JPS58124711A - Skin cosmetic - Google Patents
Skin cosmeticInfo
- Publication number
- JPS58124711A JPS58124711A JP838782A JP838782A JPS58124711A JP S58124711 A JPS58124711 A JP S58124711A JP 838782 A JP838782 A JP 838782A JP 838782 A JP838782 A JP 838782A JP S58124711 A JPS58124711 A JP S58124711A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- salts
- levulinic acid
- cosmetic
- lotion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は、皮膚角質層のターンオーバー速度(皮膚再生
速度)を促進し、肌に対する美化作用を有する皮膚化粧
料に関すゐ。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a skin cosmetic that promotes the turnover rate of the stratum corneum (skin regeneration rate) and has a beautifying effect on the skin.
従来、レブリン酸及びその塩類はと一ケト駿の最も代表
的な化合物として樹脂添加剤、消削、医薬、工業薬品、
香料中間体として用いられている。また、レブリン酸ま
たシその亭の持つ溶解性から脱毛剤の配合成分(#許出
11A会開52−79055)として、静電効果からヘ
ヤーリンス剤の配合成分(4I許出願公告54−404
14)として用いられている。Conventionally, levulinic acid and its salts have been used as the most representative compounds for resin additives, erasing agents, pharmaceuticals, industrial chemicals,
Used as a fragrance intermediate. In addition, due to the solubility of levulinic acid or Shisonotei, it is used as a compounding ingredient in depilatory agents (#11A Kaikai 52-79055), and as a compounding ingredient in hair rinses (4I patent application publication 54-404) due to its electrostatic effect.
14).
しかしながら、従来公知の文献にはレブリン駿i九はそ
の塩類の皮膚に対する美化作用勢については開示されて
いない、一般に、加齢現象に伴い、表皮細胞を再(する
働きが弱まり細胞自体が萎縮し皮膚のきめ、はり、つや
等が失なわれることが知られている0表皮角質層のター
ンオーバー速t(皮膚再生速*)は20代の女性で14
〜16日、40代の女性で15〜18日、60代の女性
で16〜20日前後であp、そしてターンオーバー速度
の適度な促進は一山番に伴う肌のおとろえを防ぎ、皮膚
自体の老化を防止し、良好な皮膚のきめ、はシ、つやを
維持させると言われている。However, the previously known literature does not disclose the beautifying effect of salts on the skin.In general, with aging, the ability to regenerate epidermal cells weakens and the cells themselves atrophy. It is known that skin texture, firmness, luster, etc. are lost.The turnover rate t (skin regeneration rate*) of the stratum corneum is 14 for women in their 20s.
Approximately 16 days, 15 to 18 days for women in their 40s, and 16 to 20 days for women in their 60s, and moderate promotion of turnover rate prevents the skin from softening due to Ichisanban, and improves the skin itself. It is said to prevent skin aging and maintain good skin texture, radiance, and luster.
本発明者等は、人体に対する生理作用について腐肉質層
のターンオーバー速度(皮膚再生速度)・を促進させ、
皮膚機能を冗遇し加齢に伴い表皮細胞を再生する働きが
弱まり、細胞自体が萎縮し皮膚のハリが失なわれるのを
防ぎ、老化を防止し、肌鳳こまやかな、しっとりとした
色ツヤのある皮膚にする所謂、肌に対する美化作用を^
備発現することを見い出し、本発明を完成した。The present inventors promoted the turnover rate (skin regeneration rate) of the carrion layer with regard to physiological effects on the human body,
As we age, the ability to regenerate epidermal cells weakens and the cells themselves atrophy, preventing the skin from losing its firmness, preventing aging and improving the skin's fine, moisturized color and luster. So-called beautifying effect on the skin that makes the skin smooth ^
The present invention has been completed based on the discovery that the present invention can be carried out in the same way.
本発明は、肌に対して、上述のすぐれ丸美化作用を有す
る新規な皮膚化粧料を提供することにある。The object of the present invention is to provide a novel skin cosmetic having the above-mentioned excellent beautifying effect on the skin.
すなわち、本発明はレブリン酸および/lたはその塩を
処方成分の総量に対してα05〜α7?い
重量%含有量ことを特徴とする皮膚化粧料である。That is, the present invention uses levulinic acid and /l or its salts at α05 to α7? based on the total amount of prescription ingredients. It is a skin cosmetic product characterized by a high content by weight.
皺記のレブリン酸の塩類としては1例えば、アン毫ニウ
ム塩、トリエタノールアミン塩などのアルカノ−ルアき
ン塩、ナトリウム塩、カリウム塩等のアルカリ金属塩、
カルシウム塩、マグネシウム塩等のアルカリ土類金属塩
等を挙げることができる。Examples of the salts of levulinic acid in Kajiki include: 1. Alkanol acine salts such as ammonium salts and triethanolamine salts; alkali metal salts such as sodium salts and potassium salts;
Examples include alkaline earth metal salts such as calcium salts and magnesium salts.
