JPH01313421A - Soft film capsule mixed with alginic acid and production thereof - Google Patents
Soft film capsule mixed with alginic acid and production thereofInfo
- Publication number
- JPH01313421A JPH01313421A JP63145123A JP14512388A JPH01313421A JP H01313421 A JPH01313421 A JP H01313421A JP 63145123 A JP63145123 A JP 63145123A JP 14512388 A JP14512388 A JP 14512388A JP H01313421 A JPH01313421 A JP H01313421A
- Authority
- JP
- Japan
- Prior art keywords
- gelatin
- alginic acid
- sodium alginate
- capsule
- plasticizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 25
- 235000010443 alginic acid Nutrition 0.000 title claims abstract description 18
- 229960001126 alginic acid Drugs 0.000 title claims abstract description 18
- 239000000783 alginic acid Substances 0.000 title claims abstract description 18
- 229920000615 alginic acid Polymers 0.000 title claims abstract description 18
- 150000004781 alginic acids Chemical class 0.000 title claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 18
- 239000007901 soft capsule Substances 0.000 claims abstract description 38
- 108010010803 Gelatin Proteins 0.000 claims abstract description 31
- 239000008273 gelatin Substances 0.000 claims abstract description 31
- 229920000159 gelatin Polymers 0.000 claims abstract description 31
- 235000019322 gelatine Nutrition 0.000 claims abstract description 31
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 31
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 27
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 27
- 239000000661 sodium alginate Substances 0.000 claims abstract description 27
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 27
- 239000004014 plasticizer Substances 0.000 claims abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 235000011187 glycerol Nutrition 0.000 claims abstract description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 5
- 239000000600 sorbitol Substances 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims abstract description 3
- 150000002500 ions Chemical class 0.000 claims abstract 3
- PYMYPHUHKUWMLA-UHFFFAOYSA-N 2,3,4,5-tetrahydroxypentanal Chemical compound OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 9
- LCWAOCHOPBSGMU-UHFFFAOYSA-J aluminum;magnesium;sodium;hydrogen carbonate;oxygen(2-);silicon;trihydroxide Chemical compound [OH-].[OH-].[OH-].[O-2].[Na+].[Mg+2].[Al+3].[Si].OC([O-])=O LCWAOCHOPBSGMU-UHFFFAOYSA-J 0.000 claims description 8
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 6
- 150000001768 cations Chemical class 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 230000037310 combination skin Effects 0.000 claims 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract description 4
- 229910001424 calcium ion Inorganic materials 0.000 abstract description 4
- 235000013305 food Nutrition 0.000 abstract description 4
- 238000004132 cross linking Methods 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 238000009826 distribution Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 1
- 239000010408 film Substances 0.000 description 11
- 235000010410 calcium alginate Nutrition 0.000 description 7
- 239000000648 calcium alginate Substances 0.000 description 7
- 229960002681 calcium alginate Drugs 0.000 description 7
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 239000003094 microcapsule Substances 0.000 description 4
- 239000008240 homogeneous mixture Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- 241001474374 Blennius Species 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 235000015429 Mirabilis expansa Nutrition 0.000 description 1
- 244000294411 Mirabilis expansa Species 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 235000012970 cakes Nutrition 0.000 description 1
- -1 calcium ions Chemical class 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 235000015071 dressings Nutrition 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 235000008960 ketchup Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000010746 mayonnaise Nutrition 0.000 description 1
- 239000008268 mayonnaise Substances 0.000 description 1
- 235000013536 miso Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 235000013555 soy sauce Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
- Jellies, Jams, And Syrups (AREA)
- Formation And Processing Of Food Products (AREA)
Abstract
Description
【発明の詳細な説明】
イ２発明の目的
（産業上の利用分野）
本発明は、水不溶性及び耐酸性（腸溶性）を有するアル
ギン酸配合剤皮軟カプセルとその製造方法。詳しくは、
従来のゼラチン質重−の軟カプセルでは不可能であった
含有水分量の多い食品等の用途の、例えば、牛乳、コー
ヒー、ミルク、ジュース、ヨーグルト、炭酸飲料、アル
コール飲料等の晴好性飲料、マヨネーズ、ドレッシング
、ケチャツプ、バター、チーズ、醤油、味噌１ソース等
の調味料、そしてパン、ケーキ、アイスクリーム等ｌ＼
の配合的用途、又は健康食品とは分離認可されている特
殊栄養食品や、機能性食品等への応用等も可能で、特に
耐酸性軟カプセルの場合、腸溶性カプセルとしての機能
性が高いアルギン酸配合剤皮軟カプセルとその製造方法
に関する。DETAILED DESCRIPTION OF THE INVENTION A2.Objective of the invention (industrial application field) The present invention provides a soft alginic acid formulation capsule having water insolubility and acid resistance (enteric coating), and a method for producing the same. For more information,
For applications such as foods with high water content, which were not possible with conventional gelatin-based soft capsules, such as milk, coffee, milk, juice, yogurt, carbonated drinks, alcoholic beverages, and mayonnaise. , seasonings such as dressing, ketchup, butter, cheese, soy sauce, miso sauce, bread, cake, ice cream, etc.
