CN112353996A - Method for manufacturing soluble hemostatic gauze - Google Patents
Method for manufacturing soluble hemostatic gauze Download PDFInfo
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- CN112353996A CN112353996A CN202011332584.4A CN202011332584A CN112353996A CN 112353996 A CN112353996 A CN 112353996A CN 202011332584 A CN202011332584 A CN 202011332584A CN 112353996 A CN112353996 A CN 112353996A
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Abstract
The invention discloses a method for manufacturing soluble hemostatic gauze, which belongs to the technical field of hemostatic gauze production and comprises the following steps: s1, preparing the following raw materials in parts by weight: 6-14 parts of rosin, 3-8 parts of alum, 5-9 parts of chitosan, 7-12 parts of konjac glucomannan, 23-55 parts of water, 4-12 parts of fructus forsythiae, 3-9 parts of fructus gardeniae, 2-5 parts of coptis chinensis, 7-14 parts of honeysuckle, 12-28 parts of calcined gypsum, 6-15 parts of bletilla striata, 6-11 parts of radix ampelopsis, 12-21 parts of polyethylene glycol terephthalate, 5-13 parts of polyacrylonitrile, 8-19 parts of an organic solvent, 25-38 parts of sodium hydroxide and 12-27 parts of an ethanol solution; the invention improves the hemostatic performance of the gauze, enables the gauze to have good wound healing effect, can help the wound to heal quickly, improves the recovery speed of patients, has good air permeability and water absorbability, and improves the solubility of fiber materials.
Description
Technical Field
The invention belongs to the technical field of hemostatic gauze production, and particularly relates to a method for manufacturing soluble hemostatic gauze.
Background
The gauze is a non-woven fabric, which is a non-woven fabric formed by directly utilizing high polymer slices, short fibers or filaments to form a net through air flow or machinery, then spunlacing, needling or hot rolling reinforcement is carried out, and finally after finishing, the non-woven fabric has a soft, breathable and planar structure, has the advantage of not generating fiber scraps, but the existing gauze has poor antibacterial performance, poor surface texture and toughness strength and poor use quality, so the problem is solved by a manufacturing method of the soluble hemostatic gauze.
Disclosure of Invention
The invention aims to provide a method for manufacturing soluble hemostatic gauze, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a method for manufacturing soluble hemostatic gauze comprises the following steps:
s1, preparing the following raw materials in parts by weight: 6-14 parts of rosin, 3-8 parts of alum, 5-9 parts of chitosan, 7-12 parts of konjac glucomannan, 23-55 parts of water, 4-12 parts of fructus forsythiae, 3-9 parts of fructus gardeniae, 2-5 parts of coptis chinensis, 7-14 parts of honeysuckle, 12-28 parts of calcined gypsum, 6-15 parts of bletilla striata, 6-11 parts of radix ampelopsis, 12-21 parts of polyethylene glycol terephthalate, 5-13 parts of polyacrylonitrile, 8-19 parts of an organic solvent, 25-38 parts of sodium hydroxide and 12-27 parts of an ethanol solution;
s2, preparation of a hemostatic agent: grinding Colophonium and Alumen, mixing, adding chitosan, konjac glucomannan and water, and stirring to obtain hemostatic;
s3, preparation of a healing agent: mixing fructus forsythiae, fructus Gardeniae, Coptidis rhizoma, flos Lonicerae, Gypsum Fibrosum Preparatum, rhizoma Bletillae, and radix Ampelopsis, decocting with water, and filtering to obtain filtrate as healing agent;
s4, preparing the spinning raw stock fiber: mixing and dissolving polyethylene glycol terephthalate, polyacrylonitrile and an organic solvent, stirring and dissolving the mixture strongly at 90-115 ℃ for 450min to prepare a semi-finished product of the spinning virgin stock fiber, and then activating the semi-finished product by using a sodium hydroxide and ethanol solution to prepare the spinning virgin stock fiber;
s5, preparing a fiber membrane: slowly injecting the spinning raw stock fiber into a spinning raw material tank through a pump, slowly increasing the speed to 100r/s at the speed of 10r/s until the speed reaches a constant speed, opening a spinning hole of a centrifugal tank of a centrifugal spinning machine, and carrying out centrifugal spinning on the spinning raw stock fiber under the action of gravity and centrifugal force to obtain a fiber membrane;
s6, preparing the hemostatic and healing fiber: placing the fiber membrane in a vacuum drying oven for drying for 4h, bathing with a hemostatic agent, placing in the vacuum drying oven for drying for 6h after bathing, then placing the fiber filament in a healing agent for bathing, placing in the vacuum drying oven for drying for 6h after bathing, and then oiling the fiber filament to obtain the hemostatic healing fiber;
s7, treating the hemostatic healing fiber with chloroacetic acid reaction liquid for 4-8 hours, then adjusting the pH to 6.5-7.5 with hydrochloric acid solution, finally washing with deionized water, and then drying at the drying temperature of 80-120 ℃ to obtain the soluble hemostatic gauze; and (3) winding the dried gauze by a roller in a winding machine under the condition of 0.1r/min to obtain the antibacterial gauze.