本発明におけるレブリン酸をよび/lえはその塩類の含
有量(配合量)は、皮膚化粧料の処方成分総量に対して
α05〜170重量X、好壇しくはα1〜α5重量%で
ある。α0505重量%も少ないと角質層の皮膚再生適
度を促進せず、また前述の知音皮膚に対する美化作用を
発現することができない、α’70重量%よ艶も多くな
ると、変色、変臭、沈澱物や凝集粒子(所謂プッを生成
する為、使用時のとれ、伸び中肌なじみがわるくなる。The content (blended amount) of levulinic acid and its salts in the present invention is α05 to 170% by weight, preferably α1 to α5% by weight, based on the total amount of prescription ingredients of the skin cosmetic. If α0505% by weight is too low, it will not promote proper skin regeneration of the stratum corneum, and the above-mentioned beautifying effect on the skin will not be achieved. Because it generates agglomerated particles (so-called puffiness), it comes off during use and does not blend well with the skin during stretching.
まえ角質層の皮膚再生速度を促進する効果も減少する為
皮膚に対する兼化作用が弱くなる。Furthermore, the effect of accelerating the skin regeneration rate of the stratum corneum is also reduced, so the chemical effect on the skin is weakened.
本発明の化粧料はレブリン酸ま大はその塩類を皮膚化粧
料、例えば、化粧クリーム、乳液に直接添加するか%ま
たはそれらの水相部分に予め溶解しておくか、あるいは
水相の一部に予め溶解したものを添加配合して乳化、混
合1分散、塩類は、安定で経時的に皮膚に吸収されて、
細胞を賦活し皮膚の機能を几遇し、皮膚角質層のターン
オーバー速度(皮膚再生速度)を促進させ、更に化粧料
中に共存する他の成分と相俟って顕著な皮膚の傭康状態
の改善と美化を増進しる他の効果は、皮膚化粧料の種類
等によって着干異なる場合があるがそれらの詳細は後述
する。The cosmetics of the present invention can be prepared by adding levulinic acid or its salts directly to skin cosmetics, such as cosmetic creams and emulsions, or by dissolving them in advance in their aqueous phases, or by adding levulinic acid or its salts to skin cosmetics, such as cosmetic creams and emulsions, or by dissolving them in advance in their aqueous phases. By adding and blending pre-dissolved salts, emulsifying, mixing and dispersing, salts are stable and absorbed into the skin over time.
Activates cells, takes care of skin functions, promotes the turnover rate of the skin's stratum corneum (skin regeneration rate), and furthermore, works in conjunction with other ingredients coexisting in cosmetics to create a remarkable state of skin health. Other effects that improve skin appearance and enhance beautification may vary depending on the type of skin cosmetic, etc., and details of these will be described later.
または
なお本発明に使用するレブリンかTあ塩類の皮膚刺激に
ついては後記のドレイズの方法に準じて行なった結果、
動物皮膚刺激スコアー、人体皮膚刺激スコアーは何れも
0で何れも無刺激であることを認めている。Furthermore, regarding skin irritation caused by levulin or T salts used in the present invention, results were obtained according to the Draize method described below.
Both the animal skin irritation score and the human skin irritation score were 0, indicating no irritation.
[Drsiiz@、7.H,、Asgoclation
of Food and Drg offioiml
sof the Unitsd ata%@a
Appraisal of the E
kf@%7 ofOhsmicals in Foo
ds Drug and C<m*%1oa、 46
(195?)TaX&s、 5tate Depar
tment of Health、 Augtin
〕以下本発明の種々の皮膚化粧料に2いて詳説する。[Drsiiz@, 7. H, Asgocration
of Food and Drug offioiml
so the units at%@a
Appraisal of the E
kf@%7 ofOhsmicals in Foo
ds Drug and C<m*%1oa, 46
(195?)TaX&s, 5tate Depar
tment of Health, Augustin
] Hereinafter, various skin cosmetics of the present invention will be explained in detail.
(1)ローシロン類
本発明は例えばアンセント化粧水、整肌化粧水、収れん
性化粧水、アフターシェープローシー7、カラミンロー
シ■ン、メイクアップ透明ローシ冒ン、栄養エツセンス
、tンタンローシ諺ン、iルキイローシ1ン等種々の塩
類の配合量は、処方成分の総量に対してα05%〜[1
7重量%、好1しくFA、(LIX〜(LSよりて皮膚
角質層ターンオーバー速度を促進し、肌に対する親和性
(肌倉じ皐)を嵐好倉らしめ、肌に艶、は如を与えるこ
とができる。(1) Loshirons The present invention includes, for example, Enscent Lotion, Skin Conditioning Lotion, Astringent Lotion, After Shape Lotion 7, Calamine Lotion, Makeup Transparent Lotion, Nutritional Essence, Tontan Loshi Proverbs, and I-Lukiirosi 1. The blending amount of various salts such as salts should be α05% to [1
7% by weight, preferably FA, (LIX~(LS) promotes the turnover rate of the skin's stratum corneum, has an affinity for the skin (Hadakura Jigo) like Arashikokura, and makes the skin shiny and smooth. can give.
アルコールの配合量は処方成分の総量に対して高々20
重量%、好ましくはtO〜10重量%である。The amount of alcohol added is at most 20% of the total amount of prescription ingredients.
% by weight, preferably from tO to 10% by weight.
配合される他の成分としては、香料1着色剤。Other ingredients that are blended include fragrance 1 coloring agent.
防腐側部の他、必要に応じて収れん剤、皮膚栄養剤、消
炎側顔料、紫外線吸収剤、可溶化剤(前述の乳化剤)保
湿剤、PH調整剤側部配合される。In addition to the antiseptic side, an astringent, a skin nutrient, an anti-inflammatory pigment, an ultraviolet absorber, a solubilizer (the above-mentioned emulsifier), a humectant, and a PH adjuster are added to the side as necessary.
