JPH0145870B2 - - Google Patents
Info
- Publication number
- JPH0145870B2 JPH0145870B2 JP3754882A JP3754882A JPH0145870B2 JP H0145870 B2 JPH0145870 B2 JP H0145870B2 JP 3754882 A JP3754882 A JP 3754882A JP 3754882 A JP3754882 A JP 3754882A JP H0145870 B2 JPH0145870 B2 JP H0145870B2
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- pipette
- amount
- container
- level height
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007788 liquid Substances 0.000 claims description 61
- 238000001514 detection method Methods 0.000 claims description 11
- 238000005303 weighing Methods 0.000 claims description 7
- 238000012790 confirmation Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000000835 fiber Substances 0.000 description 7
- 238000007726 management method Methods 0.000 description 4
- 238000012742 biochemical analysis Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000013523 data management Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
【発明の詳細な説明】
この発明は、生化学自動分析装置における液体
秤取量確認管理方法及びその装置に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method and device for confirming and managing the amount of liquid weighed in an automatic biochemical analyzer.
一般に、生化学分析においては、特に多項目分
析を行う場合、検体や試薬等の液体の秤取量を正
確に確認し管理することがデータの信頼性を維持
する上で極めて重要な作業である。 In general, in biochemical analysis, especially when performing multi-item analysis, it is extremely important to accurately confirm and manage the weighed amounts of liquids such as specimens and reagents in order to maintain data reliability. .
このような上記液体を秤取する装置としては、
従来よりピペツトが使用されているのは周知のと
おりである。 As a device for weighing the above-mentioned liquid,
It is well known that pipettes have been used for a long time.
しかしながら、このピペツトは一般に極めて細
径に形成されているため、目詰りし易く、目詰り
した場合、該ピペツトは上記液体を所定量秤取し
ないまま作動しつづけ、データ信頼度が低下する
要因となつており、かつ、このピペツトの目詰り
を検知する手段は、従来、生化学自動分析装置の
分野においては未だ使用されていないのが現状で
ある。 However, since these pipettes are generally formed to have an extremely small diameter, they easily become clogged, and if they become clogged, the pipette continues to operate without measuring the specified amount of the liquid, which can be a factor in reducing data reliability. Currently, this means for detecting pipette clogging has not yet been used in the field of automatic biochemical analyzers.
この発明は、かかる現状に鑑み創作されたもの
であつて、その目的とするところは、ピペツトの
目詰りを迅速かつ容易に検知し、以つて、生化学
自動分析におけるデータの信頼度の維持向上を図
ることができる生化学自動分析装置における液体
秤取量確認管理方法及びその装置を提供しようと
するものである。 This invention was created in view of the current situation, and its purpose is to quickly and easily detect pipette clogging, thereby maintaining and improving data reliability in automatic biochemical analysis. The present invention aims to provide a method for confirming and managing the amount of liquid weighed in an automatic biochemical analyzer and an apparatus therefor.
かかる目的を達成するため、この発明にあつて
は、容器内の液体をピペツトにより吸引秤取して
所定分注位置で分注するより構成してなる生化学
自動分析装置における上記ピペツトの液体秤取量
確認管理方法において、上記容器における液面高
さを検知して液体の減少量を確認して記録装置に
入力し、この液面高さのデータを、液面高さを検
知して自動的に下降するピペツトの下降量と比較
して、ピペツトの液体秤取量を確認するように構
成したものである。 In order to achieve this object, the present invention provides a liquid balance for the pipette in an automatic biochemistry analyzer configured to suction and weigh the liquid in a container with a pipette and dispense it at a predetermined dispensing position. In the intake amount confirmation management method, the liquid level height in the container described above is detected, the amount of liquid reduction is confirmed, and input into the recording device, and this liquid level height data is automatically recorded by detecting the liquid level height This system is configured to check the amount of liquid measured by the pipette by comparing it with the amount of descent of the pipette.