It is also possible to use alginic acid as a compound, or to apply it to special nutritional foods that are approved separately from health foods, functional foods, etc. Especially in the case of acid-resistant soft capsules, alginic acid has high functionality as enteric-coated capsules. This invention relates to a compounded soft capsule and its manufacturing method.
（従来の技術）
従来より用いられているゼラチン質を主体とする軟カプ
セル、又は海草抽出物（寒天。(Prior Art) Conventionally used soft capsules mainly made of gelatin or seaweed extract (agar).
カラギーナン、アルギン酸）を主体とするマイクロカッ
プセル或いはシームレスカプセル等は、厳密な意味での
耐水性カプセルではない。Microcapsules or seamless capsules mainly composed of (carrageenan, alginic acid) are not water-resistant capsules in the strict sense of the word.
これはカプセルの剤皮が水による膨潤或いは水分子の膜
通過を避けられないためである。This is because the shell of the capsule cannot avoid swelling with water or the passage of water molecules through the membrane.
従って、従来のカプセルで耐水性等を得ようとする場合
は、ゼラチン質皮膜で内容物を充填して一次的にカプセ
ルを形成し、その表面を寒天やアルギン酸、カラギーナ
ン等を用いて二次的にコーティングするもので、アルギ
ン酸コートの場合は、更にカルシウムイオン等により架
橋変換を行い、三次的にアルギン酸カルシウム膜による
表面コーティングをするものである。Therefore, when trying to obtain water resistance etc. with conventional capsules, the contents are first filled with a gelatinous membrane to form a capsule, and the surface is then coated with a secondary coating using agar, alginic acid, carrageenan, etc. In the case of alginic acid coating, cross-linking is further performed with calcium ions, etc., and the surface is tertiary coated with a calcium alginate film.
（発明が解決しようとする課Ｍ）
前記のようにゼラチン皮膜表面を三次的にアルギン酸カ
ルシウム皮膜で被覆、又はコーティングするカプセル又
はシームレスカプセル、マイクロカプセルセｌし等にあ
っては、ゼラチン質とアルギン酸カルシウム質との物性
の違いが品質の不安定につながる要因となる。(Problem M to be solved by the invention) As mentioned above, in capsules, seamless capsules, microcapsules, etc. in which the gelatin film surface is tertiary coated or coated with a calcium alginate film, gelatin and alginic acid Differences in physical properties from calcium substances are a factor that leads to unstable quality.
又、工程が三次的で複雑であり、作業に長時間を要して
、設備費が嵩むため経済的負担が大きい。In addition, the process is tertiary and complicated, and the work requires a long time, and the equipment cost increases, resulting in a heavy economic burden.
等の問題点を有するものであった。It had the following problems.