前記のカラぽンローシ璽ン、メイクアップ透明ローシ■
ン(水性メイクアップベース)に社、顔料(例えば、黄
色酸化鉄赤色駿化鉄、黒酸化鉄、タルク、酸化チタン、
カオリン等)が配合される。The above-mentioned carapon lotion, make-up transparent lotion ■
Pigments (e.g., yellow iron oxide, red iron sulfide, black iron oxide, talc, titanium oxide,
Kaolin, etc.) are blended.
顔料の配合量は高々10重量%、好ましくはα5〜7重
1%である。The amount of pigment blended is at most 10% by weight, preferably 1% by weight of α5-7.
本発明で得られるローシ曹ン類は、長期保存しても沈澱
物の生成や変色、変臭を惹起することなく極めて安定で
、皮膚刺激なく、肌に栄養と滑らかな感触と良好亀艷、
はりを与え、肌にじみが良い勢、レブシン駿および/ま
たはその塩類の作用効果の勢異性は着しい。The rosin soda obtained by the present invention is extremely stable without forming precipitates, discoloration, or odor even when stored for a long period of time, does not irritate the skin, provides nutrition to the skin, has a smooth texture, and has a good texture.
The effects of levcin and/or its salts are quite different, as it gives firmness and spreads well on the skin.
(21クリーム状または乳液状の皮膚化粧料本発明は1
例えば、マツサージクリーム、クレンジングクリーム、
スキンクリーム、ナンタンクリーム、ファンデージ1ン
クリーム。(21 Cream-like or emulsion-like skin cosmetics The present invention provides 1)
For example, pine surge cream, cleansing cream,
Skin cream, Nantan cream, foundation 1 cream.
液体メイクアップベース、ミルキーローシ冒ン、等のク
リーム状tたは乳液状の皮膚化粧料に適用される。It is applied to creamy or emulsion-like skin cosmetics such as liquid makeup base, milky lotion, etc.
クリーム状、または乳液状の化粧料におけるL/7’リ
ン酸および/またはその塩類のIl量は、処方成分の総
量に対して、α05−α70重量%、好ましくはQ、1
〜(L5重量%である。The amount of Il of L/7' phosphoric acid and/or its salts in cream-like or emulsion-like cosmetics is α05-α70% by weight, preferably Q, 1, based on the total amount of prescription ingredients.
~(L5% by weight.
本発明の当該化粧料は、例えばレプリy酸および/また
はその塩類を、水相成分中に防腐剤、乳化剤等水溶性成
分と共に溶存せしめ。In the cosmetic composition of the present invention, for example, Replic acid and/or its salts are dissolved in the aqueous phase component along with water-soluble components such as preservatives and emulsifiers.
仁の水相成分(約70℃)を溶融した(約70℃の)%
油相成分(油性物質等)と攪拌下に混合して乳化するこ
とによ、て製造される。% of the aqueous phase component (about 70℃) of the kernels melted (about 70℃)
It is manufactured by mixing and emulsifying oil phase components (oil-based substances, etc.) with stirring.
乳化剤としては、界面活性剤(非イオン屋やアニオン証
の界面活性剤)や、ペクチン、カラヤガム、ローカスト
ビーンガム等の界面活性物質が使用される。As the emulsifier, surfactants (non-ionic and anionic surfactants) and surface-active substances such as pectin, karaya gum, and locust bean gum are used.
前記乳化剤の配合量は処方成分の総量に対して通常10
5〜5重量%の範囲内である。The amount of the emulsifier is usually 10% based on the total amount of prescription ingredients.
It is within the range of 5 to 5% by weight.
油性物質としては、炭化水素類、動物油脂類。Oily substances include hydrocarbons and animal fats and oils.
植物油脂類、ワックス類、エステル油醇の公知、慣用の
皮膚化粧料用油性物質が適用される。その配合量は処方
成分の総量に対して通常5〜90重量%である。Known and commonly used oily substances for skin cosmetics such as vegetable oils, waxes, and ester oils may be used. The amount incorporated is usually 5 to 90% by weight based on the total amount of prescription ingredients.
配合される他の成分としては、香料、防腐剤。Other ingredients included are fragrances and preservatives.
顔料等の他、必要に応じて皮膚栄養剤、保湿剤、PH1
ill整剤、紫外線防止剤等を配合することができる。In addition to pigments, skin nutrients, moisturizers, PH1 as necessary
Ill conditioners, ultraviolet light inhibitors, etc. can be added.
前記の液体メイクアップベースやファンデージ讃ンクリ
ームには、#i料が配合される。顔料の配合量は前記ロ
ーシ冒ン類の場合と同様である。#i ingredient is blended into the liquid makeup base and foundation cream. The blending amount of the pigment is the same as in the case of the above-mentioned Roshi pigments.
本発明のクリーム状または乳液状の皮膚化粧料は前述の
如く、長期保存しても沈澱物中凝集粒子(所關プツ)の
生成中変色、変臭を生起することなく、極めて安定で、
使用時にはとれ中伸びや肌なじみが良く、肌に栄養と1
イーりングの良い感触(滑らかな感触)と喪好な艶、は
りを与え得るとと−に乳化安定性、粘度(硬度)安定性
、外観に4優れてお転しブリン駿およびその塩類の作用
効果は著しい。As mentioned above, the cream or emulsion skin cosmetic of the present invention is extremely stable, without causing discoloration or odor during the formation of aggregated particles in the precipitate, even when stored for a long period of time.