また、この発明にあつては、上記方法を実施す
るため、容器内の液体をピペツトにより吸引秤取
して所定分注位置で分注するよう構成してなる生
化学自動分析装置における上記ピペツトの液体秤
取量確認管理装置であつて、上記ピペツトは、容
器内の液面高さを検知して自動的に所定量の液体
秤取深さまで下降するよう構成すると共に、上記
容器近傍には、該容器内の液面高さを検知して液
体の減少量を確認する検知手段を設け、該検知手
段により検知された液面高さと上記ピペツトの下
降量との記録装置にて比較し、ピペツトの液体秤
取量を確認してピペツトの目詰りを確認管理する
ように構成したものである。 In addition, in order to carry out the above method, the present invention provides an automatic biochemical analyzer configured to suction and weigh the liquid in a container with a pipette and dispense it at a predetermined dispensing position. The liquid weighing amount confirmation and management device is configured such that the pipette detects the liquid level height in the container and automatically descends to a depth for measuring a predetermined amount of liquid. A detection means is provided for detecting the liquid level height in the container to confirm the amount of decrease in the liquid, and a recording device compares the liquid level detected by the detection means with the amount of descent of the pipette, and the pipette is This system is configured to check the amount of liquid that has been weighed and to check and manage pipette clogging.
以下、添付図面に示す実施例にもとづき、この
発明を詳細に説明する。 Hereinafter, the present invention will be described in detail based on embodiments shown in the accompanying drawings.
この実施例に係る生化学自動分析装置における
液体秤取量確認管理装置は、細径に、かつ深底状
に形成された容器１と、この容器１内に収容され
た検体又は試薬等の液体２を吸引秤取するピペツ
トＰと、このピペツトＰを保持してなるピペツト
ホルダー３に取り付けられたピペツト下降制御装
置４と、上記容器１近傍に配設された液面検知装
置５と、この液面検知装置５で確認された液面高
さと上記ピペツトＰの下降量を比較する記録装置
CPUとから構成されている。 A liquid weighing amount confirmation and management device in an automatic biochemical analyzer according to this embodiment includes a container 1 formed with a small diameter and a deep bottom, and a liquid such as a specimen or a reagent contained in the container 1. 2, a pipette descending control device 4 attached to a pipette holder 3 holding the pipette P, a liquid level detection device 5 disposed near the container 1, A recording device that compares the liquid level height confirmed by the liquid level detection device 5 and the amount of descent of the pipette P.
It consists of a CPU.
ピペツトＰは、非金属例えばガラス等で形成さ
れ、また上記ピペツトホルダー３は、パルスモー
タやサーボモータ等よりなる駆動装置７により昇
降案内されるよう構成されている。 The pipette P is made of a non-metallic material such as glass, and the pipette holder 3 is configured to be guided up and down by a drive device 7 consisting of a pulse motor, a servo motor, or the like.
このように構成されたピペツトホルダー３には
出光用フアイバF1と入光用フアイバF2が固持さ
れており、この出光用フアイバF1は光源光６を
その先端より容器１の液体２表面へと照射し、入
光用フアイイバF2は、この液表面で反射された
反射光をひろい、液面高さｈを検知する検知手
段、すなわちピペツト下降制御装置４へとデータ
を送り、上記駆動装置７の駆動を制御する。 The pipette holder 3 configured in this manner has a light output fiber F 1 and a light input fiber F 2 firmly supported, and the light output fiber F 1 directs the light source light 6 from its tip to the surface of the liquid 2 in the container 1. The light receiving fiber F 2 collects the reflected light reflected from the liquid surface and sends the data to the detection means for detecting the liquid level h, that is, the pipette lowering control device 4, and the above-mentioned drive Controls the drive of the device 7.
すなわち、上記ピペツトＰは、駆動装置７によ
りゆつくりと下降しつつ、上記出光用フアイバ
F1からは光源光６は液体２表面方向へと照射さ
れつづけ、ピペツトＰが所定位置、すなわち所定
量の液体秤取深さまで下降すると、出光用フアイ
ドF1より照射された光源光６は液体２表面で反
射されて入光用フアイバF2へと入光される。こ
の状態において、上記検知手段Ｓは作動して駆動
装置７を停止させ、ピペツトＰの下降は停止さ
れ、液体２の吸引秤取が行なわれると同時に、該
ピペツトＰの下降量データΔQは記録装置CPUへ
と送られる。 That is, the pipette P is slowly lowered by the drive device 7 and is moved toward the light output fiber.