本発明は、ゼラチン質又は低メトキシルペクチン質の原
料成分配合成分中にアルギン酸ソーダを０１〜２０重量
部、好ましくは０．３〜１０重量部均一に配合しな剤皮
によりカプセルを形成し、このカプセルを二価以上の陽
イオンにより架橋変換することにより、安定した物性の
アルギン酸配合剤皮軟カプセルを容易に製造できるアル
ギン酸配合剤皮軟カプセルと、その製造方法とを提供す
ることを目的としている。The present invention involves uniformly blending 01 to 20 parts by weight, preferably 0.3 to 10 parts by weight, of sodium alginate in gelatinous or low methoxyl pectin raw materials, and forming capsules with a shell. The purpose of the present invention is to provide an alginic acid compound soft capsule that can easily produce an alginic acid compound soft capsule with stable physical properties by crosslinking the capsule with divalent or higher cations, and a method for producing the same. .
口１発明の構成
（課題を解決するための手段）
前記目的を達成するための本発明の手段は、ゼラチン又
は低メトキシルペクチン１００重量部に対し、可塑剤（
グリセリン、ソルビトール等）１０〜５０重量部、アル
ギン酸ソーダを０゜３〜１０重量部を配合調製したゼラ
チン又は低メトキシルペクチンとアルギン酸ソーダの均
一混合剤皮からなる皮膜で被覆した軟カプセルを、２価
以上の陽イオン（特にカルシウムイオン）で架橋するア
ルギン酸配合剤皮軟カプセルの構成。1. Constitution of the invention (means for solving the problem) The means of the present invention for achieving the above-mentioned object is to add a plasticizer (
Gelatin or a homogeneous mixture of low methoxyl pectin and sodium alginate prepared by blending 10 to 50 parts by weight of glycerin, sorbitol, etc. and 0.3 to 10 parts by weight of sodium alginate. The structure of the alginic acid compound soft capsule is cross-linked with the above cations (especially calcium ions).
ゼラチン又は低メトキシルペクチンと可塑剤及びアルギ
ン酸ソーダの均一混合剤皮からなる皮膜が、未乾燥又は
半乾燥物であるアルギン酸配合剤皮軟カプセルの構成。A composition of an alginic acid compound soft capsule in which the film is made of a homogeneous mixture of gelatin or low methoxyl pectin, a plasticizer, and sodium alginate, and is undried or semi-dried.
ゼラチン又は低メトキシルペクチンと可塑剤及びアルギ
ン酸ソーダの均一混合剤皮からなる皮膜が、乾燥物であ
るアルギン酸配合剤皮軟カプセルの構成。The composition of the alginic acid compound soft capsule is a dry product, and the film is made of a homogeneous mixture of gelatin or low methoxyl pectin, a plasticizer, and sodium alginate.
ゼラチン又は低メトキシルペクチン１００重量部と可塑
剤及びアルギン酸ソーダ０．３〜１０重量部の配合比に
より混合した剤皮を、ロータリー式製造方法によりカプ
セルとするアルギン酸配合剤皮軟カプセルの製造方法。A method for producing soft alginic acid-containing capsules, in which a capsule is prepared by mixing 100 parts by weight of gelatin or low methoxyl pectin with a plasticizer and 0.3 to 10 parts by weight of sodium alginate in a rotary production method.
アルギン酸配合剤皮軟カプセルを０．５〜１０％の濃度
の塩化カルシウム液に０．５〜５分間浸漬し、１〜３回
水洗した後、カプセルを得るアルギン酸配合剤皮軟カプ
セルの製造方法。A method for producing an alginic acid combination soft capsule, in which the capsule is obtained by immersing the alginic acid combination soft capsule in a calcium chloride solution having a concentration of 0.5 to 10% for 0.5 to 5 minutes, and washing with water 1 to 3 times.
ゼラチン又は低メトキシルペクチン１００重量部に対し
、可塑剤（グリセリン、ソルビトール等）１０〜５０重
量部、アルギン酸ソーダを０．３〜１０重量部を配合調
製した溶液と内包液とを、シームレスカプセル製造装置
、又はマイクロカプセル製造装置によりシームレスカプ
セル、又はマイクロカプセルとしたアルギン酸配合剤皮
軟カプセルの製造方法。Seamless capsule manufacturing equipment combines a solution prepared by blending 100 parts by weight of gelatin or low methoxyl pectin with 10 to 50 parts by weight of a plasticizer (glycerin, sorbitol, etc.) and 0.3 to 10 parts by weight of sodium alginate and the encapsulating liquid. , or a method for producing soft capsules of an alginic acid combination compound made into seamless capsules or microcapsules using a microcapsule production device.
