the rotary lid due to the rise of the rotary lid The gas particles can also be dried by feeding gas into the processing container through the ventilation part of the rotating dish.
[0020]
Furthermore, the granular material is accommodated in the granular material processing apparatus, the rotary lid is set at the lowered position, and the binder liquid or the binder liquid and the powder are rotated while rotating at least one of the rotary dish and the rotary lid. After the granulation is performed by combining the granules and the powder and the supplied powder, the rotary lid and the rotary lid are set in the lowered position. It is also possible to supply a coating agent liquid or a coating agent liquid and powder while rotating at least one to form a coating layer on the granulated product.
[0021]
In addition, the granular material is accommodated in the above-described granular material processing apparatus, the rotary lid is set at its rising position, and rotated from the gap generated between the rotary dish and the rotary lid due to the rising of the rotary lid. After the gas is fed into the processing container through the aeration part of the dish to dry the powder and granule, the rotating lid is set to the lowered position, and at least one of the rotating dish and the rotating lid is rotated. It is also possible to supply a coating agent solution or a coating agent solution and a powder to form a coating layer on the granular particles.
[0022]
Furthermore, the granular material is accommodated in the granular material processing apparatus, the rotary lid is set at the lowered position, and the binder liquid or the binder liquid is rotated while rotating at least one of the rotary dish and the rotary lid. After the powder is supplied and granulated by combining the powder particles or the powder and the supplied powder, the rotating lid is set to its rising position, and the rotating lid is raised to rotate the rotating dish. After the gas is fed into the processing container through the ventilation part of the rotating dish from the gap formed between the rotating lid and the granulated product is dried, the rotating lid is set to its lowered position, The coating agent liquid or the coating agent liquid and the powder can be supplied while rotating at least one of the rotating dish and the rotating lid to form a coating layer on the granulated product.
[0023]
Further, in the above-mentioned powder particle processing method, the powder particles may be processed while gas is fed into the processing container from a gap formed between the outer edge of the rotating dish and the inner wall of the processing container. .
[0024]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
[0025]
FIG. 1 is a cross-sectional view showing a configuration of a centrifugal rolling granulation coating apparatus according to an embodiment of the present invention.
[0026]
As shown in FIG. 1, the centrifugal rolling granulation coating apparatus (powder processing apparatus) 1 according to the present embodiment centrifugally rolls a granular body 2 to which a binder or powder is added at a predetermined speed. Add and granulate spherical particles by adding powder as a core or by bonding powders together, or add powder and binder on top of them while rolling these spherical granules etc. It is an apparatus for forming a coating layer, and is composed of a centrifugal rolling part 3 located at the upper part and a rotation driving part 4 located at the lower part. In addition, a bag filter and a filtration net | network can be provided in the upper part of the centrifugal rolling part 3, and a cyclone can also be attached to an exhaust path (not shown).
[0027]
Here, the centrifugal rolling unit 3 of the centrifugal rolling granulation coating apparatus 1 centrifugally rotates the processing container 5 that performs processing such as granulation of the granular material and the granular material 2 that has been put into the processing container 5. The rotating dish 6 to be moved and a rotating lid 7 provided coaxially with the rotating dish 6 so as to be vertically movable on the upper side of the rotating dish 6 are provided. And the process of granulation etc. of the granular material 2 is performed by rotating the rotating tray 6 at a predetermined speed by the motor 14 (rotation drive means) provided in the rotation drive unit 4.
[0028]
In addition, a fixed wall 8 is provided around the rotating dish 6 so as to surround the rotating dish 6 at a predetermined interval, and a gap 9 formed between the rotating dish 6 and the fixed wall 8 is provided. Thus, air is supplied through the first gas supply path 10. Therefore, in this centrifugal rolling granulation coating apparatus 1, the powder 2 is prevented from falling by the gas fed into the processing container 5 from the gap 9 and the flow of the powder 2 is promoted. It is like that.