Further, the S1 is prepared from the following raw materials in parts by weight: preparing the following raw materials in parts by weight: 8-14 parts of rosin, 4-8 parts of alum, 6-9 parts of chitosan, 8-12 parts of konjac glucomannan, 25-55 parts of water, 5-12 parts of fructus forsythiae, 4-9 parts of fructus gardeniae, 3-5 parts of coptis chinensis, 8-14 parts of honeysuckle, 15-28 parts of calcined gypsum, 9-15 parts of bletilla striata, 8-11 parts of radix ampelopsis, 14-21 parts of polyethylene glycol terephthalate, 7-13 parts of polyacrylonitrile, 9-19 parts of an organic solvent, 27-38 parts of sodium hydroxide and 15-27 parts of an ethanol solution.
Further, the S1 is prepared from the following raw materials in parts by weight: preparing the following raw materials in parts by weight: 10 parts of rosin, 6 parts of alum, 7 parts of chitosan, 9 parts of konjac glucomannan, 38 parts of water, 8 parts of fructus forsythiae, 6 parts of fructus gardeniae, 4 parts of coptis chinensis, 11 parts of honeysuckle, 20 parts of calcined gypsum, 10 parts of bletilla striata, 8 parts of radix ampelopsis, 17 parts of polyethylene terephthalate, 8 parts of polyacrylonitrile, 14 parts of an organic solvent, 32 parts of sodium hydroxide and 20 parts of an ethanol solution.
Further, the S1 is prepared from the following raw materials in parts by weight: preparing the following raw materials in parts by weight: 6-13 parts of rosin, 3-7 parts of alum, 5-8 parts of chitosan, 7-11 parts of konjac glucomannan, 23-45 parts of water, 4-10 parts of fructus forsythiae, 3-8 parts of fructus gardeniae, 2-4 parts of coptis chinensis, 7-13 parts of honeysuckle, 12-23 parts of calcined gypsum, 6-12 parts of bletilla striata, 6-10 parts of radix ampelopsis, 12-18 parts of polyethylene glycol terephthalate, 5-9 parts of polyacrylonitrile, 8-15 parts of an organic solvent, 25-33 parts of sodium hydroxide and 12-22 parts of an ethanol solution.
Further, in the step S7, the soluble hemostatic gauze can be obtained by drying at the temperature of 80-120 ℃.
Further, in the step S6, the temperature of the vacuum drying oven is 120-145 ℃, and the drying time is 4 hours.
Further, in the step S4, the sodium hydroxide concentration is 2mol/L sodium hydroxide, the ethanol solution is 66% ethanol solution, and the activation temperature is 40-60 ℃.