When used, it comes off easily and spreads well on the skin, providing nourishment and nourishment to the skin.
It has four excellent properties such as emulsion stability, viscosity (hardness) stability, and appearance, as well as giving good eeling feel (smooth feel), pleasant luster, and firmness. The effect is remarkable.
:5)パック剤
本発明は皮膜型パック剤、拭き取りパックの塩類の配合
量は、処方成分の総量に対してα05〜070重量%、
好ましくはα1〜(15重量%の範囲である。:5) Pack agent The amount of salts in the film-type pack agent and wipe-off pack according to the present invention is α05 to 070% by weight based on the total amount of prescription ingredients.
Preferably, α1 is in the range of 15% by weight.
パック剤に使用し得る皮膜剤としては、例えばポリビニ
ルアルコール、ポリアクリル酸)−/、 INIIRI
11カルボ中シビニルボ9マー。Film agents that can be used in pack agents include, for example, polyvinyl alcohol, polyacrylic acid)-/, INIIRI
Sivinylbo 9mer in 11 carbo.
カルボキシメチル七ルロース、ポリビニルピロリドン、
アルギン酸ソーダ、ペクチン、ゼンチン、天然ゴムラテ
ックス、合成ゴムラテックス、ビーガム等が挙げられる
。皮膜剤の配合量は、その乾燥物として処方成分の総量
に対してα01〜15重量%、好ましくはα05〜10
重量%である。アルコールの配合量は、高々20重量%
、好ましくは5〜10重量%である。Carboxymethyl heptalulose, polyvinylpyrrolidone,
Examples include sodium alginate, pectin, zentin, natural rubber latex, synthetic rubber latex, and vegum. The blending amount of the coating agent is α01 to 15% by weight, preferably α05 to 10% by weight, based on the total amount of prescription ingredients as a dry product.
Weight%. The amount of alcohol blended is at most 20% by weight.
, preferably 5 to 10% by weight.
本発明のパック剤に配合し得る慣用成分としては、香料
、防腐剤、染料、顔料、保湿剤、可溶化剤、PH調整剤
、油性物質、美容薬効成分等を挙げることができる。Commonly used ingredients that can be incorporated into the pack agent of the present invention include perfumes, preservatives, dyes, pigments, humectants, solubilizers, pH adjusters, oily substances, cosmetic medicinal ingredients, and the like.
本発明で得られるパック剤は、長期保存しても凝集物や
沈降物の生成や、変色、変臭、粘度低下等を起すことな
く、安定で、使用時には容易、均一に塗布、剥離し得る
と共に、適度のつっばり感を与え、皮膜剥離後は肌にし
っとりとした感触と艶を与えることができる。The pack agent obtained by the present invention is stable without producing aggregates or sediments, discoloration, odor, or viscosity reduction even after long-term storage, and can be easily and uniformly applied and peeled off during use. At the same time, it gives a moderate feeling of firmness, and after peeling off the film, it can give a moist feel and gloss to the skin.
以下実施例について説明する。Examples will be described below.
実施例に示した部とは重量部を、%とは重量部を意味す
る。The parts shown in the examples mean parts by weight, and the percentages shown in the examples mean parts by weight.
1&、皮膚角質層ターンオーバー速度の測定は、後記の
ジキン七ンらの方法に準じ%2550才の女性パネラ−
20名に対し顔面皮膚に4X4−平方の蛍光色素ダンシ
ルク−ライドによる皮膚角質層タンパク質染色を行−)
えのち、1日に2回(朝、夕)レブリン酸および/を九
はその塩類を配合し大皮膚化粧料を塗布し、経日変化に
て、ダンジルクロフィト01mpro、 @d Flu
or@acene* 8taining Jschni
que For ikilmtl、 Jurnovo
r of th@Hmars 8tratum Oor
naum ; Br1tiahJournal of
D@rmtolo訂、 1974909 )実施例1(
整肌化粧水)
エタノール10部、グリセリン5s1ポリオキシエチレ
ンラウリルエーテル(ZOR,O,) (可溶化剤)1
5部、メチルパラベン[LI部、香料α05部、水B&
55部と下記の各レブリン酸またはその塩類α5部とか
ら1kb本発明の整肌化粧水を常法によ1lilllし
た。また比較のための
に、レブリン酸表た邑よその塩11添加の整肌化粧水を
調製した。?:、れらの整肌化粧水の品質特性および官
能特性を調べた結果を第1表に示す。1 & The skin stratum corneum turnover rate was measured according to the method of Jikin Shichinin et al. described below.
Skin stratum corneum protein staining was performed on the facial skin of 20 people using a 4x4 square of fluorescent dye dansyl-lide.
Afterwards, apply a large skin cosmetic containing levulinic acid and/or its salts twice a day (morning and evening), and as it changes over the course of the day, it will change over time.
or@acene* 8taining Jschni
que For ikilmtl, Jurnovo
r of th@Hmars 8tratum Oor
naum; Br1tiahJournal of
Edited by D@rmtolo, 1974909) Example 1 (
Skin conditioning lotion) 10 parts ethanol, 5s1 glycerin, 1 polyoxyethylene lauryl ether (ZOR, O,) (solubilizer) 1
5 parts, methylparaben [LI part, fragrance α05 parts, water B&
55 parts and α5 parts of each of the following levulinic acids or salts thereof to prepare 1 kb of the skin conditioning lotion of the present invention in a conventional manner. For comparison, a skin toning lotion containing levulinic acid and salt 11 was prepared. ? Table 1 shows the results of examining the quality characteristics and sensory characteristics of these skin lotions.