From F1 , the light source light 6 continues to be emitted toward the surface of the liquid 2, and when the pipette P descends to a predetermined position, that is, to a predetermined amount of liquid weighing depth, the light source light 6 emitted from the light emitting fibre 2 surface and enters the light input fiber F2 . In this state, the detection means S operates to stop the drive device 7, the descent of the pipette P is stopped, and the liquid 2 is suctioned and weighed.At the same time, the data ΔQ of the descent amount of the pipette P is Sent to CPU.
一方、細径かつ深底状に形成された容器１内に
は、予じめ正確に秤取された液体２が収容されて
おり、この秤取量は上記記録装置CPUに入力さ
れている。そして、この容器１の外壁には１mm単
位で目盛８が表示されており、この１mm間の液体
２量は、予じめ正確に計量（１mm＝xul）されて
上記記録装置CPUに入力されており、上記ピペ
ツトＰで吸引され、減少した液体２高さｈを、容
器１近傍に配設された検知装置９により検知し
て、液体２の減少量データΔlは上記録装置CPU
に入力される。 On the other hand, a container 1 formed with a small diameter and a deep bottom contains a liquid 2 that has been accurately weighed in advance, and this weighed amount is input to the recording device CPU. A scale 8 is displayed on the outer wall of this container 1 in units of 1 mm, and the amount of liquid 2 between these 1 mm is accurately measured in advance (1 mm = xul) and input into the recording device CPU. Then, the reduced height h of the liquid 2 sucked by the pipette P is detected by the detection device 9 disposed near the container 1, and the decrease amount data Δl of the liquid 2 is recorded by the upper recording device CPU.
is input.
そして、この記録装置CPUでは、上記ピペツ
トＰの下降量データΔQと容器１の液体２の減少
量データΔlとを比較し、ピペツトＰが所定量の
液体２を吸引したか否かを確認し、上記データ
ΔQとΔlとの差が、例えば±10〜±20％以上とな
つた場合には、ピペツトＰが目詰りを起こしたも
のと判断してNG表示をしてピペツトＰの作動を
停止させる。 Then, this recording device CPU compares the descending amount data ΔQ of the pipette P with the decreasing amount data Δl of the liquid 2 in the container 1 to check whether the pipette P has aspirated a predetermined amount of the liquid 2, If the difference between the above data ΔQ and Δl is, for example, ±10 to ±20% or more, it is determined that the pipette P is clogged, an NG display is displayed, and the operation of the pipette P is stopped. .
尚、上記実施例では、容器１に目盛り８を表示
した場合を例にとり説明したが、液体２の一定間
隔毎の液体量が正確に計量され、このデータが記
録装置CPUに入力されていれば、目盛り８を表
示する必要は必らずしも要しない。また第２図中
符号Ｌは、ピペツトＰの最下降位置を示す。 In the above embodiment, the scale 8 is displayed on the container 1. However, if the amount of liquid 2 is accurately measured at regular intervals and this data is input to the recording device CPU. , it is not necessary to display the scale 8. Further, the symbol L in FIG. 2 indicates the lowest position of the pipette P.
この発明は、以上の構成を含むので、生化学自
動分析装置におけるピペツトの目詰りを容易に確
認でき、以つて生化学分析におけるデータの信頼
度を維持向上することができるのでデータ管理も
容易となる等の効果を奏する。 Since this invention includes the above-described configuration, it is possible to easily check for pipette clogging in an automatic biochemical analyzer, thereby maintaining and improving the reliability of data in biochemical analysis, thereby facilitating data management. It has the effect of becoming.
また、上記実施例にあつては、容器１を細径に
形成できるので、開口面積を狭くでき、容器１内
の液体２の蒸発による濃縮を防止することができ
る。 Further, in the above embodiment, since the container 1 can be formed to have a small diameter, the opening area can be narrowed, and concentration of the liquid 2 in the container 1 due to evaporation can be prevented.
図面は、この発明の一実施例に係る液体秤取量
確認管理装置を示すものであつて、第１図は構成
を概略的に示す説明図、第２図は容器の構成を示
す正面図である。
１……容器、２……液体、４……ピペツト下降
制御装置、５……液面検知装置、７……駆動装
置、CPU……記録装置、ｈ……液面高さ、Ｐ…
…ピペツト、Ｓ……検知手段、ΔQ……ピペツト
下降量、Δl……液減少量。
The drawings show a liquid weighing amount confirmation and management device according to an embodiment of the present invention, in which FIG. 1 is an explanatory diagram schematically showing the structure, and FIG. 2 is a front view showing the structure of the container. be. 1... Container, 2... Liquid, 4... Pipette lowering control device, 5... Liquid level detection device, 7... Drive device, CPU... Recording device, h... Liquid level height, P...
