JPS58150504A - High-strength material for living body and its production - Google Patents

Abstract

PURPOSE:A high-strength material for dental or orthopaedic endo-osseous implant that is made by covering the base of a metallic material such as high- strength stainless steel with calcium phosphate glass, thus showing good compatibility to living bodies and not hurting them. CONSTITUTION:The metallic base material with higher strength than sintered calcium phosphate is coated with calcium phosphate by dipping, brushing, spraying a suspension or slurry containing a powdery material forming calcium phosphate by calcination or combination thereof to give the objective material with the surface layer of calcium phosphate. The resultant material is preferably porous on the surface of the cintered calcium phosphate or crystallized, after coated in a glass state.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a non-deformable and high-strength biological component used for dental intraosseous implants or orthopedic intraosseous implants.

Conventionally, corrosion-resistant metal materials such as stainless steel or ceramicsex materials have been used for such biological components, but the former corrosion-resistant metal materials deteriorate due to long-term use.
The latter type of ramix material has attracted attention because fragrant heavy metals such as I-pult are accumulated in the body.

Aluminum ceramics with high mechanical strength, such as high-altitude porcelain or sapphire, were used as the ceramic materials; Calcium phosphate glass, which has similar composition to aggregate, has been attracting attention because it has poor compatibility with anti-paintings, living body parts, and aggregates.

For calcium phosphate based materials, please contact Special@18xi
-'yioit issue@: [atomic ratio of calcium and phosphorus Ca/] is t7 or less, and phosphoric acid is 1%Os
Calcium phosphate-based crystallized glass having various crystallization degrees from I to 100-crystallinity obtained by roasting a composition containing 10-weight or more of material. ” was disclosed,
In the previous Japanese Patent Application Publication No. 18J-14#/ff issue, [Avatai]
o- and Cai (POi) m#aj-10% Yoli fk
MgO*Nano
s K10 * CaFg * AbOi e810m
Seven or more selected species are αt-Uj
However, all of them lack strength and may break if large stress or impact is applied to bones or teeth.

The present invention has been developed to improve this problem, and uses calcium phosphate glass as a surface layer, which is compatible with living organisms and does not have the O-formation properties characteristic of Sela-ken ivy. Concerning a strong biological material that is adhered to a substrate made of a metal material such as high-strength stainless steel, has good compatibility with living organisms, is free from paper-like properties, and has satisfactory mechanical strength. It is something.

Including the calcium phosphate-based glass foam described in this ζ, calcium phosphate Ca Hatake (POa) Maro, the Ca/PO atomic ratio is at.
-/, 'It is a glassy iris-formed glass whose main components are calcium phosphate and apatite near IJ, and a small amount of reinforcing agent. As a metal material, the thermal conductivity coefficient of calcium fluorate / 00 =
710 Yachitan alloy is most preferred.

Next, the manufacturing method is as follows: phosphoric acid, calcium carbonate, calcium dihydrogen phosphate, and other materials that produce calcium phosphate by thin noodles are thoroughly mixed as raw materials, and the mixture is heated to a semi-molten temperature by heating. This is ground to obtain calcium phosphate powder. Among these Kt
Crystalline calcium phosphate and/or glass are present. This is suspended in water containing a well-known binder to form a slurry, which is finished to a size slightly smaller than the desired shape of the high-strength metal material base.The high-strength metal base is immersed in the slurry and dried at a temperature at which calcium phosphate melts. It can be cured by providing a coating of calcium phosphate around the surface Ka/- of the surface. If organic powder that evaporates during firing is mixed into the calcium phosphate ceramic, it becomes porous.

The fact that this surface layer is porous has the effect of alleviating internal stress due to the difference in thermal expansion coefficient with the substrate and improving compatibility with living organisms as an implant material. Another manufacturing method is to coat the surface of the metal material substrate with the above calcium phosphate powder by thermal spraying using a spray gun or an oxyacetylene flame. In this case, making the coating layer porous means that the high-strength metal material base and the shell spray nozzle O
It can be freely adjusted by adjusting the distance.

In addition, the calcium phosphate powder may be used in the form of Cerben, or its raw material may be used in an unfired state.The surface layer of the calcium phosphate powder may be glassy or crystalline, and after baking Heat l&ring may be performed to crystallize the glass.

This will be explained in more detail below with reference to Examples.

Example 1 Mixing CaCO5J O- and PsOs/4'le 11
The mixture was calcined at 00° C. for 1 hour to bring it to a living state, producing a mixture of calcium phosphate glass and crystals. Ca/ in this case
The atomic ratio of P is approximately 1. Enjoy this at Trommel! The particles were crushed so that the particles were 41L0-. This was put into water in which methyl cellulose was dissolved and stirred to make a slurry of calcium phosphate.The slurry was made of stainless steel and a high strength metal material base with dimensions of 9 x J x 111 was added to the calcium phosphate slurry 11. Soaked and dried in air for 70 minutes
A 914-strength biological component was produced by baking at 0°C and coating the surface with calcium phosphate with a thickness of a/cm, and then molding it by casting using the same calcium phosphate slurry in the atmosphere at 700°C. The transverse rupture strength was measured for the comparative product of the same product, and it was found that the latter comparative product broke at Ih/-, while the former invention product broke at a load of 40-/- Also, we succeeded in obtaining satisfactory mechanical strength in the calcium phosphate coating layer without causing any abnormalities such as peeling or middle surface.

