JPS58194810A - Coated soft miniature capsule - Google Patents

Abstract

PURPOSE:To prepare the titled soft miniature capsule capable of effectively suppressing the deterioration of the skin and the content of the capsule with time, without lowering the commercial value nor giving unagreeable feeling to the palate, by coating a filled soft miniature capsule with a powder coating layer and an overcoating layer. CONSTITUTION:A soft miniature capsule 2 having a diameter of <=5mm. and containing the content 1, especially a capsule obtained by treating a filled soft miniature capsule having a skin containing (A) gelatin, (B) a water-soluble polyhydric alcohol or its water-soluble derivative and (C) a low methoxyl pectin or sodium alginate with the compound capable of causing gelation of the aqueous solution of the component (C), is coated with the powder coating layer 3 and an overcoating layer 4 to obtain the objective coated soft miniature capsule. The miniaturization of the capsule 2 and the double-layer coating (3, 4) of the capsule result in the above advantages, and accordingly, the capsule is suitable as food, drink, candy or drug.

Description

[Detailed description of the invention] The present invention relates to multilayer coated soft minicapsules.

BACKGROUND ART Conventionally, various encapsulated foods and the like have been widely available. In particular, liquid foods that are relatively difficult to eat or drink, and medicines that are difficult to take are made into products by encapsulating them into seamless soft capsules and then applying a coating such as sugar coating to the outside to make them more palatable.

However, the soft capsules traditionally used for this type of food have a relatively large particle size (approximately 8~lomyn).
(Mini-capsules are difficult to achieve with conventional encapsulation technology); applying a coating such as sugar coating will make the entire capsule even larger, lowering its commercial value and causing the capsule to collapse in the mouth when ingested. There are disadvantages such as a relatively large amount of the contents being spread in the mouth at once, resulting in an unpleasant sensation.

In addition, with conventional soft encapsulated foods, the capsule film itself deteriorates over time, becoming insolubilized or having a bad taste, which not only reduces or offsets the coating effect of sugar coating, etc., but also because the film is weak. There are some drawbacks, such as the fact that the coating process itself is difficult to perform.

The present inventor has completed the present invention by discovering that it is possible to obtain a soft capsule by converting a capsule containing a filler into a soft mini-capsule and coating the capsule in a multi-layered manner.

As shown in the schematic longitudinal cross-sectional view of FIG. ) about coated soft minicapsules.

The coating material for the soft minicapsules used in the present invention is not particularly limited, but preferred ones are fa) gelatin, (1))
Water-soluble polyhydric alcohol or its water-soluble derivative and i
c) It is obtained by treating a base material containing low methoxyl pectin or sodium alginate with a compound capable of kelizing an aqueous solution of low methoxyl pectin or sodium alginate, which will be described in more detail below.

Among the materials for the soft minicapsules, gelatin and water-soluble polyhydric alcohols or water-soluble derivatives thereof may be of the same grade as used in the production of conventional capsules.

Examples of water-soluble polyhydric alcohols or their water-soluble derivatives include glycerin, polyglycerin, sorbitol, ethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, ethylene oxide-propylene oxide copolymerized oligosaccharide, sugar ester, glyceride, Examples include, but are not limited to, sorbitan esters.

Normally, the amount of gelatin used is 60 to 9 for the capsule coating.
0 weight percent, preferably 65 to 75 weight percent when using low Me xyl pectin, and 65 to 85 weight percent when using sodium alginate, and water-soluble polyhydric alcohol or its water-soluble The amount of the sexual derivative used is 10 to 30% by weight, preferably 15 to 25% by weight of the total weight of the film.

On the other hand, low methoxyl pectin has a molecular weight of 200,000 or more, a degree of methoxylation of 1 to 6%, and a degree of methoxylation of 3.5 to 5.
% is preferable, and those available from →J-Nquist Co., Ltd. may be used as appropriate, and the amount used is 5 to 20% by weight, preferably 10 to 15% by weight, and 20 to 20% by weight of the total weight of the film. When it is more than 5% by weight, it becomes difficult to produce soft capsules, and when it is less than 5% by weight, water resistance becomes poor.

When using sodium alginate, its usage range is 1 to 10% by weight, preferably 3 to 5% by weight, based on the total weight of the film.
When the amount is more than 10% by weight or less than 1% by weight, the same drawbacks as mentioned for low methoxyl pectin occur, respectively.

Furthermore, compounds that can gel an aqueous solution of low methoxyl pectin or calcium alginate include salts of divalent or higher polyvalent metals, especially water-soluble salts such as calcium and magnesium in the case of low methoxyl pectin, and water-soluble salts such as sodium alginate. Typically, a water-soluble calcium salt such as chloride, calcium phosphate, etc. may be used as appropriate.

To prepare the filled soft minicapsules according to the present invention, first, gelatin and a water-soluble polyhydric alcohol or a water-soluble derivative thereof are blended with low methoxyl pectin or sodium alginate in the above ratio, and then the encapsulated material is Seamless soft minicapsules are produced by coating with certain fillings. Such seamless soft minicapsules may be manufactured according to conventionally known soft capsule manufacturing methods.

The resulting filled soft minicapsules are contacted with a solution of a compound capable of gelling, typically an aqueous solution of low methoxyl pectin or sodium alginate. The minicapsules to be treated are usually 1 to 10% by weight, preferably 3 to 5% by weight of an aqueous solution of the compound at 5 to 30°C.
Preferably at 10-15°C for 1-5 minutes, preferably 1-5 minutes.
Soak for 3 minutes. Contact with the treatment liquid may be carried out by other methods such as a spraying method in addition to the immersion method, but the immersion method is the method that can be carried out most easily and uniformly.

