JPS5813526B2 - Grasshopper's garden - Google Patents
Grasshopper's gardenInfo
- Publication number
- JPS5813526B2 JPS5813526B2 JP3500874A JP3500874A JPS5813526B2 JP S5813526 B2 JPS5813526 B2 JP S5813526B2 JP 3500874 A JP3500874 A JP 3500874A JP 3500874 A JP3500874 A JP 3500874A JP S5813526 B2 JPS5813526 B2 JP S5813526B2
- Authority
- JP
- Japan
- Prior art keywords
- salts
- cloxacillin
- cefazolin
- grasshopper
- garden
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
【発明の詳細な説明】
この発明はセファゾリンもしくはその塩類１重量部およ
びクロキサシリンもしくはその塩類約１〜１０００重量
部を含む新規な牛乳房炎用殺菌粗成物に関するものであ
る。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel antiseptic crude product for bovine mastitis containing 1 part by weight of cefazolin or a salt thereof and about 1 to 1000 parts by weight of cloxacillin or a salt thereof.
セファゾリンもしくはその塩類およびクロキサシリンも
しくはその塩類は、それぞれ広範囲な抗菌スペクトラム
を有する抗生物質としてよく知られている。Cefazolin or its salts and cloxacillin or its salts are well known as antibiotics each having a broad antibacterial spectrum.
この発明者等は鋭意研究の結果、セファゾリンもしくは
その塩類およびクロキサシリンもしくはその塩類が協力
作用を有しているという新知見を得、この発明を完成し
た。As a result of intensive research, the inventors obtained the new finding that cefazolin or its salts and cloxacillin or its salts have a synergistic effect, and completed this invention.
この発明の目的の一つは、セファゾリンもしくはその塩
類およびクロキサシリンもしくはその塩類をそれぞれ単
独で使用した場合には、抗菌活性を示さないかあるいは
ほとんど示さない病原菌、殊に、プロテウス等の如きダ
ラム陰性菌に対して、セファゾリンもしくはその塩類お
よびクロキサシリンもしくはその塩類を併用することに
より強力な抗菌活性を示す有効な牛乳房炎用殺菌組成物
を提供することにある。One of the objects of the present invention is that when cefazolin or its salts and cloxacillin or its salts are used alone, pathogenic bacteria, particularly Durham-negative bacteria such as Proteus, which exhibit no or almost no antibacterial activity. An object of the present invention is to provide an effective bactericidal composition for bovine mastitis that exhibits strong antibacterial activity by using cefazolin or its salts and cloxacillin or its salts in combination.
また他の目的は、セファゾリンもしくはその塩類および
クロキサシリンもしくはその塩類のそれぞれに耐性を示
す病原菌に対して有効な牛乳房炎用殺菌組成物を提供す
ることにある。Another object of the present invention is to provide a bactericidal composition for bovine mastitis that is effective against pathogenic bacteria that are resistant to cefazolin or its salts and cloxacillin or its salts.
さらに他の目的は、殺菌速度を促進し、治療効果を高め
る牛乳房炎用殺菌組成物を提供することにある。Yet another object is to provide a disinfectant composition for bovine mastitis that accelerates the disinfection rate and enhances the therapeutic effect.
この発明は、セファゾリンもしくはその塩類およびクロ
キサシリンもしくはその塩類を含む牛乳房炎用殺菌組成
物であるが、ここで塩類としては例えばナトリウム、カ
リウム、カルシウム等の金属塩、アンモニウム塩および
トリメチルアミン、トリエチルアミン、プロカイン、ジ
ベンジルアミン塩等の通常セファロスポリンおよびペニ
シリンの塩として用いられる塩が挙げられる。The present invention is a sterilizing composition for bovine mastitis containing cefazolin or its salts and cloxacillin or its salts, where the salts include, for example, metal salts such as sodium, potassium, and calcium, ammonium salts, and trimethylamine, triethylamine, and procaine. and dibenzylamine salts, which are commonly used as salts of cephalosporins and penicillins.
この発明の動物用殺菌組成物は、公知のペニシリン製剤
等抗生物質製剤と同様な剤形、使用方法で用いられるが
、注乳剤として使用するのが適当である。The sterilizing composition for animals of the present invention can be used in the same dosage form and method of use as known antibiotic preparations such as penicillin preparations, but it is suitable to use it as an emulsion.
またこの動物用殺菌組成物を局所に撒布することができ
、さらには軟膏としても使用できる。This antiseptic composition for animals can also be applied topically and can even be used as an ointment.
注射剤、注入剤として使用する際には、通常注射剤、注
入剤に使用される公知の抗生物質注射剤、注入剤で使用
する固体または液体の担体、あるいは稀釈剤と共に混合
して使用することもできる。When used as an injection or infusion, it should be mixed with a solid or liquid carrier or diluent used in known antibiotic injections or infusions. You can also do it.
このうち、担体としては、水、パラフィン類が最も繁用
される。Among these, water and paraffins are most frequently used as carriers.
また軟膏として使用する場合には、通常使用される軟膏
基剤と共に使用される。When used as an ointment, it is used together with a commonly used ointment base.