尚、実施例1で使用したレブリン酸およびその塩類、と
、それらの記号は下記の通りである。c以下同様ン
記号 レブリン酸およびその塩類
へ・ ; レブリン酸
B・ ; レブリン酸トリエタノールアミンO1;
レブリン酸アンモニウム
D、; レブリン酸ナトリウム
鎮 1 表
実施例2
レブリン酸の配合量を第2表のように変化させる他は、
11施例1の本発明と同様にして整肌化粧水を#l#し
た。The levulinic acid and its salts used in Example 1 and their symbols are as follows. c Same as below. To levulinic acid and its salts; levulinic acid B; levulinic acid triethanolamine O1;
Ammonium Levulinate D; Sodium Levulinate 1 Table Example 2 Other than changing the amount of levulinic acid as shown in Table 2,
11 A skin conditioning lotion #l# was prepared in the same manner as in Example 1 of the present invention.
これらの整肌化粧水の品質特性、官能特性、および角質
層ターンオーバー速度を調べた結果を@2表に示す。Table 2 shows the results of examining the quality characteristics, sensory characteristics, and stratum corneum turnover rate of these skin lotions.
実施例5
レブリン酸ナトリウムの配合量を第5表の如て整肌化粧
水を調製した。Example 5 A skin lotion was prepared with the amount of sodium levulinate shown in Table 5.
得られ九整肌化粧水の品質特性、官能特性、及び角質層
ターンオーバー速度は縞3表の如く実施例2の整肌化粧
水とtt y同じであうた。The quality characteristics, organoleptic properties, and stratum corneum turnover rate of the obtained skin conditioning lotion were the same as those of the skin conditioning lotion of Example 2, as shown in Table 3.
比較例ル
プリン酸の代りにグリオキシル、またはアセトンジカル
ボン酸を使用する他は実施例1の本発明因と同様にして
整肌化粧水を調製した。Comparative Example A skin lotion was prepared in the same manner as in Example 1, except that glyoxyl or acetone dicarboxylic acid was used instead of lupulic acid.
得られた整肌化粧水の外観及びKおいは実施例1の整肌
化粧水と同じであった。tたグリオキシルの整肌化粧水
およびアセトンジカルボン酸の整肌化粧水の何れも、官
能特性で、きめが細やかになったが1人/20人で、艶
がよくなうたが1人720人、はりがでてきたが0人/
20人であった。角質層ターンオーバー速度は1翫5±
1.0であシ、角質層のターンオーバー速度を促進せず
、皮膚に対する美化作用は認められなかった。The appearance and K odor of the obtained skin conditioning lotion were the same as those of the skin conditioning lotion of Example 1. Both the glyoxyl skin toning lotion and the acetone dicarboxylic acid skin toning lotion had sensory properties that made the texture finer in 1/20 people, and improved luster in 1/720 people. The girth has come out, but 0 people/
There were 20 people. The stratum corneum turnover rate is 1 line 5±
At 1.0, the turnover rate of the stratum corneum was not promoted, and no beautifying effect on the skin was observed.
実施例4 収れん性化粧水
レブリン酸α2部、エストラジオールαロ1部、エタノ
ール15部、香料α05部、水84゜8部1色素適量と
からなる本発明の収れん性化粧水を常法によ動詞製した
。tた比較の為にレプリ/#2をクエン酸に代えた収れ
ん性化粧水を#JI4JIllした。これらの収れん性
化粧水の品質特性。Example 4 Astringent lotion An astringent lotion of the present invention consisting of 2 parts of levulinic acid α, 1 part of estradiol α, 15 parts of ethanol, 05 parts of fragrance α, 84°8 parts of water and 1 appropriate amount of pigment was prepared in the usual way. Manufactured. For comparison, an astringent lotion #JI4JIll was prepared by replacing Repli/#2 with citric acid. Quality characteristics of these astringent lotions.
官能特性、及び角質層ターンオーバー速度を調べた結果
t−第4表に示す。The results of the investigation of sensory characteristics and stratum corneum turnover rate are shown in Table 4.
第4表
実施例5(アフターシェープローシーン)エタノール5
0部、香料α1部、イソグルビルメチルフェノールα0
1部、ポリエチレンダリ:z−+2(10zs、イグシ
ロンアミノヵ7’aン酸α1部、色素適量、水67.5
部とレプリンブローシーンを常法に準じて調製した。ま
た比較のためにレブリン酸またdその塩類無添加の整肌
化粧水を調製した。Table 4 Example 5 (After Shape Low Scene) Ethanol 5
0 parts, fragrance α 1 part, isoglubil methylphenol α 0
1 part, polyethylene dari: z-+2 (10zs, igsilon amino 7'a acid α 1 part, appropriate amount of dye, water 67.5
A part and a replin blow scene were prepared according to a conventional method. For comparison, a skin conditioning lotion without the addition of levulinic acid or its salts was also prepared.
レブリン酸またはその塩類(B、O,D、K )配合シ
タアフターシエープローシ曽ン、レブリン酸無添加のア
フターシェープローシーンも日光照射2ケ月後の外観は
製造直後と同じであ妙。After Shape Law Sheen containing levulinic acid or its salts (B, O, D, K) and After Shape Law Sheen without the addition of levulinic acid look strangely the same after 2 months of sunlight irradiation as they did immediately after manufacture.