Compared with the prior art, the invention has the beneficial effects that:
the hemostatic agent is prepared by grinding and mixing rosin and alum, then adding chitosan, konjac glucomannan and water, mixing and stirring, and is blended into gauze, so that the hemostatic performance of the gauze is greatly improved;
fructus forsythiae, fructus gardeniae, coptis chinensis, honeysuckle, calcined gypsum, bletilla striata and radix ampelopsis are mixed and blended into a healing agent, so that the gauze has a good effect of healing wounds, can help the wounds to heal more quickly, and can improve the recovery speed of patients;
the gauze is prepared by taking polyethylene glycol terephthalate, polyacrylonitrile and an organic solvent as raw materials, so that the produced gauze has excellent flexibility, good air permeability and water absorbability and improved solubility of fiber materials.
The invention improves the hemostatic performance of the gauze, enables the gauze to have good wound healing effect, can help the wound to heal quickly, improves the recovery speed of patients, has good air permeability and water absorbability, and improves the solubility of fiber materials.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.
Example one
The invention provides a method for manufacturing soluble hemostatic gauze, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 6 parts of rosin, 3 parts of alum, 5 parts of chitosan, 7 parts of konjac glucomannan, 23 parts of water, 4 parts of fructus forsythiae, 3 parts of cape jasmine, 2 parts of coptis chinensis, 7 parts of honeysuckle, 12 parts of calcined gypsum, 6 parts of bletilla striata, 6 parts of radix ampelopsis, 12 parts of polyethylene terephthalate, 5 parts of polyacrylonitrile, 8 parts of an organic solvent, 25 parts of sodium hydroxide and 12 parts of an ethanol solution;
s2, preparation of a hemostatic agent: grinding Colophonium and Alumen, mixing, adding chitosan, konjac glucomannan and water, and stirring to obtain hemostatic;
s3, preparation of a healing agent: mixing fructus forsythiae, fructus Gardeniae, Coptidis rhizoma, flos Lonicerae, Gypsum Fibrosum Preparatum, rhizoma Bletillae, and radix Ampelopsis, decocting with water, and filtering to obtain filtrate as healing agent;
s4, preparing the spinning raw stock fiber: mixing and dissolving polyethylene terephthalate, polyacrylonitrile and an organic solvent, stirring and dissolving strongly at 90 ℃ for 300min to obtain a semi-finished product of the spinning virgin stock fiber, and activating with a sodium hydroxide and ethanol solution to obtain the spinning virgin stock fiber;
s5, preparing a fiber membrane: slowly injecting the spinning raw stock fiber into a spinning raw material tank through a pump, slowly increasing the speed to 100r/s at the speed of 10r/s until the speed reaches a constant speed, opening a spinning hole of a centrifugal tank of a centrifugal spinning machine, and carrying out centrifugal spinning on the spinning raw stock fiber under the action of gravity and centrifugal force to obtain a fiber membrane;
s6, preparing the hemostatic and healing fiber: placing the fiber membrane in a vacuum drying oven for drying for 4h, bathing with a hemostatic agent, placing in the vacuum drying oven for drying for 6h after bathing, then placing the fiber filament in a healing agent for bathing, placing in the vacuum drying oven for drying for 6h after bathing, and then oiling the fiber filament to obtain the hemostatic healing fiber;
s7, treating the hemostatic healing fiber with chloroacetic acid reaction liquid for 4 hours, then adjusting the pH to 6.5 with hydrochloric acid solution, finally washing with deionized water, and then drying at 80 ℃ to obtain soluble hemostatic gauze; and (3) winding the dried gauze by a roller in a winding machine under the condition of 0.1r/min to obtain the antibacterial gauze.