[0029]
In this case, a portion of the inside of the fixed wall 8 that is in contact with the granular material 2 at the time of centrifugal rolling, that is, the powder contact portion 8a has a horizontal cross section in order to make the rolling and flow of the granular material 2 uniform. Is circular. For this reason, the overall shape of the processing vessel 5 is selected from a cylindrical shape, an inverted conical shape, a part of a spherical shape, etc. whose horizontal cross section is circular, but the vertical cross section may be any shape, and the powder contact portion There are no particular restrictions on the shape of the other parts. Furthermore, the said powder contact part 8a is formed substantially perpendicular | vertical with respect to the rotating tray 6, and, thereby, the powder contact part without the powder body 2 centrifugally rolled by the rotating dish 6 receiving extra resistance. It is pushed upward along 8a.
[0030]
In addition, the shape of the rotating dish 6 may be any shape as long as the powder body 2 can roll well, a flat plate shape, a dish shape whose peripheral edge is curved upward, an inverted conical shape having a large apex angle, A curved surface slightly convex downward is exemplified. Further, the rotation shaft 13 of the rotating dish 6 is perpendicular to the center of the circle forming the horizontal section of the processing vessel 5 in order to prevent the rolling operation of the granular material 2 from being defective due to the eccentricity of the rotation shaft 13. It is provided in line with the line.
[0031]
On the other hand, as shown in FIG. 1, the rotating dish 6 of the present embodiment is provided with a ventilation portion 11, and air is supplied from below the rotating dish 6 via the second gas supply path 12. It can be done. In this case, the ventilation part 11 is normally provided uniformly distributed in an annular area excluding the outer peripheral part of the rotating dish 6 and the part in the vicinity of the rotating shaft 13 of the rotating dish 6, for example, as shown in FIG. Such a hole 15 is used. When the rotary lid 7 is in the lowered state (the state indicated by a solid line in FIG. 1, hereinafter abbreviated as the lowered position), the ventilation portion 11 is covered by the rotary lid 7, and from this covered portion The gas flow is blocked. On the other hand, when the rotary lid 7 is in its raised state (the state indicated by the alternate long and short dash line in FIG. 1, hereinafter abbreviated as the raised position), the ventilation portion 11 is opened and the rotary dish 6 and the rotary lid 7 are opened. A gap is formed between them so that ventilation is possible.
[0032]
In addition, as long as the air permeability can be ensured, there is no particular limitation on the shape and the ventilation area of the ventilation portion 11, such as a band shape, a porous shape, a groove shape, and the like, as shown in FIG. Various forms such as those can be adopted. Further, in the lowered position, the ventilation portion 11 is not completely sealed, leaving a slight gap between the rotating dish 6 and the rotating lid 7, and processing the powder and particles while introducing the airflow from this gap. It is also possible to adopt a simple configuration.
[0033]
By the way, as described above, the rotary lid body 7 is provided on the upper side of the rotary dish 6 so as to be concentric with the rotary dish 6 and to be able to rotate in the left-right direction and to be lifted and lowered in the axial direction. In the centrifugal rolling granulation coating apparatus 1, the rotating shaft 16 of the rotary lid 7 has a double structure with the rotating shaft 13 of the rotating dish 6, and the screw portion 18 rotates and rotates by rotating the handle 17. The lid 7 moves up and down. Then, when the rotary lid 7 is moved to a predetermined position (ascending position and descending position), it is fixed to the rotating shaft 13 of the rotating dish 6 with a screw 19. At this time, the rotating shaft 13 of the rotating dish 6 is connected to the motor 14 via the pulley 20 and the belt 21, and the rotating dish 6 and the rotating lid 7 are coaxially integrated by operating the motor 14. Rotate to. In the above example, the rotating shaft 16 of the rotating lid 7 and the rotating shaft 13 of the rotating plate 6 are driven integrally, but they may be driven by independent driving means.
[0034]
From above the processing container 5, a supply pipe 22 for supplying the granular material 2 to the rotating dish 6 is provided with its input port 22 a facing the rotating dish 6. In addition, a spray nozzle 23 having a two-fluid or three-fluid structure for spraying the binder or powder stored in a tank (not shown) onto the granular material 2 is provided.