にある。It is in.
（作 用）
前記のようにゼラチン又は低メトキシルペクチンの一定
量に対し、可塑剤の一定量とアルギン酸ソーダの一定量
を配合調製した溶解液を用いて製造したゼラチン又は低
メトキシルペクチンとアルギン酸ソーダ配合の軟カプセ
ルをロータリー式製造機により製造するときは、塩化カ
ルシウム溶液への浸漬工程を経るだけで、強度の高いゼ
ラチン又は低メトキシルペクチン質アルギン酸カルシウ
ム皮膜の軟カプセルが安全に、且つ高品質に得られる。(Function) A combination of gelatin or low methoxyl pectin and sodium alginate produced using a solution prepared by mixing a certain amount of gelatin or low methoxyl pectin with a certain amount of plasticizer and a certain amount of sodium alginate as described above. When manufacturing soft capsules using a rotary type manufacturing machine, soft capsules made of strong gelatin or low methoxyl pectin calcium alginate film can be obtained safely and with high quality simply by immersing them in a calcium chloride solution. It will be done.
（実 施 例） 以下に本発明に関する軟カプセルの実施例を説明する。(Example) Examples of soft capsules related to the present invention will be described below.
実施例１゜
濃グリセリン３０重量部を加えたゼラチン１００重量部
に対して、アルギン酸ソーダを０．３ 、０．５ 、１
．０ 、３．０ 、５．０ 、１０．０重量部配合して
ゼラチン、アルギン酸ソーダ剤皮膜カプセルを形成し、
この軟カプセルを二価以上の陽イオン、特にカルシウム
イオンにより架橋変換して、ゼラチン、アルギン酸カル
シウム剤皮軟カプセルを得た。Example 1 0.3, 0.5, 1 of sodium alginate was added to 100 parts by weight of gelatin to which 30 parts by weight of concentrated glycerin was added.
．． 0, 3.0, 5.0, and 10.0 parts by weight to form gelatin and sodium alginate film capsules,
This soft capsule was cross-linked with divalent or higher cations, particularly calcium ions, to obtain gelatin and calcium alginate soft capsules.
そしてこの軟カプセルを耐酸性軟カプセル（腸溶性軟カ
プセル）として日本薬局方に基づいて崩壊試験を行った
。その結果は、別表１の通りであり、アルギン酸ソーダ
の最適配合割合は、１．０・〜５．０が最も効果的であ
ることが確認された。Then, a disintegration test was conducted using this soft capsule as an acid-resistant soft capsule (enteric-coated soft capsule) based on the Japanese Pharmacopoeia. The results are shown in Attached Table 1, and it was confirmed that the optimum mixing ratio of sodium alginate is 1.0 to 5.0 is most effective.
次に、ゼラチン、アルギン酸ソーダ剤皮軟カプセルをゼ
ラチン、アルギン酸カルシウム剤皮軟カプセルに変換す
るときの塩化カルシウム濃度と処理時間に付いての結果
を測定した。その結果は別表２の通りであり、この結果
から塩化カルシウムの濃度が０．５％のとき３分以上、
１．０％のとき１分以上、５．０％以上で０．５分程度
の浸漬時間があれば良いことが確認された。Next, the results regarding calcium chloride concentration and processing time when converting gelatin and sodium alginate soft capsules into gelatin and calcium alginate soft capsules were measured. The results are shown in Attached Table 2, and from this result, when the concentration of calcium chloride is 0.5%, for more than 3 minutes,
It was confirmed that the immersion time is 1 minute or more when the content is 1.0%, and about 0.5 minutes when the content is 5.0% or more.
尚、低メトキシルペクチンとアルギン酸ソ一ダとの混合
剤皮による軟カプセルは、前記実施例に示したゼラチン
とアルギン酸ソーダとの混合剤皮による軟カプセルと同
様なものであるから、これに付いての実施例は省略する
。Note that the soft capsules with a mixed shell of low methoxyl pectin and sodium alginate are similar to the soft capsules with a mixed shell of gelatin and sodium alginate shown in the above example. Examples will be omitted.