におい445℃2ケ月後も異臭が無く良好であったが、
官能特性、角質層のターンオーバー速度でレブリン酸ま
たはその塩*(AIBIOID)添加のアフターシェー
ブローフ■ンが良好すのに対し、レブリン酸無添加のア
フターシェーブローV m 7 rt不艮であった。Smell: Even after 2 months at 445℃, there was no strange odor and the condition was good.
In terms of organoleptic properties and turnover rate of the stratum corneum, the aftershave bread containing levulinic acid or its salt* (AIBIOID) was good, whereas the aftershave bread without the addition of levulinic acid was unfavorable.
ポリオキシエチレンラウリルエーテル50部、スクワラ
ンtag、セチルアルコールtag。50 parts of polyoxyethylene lauryl ether, squalane tag, cetyl alcohol tag.
イソプロピルミリステー)aO部、ステアリン酸50部
、コレステロール50部、ミツロウ20部、メチルパラ
ベンα1部、水yrlss部と下記の各レブリン酸およ
びその塩類α5部とからなる各スキンクリーム(0/W
ll)を、前記の調製方法に準じて調製した。また比較
の為にレブリン酸およびその塩類無添加のスキンクリー
ムを調製した。Each skin cream (0/W
ll) was prepared according to the method described above. For comparison, a skin cream without the addition of levulinic acid or its salts was also prepared.
1)品質特性
レブリン酸およびその塩1ii1 (A* B* ’
* ’ *II)のスキンクリームも、レブリン酸無添
加のスキンクリームも、外観は日光照射2ケ月後も製造
直後と同じ白色クリーム状であ勤、においは、45℃2
ケカ後も異臭がなく良好であ如、硬度(50℃)も45
℃2ケカ後は7で、製造直後は8と変化がみられず安定
であった・
U)官能特性
レブリン酸およびその塩@ (A I ” t ’ e
Ω参E)のスキンクリームは1g68の如< JIIL
K *め、艶、はりを与えるがレブリン酸無添加のス
キンクリームは与えない。1) Quality characteristics Levulinic acid and its salts 1ii1 (A*B*'
*' *Both the skin cream in II) and the skin cream without the addition of levulinic acid, the appearance remains the same white cream after 2 months of sunlight exposure as immediately after manufacture, and the odor remains at 45℃2.
Even after heating, it is in good condition with no strange odor, and the hardness (50℃) is 45.
It was 7 after heating at 2 degrees Celsius, and 8 immediately after production, showing no change and being stable. U) Sensory characteristics Levulinic acid and its salts @ (A I ” t ' e
Ωsan E)'s skin cream weighs 1g68 < JIIL
K * Gives skin shine, firmness, but does not give skin cream without levulinic acid.
1ii)角質層ターンオーバー速度 レブリン酸およびその塩類(A、B、O,D。1ii) Stratum corneum turnover rate Levulinic acid and its salts (A, B, O, D.
E)のスキンクリームは第6表の如く角質層I−ンオー
パ速度を促進するがレブ’)7’ll無添加のスキンク
リームは促進しない。As shown in Table 6, the skin cream E) promotes the stratum corneum I-operation speed, but the skin cream containing no additives does not.
実施例7
レブリン酸O濃変な第79のように変化させる他は実施
例6の本発明と同様にして各スキンクリームを調製した
。Example 7 Each skin cream was prepared in the same manner as in Example 6 of the present invention except that the concentration of levulinic acid O was changed as in No. 79.
各スキンクリームの品質特性、官能特性、及び角質層タ
ーンオーバー速度を調べ九結果を11117表に示す。The quality characteristics, sensory characteristics, and stratum corneum turnover rate of each skin cream were investigated and the results are shown in Table 11117.
実施例8
レフリン酸を、レブリン酸トリエタノールアミンに代え
る以外は実施例7と同様にして各スキンクリームを調製
しえ、得られた各スキンクリームの品質特性、官能特性
および角質層ターンオーバー速度は第8表の如〈実施例
7の各スキンクリームとはソ同じであった。Example 8 Skin creams were prepared in the same manner as in Example 7, except that levulinic acid was replaced with triethanolamine levulinate, and the quality characteristics, sensory characteristics, and stratum corneum turnover rate of each skin cream obtained were as follows. As shown in Table 8, the skin creams in Example 7 were the same.
ポリビニルアルコール11071+、エタノール50部
、ボV矛キシエチレンソルビタン脂肪酸エステルIIL
s部、香料α05部、メチルノくツペン[1111,水
8i9部と下記の各レブリン酸およびその塩Ii[L5
部とからなる透明な皮膜層−くツクを調製した。また比
較の為にレブリン酸またはその塩類無添加のパックを調
製し九。Polyvinyl alcohol 11071+, 50 parts of ethanol, ethylene sorbitan fatty acid ester IIL
Part s, 05 parts of fragrance α, methyl noxpene [1111, 8i 9 parts of water and each of the following levulinic acid and its salts Ii [L5
A transparent film layer was prepared consisting of: For comparison, a pack without the addition of levulinic acid or its salts was also prepared.