[0035]
Next, the granular material processing method by this invention using the centrifugal rolling granulation coating apparatus 1 mentioned above is demonstrated. Here, as an example of the treatment, a case will be described in which a granular material is granulated into spherical particles and subsequently dried. 4 and 5 are explanatory views showing states of the rotating dish 6 and the rotating lid 7 during granulation and drying, respectively. In these drawings, only the rotating plate 6 and the rotating lid 7 are shown in a simplified manner for easy understanding, and other components are omitted.
[0036]
In this case, first, the granular material 2 is accommodated in the centrifugal rolling granulation coating apparatus 1, and the rotary lid 7 is set at the lowered position. That is, the handle 17 is turned to lower the rotary lid 7 and fixed with screws 19. In this state, the rotating liquid 6 and the rotating lid 7 are rotated at the same speed while the binder liquid, or the binder liquid and the powder are supplied into the processing container 5, thereby the powder particles or Granulation is performed by combining the powder and the powder added later. FIG. 4 shows this state, and the granular material 2 is granulated by centrifugal rolling along the rotating plate 6, the rotating lid 7 and the powder contact portion 8 a of the fixed wall 8. In the case where spherical coating particles are produced by applying a coating film on spherical particles, the coating liquid or the coating liquid and powder are supplied into the processing container 5, thereby forming a coating layer on the granular material. Let it form.
[0037]
After such a granulation process, the process proceeds to a drying process. In the centrifugal tumbling granulation coating apparatus 1 of the present invention, it is possible to proceed to the drying process as it is after granulation. Here, the drying step is performed with the rotary lid 7 set to the raised position. That is, first, the handle 17 is operated again to raise the rotary lid 7 and fix it with the screw 19. Then, the gas is fed into the processing container 5 from the gap formed between the rotating dish 6 and the rotating lid 7 through the ventilation portion 11 of the rotating dish 6 to dry the granulated product. FIG. 5 shows this state, and the granular material 2 is dried by the air from the ventilation portion 11. In this case, the amount of gas fed from the ventilation section 11 should be such that the granular material 2 is fluidized, and is subjected to dust removal and dehumidification and at a temperature suitable for each step and the object to be processed. It is desirable to adjust.
[0038]
In the above-described example, since the rotary lid 7 and the rotary dish 6 are integrated, both rotate at a constant speed. However, in the case of driving both separately, only one of them can be rotated, Both may be rotated at different speeds. Further, the rotation may be continuous or intermittent. Furthermore, in the method of the present invention, gas may be fed from the gap 9 between the inner wall of the processing vessel 5 and the outer edge of the rotating dish 6 in any step of granulation, coating, and drying. In addition, it goes without saying that the centrifugal rolling granulation coating apparatus 1 can be used as an independent drying apparatus.
[0039]
Furthermore, in the above example, the example in which the apparatus and method of the present invention are applied to the granulation-drying process has been described, but in addition, granulation-drying, coating-drying, granulation-coating-drying, granulation- Various combinations of processes such as drying-coating-drying can be performed. Moreover, it is also possible to repeat coating several times as needed.
[0040]
As described above, in the method of the present invention, the granulation, coating, and drying steps can be successively performed in a desired order without removing the powder from the processing container. Therefore, it is possible to achieve a process that has conventionally required installation of a plurality of apparatuses such as a CF apparatus and a fluidized bed dryer with a single apparatus, and it is possible to reduce the equipment cost and the space for it. In addition, there is no need for troubles such as discharging, transporting and re-feeding the granulated spherical particles, and the man-hours for that purpose can be greatly reduced. Furthermore, there is no risk of spherical particles being contaminated during these operations, and product quality in products, particularly pharmaceuticals, can be improved.
[0041]
Next, modified examples of the rotating dish 6 and the rotating lid 7 of the present invention will be described. FIGS. 6-11 is sectional drawing which simplified and showed the structure of the 1st-6th modification. In the following modifications, the same members as those in the previous embodiment are denoted by the same reference numerals, and the details thereof are omitted.
