JPS58143749A - Medical and sanitary base material - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] The present invention is a medical treatment with durable antibacterial action.

Concerning sanitary materials.

Conventionally, products made of synthetic fibers or films lacked antibacterial properties and were considered unsuitable as medical or sanitary materials.

The present inventors focused on these problems and, as a result of intensive studies, succeeded in imparting these properties by modifying synthetic fibers or synthetic films.

That is, the gist of the present invention is 3'x10-' gram equivalent/
For molded products made of polyamide, polyester or polyacrylonitrile resin having acidic groups of gram or more,
5. Quaternary nitrogen compound with antibacterial properties. Ox10
- A medical and sanitary material consisting of a modified molded product containing at least 5 gram equivalent/gram.

By employing such a configuration, the present invention is the first to be able to apply molded articles made of synthetic fibers or synthetic films to medical and sanitary applications.

It also has an extremely high resistance to the growth of fungi including germs, and in terms of the durability of this resistance, it has a washing resistance that has not been seen in conventional medical and sanitary products. We were able to provide something with these characteristics. Therefore, the product of the present invention does not require disinfection treatment every time it is washed, and has the advantage that it can be used extremely efficiently.

The polyamide used in the present invention is, for example, nylon 6, nylon 6/6. A copolymer formed by copolymerizing a normal polyamide polymer such as nylon 6/10 and another diamine or dicarboxylic acid component, and having film-forming or fiber-forming properties. .

Polyester also refers to polyethylene terephthalate,
A copolymer formed by copolymerizing a common polyester polymer such as polybutylene terephthalate and another dicarboxylic acid or glycol component, and having the ability to form a film or fiber as described above. Further, in the case of polyacrylonitrile, as mentioned above, it is a common polyacrylonitrile polymer and a copolymer mainly composed of polyacrylonitrile, and has fiber-forming properties.

In the present invention, the above polymer has a weight of 6×10 gram equivalent/
Those into which acidic groups are introduced in an amount of gram or more, preferably 5.5 x 10-' gram equivalent/gram, are used.

As such acidic groups, carboxylic acids and sulfonic acids are preferable from the viewpoint of the subsequent substitution reaction treatment of the quaternary nitrogen compound.

Such acidic groups can be introduced into the above polymer by the following compounds.

For example, carboxylic acid groups include acrylic acid, methacrylic acid, derivatives thereof, and unsaturated aliphatic polycarboxylic acids such as itaconic acid and butenetricarboxylic acid, and sulfonic acid groups include styrene sulfonic acid, 2- Acrylamido-2-methyl-propanesulfonic acid, 2-acrylamido-2-phenyl-ethanesulfonic acid.

Examples include allylsulfonic acid and derivatives thereof, but in short, any compound containing a carboxylic acid group or sulfonic acid group having a functional group capable of radical polymerization may be used.

In addition to the above, in the case of polyamide or polyester, a functional group that can be copolymerized with these polymers.

For example, the above acid group-containing compounds having an amino group, a carboxyl group, or a hydroxyl group may be used.

The introduction of acidic groups may be carried out by copolymerization during the polymerization stage of the above-mentioned polymer, by blending at the molding stage of the polymer, or by graft polymerization into the molded product, and any of these may be used in the present invention. .

However, it is preferable to graft-polymerize the molded article from the viewpoint of the physical properties of the molded article and the ease of production on a quantitative scale.

Such graft polymerization methods include radiation irradiation.

A known method may be used in which the above-mentioned monomers are graft-polymerized by activation using an initiator such as ozone oxidation or peroxide.

In addition to the above methods, polyacrylonitrile fibers can also be produced using
A nitrile group can be converted to a carboxyl group by heat treatment with a concentrated aqueous alkaline solution.

In any case, the amount of acidic groups introduced or contained in the molded product is 5 x 10'' t/g per molded product.
If it is less than 2 grams, sufficient antibacterial performance, which is the objective of the present invention, cannot be imparted even if a subsequent substitution treatment is performed with a basic nitrogen compound having antibacterial properties.

The quaternary nitrogen compound having antibacterial properties to be substituted with such an acidic group includes a saturated or unsaturated aliphatic hydrocarbon group or an aromatic hydrocarbon group, or a hydrocarbon group constituting the nitrogen heterocycle of the nitrogen compound. A quaternary nitrogen compound consisting of a hydrocarbon group that is a combination of these groups can be applied as long as it has antibacterial and antifungal properties, but it is particularly preferable that the total number of carbon atoms in the hydrocarbon group is 10 or more. is 15
The above-mentioned quaternary nitrogen compounds are excellent in this performance.

A typical example of the quaternary nitrogen compound of the present invention is a quaternary ammonium salt represented by the following general formula.

Here, R4-R4 is a hydrocarbon group, and when it simply has a nitrogen-containing heterocycle, it takes the following structure in which R, R4 in the above general formula is represented by R5.

Here, R6 is a hydrocarbon group having 2 or more carbon atoms, preferably 5 or more carbon atoms, and R6 may have a structure that includes R1 to R4 hydrocarbon groups in its history. In either case, the total number of carbon atoms in all hydrocarbon groups is preferably 10 or more, especially 15 or more,
X represents halogen, particularly chlorine and bromine.

Specific examples of compounds represented by the general formula include lauryl dimethyl benzyl ammonium chloride, cetyl dimethyl benzyl ammonium bromide,
stearyl trimethyl ammonium chloride,
Examples include cetyl pyridinium chloride. Of course, those in which R1 to R, and R5 of the above compounds are appropriately substituted within the range of a total number of carbon atoms of 10 or more, preferably 15 or more, or those in which X is replaced from chromium to bromine or vice versa, are particularly effective. Needless to say. However, depending on the number of carbon atoms in the hydrocarbon group, such as hexyl trimethyl ammonium chloride, the sum is i,
Compounds with less than .