ハ１発明の効果
本発明のアルギン酸配合剤皮軟カプセルは、一定量のゼ
ラチン又は低メトキシルペクチンに対して、一定量の可
塑剤と一定量のアルギン酸ソーダを均一に配合調製した
溶解液を用いて、ゼラチン又は低メトキシルペクチンと
アルギン酸ソーダ皮膜の軟カプセルを製造したものが基
本になっているので、従来のゼラチン等の表面皮膜物に
耐水性、耐酸性の外皮層を形成させる二重膜構造とは構
造的に異なる。C1 Effects of the invention The alginic acid compound soft capsule of the present invention is prepared by using a solution prepared by uniformly blending a certain amount of gelatin or low methoxyl pectin with a certain amount of plasticizer and a certain amount of sodium alginate. , is basically a soft capsule made of gelatin or low methoxyl pectin and sodium alginate film, so it has a double membrane structure that forms a water-resistant and acid-resistant outer skin layer on the surface film of conventional gelatin etc. are structurally different.
従って、ゼラチン又は低メトキシルペクチンと可塑剤及
びアルギン酸ソーダが均一に一体化された皮膜構造を持
つ軟カプセルを塩化カルシウム溶液中でゼラチン又は低
メトキシルペクチンとアルギン酸カルシウム皮膜及び被
膜に構造変換するので、皮膜並びに被膜が均一に構成さ
れ、強度の高い高品質の軟カプセルが最も安定して得ら
れる。Therefore, a soft capsule having a film structure in which gelatin or low methoxyl pectin, a plasticizer, and sodium alginate are uniformly integrated is structurally converted into gelatin or low methoxyl pectin and calcium alginate film and coating in a calcium chloride solution, so that the film becomes In addition, the coating has a uniform structure, and high-strength, high-quality soft capsules can be obtained most stably.
このゼラチン又は低メトキシルペクチンとアルギン酸カ
ルシウム被膜の軟カプセルは、耐水性的、耐熱性的に独
特の高い強度構造を持つもので、前記のように食品加二
［、医薬。This soft capsule made of gelatin or low methoxyl pectin and calcium alginate coating has a unique high-strength structure with water resistance and heat resistance, and as mentioned above, it is used in foods, medicines, etc.
医薬部外品、化粧品等に用途が期待でき、尚、流通段階
での保持保管が容易であり、品質の安定も保証される。It can be expected to be used in quasi-drugs, cosmetics, etc. Furthermore, it is easy to maintain and store during the distribution stage, and stable quality is guaranteed.
特に医薬分野での腸溶性カプセルとしての機能性に優れ
ている。In particular, it has excellent functionality as an enteric-coated capsule in the pharmaceutical field.
従って、本発明によれば、製造工程の短縮。According to the invention, therefore, the manufacturing process is shortened.
作業の簡易化による作業能率の向上、更には設備費の節
減により生産性の一段の向上が計れる。Work efficiency can be improved by simplifying work, and productivity can be further improved by reducing equipment costs.
等の特有の効果を奏するものである。It has the following unique effects.
−１１，−一-11, -1
Claims (6)
に対し、可塑剤（グリセリン、ソルビトール等）１０〜
５０重量部、アルギン酸ソーダを０．３〜１０重量部を
配合調製したゼラチン又は低メトキシルペクチンとアル
ギン酸ソーダの均一混合剤皮からなる皮膜により被覆し
た軟カプセルを、２価以上の陽イオン（特にカルシウム
イオン）で架橋することを特徴としたアルギン酸配合剤
皮軟カプセル。(1) Plasticizer (glycerin, sorbitol, etc.) 10 to 100 parts by weight of gelatin or low methoxyl pectin
Soft capsules coated with a film made of a uniform mixture of gelatin or low methoxyl pectin and sodium alginate prepared by blending 50 parts by weight and 0.3 to 10 parts by weight of sodium alginate are coated with cations of divalent or higher valence (especially calcium). Soft capsules containing alginic acid that are cross-linked with ions.