[0042]
First, in the first modification shown in FIG. 6, a raised portion 24 is provided at the center of the rotary lid 7, and the entire cross section of the rotary lid 7 is formed in a trapezoidal shape. In this case, the bottom outer edge 25 of the rotary lid 7 is formed in a circular shape, and covers all the ventilation portions 11 of the rotary dish 6 at the lowered position. Further, the slope 24 a of the raised portion 24 is a rolling and granulating surface of the granular material 2. In this modification, the granular material 2 is between the inner surface of the fixed wall 8 and the slope 24 a of the raised portion 24. It can roll and perform processing such as granulation more efficiently.
[0043]
FIG. 7 shows a second modified example, in which a raised portion 26 is provided in the central portion of the rotating dish 6, and a raised portion 27 is formed in the central portion of the rotating lid 7 accordingly. A flange portion 28 is formed at the bottom thereof. In this case, the ventilation part 11 of the rotating dish 6 is provided at the top part 26 a of the raised part 26, and the air that has descended the slope of the raised part 26 from the lower side of the flange part 28 by raising the rotating lid 7. It comes to blow out. Further, the flange portion 28 of the rotary lid body 7 comes into close contact with the upper surface of the rotating dish 6 at the lowered position of the rotary lid body 7, and the airflow from the ventilation portion 11 is sealed by the flange portion 28. Therefore, by bringing the collar portion 28 into close contact with the rotating dish 6, the same effect as that in which the vent portion 11 is directly covered can be achieved without directly sealing the vent portion 11. That is, the concept of covering the ventilation part in the present application is a broad meaning including such a form, and if it is an aspect that seals the air flow in the ventilation part 11, the ventilation part 11 is not necessarily sealed directly. There is no. In this modification as well, the slope 27a of the raised portion 27 in the rotary lid 7 constitutes the rolling and granulating surface of the powder body 2. The outer peripheral edge of the rotating dish 6 has a shape that rises upward.
[0044]
FIG. 8 shows a third modified example. Here, the rotating dish 6 has a shape in which the central part is depressed, and a hollow rotating lid 7 having a cross-sectional shape as shown in FIG. 6 is provided thereon. It is the composition which was made. In this case, a raised portion 29 is formed at the center of the rotating lid 7, and a collar portion 30 is formed along the slope of the rotating dish 6 at the bottom. The ventilation portion 11 is provided in the vicinity of the central portion of the rotating dish 6, and when the rotating lid body 7 is in the lowered position, all of it is covered with the rotating lid body 7.
[0045]
FIG. 9 shows a fourth modification example, in which a part of the ventilation portion 11 of the rotating dish 6 is exposed without being covered by the rotating lid 7. Therefore, the ventilation part 11 is a normally open state, and it is possible to introduce air from this part also at the time of granulation.
[0046]
FIG. 10 shows a fifth modification example, in which a raised portion 31 is provided at the center of the rotating dish 6, and the rotating lid 7 is formed in a dome shape accordingly. In this case, the ventilation part 11 of the rotating dish 6 is provided in the top part 31a and the inclined surface 31b of the protruding part 31, and the ventilation area can be taken larger compared with the case where the rotating dish 6 is formed in flat form. . The outer peripheral edge of the rotating dish 6 has a shape that rises upward.
[0047]
FIG. 11 shows a sixth modification. Here, a ventilation portion 32 is also formed in the rotary lid 7, and the ventilation portion 32 and the ventilation portion 11 of the rotating dish 6 are arranged at a position where they do not overlap. Yes. Therefore, in this case, when the rotary lid 7 is in the lowered position and is in close contact with the rotary dish 6, the ventilation portion 11 of the rotary dish 6 is blocked by the rotary lid 7, and air is not introduced. On the other hand, when the rotary lid 7 is raised, air is introduced not only from the outer edge portion of the rotary lid 7 but also from the ventilation portion 32 provided in the rotary lid 7.
