JPS58154664A - Method and apparatus for confirmation control of weighing quantity of liquid in biochemical automatic analyzing apparatus - Google Patents

Abstract

PURPOSE:To detect quickly and easily clogging of a pipette and to improve the maintenance of reliability of data in biochemical automatic analysis, by constituting so as to confirm the weighing quantity of a liquid of the pipette by detecting height of the liquid surface and comparing the data of the height of the liquid surface with descent quantity of the pipette descending automatically. CONSTITUTION:A confirmation control apparatus for weighing quantity of liquid is constituted by a deep-bottomed vessel 1 having a slender diameter, a pipette P sucking and weighing a liquid 2 such as material to be inspected or a reagent stored in the vessel 1, a pipette descent control device 4 attached to a pipette holder 3 holding the pipette P, a liquid surface detection device 5 provided near the vessel 1 and a recording device CPU which compares descent quantity of the pipette P with the height of the liquid surface confirmed by the device 5. The pipette P is formed with a nonmetal such as glass etc. and the holder 3 is so constituted that the holder is guided to move upwards and upwards by a driving device 7 consisting of a pulse motor or a servomotor, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method and device for confirming and managing the amount of liquid weighed in an automatic biochemical analyzer.

In general, in biochemical analysis, especially when performing multi-item analysis, the amount of liquids such as specimens and reagents to be weighed? Accurate confirmation and management is an extremely important task in maintaining data reliability.

A pipette is conventionally used as a device for weighing out the above-mentioned liquid, as is well known.

However, since these pipettes are generally formed to have an extremely small diameter, they easily become clogged, and if they become clogged, the pipette continues to operate without measuring the prescribed amount of the liquid, which is a factor that reduces data reliability. And is this pipette clogged? Currently, detection means have not yet been used in the field of automatic biochemical analyzers.

This invention was created in view of the current situation, and its purpose is to quickly and easily detect clogging of pipettes, thereby maintaining data reliability in automatic biochemical analysis. A method and device for confirming the amount of liquid weighed in an automatic biochemical analyzer that can be improved?
This is what we are trying to provide.

In order to achieve this object, the present invention provides a liquid weigher for the pipette in an automatic biochemical analyzer configured to suction and weigh the liquid in a container with a pipette and dispense it at a predetermined dispensing position. In the intake amount confirmation management method, the liquid level height in the container described above is detected, the amount of liquid reduction is confirmed, and input into the recording device, and this liquid level height data is automatically recorded by detecting the liquid level height This system is configured to check the amount of liquid measured by the pipette by comparing it with the amount of descent of the pipette.

In addition, in this invention, in order to implement the above method,
A liquid weighing amount M, d management device of the pipette in an automatic biochemistry analyzer configured to suction and weigh the liquid in a container with a pipette and dispense it at a predetermined dispensing position, the pipette comprising: , the liquid level height in the container? The device is configured to detect and automatically descend to a predetermined amount of liquid measurement depth, and is provided near the container with a detection means for detecting the liquid level height in the container and confirming that the amount of liquid has decreased. What is the liquid level height detected by the detection means and the amount of descent of the pipette? This is configured to check and manage the clogging 9 of the pipette by comparing it with the measured amount of liquid in the pipette using a recording device.

Hereinafter, the present invention will be described in detail based on embodiments shown in the accompanying drawings.

The liquid weighing rat confirmation management device in the automatic biochemical analyzer according to this embodiment includes a container 1 formed with a small diameter and a deep bottom, and a liquid such as a specimen or a reagent contained in the container 1. A pipette P for suctioning and weighing 2, a pipette lowering control device 4 attached to a pipette holder 3 holding this pipette Pt, and a liquid level detection device disposed near the container 1! i5, a recording device C that compares the liquid level height confirmed by this liquid level detection device 5 and the amount of descent of the above-mentioned bipetu) P.
It is composed of PU.

The pipette P is made of a non-metallic material such as glass, and the pipette holder 3 is configured to be guided up and down by a drive device 7 consisting of a pulse motor, a servo motor, or the like.