1)品質特性
レブリン酸およびその塩類(A+ Be○l D4K)
のパックもレブリン酸無添加のノ(ツクも共に%外観は
日光照射2ケ月後も製造直後と同じ無色透明であり、に
おいは45℃2ケ月後も異臭がなく良好であり、粘度も
45℃2ケ月後で変化が与られなかツ九
1i)官能特性
レブリン酸およびその塩類(AeBsO*D+ic)の
パックは、肌にきめ、艶、はりを与えるが、レブリン酸
無添加のパックは与えない。1) Quality characteristics Levulinic acid and its salts (A+ Be○l D4K)
Both the levulinic acid-free pack and the pack without the addition of levulinic acid (%) appear as colorless and transparent even after 2 months of sunlight irradiation, as they did immediately after production, and the odor remains good with no off-odor even after 2 months at 45°C, and the viscosity remains at 45°C. No change was observed after 2 months. 1i) Sensory properties A pack containing levulinic acid and its salts (AeBsO*D+ic) gives texture, shine, and firmness to the skin, but a pack without levulinic acid does not.
1li)角質層ターンオーバー速度 レブリン酸およびその塩類(A、B、C,D。1li) Stratum corneum turnover rate Levulinic acid and its salts (A, B, C, D.
E)のパックは、第9表の如く角質層ターンオーバ下速
度を促進するがレブリン酸無゛添加のパックは促進しな
い。The pack E) promotes the lower rate of turnover of the stratum corneum as shown in Table 9, but the pack without levulinic acid does not.
第 9 表
実施例10
レフリン酸の配合量を#110表のように変化させる他
は、実施例90本発明と同様にして各パックを調製した
。Table 9 Example 10 Each pack was prepared in the same manner as in Example 90 of the present invention, except that the amount of levulinic acid was changed as shown in Table #110.
各パックの品質特性、官能特性、および角質層ターイオ
ーバー速度を調べた結果を第10表に示す。Table 10 shows the results of examining the quality characteristics, sensory characteristics, and stratum corneum turnover rate of each pack.
@10 表
このパック剤はレブリン酸およびその塩類が前記の範囲
で透明なる外観を呈し、粘度低下がみもれず安定で、使
用時には容易、均一に塗布、剥離し得るとともに皮膜剥
離後は肌に艶、はシ、きめを与え、角質層のターンオー
バー速度を促進させ大、このようにレブリン酸およびそ
の塩の効果は著し−0
出願人 鐘紡株式会社
手続補正書(0尭)
昭和57年3 目3 日
特許庁長官島田春禰殿
1.1件の表示
昭和57年特許願第8687号
2、発明の名称
皮膚化粧料
五補正をする者
事件との関係 特許出願人
住所 東京都墨田区墨田五丁目+7番4号〒534大阪
市部島区友1町1丁目5番80号鐘紡株式会社特許部
電話(06)925−1145
4、補正により増加する発明の数 な し5、補正
の討議
Z補正の内容
(1)明細書、第4頁第15行〜同頁第16行に記載の
「凝集粒?(所謂グツを」を、「凝集粒子(所閘グツン
を」に補正する。@10 Table This pack has a transparent appearance when the levulinic acid and its salts are in the above range, is stable without any noticeable decrease in viscosity, can be applied and peeled off easily and uniformly during use, and does not touch the skin after peeling off the film. It gives luster, plumpness, and texture, and promotes the turnover rate of the stratum corneum.As such, the effects of levulinic acid and its salts are remarkable. 3 Item 3 Mr. Harune Shimada, Commissioner of the Japan Patent Office 1. Indication of 1 Patent Application No. 8687 of 1986 2, Name of Invention Relationship to Case of Person Who Makes Five Amendments to Skin and Cosmetics Patent Applicant Address Sumida-ku, Tokyo Sumida 5-chome +7-4, 5-80 Tomo 1-cho, Bejima-ku, Osaka 534, Japan Patent Department, Kanebo Co., Ltd. Telephone: (06) 925-1145 4. Number of inventions increased by amendment None 5. Amendment Discussion Z Contents of amendment (1) "Agglomerated particles?" (so-called gutsu wo) described in the specification, page 4, line 15 to line 16 of the same page, is amended to "agglomerated particle (so-called gutsu wo)."
(2)明細書、第12頁第14行に記載の9hn an
Jを、「Jan−・nJ[補正する。(2) 9hn an as stated in the specification, page 12, line 14
J is corrected by "Jan-・nJ.
(5)明細書、第12頁第14行に記載のjJurno
verJf Cturnover Jに補正する。(5) jJurno described in the specification, page 12, line 14
verJf Correct to Cturnover J.
(4)明細1.第12頁下から4行目に記載のr(zo
g・0)」をf(2LIE・O)Jに補正する。(4) Details 1. r (zo
g・0)” is corrected to f(2LIE・O)J.
(目明J8書、第19頁第5行に記載の「(B%C%D
、g)Jt−j(^、a%c、p、g)J[補正する。(Memei J8 book, page 19, line 5, “(B%C%D
, g) Jt-j (^, a%c, p, g) J [correct.
(6)明細書、第20員第1O行番で記載の「塩類無添
加」を「塩類の無感IFl’ljJに補正する。(6) "No salts added" stated in the specification, No. 20, No. 1 O, is corrected to "Insensitive to salts IFl'ljJ."
(7)明細書、第2S頁の第8表の中で、0.5のタテ
の欄の最下行に記載のj12.5±[15」を、r12
.s±α2」に補正する。(7) In Table 8 on page 2S of the specification, j12.5±[15'' written in the bottom line of the vertical column of 0.5 is
.. s±α2”.