[0048]
【Example】
Example 1
Spherical particles were granulated using the centrifugal rolling granulation coating apparatus 1 of FIG. In Example 1, the granular material and the powder are combined by powder dispersion. In FIG. 1, the inner diameter of the processing vessel 5 is a cylindrical shape of 360 mm, the rotary lid 7 is fixed at the lowered position, the ventilation portion 11 of the rotating dish 6 is closed, and the granule having a particle size of 0.30 to 0.42 mm. 600 g of sugar (sucrose crystals) was charged, rotated at 180 RPM, and air at room temperature was introduced into the processing container 5 from the gap 9 between the rotating dish 6 and the inner wall of the processing container 5 at a rate of 200 l / min. Fine powder sucrose (powder sugar, particle size 5-30 μm) 1.5 kg and 50 wt% sucrose aqueous solution (syrup) 500 g are sprayed in the processing container 5 for 40 minutes to attach powdered sugar around the granulated sugar. Granulated to obtain spherical particles (undried).
[0049]
(Example 2)
In this embodiment, the powders are bonded to each other without powder dispersion. Here, a mixture of 1750 g of Japanese Pharmacopoeia powdered lactose and 750 g of Japanese Pharmacopoeia crystalline cellulose was charged into a kneader, and 800 g of water was added and kneaded for 20 minutes. After kneading, the mixture was loosened using a power mill equipped with a 4 mmφ screen to obtain a wet mixed powder. 1500 g of the mixed powder is charged into the centrifugal tumbling granulation coating apparatus 1, the rotating dish 6 is rotated at 200 RPM, and the processing container is rotated at a speed of 200 l / min at room temperature from the gap 9 between the rotating dish 6 and the inner wall of the processing container 5. 5 was introduced. 230 ml of water was sprayed at a rate of 30 ml / min to combine the mixed powders and granulate to obtain undried spherical particles having a particle size of 500 to 710 μm (when dried).
[0050]
Example 3
Subsequent to Example 2, the resulting spherical particles were dried. First, the first gas passage 10 leading to the ventilation portion 11 is connected to a blower (not shown) so that the ventilation portion 11 of the rotating dish 6 can be ventilated, and the handle 17 is turned to bring the rotary lid 7 to the raised position. The vent 11 was opened and fixed with screws 19. The air from the gap 9 in Example 2 is left as it is, and the air supplied from the blower is heated to 80 ° C. and 1.5 m. ^Three / Min of air was introduced into the processing container 5 from the vent 11 of the rotating dish 6. Fluidized drying was performed while rotating the rotating dish 6 at 180 RPM. The flow state was good, and drying was completed in 30 minutes, and good spherical particles having a particle size of 0.5 to 0.7 mm were obtained.
[0051]
Example 4
A commercially available non-barrel-101 500 to 710 μm product (manufactured by Freund Sangyo Co., Ltd.), 1.2 kg, was charged into the apparatus of FIG. 1 with the rotating lid 7 set at the lowered position, and the rotating pan 6 was rotated at 200 RPM. Room temperature air was introduced into the processing vessel 5 at a rate of 200 l / min from the gap 9 between the inner wall of the processing vessel 6 and the processing vessel 5. While spraying a mixed powder of 360 g of acetaminophen, 420 g of corn starch and 420 g of lactose, 650 g of a 5% aqueous solution of hydroxypropylcellulose HPC-L (manufactured by Nisso Co., Ltd.) is sprayed over 60 minutes to give undried acetaminophen coated spherical particles Got. The coating layer was uniform and good spherical particles.
[0052]
(Example 5)
Subsequent to Example 4, the obtained coated spherical particles were dried. The operating condition was that the drying was completed in 30 minutes in the same manner as in Example 3 except that the rotating dish 6 was not rotated and the air from the gap 9 between the rotating dish 6 and the processing container 5 was 300 l / min. Good spherical particles were obtained with little cracking and wear during drying.