These basic nitrogen compounds having antibacterial properties may be used alone or in combination of two or more. In addition, these basic nitrogen compounds having antibacterial properties have a 5.0 x 10
Gram equivalent/g or more preferably 1. Ox ID-
'Replace more than gram equivalent/gram. If the filtration OxlO gram equivalent/g is more than 1, it is difficult to provide good antibacterial performance, which is the objective of the present invention, and 1, Ox 1
Even if the substitution exceeds 0-3 mol/g, the antibacterial performance reaches equilibrium and no further improvement in antibacterial performance can be expected.

The medical and sanitary material of the present invention may be composed solely of a molded article having antibacterial properties as described above.

It may also be applied in the form of a mixture with other cotton or synthetic resin moldings. Examples of such materials include medical tape such as pansouko, cut tape, gauze,
Such as bandages, sanitary products, diapers, sanitary products, etc.
The main use is for direct contact with the skin or affected area, but there is no need to limit it to this.

The medical and sanitary material of the present invention has extremely high antibacterial properties, for example, when compared to gauze made of ordinary nylon stable spun yarn.

After one day of practical use, the number of cultured bacteria (bacteria such as Escherichia coli and staphylococcus) was O for the gauze of the present invention, whereas 40,000/(2)2 #I bacteria were found for the above gauze made of normal nylon. There is a significant difference in that it emits an unusual odor.

The present invention will be further explained below with reference to Examples.

Example 1. Comparative Examples 1 and 2 By kraft polymerizing acrylic acid, carboxyl groups were introduced in an amount of 2 gram equivalents/gram fiber. A tape-shaped plain weave fabric made of 6-nylon fibers (5 d x 88 m) was placed in an aqueous solution containing 0% by weight of lauryl dimethyl benzyl ammonium chlorite cuff (ti per weight of broken material) at a bath ratio of 1:50. 95
A heat treatment was performed at °C for 20 minutes to perform a displacement treatment. It was found from the weight change of 2 that this product was substituted with 33 x 10 mol/g of lauryl dimethyl benzyl ammonium chloride.

Is the antibacterial property of this product JIS Z-2'? Measured by method No. 11. The results were as shown in the table below.

Note that as a comparative example, no acidic group was introduced.

Tape-shaped plain fabric made of ordinary 6-nylon (Comparative Example 1
), a tape-shaped plain fabric made of 100% natural cotton (Comparative Example 2) which was subjected to substitution treatment with a basic nitrogen compound in the same manner as in this example also exhibited antibacterial properties.

This mold resistance was determined based on the JIS 22911 criteria.

3: No growth of hyphae is observed.

2: Mycelial growth is less than 1/3 of the total product volume.

1: Growth of hyphae exceeds 1/3 of the total area.

Also, washing once means washing in a household washing machine.

Commercially available neutral detergent Zabu (Kao Soap Co., Ltd.) 2 g/
I! This means washing by operating at 40°C for 20 minutes using a washing liquid consisting of:

Example 2. Comparative Example 6 Similar to Example 1, the carboxyl group was 1.4 x I
D-' Gram equivalent/gram fiber introduced. A gauze fabric made of polyamide fibers (3dx54cm).

In an aqueous solution containing 5 g/l of cetyl dimethyl be/dyl ammonium bromide, the bath ratio was 1:5.
After heating to 95° C. so that the temperature was 0.0, the temperature was raised to 95° C., and then treated for 60 minutes. This material was substituted with cetyl dimethyl benzyl ammonium promyol, 5.1 x 10 moles/gram (based on the weight of the material to be treated). Similar to Example 1, the antibacterial property was examined based on J-Ko S-Z-2911, and it was found to have good performance with excellent wash resistance (this example).

For reference, in place of cetyl dimethyl-benzyl ammonium furomite in this example, octyl dimethyl-benzyl ammonium
Although treated with pyridinium bromide (Comparative Example 6), it was not possible to impart good antibacterial properties as in the two examples.

Example Ordinary polyester fiber (1.5a x 44m
) 65 pieces of gauze and 35 pieces of cotton were graft-modified with acrylic acid to form a 4.2 x 10 gauze on polyester.
A gram equivalent/gram fiber carboxyl group was introduced. Next, this material was treated with dimethyl benzyl ammonium chloride in the same manner as in Example 1 to produce medical gauze.

Similar to Example 1, this material was an antibacterial material with excellent wash resistance. As a comparison, a gauze of the same W as that of this example without introducing a carboxyl group was treated with dimethyl benzyl ammonium chloride, but the wash resistance was poor.

Example 6 A 48 count single spun yarn made of ordinary polyacrylonitrile fibers 5 d x 76 am was woven into a medical bandage, and the bandage was immersed in an aqueous solution consisting of 2011 hydroxide with a hydration power of 1, and heated to raise the temperature. It was then treated at 95°C for 3 UJ minutes. Next, after rinsing with water, the object to be treated is immersed in an aqueous solution containing lau 1) trimethyl ammonium fluoride in an amount of over 20% by weight, and heated to raise the temperature.
95'a for 30 minutes.

Heat treated.

This bandage was extremely antibacterial.

Claims (1)

[Claims] A molded product made of polyamide, polyester or polyacrylonitrile resin having acidic groups of 5×10 gram equivalent/gram or more is substituted with a quaternary nitrogen compound having antibacterial properties of 3.0×10 mol/gram or more. Medical products consisting of modified molded products containing Sanitary materials.