...pipette, S...detection means, ΔQ...pipette descending amount, Δl...liquid decrease amount.
Claims (1)
所定分注位置で分注するよう構成してなる生化学
自動分析装置における上記ピペツトの液体秤取量
確認管理方法において、上記容器における液面高
さを検知して液体の減少量を確認して記録装置に
入力し、この液面高さのデータを、液面高さを検
知して自動的に下降するピペツトの下降量と比較
して、ピペツトの液体秤取量を確認するように構
成したことを特徴とする生化学自動分析装置にお
ける液体秤取量確認管理方法。 ２ 容器内の液体をピペツトにより吸引秤取して
所定分注位置で分注するよう構成してなる生化学
自動分析装置における上記ピペツトの液体秤取量
確認管理装置において、上記ピペツトは、容器内
の液面高さを検知して、自動的に所定量の液体秤
取深さまで下降するよう構成すると共に、上記容
器近傍には、該容器内の液面高さを検知して液体
の減少量を確認する検知手段を設け、該検知手段
により検知された液面高さと上記ピペツトの下降
量とを記録装置にて比較し、ピペツトの液体秤取
量を確認するよう構成したことを特徴とする生化
学自動分析装置における液体秤取量確認管理装
置。[Scope of Claims] 1. A method for confirming and managing the amount of liquid measured by the pipette in an automatic biochemistry analyzer configured to suction and weigh the liquid in the container with a pipette and dispense it at a predetermined dispensing position, The liquid level height in the container is detected, the amount of liquid decrease is confirmed and inputted into the recording device, and this liquid level height data is sent to the pipette, which automatically descends when the liquid level height is detected. 1. A method for confirming and managing the amount of liquid measured in a biochemical automatic analyzer, characterized in that the amount of liquid measured by a pipette is confirmed by comparing the amount of liquid measured by a pipette. 2. In the liquid weighing amount confirmation and management device of the above-mentioned pipette in an automatic biochemistry analyzer configured to suction and weigh the liquid in the container with a pipette and dispense it at a predetermined dispensing position, the pipette The system is configured to detect the liquid level height in the container and automatically lower the liquid to a predetermined measuring depth. The method is characterized in that a detection means is provided for confirming the amount of liquid measured by the pipette, and the liquid level height detected by the detection means is compared with the amount of descent of the pipette using a recording device, thereby confirming the amount of liquid measured by the pipette. Liquid weighing amount confirmation and management device for automatic biochemistry analyzer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3754882A JPS58154664A (en) | 1982-03-10 | 1982-03-10 | Method and apparatus for confirmation control of weighing quantity of liquid in biochemical automatic analyzing apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3754882A JPS58154664A (en) | 1982-03-10 | 1982-03-10 | Method and apparatus for confirmation control of weighing quantity of liquid in biochemical automatic analyzing apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58154664A JPS58154664A (en) | 1983-09-14 |
| JPH0145870B2 true JPH0145870B2 (en) | 1989-10-05 |
Family
ID=12500572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3754882A Granted JPS58154664A (en) | 1982-03-10 | 1982-03-10 | Method and apparatus for confirmation control of weighing quantity of liquid in biochemical automatic analyzing apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58154664A (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS615475U (en) * | 1984-06-15 | 1986-01-13 | オリンパス光学工業株式会社 | Analysis equipment |
| FR2591745B1 (en) * | 1985-12-12 | 1988-03-18 | Beauvais Inst Sup Agricole | APPARATUS FOR DETERMINING THE GRANULOMETRY OF EARTHS |
| JPS62141760U (en) * | 1986-02-28 | 1987-09-07 | ||
| JP2717395B2 (en) * | 1995-11-17 | 1998-02-18 | 株式会社エムディファクトリー | Disc case |
| JP2001183382A (en) | 1999-12-28 | 2001-07-06 | Roche Diagnostics Gmbh | Apparatus and method for confirming operation of dispensing machine |
-
1982
- 1982-03-10 JP JP3754882A patent/JPS58154664A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58154664A (en) | 1983-09-14 |
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