In addition, the mechanical strength (peeling resistance, cracking resistance) of the calcium phosphate coating layer of the above-mentioned product of the present invention is 40b/- ts @ high full 1?
This is a high value even compared to the pile breaking force of porcelain W4/-14[K.

The average grain size of the solid content (calcicium phosphate) of the calcium nonaphosphate slurry used in Example /J weight IJ6*
After adding 1p of carbon powder and heating it, the other conditions were exactly the same as in Example I, and a calcium phosphate sintered body having a porous surface layer was placed in an 1I box made of a high-strength metal base material made of stainless steel. A high-strength biomaterial having a coating layer having a thickness of α/jmo was obtained.

The surface layer of this member made of calcium phosphate was as described in Example IO.
9.Different from dense, 9J0~! The 9J0~, which is added as a starting material, is oxidized during firing to become carbon oxide and burnt out, and the carbon is gasified and expanded. A porous material containing countless large pores of 00μ on the surface layer, and its porosity is Fiay
Part 9. This porous structure alleviates the internal stress caused by the difference in thermal expansion coefficient between the high-strength material base and the surface layer, and prevents peeling and cracking during firing, so there is a wide range in the selection of the base material. On the other hand, by increasing the surface layer and making it uneven, it improves the connection of blood vessels and muscles and improves adhesive strength. In addition, the hardness of the surface layer itself decreased, and the same transverse rupture strength test as in Example 1 showed that the part of the surface that contacted the notch became Kll due to a load of 40-/-. Line contact cannot occur in living organisms, and its transverse rupture strength is higher than that of high-aluminum porcelain.

Example J The calcium phosphate powder used in Example 1 was also used in Example 1.
The high-strength metal material base used in the above was flame-sprayed with an oxygen-acetylene flame, and a calcium phosphate layer with a thickness of aJ■ was provided on the surface, so that the high-strength biomaterial could peel off on the surface layer despite rapid heating and cooling. Even in the transverse rupture strength test, the mechanical strength was approximately equal to that of Example 1 without causing any intermediate cracks.

If the degree of crystallinity can be increased to fj-1 by heat treatment at 400° C. before flame spraying, the mechanical strength of the surface layer can be further increased.

As described above, the present invention forms a thin layer of a sintered body of calcium phosphate, which is compatible with living organisms and has no textural properties, on the surface of a substrate made of a high-strength metal material, and therefore has sufficient mechanical properties. The object of the present invention is to provide an extremely excellent member for a patient's body, which maintains physical strength and health safety, and improves connections between blood vessels and muscles of the living body, and a method for manufacturing the same.

In each of the above examples, calcium carbonate and phosphoric acid were used as the starting materials for the sintered body of calcium phosphate. However, in any case, the sintered body of calcium phosphate must be 9.9J- or less, %yctxoz~ai to avoid the influence of the difference in thermal expansion during firing with the high-gIi metal material substrate described below.
The high-strength metal material base is preferably not limited to stainless steel, but may also be made of other metals such as titanium alloys, and the surface of the Ka base may be made uneven by a well-known method such as Nando Plast. Therefore, the adhesive strength with the surface layer can be increased.

Claims (1)

[Claims] (1) 11 layers and 6 cs of scissor surface layer due to 1111 force Lucicum hook body? It is a high-strength biomedical component made of a high-strength metal material base that has a high mechanical strength and strong mechanical shock. Sakaki The high-strength biological member according to claim osssz, wherein the surface layer of the calcium phosphate sintered body is a porous layer. -) The highly rigid biological member according to claim @II, Paragraph 1, Paragraph 9, 92, wherein the highly rigid metallic material base is a corrosion-resistant metallic material. -) *mwti of the patent claim, in which the surface layer of calcium phosphate is deposited in a glass O state and then crystallized.
- The highly rigid biological component according to any one of Section J. (2) Calcium phosphate is made into a high-strength metal material base OII that is more rigid than the body of the earth, and the material that produces calcium phosphate is dissolved in the suspension. It is characterized by being formed by dipping, applying, *m, or combining 9 mud and drying.
Table 11 shows a method for preparing a high-strength member for the elbow body by forming a surface layer of 1111 oxide*lucium O. Claim 1, characterized in that a substance that is hooked by Zengji's calcium scalinate bucket INK is suspended.
Item Ij Item 60: A method for producing a high-strength biomaterial O by forming calcium phosphate or a porous surface layer on the surface. (7) Calcium phosphate sintered body) Apply calcium phosphate powder to the surface of a high-strength metal material base.
TE is characterized by being self-attached using flame spraying.
A method for manufacturing a high-molecular-weight biomedical part #O in which a surface layer of calcium phosphate is formed on the surface.