ペクチンと可塑剤及びアルギン酸ソーダの均一混合剤皮
からなる皮膜が、未乾燥又は半乾燥物であることを特徴
としたアルギン酸配合剤皮軟カプセル。(2) An alginic acid combination skin according to claim 1, characterized in that the film consisting of a uniform mixture skin of gelatin or low methoxyl pectin, a plasticizer, and sodium alginate is undried or semi-dried. capsule.
ペクチンと可塑剤及びアルギン酸ソーダの均一混合剤皮
からなる皮膜が、乾燥物であることを特徴としたアルギ
ン酸配合剤皮軟カプセル。(3) The alginic acid combination soft capsule according to claim 1, characterized in that the film consisting of a uniform mixture skin of gelatin or low methoxyl pectin, a plasticizer, and sodium alginate is a dried product.
アルギン酸ソーダを請求項第１項の配合比により均一に
混合した剤皮を用い、ロータリー式製造方法によりカプ
セルを得ることを特徴としたアルギン酸配合剤皮軟カプ
セルの製造方法。(4) An alginic acid compound skin, characterized in that capsules are obtained by a rotary production method using a skin in which gelatin or low methoxyl pectin, a plasticizer, and sodium alginate are uniformly mixed according to the mixing ratio set forth in claim 1. Method for manufacturing soft capsules.
好ましくは０．５〜１０％の濃度の塩化カルシウム液に
０．１〜１０分間、好ましくは０．５〜５分間浸漬し、
１〜３回水洗した後、請求項第２項〜第３項記載の軟カ
プセルを得ることを特徴としたアルギン酸配合剤皮軟カ
プセルの製造方法。(5) Alginic acid combination soft capsule 0.1-50%
Preferably immersed in a calcium chloride solution with a concentration of 0.5 to 10% for 0.1 to 10 minutes, preferably 0.5 to 5 minutes,
4. A method for producing alginic acid compound soft capsules, which comprises obtaining the soft capsules according to claims 2 to 3 after washing 1 to 3 times with water.
に対し、可塑剤（グリセリン、ソルビトール等）１０〜
５０重量部、アルギン酸ソーダを０．３〜１０重量部配
合調製した剤皮溶液と内包液とを、シームレスカプセル
製造装置、又はマイクロカプセル製造装置によりシーム
レスカプセル、又はマイクロカプセルに成形するたこと
を特徴としたアルギン酸配合剤皮軟カプセルの製造方法
。(6) Plasticizer (glycerin, sorbitol, etc.) 10 to 100 parts by weight of gelatin or low methoxyl pectin
50 parts by weight of sodium alginate and 0.3 to 10 parts by weight of sodium alginate. A method for producing soft capsules containing alginic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63145123A JPH01313421A (en) | 1988-06-13 | 1988-06-13 | Soft film capsule mixed with alginic acid and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63145123A JPH01313421A (en) | 1988-06-13 | 1988-06-13 | Soft film capsule mixed with alginic acid and production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01313421A true JPH01313421A (en) | 1989-12-18 |
Family
ID=15377932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63145123A Pending JPH01313421A (en) | 1988-06-13 | 1988-06-13 | Soft film capsule mixed with alginic acid and production thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01313421A (en) |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0749697A1 (en) * | 1995-06-22 | 1996-12-27 | Hercules Incorporated | Coated food |
| US5795606A (en) * | 1995-10-02 | 1998-08-18 | Hercules Incorporated | Method for preparing a coated food |
| WO1999001115A1 (en) * | 1997-07-03 | 1999-01-14 | Samyang Corporation | Colon selective drug delivery composition |
| US6099876A (en) * | 1994-10-11 | 2000-08-08 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Temperature-stable liquid cells |
| US6436453B1 (en) | 2000-06-16 | 2002-08-20 | General Mills, Inc. | Production of oil encapsulated minerals and vitamins in a glassy matrix |
| US6468568B1 (en) | 2000-06-16 | 2002-10-22 | General Mills, Inc. | Oligosaccharide encapsulated mineral and vitamin ingredients |
| US6500463B1 (en) | 1999-10-01 | 2002-12-31 | General Mills, Inc. | Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles |
| WO2003004003A1 (en) * | 2001-07-05 | 2003-01-16 | Wakunaga Pharmaceutical Co., Ltd. | Soft capsules |
| US6558718B1 (en) | 2000-06-19 | 2003-05-06 | General Mills, Inc. | Nutrient clusters for food products and methods of preparation |
| US6723358B1 (en) | 1998-03-23 | 2004-04-20 | General Mills, Inc. | Encapsulation of components into edible products |
| WO2007019882A1 (en) * | 2005-08-16 | 2007-02-22 | Symrise Gmbh & Co. Kg | Seamless coated spherical filled capsules |
| KR100860519B1 (en) * | 2008-03-03 | 2008-09-26 | 주식회사 에스앤텍 | Alginate-calcium-capsule and the method therof |
| JP2009185022A (en) * | 2008-01-11 | 2009-08-20 | Unimedical Inc | Enteric, sustained-release soft capsule, and its production method |
| US7803413B2 (en) | 2005-10-31 | 2010-09-28 | General Mills Ip Holdings Ii, Llc. | Encapsulation of readily oxidizable components |
| WO2011002034A1 (en) * | 2009-07-01 | 2011-01-06 | 凸版印刷株式会社 | Needle-like material |
| JP2013520203A (en) * | 2010-02-22 | 2013-06-06 | ル ラボグループ ソシエテ パール アクシオン サンプリフィエ | Contain materials in natural transportation systems |
| WO2014034548A1 (en) * | 2012-08-29 | 2014-03-06 | フロイント産業株式会社 | Method for producing seamless capsule |
| CN103750523A (en) * | 2014-01-28 | 2014-04-30 | 黄遂深 | Candy-type soft capsule |
| US8820331B2 (en) | 2005-06-21 | 2014-09-02 | V. Mane Fils | Smoking device incorporating a breakable capsule, breakable capsule and process for manufacturing said capsule |
| JP2014185177A (en) * | 2008-04-02 | 2014-10-02 | Hayashibara Co Ltd | Soft capsule film and soft capsule |
| US9456991B2 (en) | 2011-12-22 | 2016-10-04 | Erik Baes | Gelatin/alginate delayed release capsules comprising omega-3 fatty acids, and methods and uses thereof |
| JPWO2014192566A1 (en) * | 2013-05-26 | 2017-02-23 | 三粧化研株式会社 | Fish-like capsule body, method for producing the same, and apparatus for producing the same |
| US9622506B2 (en) | 2014-02-19 | 2017-04-18 | Incredible Foods, Inc. | Encapsulated soft food compositions and methods of making |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58172313A (en) * | 1982-04-01 | 1983-10-11 | Morishita Jintan Kk | Enteric soft capsule |
| JPS58194810A (en) * | 1982-05-07 | 1983-11-12 | Morishita Jintan Kk | Coated soft miniature capsule |
-
1988
- 1988-06-13 JP JP63145123A patent/JPH01313421A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58172313A (en) * | 1982-04-01 | 1983-10-11 | Morishita Jintan Kk | Enteric soft capsule |
| JPS58194810A (en) * | 1982-05-07 | 1983-11-12 | Morishita Jintan Kk | Coated soft miniature capsule |
Cited By (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6099876A (en) * | 1994-10-11 | 2000-08-08 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Temperature-stable liquid cells |
| US6680184B2 (en) | 1994-10-11 | 2004-01-20 | Yissum Research & Development Co. Of Hebrew University | Encapsulating liquid with hydrocolloid membrane stable from about -20 to 90 degrees C without bursting |
| EP0749697A1 (en) * | 1995-06-22 | 1996-12-27 | Hercules Incorporated | Coated food |
| US5795606A (en) * | 1995-10-02 | 1998-08-18 | Hercules Incorporated | Method for preparing a coated food |
| US5972399A (en) * | 1995-10-02 | 1999-10-26 | Hercules Incorporated | Coated food |
| WO1999001115A1 (en) * | 1997-07-03 | 1999-01-14 | Samyang Corporation | Colon selective drug delivery composition |
| US6723358B1 (en) | 1998-03-23 | 2004-04-20 | General Mills, Inc. | Encapsulation of components into edible products |