またこの発明の牛乳房炎用殺菌組成物の投与量は、セフ
ァゾリンもしくはその塩類およびクロキサシリンもしく
はその塩類の混合比、感染症の種類あるいは症状等に応
じて適宜選択されるが、通常例えば泌乳期においては２
００ｍｇ／牛位が適当である。The dosage of the sterilizing composition for bovine mastitis of the present invention is appropriately selected depending on the mixing ratio of cefazolin or its salts and cloxacillin or its salts, the type of infection or symptoms, etc., but usually, for example, during the lactation period. is 2
00mg/cow is appropriate.
次にこの発明の効果を試験例により説明する。Next, the effects of this invention will be explained using test examples.
試験例 １
牛の乳房炎より分離した菌株に対する試験管内発育阻止
試験による併用効果：
クロキサシリンおよびセファゾリンの各所定量を含有す
るハートインフエージョン培地を用い、これに各病原菌
の約１０５／ｍｌ（細肪数／ｍｌ）を植菌し、３７℃で
２０時間培養したのち、被検病原菌の生育状況を測定し
た。Test Example 1 Combined effect on bacterial strains isolated from mastitis in cows by in vitro growth inhibition test: Using Heart Infusion medium containing predetermined amounts of each of cloxacillin and cefazolin, approximately 10 After culturing at 37° C. for 20 hours, the growth status of the pathogenic bacteria to be tested was measured.
結果は次表のとおりで、各表中＋は被検菌の生育するこ
とを、一は生育しないことを意味する。The results are shown in the following table, where + in each table means that the test bacteria grew, and 1 means that the test bacteria did not grow.
次にこの発明の実施例を示す。Next, examples of this invention will be shown.
実施例 １
セファゾリンナトリウム １００ｍｇクロキサ
シリン １００ｍｇラネット・ワック
スＳ・Ｘ（商標） ５０ｍｇ軟質パラフィン
１００ｍｇ食用青色 １号
２５ｍｇ上記を液体パラフィンと混合し全体を３ｇと
して注入剤とする。Example 1 Cefazolin sodium 100mg Cloxacillin 100mg Lanette Wax S.X (trademark) 50mg Soft paraffin
100mg food blue No. 1
Mix 25 mg of the above with liquid paraffin to make a total of 3 g and use it as an injection.
Claims (1)
キサシリンもしくはその塩類約１〜１０００重量部を含
む牛乳房炎用殺菌組成物。1. A disinfectant composition for bovine mastitis containing 1 part by weight of cefazolin or a salt thereof and about 1 to 1000 parts by weight of cloxacillin or a salt thereof.
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3500874A JPS5813526B2 (en) | 1974-03-27 | 1974-03-27 | Grasshopper's garden |
| IT6748475A IT1036078B (en) | 1974-03-27 | 1975-02-25 | Beta-Lactam antibiotic combination preparations - contg a 7-tetrazolylacetamido-cephem cpd and penicillin |
| FR7506201A FR2262519B1 (en) | 1974-02-28 | 1975-02-27 | |
| AU78654/75A AU490435B2 (en) | 1975-02-27 | Antibacterial composition | |
| NL7502333A NL180071C (en) | 1974-02-28 | 1975-02-27 | METHOD FOR PREPARING MEDICINES WITH AN ANTIBIOTIC ACTIVITY |
| GB832775A GB1479838A (en) | 1974-02-28 | 1975-02-27 | Antibacterial composition |
| DE19752508443 DE2508443C2 (en) | 1974-02-28 | 1975-02-27 | Mixed pharmaceutical preparation with antibiotic effect |
| CA221,406A CA1038759A (en) | 1974-03-27 | 1975-03-06 | Mixtures of cephalosporin and penicillin type antibiotics |
| DK132675A DK132675A (en) | 1974-03-27 | 1975-03-26 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3500874A JPS5813526B2 (en) | 1974-03-27 | 1974-03-27 | Grasshopper's garden |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS50126816A JPS50126816A (en) | 1975-10-06 |
| JPS5813526B2 true JPS5813526B2 (en) | 1983-03-14 |
Family
ID=12430047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3500874A Expired JPS5813526B2 (en) | 1974-02-28 | 1974-03-27 | Grasshopper's garden |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5813526B2 (en) |
| CA (1) | CA1038759A (en) |
| DK (1) | DK132675A (en) |
| IT (1) | IT1036078B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0214046Y2 (en) * | 1983-08-22 | 1990-04-17 | ||
| JPH0310514Y2 (en) * | 1983-02-15 | 1991-03-15 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54126735A (en) * | 1978-03-24 | 1979-10-02 | Toyama Chem Co Ltd | Bactericidal composition for medical use |
| JPH0582374U (en) * | 1992-04-08 | 1993-11-09 | 元実 原田 | Clothes cover |
-
1974
- 1974-03-27 JP JP3500874A patent/JPS5813526B2/en not_active Expired
-
1975
- 1975-02-25 IT IT6748475A patent/IT1036078B/en active
- 1975-03-06 CA CA221,406A patent/CA1038759A/en not_active Expired
- 1975-03-26 DK DK132675A patent/DK132675A/da not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0310514Y2 (en) * | 1983-02-15 | 1991-03-15 | ||
| JPH0214046Y2 (en) * | 1983-08-22 | 1990-04-17 |
Also Published As
| Publication number | Publication date |
|---|---|
| DK132675A (en) | 1975-09-28 |
| CA1038759A (en) | 1978-09-19 |
| JPS50126816A (en) | 1975-10-06 |
| IT1036078B (en) | 1979-10-30 |
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