JPS5799199A - Preparation of 8-adenosyl-l-methionine - Google Patents
Preparation of 8-adenosyl-l-methionineInfo
- Publication number
- JPS5799199A JPS5799199A JP17552280A JP17552280A JPS5799199A JP S5799199 A JPS5799199 A JP S5799199A JP 17552280 A JP17552280 A JP 17552280A JP 17552280 A JP17552280 A JP 17552280A JP S5799199 A JPS5799199 A JP S5799199A
- Authority
- JP
- Japan
- Prior art keywords
- methionine
- mold
- adenosyl
- adenosine triphosphate
- treated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 abstract 3
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 abstract 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 3
- 229960004452 methionine Drugs 0.000 abstract 3
- 229930182817 methionine Natural products 0.000 abstract 3
- 241000235395 Mucor Species 0.000 abstract 2
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 241001149669 Hanseniaspora Species 0.000 abstract 1
- 241000235003 Saccharomycopsis Species 0.000 abstract 1
- 241000235346 Schizosaccharomyces Species 0.000 abstract 1
- 241000222068 Sporobolomyces <Sporidiobolaceae> Species 0.000 abstract 1
- 241001149962 Sporothrix Species 0.000 abstract 1
- 241000223230 Trichosporon Species 0.000 abstract 1
- 238000007605 air drying Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare the titled substance efficiently, by bringing a treated mold of a microorganism belonging to the genus Saccharomycedes, Mucor, etc. into contact with adenosine triphosphate and methionine in an aqueous solution.
CONSTITUTION: A microorganism belonging to the genus Sccharomycedes, Hanseniaspora, Sporobolomyces, Trichosporon, Saccharomycopsis, Schizosaccharomyces, Mucor, Sporothrix, etc., capable of producing S-adenosyl-L-methionine from adenosine triphosphate and methionine, is cultivated in a common nutrient medium, and a mold is collected. The mold is treated by a method, e.g., air-drying, treatment with a surface active agent, etc., to give the treated mold. The mold is reacted with adenosine triphosphate and methionine in an aqueous solution to give S-adenosyl-L-methionine, which is convertionally separated from the reaction solution.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17552280A JPS5799199A (en) | 1980-12-12 | 1980-12-12 | Preparation of 8-adenosyl-l-methionine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17552280A JPS5799199A (en) | 1980-12-12 | 1980-12-12 | Preparation of 8-adenosyl-l-methionine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5799199A true JPS5799199A (en) | 1982-06-19 |
| JPS6339236B2 JPS6339236B2 (en) | 1988-08-04 |
Family
ID=15997524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17552280A Granted JPS5799199A (en) | 1980-12-12 | 1980-12-12 | Preparation of 8-adenosyl-l-methionine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5799199A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6078594A (en) * | 1983-10-05 | 1985-05-04 | Yamasa Shoyu Co Ltd | Preparation of s-adenosyl-l-methionine |
| US6881837B2 (en) | 2001-06-07 | 2005-04-19 | Orchid Chemicals & Pharmaceuticals Ltd. | Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer |
| US7667034B2 (en) | 2004-06-23 | 2010-02-23 | Orchid Chemicals & Pharmaceuticals Limited | Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5082288A (en) * | 1973-11-27 | 1975-07-03 | ||
| JPS548794A (en) * | 1977-06-17 | 1979-01-23 | Yamasa Shoyu Co Ltd | Preparation of s-adenosyl-l-methionine |
| JPS5581592A (en) * | 1978-12-12 | 1980-06-19 | Yamasa Shoyu Co Ltd | Method of preparing s-adenosyl-l-methionine |
-
1980
- 1980-12-12 JP JP17552280A patent/JPS5799199A/en active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5082288A (en) * | 1973-11-27 | 1975-07-03 | ||
| JPS548794A (en) * | 1977-06-17 | 1979-01-23 | Yamasa Shoyu Co Ltd | Preparation of s-adenosyl-l-methionine |
| JPS5581592A (en) * | 1978-12-12 | 1980-06-19 | Yamasa Shoyu Co Ltd | Method of preparing s-adenosyl-l-methionine |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6078594A (en) * | 1983-10-05 | 1985-05-04 | Yamasa Shoyu Co Ltd | Preparation of s-adenosyl-l-methionine |
| US6881837B2 (en) | 2001-06-07 | 2005-04-19 | Orchid Chemicals & Pharmaceuticals Ltd. | Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer |
| US7667034B2 (en) | 2004-06-23 | 2010-02-23 | Orchid Chemicals & Pharmaceuticals Limited | Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6339236B2 (en) | 1988-08-04 |
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