[0053]
(Example 6)
The undried spherical particles obtained in Example 1 were subsequently coated. The operating conditions of the apparatus were the same as those in Example 4, and an aqueous solution of hemicellulose (10% aqueous solution, viscosity at 25 ° C., 88.7 mPa · s, manufactured by Fuji Oil Co., Ltd.) 400 ml of an aqueous solution of 5% and glycerin 2% was sprayed at a rate of 20 ml / min to obtain ascorbic acid-coated spherical particles.
[0054]
(Example 7)
The undried ascorbic acid-coated spherical particles obtained in Example 6 were subsequently dried under the same conditions as in Example 3 and then further coated. The operating conditions of the apparatus were the same as in Example 4, and a 3.0 wt% ethanol solution of an equal amount mixture of ethyl cellulose and shellac was used as a coating agent and sprayed at a rate of 100 ml / min for 50 minutes to obtain a coating amount of 3.8. % (Against spherical particles) of coated spherical particles were obtained.
[0055]
As mentioned above, the invention made by the present inventor has been specifically described based on the embodiment. However, the present invention is not limited to the embodiment, and various modifications can be made without departing from the scope of the invention. Needless to say.
[0056]
For example, the shape of the rotary lid 7 can be various shapes such as a flat shape, a cone or pyramid shape, a truncated cone or pyramid shape, a hemispherical shape, and a mountain shape, and the shape is not particularly limited. Moreover, although the lower edge part of the rotary cover body 7 is usually circular, it is not restricted to it, It is good also as what provided the ventilation hole in polygonal shape, flower shape, or partially. Further, the rotary lid 7 may be in close contact with the rotary dish 6 at the lowered position so as to cover the entire ventilation part 11 or only a part thereof. In this case, for example, the ventilation portion 11 of the rotating dish 6 is provided in a donut shape, the rotation lid body 7 is formed in a disk shape or a conical shape, and only the inner portion of the ventilation portion 11 is covered by the circular end surface of the lower edge portion thereof. You may make it cover a part of. Further, the rotary lid 7 may be formed as a flower-shaped flat plate so that a part of the ventilation portion 11 is exposed without being covered from a recessed portion formed between the petal-like portions. Can be adopted.
[0057]
Further, in the centrifugal rolling granulation coating apparatus 1 described above, the rotary lid 7 is manually moved up and down by the handle 17, but this may be automatically raised and lowered by a motor, a fluid pressure actuator, or the like. In addition, the gas supplied to the ventilation portion 11 and the gas supplied to the gap 9 may be supplied from a common supply source or may be supplied from another supply source. However, there is usually a large difference between the flow rates of both gases, and it is desirable to provide a control means for the gas supply amount so that the supply amounts of both gases can be controlled separately.
[0058]
In the above description, the case where the invention made mainly by the present inventor is applied to the processing of the granular material, which is the application field thereof, has been described, but the present invention is not limited to this.
[0059]
【The invention's effect】
Of the inventions disclosed in the present application, effects obtained by typical ones will be briefly described as follows.
[0060]
(1) By providing a ventilation part in the rotating dish and a rotating lid that is movable in the vertical direction above the rotating dish, each step of granulation, coating, and drying is performed in a desired order and powdered. It can be carried out continuously without removing the granules from the processing vessel.
[0061]
(2). Processing that conventionally required installation of a plurality of devices can be achieved with a single device, and the equipment cost and the space for it can be reduced.
[0062]
(3). Eliminates the hassle of discharging, transporting, re-charging, etc. when transferring the granulated spherical particles to the next process such as coating or drying. For this reason, there is no possibility that spherical particles are contaminated during these operations, and the product quality of products, particularly pharmaceuticals, can be improved.
[Brief description of the drawings]
FIG. 1 is a cross-sectional view showing a configuration of a centrifugal rolling granulation coating apparatus according to an embodiment of the present invention.
FIG. 2 is a perspective view showing an example of a rotating dish used in a centrifugal rolling granulation coating apparatus according to an embodiment of the present invention.
FIG. 3 is a perspective view showing another example of a rotating dish used in the centrifugal rolling granulation coating apparatus according to an embodiment of the present invention.