(8)明細書、第26頁の第10表の中で、試験項目の
1創に記載している、「外賜jをr外観jに補正する。(8) In Table 10 on page 26 of the specification, it is stated in one of the test items that ``External appearance j is corrected to r appearance j.''
(9)明細書%第12員第2行〜同頁第6行に記載のr
2550iJをr2s〜so才JK補正する。(9) r stated in % 12th member line 2 of the specification to line 6 of the same page
2550iJ is corrected by r2s~so JK.
(ILIJ明細書、第+2頁下から7行目に記載のj1
974” 9J’kr197a、90,9 JKil
l正tb。(j1 described in ILIJ specification, page +2, line 7 from the bottom)
974"9J'kr197a, 90,9 JKil
l positive tb.
Claims (4)
総量に対して0.05〜0.7重量%含有していること
を特徴とする皮膚化粧料。(1) A skin cosmetic containing 0.05 to 0.7% by weight of leplic acid and/or its salts based on the total amount of prescription ingredients.
総量に対して01〜115重量%含有されている。特許
請求の範囲第(1)項記載の皮膚化粧料。(2) Leplic acid and/or its salts are contained in an amount of 01 to 115% by weight based on the total amount of prescription ingredients. A skin cosmetic according to claim (1).
塩、アルカリ金属塩、アルカリ土類金属塩、アルカノー
ルアミン塩である特許請求の範囲第(1) JJ記載の
皮膚化粧料。(3) The skin cosmetic according to Claim No. (1) JJ, wherein the salts of leplic acid are ammonium salts, alkali metal salts, alkaline earth metal salts, and alkanolamine salts of leplic acid.
記載の皮膚化粧料。(4) Skin cosmetics include Rosi soda and creams. The skin cosmetic according to claim (1), which is an emulsion or a pack agent 4.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP838782A JPS58124711A (en) | 1982-01-21 | 1982-01-21 | Skin cosmetic |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP838782A JPS58124711A (en) | 1982-01-21 | 1982-01-21 | Skin cosmetic |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS58124711A true JPS58124711A (en) | 1983-07-25 |
Family
ID=11691792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP838782A Pending JPS58124711A (en) | 1982-01-21 | 1982-01-21 | Skin cosmetic |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS58124711A (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4830028A (en) * | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
WO1996019975A1 (en) * | 1994-12-24 | 1996-07-04 | Lts Lohmann Therapie-Systeme Gmbh | Transdermal resorption of active substances from supercooled masses |
US6344211B1 (en) | 1994-12-24 | 2002-02-05 | Lts Lohmann Therapie-Systeme Gmbh | Transdermal absorption of active substances from subcooled melts |
JP2002326918A (en) * | 2001-05-01 | 2002-11-15 | Dhc Co | Bleaching cosmetic |
WO2002078687A3 (en) * | 2001-03-30 | 2003-12-11 | Biochimici Psn S P A | Delta-aminolevulinic acid for the therapeutical and cosmetic use |
WO2006005561A1 (en) * | 2004-07-09 | 2006-01-19 | Wella Aktiengesellschaft | Use of combinations containing oxocarboxylic acids for deodorising skin and hair |
JP2008184402A (en) * | 2007-01-29 | 2008-08-14 | Medorekkusu:Kk | Low-irritation dissolution auxiliary for external preparation |
US9156809B2 (en) | 2012-11-29 | 2015-10-13 | Segetis, Inc. | Carboxy ester ketals, methods of manufacture, and uses thereof |
US9549886B2 (en) | 2010-05-10 | 2017-01-24 | Gfbiochemicals Limited | Personal care formulations containing alkyl ketal esters and methods of manufacture |
-
1982
- 1982-01-21 JP JP838782A patent/JPS58124711A/en active Pending
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4830028A (en) * | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
US4836224A (en) * | 1987-02-10 | 1989-06-06 | R. J. Reynolds Tobacco Company | Cigarette |
WO1996019975A1 (en) * | 1994-12-24 | 1996-07-04 | Lts Lohmann Therapie-Systeme Gmbh | Transdermal resorption of active substances from supercooled masses |
US6264980B1 (en) * | 1994-12-24 | 2001-07-24 | Lts Lohmann Therapie-Systeme Gmbh | Transdermal resorption of active substances from supercooled masses of levulic acid |
US6344211B1 (en) | 1994-12-24 | 2002-02-05 | Lts Lohmann Therapie-Systeme Gmbh | Transdermal absorption of active substances from subcooled melts |
WO2002078687A3 (en) * | 2001-03-30 | 2003-12-11 | Biochimici Psn S P A | Delta-aminolevulinic acid for the therapeutical and cosmetic use |
JP2002326918A (en) * | 2001-05-01 | 2002-11-15 | Dhc Co | Bleaching cosmetic |
WO2006005561A1 (en) * | 2004-07-09 | 2006-01-19 | Wella Aktiengesellschaft | Use of combinations containing oxocarboxylic acids for deodorising skin and hair |
JP2008184402A (en) * | 2007-01-29 | 2008-08-14 | Medorekkusu:Kk | Low-irritation dissolution auxiliary for external preparation |
US9549886B2 (en) | 2010-05-10 | 2017-01-24 | Gfbiochemicals Limited | Personal care formulations containing alkyl ketal esters and methods of manufacture |
US9156809B2 (en) | 2012-11-29 | 2015-10-13 | Segetis, Inc. | Carboxy ester ketals, methods of manufacture, and uses thereof |
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