Example two
The invention provides a method for manufacturing soluble hemostatic gauze, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 10 parts of rosin, 6 parts of alum, 7 parts of chitosan, 9 parts of konjac glucomannan, 38 parts of water, 8 parts of fructus forsythiae, 6 parts of fructus gardeniae, 4 parts of coptis chinensis, 11 parts of honeysuckle, 20 parts of calcined gypsum, 10 parts of bletilla striata, 8 parts of radix ampelopsis, 17 parts of polyethylene terephthalate, 8 parts of polyacrylonitrile, 14 parts of an organic solvent, 32 parts of sodium hydroxide and 20 parts of an ethanol solution;
s2, preparation of a hemostatic agent: grinding Colophonium and Alumen, mixing, adding chitosan, konjac glucomannan and water, and stirring to obtain hemostatic;
s3, preparation of a healing agent: mixing fructus forsythiae, fructus Gardeniae, Coptidis rhizoma, flos Lonicerae, Gypsum Fibrosum Preparatum, rhizoma Bletillae, and radix Ampelopsis, decocting with water, and filtering to obtain filtrate as healing agent;
s4, preparing the spinning raw stock fiber: mixing and dissolving polyethylene terephthalate, polyacrylonitrile and an organic solvent, stirring and dissolving under strong force at 103 ℃ for 375min to obtain a semi-finished product of the spinning virgin stock fiber, and activating with a sodium hydroxide and ethanol solution to obtain the spinning virgin stock fiber;
s5, preparing a fiber membrane: slowly injecting the spinning raw stock fiber into a spinning raw material tank through a pump, slowly increasing the speed to 100r/s at the speed of 10r/s until the speed reaches a constant speed, opening a spinning hole of a centrifugal tank of a centrifugal spinning machine, and carrying out centrifugal spinning on the spinning raw stock fiber under the action of gravity and centrifugal force to obtain a fiber membrane;
s6, preparing the hemostatic and healing fiber: placing the fiber membrane in a vacuum drying oven for drying for 4h, bathing with a hemostatic agent, placing in the vacuum drying oven for drying for 6h after bathing, then placing the fiber filament in a healing agent for bathing, placing in the vacuum drying oven for drying for 6h after bathing, and then oiling the fiber filament to obtain the hemostatic healing fiber;
s7, treating the hemostatic healing fiber with chloroacetic acid reaction liquid for 6 hours, then adjusting the pH to 7 with hydrochloric acid solution, finally washing with deionized water, and then drying at 100 ℃ to obtain the soluble hemostatic gauze; and (3) winding the dried gauze by a roller in a winding machine under the condition of 0.1r/min to obtain the antibacterial gauze.
EXAMPLE III
The invention provides a method for manufacturing soluble hemostatic gauze, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 14 parts of rosin, 8 parts of alum, 9 parts of chitosan, 12 parts of konjac glucomannan, 55 parts of water, 12 parts of fructus forsythiae, 9 parts of fructus gardeniae, 5 parts of coptis chinensis, 14 parts of honeysuckle, 28 parts of calcined gypsum, 15 parts of bletilla striata, 11 parts of radix ampelopsis, 21 parts of polyethylene terephthalate, 13 parts of polyacrylonitrile, 19 parts of an organic solvent, 38 parts of sodium hydroxide and 27 parts of an ethanol solution;
s2, preparation of a hemostatic agent: grinding Colophonium and Alumen, mixing, adding chitosan, konjac glucomannan and water, and stirring to obtain hemostatic;
s3, preparation of a healing agent: mixing fructus forsythiae, fructus Gardeniae, Coptidis rhizoma, flos Lonicerae, Gypsum Fibrosum Preparatum, rhizoma Bletillae, and radix Ampelopsis, decocting with water, and filtering to obtain filtrate as healing agent;
s4, preparing the spinning raw stock fiber: mixing and dissolving polyethylene terephthalate, polyacrylonitrile and an organic solvent, stirring and dissolving strongly at 115 ℃ for 450min to obtain a semi-finished product of the spinning virgin stock fiber, and activating with a sodium hydroxide and ethanol solution to obtain the spinning virgin stock fiber;
s5, preparing a fiber membrane: slowly injecting the spinning raw stock fiber into a spinning raw material tank through a pump, slowly increasing the speed to 100r/s at the speed of 10r/s until the speed reaches a constant speed, opening a spinning hole of a centrifugal tank of a centrifugal spinning machine, and carrying out centrifugal spinning on the spinning raw stock fiber under the action of gravity and centrifugal force to obtain a fiber membrane;
s6, preparing the hemostatic and healing fiber: placing the fiber membrane in a vacuum drying oven for drying for 4h, bathing with a hemostatic agent, placing in the vacuum drying oven for drying for 6h after bathing, then placing the fiber filament in a healing agent for bathing, placing in the vacuum drying oven for drying for 6h after bathing, and then oiling the fiber filament to obtain the hemostatic healing fiber;
s7, treating the hemostatic healing fiber with chloroacetic acid reaction liquid for 4-8 hours, then adjusting the pH to 7.5 with hydrochloric acid solution, finally washing with deionized water, and then drying at 120 ℃ to obtain soluble hemostatic gauze; and (3) winding the dried gauze by a roller in a winding machine under the condition of 0.1r/min to obtain the antibacterial gauze.