FIG. 4 is an explanatory view showing a state of a rotating dish and a rotating lid during granulation.
FIG. 5 is an explanatory view showing a state of a rotating plate and a rotating lid during drying.
FIG. 6 is a cross-sectional view showing a simplified configuration of a first modified example of a rotating plate and a rotating lid used in the centrifugal rolling granulation coating apparatus according to the present invention.
FIG. 7 is a cross-sectional view showing a simplified configuration of a second modified example of a rotating plate and a rotating lid used in the centrifugal rolling granulation coating apparatus according to the present invention.
FIG. 8 is a cross-sectional view showing a simplified configuration of a third modified example of a rotating plate and a rotating lid used in the centrifugal rolling granulation coating apparatus according to the present invention.
FIG. 9 is a cross-sectional view showing a simplified configuration of a fourth modified example of a rotating plate and a rotating lid used in the centrifugal rolling granulation coating apparatus according to the present invention.
FIG. 10 is a cross-sectional view showing a simplified configuration of a fifth modified example of a rotating plate and a rotating lid used in the centrifugal rolling granulation coating apparatus according to the present invention.
FIG. 11 is a cross-sectional view showing a simplified configuration of a sixth modified example of a rotating plate and a rotating lid used in the centrifugal rolling granulation coating apparatus according to the present invention.
FIG. 12 is a cross-sectional view showing a configuration of a conventional spherical granulating apparatus.
13 is a cross-sectional view showing a configuration of a centrifugal flow granulation apparatus in which the apparatus of FIG. 12 is improved and can be used industrially.
FIG. 14 is an explanatory diagram showing a configuration of a rotating dish used in a conventional centrifugal fluid device.
FIG. 15 is an explanatory view showing a configuration of a rotating dish used in a conventional centrifugal fluid device.
FIG. 16 is an explanatory view showing a configuration of a rotating dish used in a conventional centrifugal fluid device.
FIG. 17 is an explanatory diagram showing a configuration of a rotating dish used in a conventional centrifugal fluid device.
FIG. 18 is an explanatory diagram showing a configuration of a rotating dish used in a conventional centrifugal fluid device.
FIG. 19 is an explanatory diagram showing a configuration of a rotating dish used in a conventional centrifugal fluid device.
[Explanation of symbols]
1 Centrifugal rolling granulation coating equipment (powder processing equipment)
2 powder
3 Centrifugal rolling part
4 Rotation drive part
5 processing containers
6 rotating dishes
7 Rotating lid
8 fixed walls
8a Wetted part
9 gap
10 First gas supply path
11 Ventilation part
12 Second gas supply path
13 Rotating shaft
14 Motor (Rotary drive means)
15 holes
16 Rotating shaft
17 Handle
18 Screw part
19 Screw
20 pulley
21 belt
22 Supply pipe
22a inlet
23 Spray nozzle
24 ridges
24a slope
25 Bottom edge
26 Raised part
26a top
27 Raised part
27a slope
28 Buttocks
29 Raised part
30 buttock
31 Uplift
31a top
31b slope
32 Ventilation part
33 Net
51 Processing container
52 Rotating disc
53 inner wall
54 Gap
55 CF device
56 Processing container
57 Rotating dish
58 inner wall
59 Gap
60 rotating dish
61 Fumarole
62 Concentric rotating annular plate
63 gap
64 Rotating plate
65 Air circulation hole
66 intervals
67 Rotating plate
68 turntable
69 Raised part
70 spout
71 rotating disc
72 ascending slope
73 rear wall
74 pores

Claims (10)

A processing vessel in which the horizontal cross section of the contact portion is circular,
Rotation having a ventilation portion provided at the bottom of the processing vessel so as to be rotatable in a horizontal direction by a rotation driving means about a vertical line passing through the center of the powder contact portion, and allowing gas to flow from the lower surface side to the upper surface side. A dish,
A powder particle provided above the rotating dish so as to be movable in the vertical direction concentrically with the rotating dish, and having a rotating lid that covers at least a part of the ventilation part of the rotating dish at the lowered position. Body treatment device. 