The soft minicapsules subjected to the above treatment are then dried and washed to give one filler containing one filler used in the present invention.

1. The right side of the European mini-capsule, the light tomb that the child keeps as a pet - the 15th anniversary of the 15th anniversary, which can be changed depending on the type and purpose of the temporary covering layer. - Preferably 1 to 5
In particular, mξ is generally set to 2 to 411 m.Since it includes mξ, m = m1z of the filling to be enclosed in the Ikken mini capsule.
Particularly limited to a wide range of drinks - 1,1i7I2
Items 1 - Pharmaceuticals, etc., reactive adhesives for bicomponent threads, etc. may be selected as appropriate depending on the industrial application.

The surface of the soft minicapsules containing the filler 1 obtained as described in Section 2 is coated with powder by a conventional method such as the pancoach ink method or the fluidized bed seeding method, and then by a conventional method. Coated soft minicapsules according to the present invention are prepared by coating the powdered powder with Koiji's Seven II Coated Ink.

The type and combination of the powder to be used in the mini-II tube cell is completely arbitrary; similarly to capsule filling 1, it can be appropriately selected from a wide range of foods, drinks, luxury goods, medicines, etc. according to the purpose. Yes.

As a particularly preferred embodiment, an oil-soluble component is contained in a capsule, the capsule is coated with an oil-insoluble powder component or a powder component reactive with the component in the capsule, and the powder coating layer is coated as an overcoat. various complex nutritious foods and drinks that are easy to ingest and have little deterioration over time;
Luxury items with rich palatability, medicines with excellent medicinal effects, etc. are prepared.

For example, a health food can be obtained by containing wheat germ oil in the capsule, coating the capsule with powdered vitamin C, and coating the top with sugar or low-calorie sugar, and containing flavoring in the capsule. By coating the capsule with powdered sugar and coating the top with sugar, a luxurious item rich in aroma can be obtained. Confectionery is obtained by coating, and
A multivitamin preparation can be obtained by adding oil-soluble vitamins such as vitamin A and vitamin E to capsules, coating the capsules with powdered vitamin C, and coating them with sucrose or low-calorie soyugat. .

As described above, since the coated soft minicapsules according to the present invention are miniaturized, even if an additional coating layer is provided on the capsule surface, the overall size will not increase and the commercial value will not be reduced. Furthermore, since the capsule is coated with multiple layers, it effectively suppresses deterioration of the capsule film and capsule filling over time, and all of the above problems are solved.

The present invention is particularly effective when combining and unifying ingredients that cannot be encapsulated at the same time in a single capsule or ingredients that are difficult to encapsulate and encapsulated ingredients in foods, drinks, luxury goods, medicines, etc. A novel form of ingestion is provided.

The present invention will be explained below with reference to Examples.

Example 1 A coating solution was prepared using the following ingredients.

”L:L Heavy part gelatin 14 glycerin
3 low metquinlupectin
3゜purified water
8゜According to the method described in JP-A No. 51-8875, this coating liquid is extruded through the annular hole, and at the same time, citrus oil and citrus oil as the encapsulated material are extruded through the inner hole opening provided concentrically on the same side of the annular hole. A mixture of vegetable oils (weight ratio 10 nia 5) is extruded and this composite jet is ejected into a cooling liquid (vegetable oil, liquid paraffin, etc.) with a particle size of 4wn.
(weight 3oTng/P; filler 85% by weight;
Film: 15% by weight].

The obtained filled soft minicapsules were immersed in a 5% aqueous calcium chloride solution (15° C.) for 3 minutes, then dried and washed.

The surface of this capsule was coated with 25% by weight of vitamin C and 25% of powdered sugar.
% by weight, 1% by weight of flavoring, 455% by weight of sugar and Arabi T
It was coated to a thickness of 2 mm with a mixture consisting of 4% rubber (superposition 240''f/P).

A multilayer soft mini-encapsulated food was prepared by further coating the coated capsules with sugar to a thickness of 0.5 mm.

Example 2 Example 1 except that the coating liquid was prepared according to the following formulation.
A multi-layered soft mini-encapsulated food was prepared in the same manner as above.

Ingredients Part by weight Gelatin
13.3 Glycerin
5.7 Sodium alginate
1 purified water
80

[Brief explanation of the drawing]

FIG. 1 is a schematic longitudinal cross-sectional view of a multilayer coated soft minicapsule according to the present invention. (1) is capsule filling, (2) is capsule membrane, (3
) indicates a powder coating layer, and (4) indicates a coating layer. Patent applicant Renshita Jintan Co., Ltd. Representative patent attorney Aoyama Hao and one other person Figure 1 58-

Claims (1)

[Claims] 1. A soft minicapsule (2) containing a filler (1),
Coated soft minicapsules covered with a powder coating layer (3) and a coating layer (4). 2. A soft minicapsule containing a filling having a film containing (a) gelatin, (b) a water-soluble polyhydric alcohol or a water-soluble derivative thereof, and (C1 low methoxyl pectin or alginate) IJium. 2. The coated soft minicapsules according to claim 1, which are filled soft minicapsules obtained by treating the filled soft minicapsules with a compound capable of gelling an aqueous solution of low methoxyl pectin or sodium alginate. 3. The coated soft minicapsule according to item 1, wherein the soft minicapsule has a particle size of 5+o+ or less. 4. The coated soft minicapsule according to item 1, wherein the coach ink minicapsule is a food or drink, a luxury item, or a medicine.