| US8313757B2 (en) | 1998-03-23 | 2012-11-20 | General Mills, Inc. | Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles |
| US6500463B1 (en) | 1999-10-01 | 2002-12-31 | General Mills, Inc. | Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles |
| US6436453B1 (en) | 2000-06-16 | 2002-08-20 | General Mills, Inc. | Production of oil encapsulated minerals and vitamins in a glassy matrix |
| US6468568B1 (en) | 2000-06-16 | 2002-10-22 | General Mills, Inc. | Oligosaccharide encapsulated mineral and vitamin ingredients |
| US6837682B2 (en) | 2000-06-19 | 2005-01-04 | General Mills, Inc. | Nutrient clusters for food products and methods of preparation |
| US6558718B1 (en) | 2000-06-19 | 2003-05-06 | General Mills, Inc. | Nutrient clusters for food products and methods of preparation |
| WO2003004003A1 (en) * | 2001-07-05 | 2003-01-16 | Wakunaga Pharmaceutical Co., Ltd. | Soft capsules |
| US7846475B2 (en) | 2001-07-05 | 2010-12-07 | Wakunaga Pharmaceutical Co., Ltd. | Soft capsules |
| US10278418B2 (en) | 2005-06-21 | 2019-05-07 | V. Mane Fils | Smoking device incorporating a breakable capsule, breakable capsule and process for manufacturing said capsule |
| US9339060B2 (en) | 2005-06-21 | 2016-05-17 | V. Mane Fils | Smoking device incorporating a breakable capsule, breakable capsule and process for manufacturing said capsule |
| US8820331B2 (en) | 2005-06-21 | 2014-09-02 | V. Mane Fils | Smoking device incorporating a breakable capsule, breakable capsule and process for manufacturing said capsule |
| WO2007019882A1 (en) * | 2005-08-16 | 2007-02-22 | Symrise Gmbh & Co. Kg | Seamless coated spherical filled capsules |
| US7803413B2 (en) | 2005-10-31 | 2010-09-28 | General Mills Ip Holdings Ii, Llc. | Encapsulation of readily oxidizable components |
| US7803414B2 (en) | 2005-10-31 | 2010-09-28 | General Mills Ip Holdings Ii, Llc | Encapsulation of readily oxidizable components |
| US8142831B2 (en) | 2005-10-31 | 2012-03-27 | General Mills Ip Holdings Ii, Llc | Encapsulation of readily oxidizable components |
| JP2009185022A (en) * | 2008-01-11 | 2009-08-20 | Unimedical Inc | Enteric, sustained-release soft capsule, and its production method |
| KR100860519B1 (en) * | 2008-03-03 | 2008-09-26 | 주식회사 에스앤텍 | Alginate-calcium-capsule and the method therof |
| JP2014185177A (en) * | 2008-04-02 | 2014-10-02 | Hayashibara Co Ltd | Soft capsule film and soft capsule |
| JPWO2011002034A1 (en) * | 2009-07-01 | 2012-12-13 | 凸版印刷株式会社 | Acicular body |
| JP5663477B2 (en) * | 2009-07-01 | 2015-02-04 | 凸版印刷株式会社 | Acicular body |
| WO2011002034A1 (en) * | 2009-07-01 | 2011-01-06 | 凸版印刷株式会社 | Needle-like material |
| JP2013520203A (en) * | 2010-02-22 | 2013-06-06 | ル ラボグループ ソシエテ パール アクシオン サンプリフィエ | Contain materials in natural transportation systems |
| US9795990B2 (en) | 2010-02-22 | 2017-10-24 | Incredible Foods, Inc. | Enclosing materials in natural transport systems |
| US9456991B2 (en) | 2011-12-22 | 2016-10-04 | Erik Baes | Gelatin/alginate delayed release capsules comprising omega-3 fatty acids, and methods and uses thereof |
| WO2014034548A1 (en) * | 2012-08-29 | 2014-03-06 | フロイント産業株式会社 | Method for producing seamless capsule |
| JPWO2014192566A1 (en) * | 2013-05-26 | 2017-02-23 | 三粧化研株式会社 | Fish-like capsule body, method for producing the same, and apparatus for producing the same |
| CN103750523A (en) * | 2014-01-28 | 2014-04-30 | 黄遂深 | Candy-type soft capsule |
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