2. The granular material processing apparatus according to claim 1, wherein the granular material is accommodated, the rotating lid is set at a lowered position, and at least one of the rotating dish and the rotating lid is rotated and a binder liquid or a bond is formed. A powder processing method comprising: supplying an agent solution and powder, and combining the powder particles or the powder particles with the supplied powder for granulation. A granular material processing apparatus according to claim 1, wherein the granular material is accommodated, the rotating lid is set at a lowered position, and at least one of the rotating dish and the rotating lid is rotated, and a coating liquid or a coating is provided. A method for treating a granular material, comprising supplying an agent solution and powder and forming a coating layer on the granular material particles. A granular material is accommodated in the granular material processing apparatus according to claim 1, wherein the rotary lid is set at its rising position, and the rotary lid is raised between the rotary dish and the rotary lid. A method for treating a granular material, characterized in that gas is fed into the processing container from the gap through the vent of the rotating dish to dry the granular material. 2. The granular material processing apparatus according to claim 1, wherein the granular material is accommodated, the rotating lid is set at a lowered position, and at least one of the rotating dish and the rotating lid is rotated and a binder liquid or a bond is formed. After supplying the agent solution and powder, and granulating the powder particles or the powder particles and the supplied powder, the rotary lid is set to its raised position, The granulated product is dried by feeding gas into the processing container through the ventilation portion of the rotating dish from the gap formed between the rotating dish and the rotating lid due to the rising of the rotating cover. A method for treating a granular material. A granular material processing apparatus according to claim 1, wherein the granular material is accommodated, the rotating lid is set at a lowered position, and at least one of the rotating dish and the rotating lid is rotated, and a coating liquid or a coating is provided. After supplying the liquid agent and the powder and forming the coating layer on the powder particles, the rotary lid is set at its rising position, and the rotary plate and the rotation are rotated by raising the rotary lid. A method for processing a granular material, characterized in that a gas is fed into the processing container through a vent of the rotating dish from a gap formed between the lid and the granular material particles to dry the granular material particles. 2. The granular material processing apparatus according to claim 1, wherein the granular material is accommodated, the rotating lid is set at a lowered position, and at least one of the rotating dish and the rotating lid is rotated and a binder liquid or a bond is formed. After supplying the chemical liquid and the powder, combining the powder particles or the powder particles and the supplied powder and granulating, the rotary lid is set at the lowered position A granular material treatment comprising: supplying a coating liquid or a coating liquid and powder while rotating at least one of the rotating dish and the rotating lid, and forming a coating layer on the granulated material. Method. A granular material is accommodated in the granular material processing apparatus according to claim 1, wherein the rotary lid is set at its rising position, and the rotary lid is raised between the rotary dish and the rotary lid. After the gas is fed into the processing container through the ventilation gap of the rotating dish to dry the granular material, the rotating lid is set to the lowered position, and the rotating dish and the rotating A powder processing method comprising: supplying a coating liquid or a coating liquid and powder while rotating at least one of the lids to form a coating layer on the powder particles. 2. The granular material processing apparatus according to claim 1, wherein the granular material is accommodated, the rotating lid is set at a lowered position, and at least one of the rotating dish and the rotating lid is rotated and a binder liquid or a bond is formed. After supplying the agent solution and powder, and granulating the powder particles or the powder particles and the supplied powder, the rotary lid is set to its raised position, After the granulated product is dried by feeding gas into the processing container through the ventilation portion of the rotating dish from the gap formed between the rotating dish and the rotating lid due to the rising of the rotating cover. The rotary lid is set at the lowered position, and at least one of the rotary dish and the rotary lid is rotated, and the coating agent liquid or the coating agent liquid and the powder are supplied to coat the granulated material. A method for treating a granular material, comprising forming a layer. The method for processing a granular material according to any one of claims 2 to 9, wherein gas is sent into the processing container from a gap formed between an outer edge of the rotating dish and an inner wall of the processing container. A method for treating a granular material, comprising:

Images