A light output fiber F and a light input fiber F are firmly supported in the pipette holder 3 configured in this way, and the light output fiber F directs the light source light 6 from its tip into the container 1.
The light receiving fiber F2 picks up the reflected light reflected on the liquid surface and sends the data to the detection means for detecting the liquid level height h, that is, the pipette lowering control device 4. , the drive of the drive device 17? Control.

That is, while the pipette P is slowly lowered by the drive device I, the light source light 6 continues to be irradiated from the light output fiber F1 toward the surface of the liquid 2, and the pipette P is at a predetermined position, that is, by a predetermined amount. When descending to the liquid weighing depth, the light source light 6 irradiated from the light output fiber F1 is reflected by the surface of the liquid 2 and enters the light input fiber F. In this state, the detection means S operates to stop the drive device 7, the descent of the pipette P is stopped, and the liquid 2
At the same time as the suction and weighing of the pipette P is carried out, data ΔQ on the amount of descent of the pipette P is sent to the recording device CPU.

On the other hand, a T-container 1 having a narrow diameter and a deep bottom shape contains a liquid 2 that has been accurately weighed in advance, and this weighed amount is manually input to the recording device CPU. On the outer wall of this container 1, a scale 8 is displayed in 11 units, and the amount of liquid between 1 and 2 is accurately measured in advance (1 interval =
xu/, ) is input to the recording device CPU, and the height h of the liquid 2 reduced by suction with the pipette P
is detected by a detection device 9 disposed near the container 1, and the decrease amount data Δl of the liquid 2 is input to the recording device fCPU.

Then, this recording device CPU compares the descending data ΔQ of the pipette P with the decrease amount data Δt of the liquid 2 in the container 1, and confirms whether or not the pipette P has aspirated all of the predetermined amount of liquid 2. , the difference between the first data ΔQ and Δt is, for example, +
If the value exceeds 10 to ±20%, it is assumed that the pipette P has become clogged, and an NG display is displayed.
Stop the operation of P.

In the above embodiment, the scale 8 is displayed on the container 1. However, the amount of the liquid 2 at regular intervals is accurately measured and this data is input to the recording device CPU. For example, it is not necessary to display the scale 8. Further, the reference numeral in FIG. 2 indicates the lowest position of the pipette P.

Does this invention consist of the following? Including clogging of pipettes in biochemical automatic analyzers? It can be easily confirmed, which improves the reliability and maintenance of data in biochemical analysis, making data management easier. play.

Further, in the embodiment L, since the container 1 can be formed to have a small diameter, the opening area can be narrowed, and the liquid 2 in the container 1 can be concentrated by evaporation. You can prevent this.

[Brief explanation of the drawing]

The drawings show a liquid scale lid confirmation and management device according to an embodiment of the present invention, in which FIG. 1 is an explanatory view schematically showing the structure, and FIG. 2 is a front view showing the structure of the container. be. 1... Container 2... Liquid 4... Pipette descending control device 5... Liquid level detection device 7... Drive device CPU... Recording device h... Liquid level height P... Pipette S...Detection means
ΔQ...Pipette Descent Company Δt...Liquid Reduction Wrinkle Patent Applicant: Nippon Techtron Co., Ltd.

Claims (1)

[Scope of Claims] 1) In a method for managing liquid weighing of a pipette in an automatic biochemical analyzer configured to suck and weigh a liquid with a pipette in a container and dispense the liquid at a predetermined dispensing position. , the liquid level height in the container is detected, the amount of liquid decrease is confirmed and input into the recording device, and this liquid level height data is automatically lowered by detecting the liquid level height. 1. A method for confirming and managing the amount of liquid weighed in an automatic biochemistry analyzer, characterized in that the amount of liquid weighed by a pipette is confirmed by comparing the amount. 2) In an automatic biochemistry analyzer configured to suction and weigh the liquid in a container with a pipette and dispense it at a predetermined dispensing position, the amount of liquid weighed by the pipette WIIil! ! In the management device, the pipette is configured to detect the liquid level height in the container and automatically descend to a liquid measuring depth of a predetermined St. A detection means for detecting the height and confirming the amount of decrease in liquid is provided, and a recording device compares the liquid level detected by the detection means with the amount of descent of the pipette, and calculates the amount of liquid measured by the pipette. A liquid weighing amount confirmation and management device in an automatic biochemical analyzer, characterized in that it is configured to perform confirmation.