According to the invention, the rosin and the alum are ground and mixed, and then the chitosan, the konjac glucomannan and the water are added for mixing and stirring to prepare the hemostatic agent which is blended into the gauze, so that the hemostatic performance of the gauze is greatly improved; fructus forsythiae, fructus gardeniae, coptis chinensis, honeysuckle, calcined gypsum, bletilla striata and radix ampelopsis are mixed and blended into a healing agent, so that the gauze has a good effect of healing wounds, can help the wounds to heal more quickly, and can improve the recovery speed of patients; the gauze is prepared by taking polyethylene glycol terephthalate, polyacrylonitrile and an organic solvent as raw materials, so that the produced gauze has excellent flexibility, good air permeability and water absorbability and improved solubility of fiber materials. The invention improves the hemostatic performance of the gauze, enables the gauze to have good wound healing effect, can help the wound to heal quickly, improves the recovery speed of patients, has good air permeability and water absorbability, and improves the solubility of fiber materials.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The method for manufacturing the soluble hemostatic gauze is characterized by comprising the following steps of:
s1, preparing the following raw materials in parts by weight: 6-14 parts of rosin, 3-8 parts of alum, 5-9 parts of chitosan, 7-12 parts of konjac glucomannan, 23-55 parts of water, 4-12 parts of fructus forsythiae, 3-9 parts of fructus gardeniae, 2-5 parts of coptis chinensis, 7-14 parts of honeysuckle, 12-28 parts of calcined gypsum, 6-15 parts of bletilla striata, 6-11 parts of radix ampelopsis, 12-21 parts of polyethylene glycol terephthalate, 5-13 parts of polyacrylonitrile, 8-19 parts of an organic solvent, 25-38 parts of sodium hydroxide and 12-27 parts of an ethanol solution;
s2, preparation of a hemostatic agent: grinding Colophonium and Alumen, mixing, adding chitosan, konjac glucomannan and water, and stirring to obtain hemostatic;
s3, preparation of a healing agent: mixing fructus forsythiae, fructus Gardeniae, Coptidis rhizoma, flos Lonicerae, Gypsum Fibrosum Preparatum, rhizoma Bletillae, and radix Ampelopsis, decocting with water, and filtering to obtain filtrate as healing agent;
s4, preparing the spinning raw stock fiber: mixing and dissolving polyethylene glycol terephthalate, polyacrylonitrile and an organic solvent, stirring and dissolving the mixture strongly at 90-115 ℃ for 450min to prepare a semi-finished product of the spinning virgin stock fiber, and then activating the semi-finished product by using a sodium hydroxide and ethanol solution to prepare the spinning virgin stock fiber;
s5, preparing a fiber membrane: slowly injecting the spinning raw stock fiber into a spinning raw material tank through a pump, slowly increasing the speed to 100r/s at the speed of 10r/s until the speed reaches a constant speed, opening a spinning hole of a centrifugal tank of a centrifugal spinning machine, and carrying out centrifugal spinning on the spinning raw stock fiber under the action of gravity and centrifugal force to obtain a fiber membrane;
s6, preparing the hemostatic and healing fiber: placing the fiber membrane in a vacuum drying oven for drying for 4h, bathing with a hemostatic agent, placing in the vacuum drying oven for drying for 6h after bathing, then placing the fiber filament in a healing agent for bathing, placing in the vacuum drying oven for drying for 6h after bathing, and then oiling the fiber filament to obtain the hemostatic healing fiber;
s7, treating the hemostatic healing fiber with chloroacetic acid reaction liquid for 4-8 hours, then adjusting the pH to 6.5-7.5 with hydrochloric acid solution, finally washing with deionized water, and then drying at the drying temperature of 80-120 ℃ to obtain the soluble hemostatic gauze; and (3) winding the dried gauze by a roller in a winding machine under the condition of 0.1r/min to obtain the antibacterial gauze.
2. The method for making the soluble hemostatic gauze of claim 1, wherein the method comprises the following steps: and S1, preparing the following raw materials in parts by weight: preparing the following raw materials in parts by weight: 8-14 parts of rosin, 4-8 parts of alum, 6-9 parts of chitosan, 8-12 parts of konjac glucomannan, 25-55 parts of water, 5-12 parts of fructus forsythiae, 4-9 parts of fructus gardeniae, 3-5 parts of coptis chinensis, 8-14 parts of honeysuckle, 15-28 parts of calcined gypsum, 9-15 parts of bletilla striata, 8-11 parts of radix ampelopsis, 14-21 parts of polyethylene glycol terephthalate, 7-13 parts of polyacrylonitrile, 9-19 parts of an organic solvent, 27-38 parts of sodium hydroxide and 15-27 parts of an ethanol solution.
3. The method for making the soluble hemostatic gauze of claim 1, wherein the method comprises the following steps: and S1, preparing the following raw materials in parts by weight: preparing the following raw materials in parts by weight: 10 parts of rosin, 6 parts of alum, 7 parts of chitosan, 9 parts of konjac glucomannan, 38 parts of water, 8 parts of fructus forsythiae, 6 parts of fructus gardeniae, 4 parts of coptis chinensis, 11 parts of honeysuckle, 20 parts of calcined gypsum, 10 parts of bletilla striata, 8 parts of radix ampelopsis, 17 parts of polyethylene terephthalate, 8 parts of polyacrylonitrile, 14 parts of an organic solvent, 32 parts of sodium hydroxide and 20 parts of an ethanol solution.
4. The method for making the soluble hemostatic gauze of claim 1, wherein the method comprises the following steps: and S1, preparing the following raw materials in parts by weight: preparing the following raw materials in parts by weight: 6-13 parts of rosin, 3-7 parts of alum, 5-8 parts of chitosan, 7-11 parts of konjac glucomannan, 23-45 parts of water, 4-10 parts of fructus forsythiae, 3-8 parts of fructus gardeniae, 2-4 parts of coptis chinensis, 7-13 parts of honeysuckle, 12-23 parts of calcined gypsum, 6-12 parts of bletilla striata, 6-10 parts of radix ampelopsis, 12-18 parts of polyethylene glycol terephthalate, 5-9 parts of polyacrylonitrile, 8-15 parts of an organic solvent, 25-33 parts of sodium hydroxide and 12-22 parts of an ethanol solution.
5. The method for making the soluble hemostatic gauze of claim 1, wherein the method comprises the following steps: and in the S7, the drying temperature is 80-120 ℃ to obtain the soluble hemostatic gauze.
6. The method for making the soluble hemostatic gauze of claim 1, wherein the method comprises the following steps: in the S6, the temperature of the vacuum drying oven is 120-145 ℃, and the drying time is 4 h.
7. The method for making the soluble hemostatic gauze of claim 1, wherein the method comprises the following steps: in the S4, the sodium hydroxide concentration is 2mol/L sodium hydroxide, the ethanol solution is 66% ethanol solution, and the activation temperature is 40-60 ℃.
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| CN113577365A (en) * | 2021-07-30 | 2021-11-02 | 湖南联肯信息技术咨询有限公司 | Breathable anti-inflammation antibacterial medical non-woven fabric |
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