JPS5788197A - Preparation of synthetic intermediate of corticoids - Google Patents

Preparation of synthetic intermediate of corticoids

Info

Publication number
JPS5788197A
JPS5788197A JP16441980A JP16441980A JPS5788197A JP S5788197 A JPS5788197 A JP S5788197A JP 16441980 A JP16441980 A JP 16441980A JP 16441980 A JP16441980 A JP 16441980A JP S5788197 A JPS5788197 A JP S5788197A
Authority
JP
Japan
Prior art keywords
hydrolyzed
peroxide
compound
corticoids
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16441980A
Other languages
Japanese (ja)
Other versions
JPS6352631B2 (en
Inventor
Kazumasa Nitta
Toshio Haruyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP16441980A priority Critical patent/JPS5788197A/en
Publication of JPS5788197A publication Critical patent/JPS5788197A/en
Publication of JPS6352631B2 publication Critical patent/JPS6352631B2/ja
Granted legal-status Critical Current

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  • Steroid Compounds (AREA)

Abstract

PURPOSE: Acylaminopregnatriene-one is epoxidized with a peroxide and hydrolyzed to produce 17α-hydroxypregna-1,4-diene-3,20-dione used as an intermediate of adrenocortical hormones in high yield.
CONSTITUTION: The epoxidation of 20-acylaminopregna-1,4,17 or 20-triene-3-one of formulaI(R is alkyl of 5 or less carbon atoms; Wis either of E or Z steric configuration in methyl and acylamino groups on the 20-position carbon atom) is conducted using a peroxide, preferably a peracid such as peracetic acid in an amount of 1W1.3 times the molar quantity of the compound, preferably in a solvent of dichloromethane at -10W+30°C to form an epoxysteroid of formula II. Then, the product is hydrolyzed, preferably under alkaline conditions in an aqueous alcohol to give the objective compound. The starting steroid is obtained as a maxture of E and Z isomers by hydrolysis of the diacyl derivative.
COPYRIGHT: (C)1982,JPO&Japio
JP16441980A 1980-11-21 1980-11-21 Preparation of synthetic intermediate of corticoids Granted JPS5788197A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16441980A JPS5788197A (en) 1980-11-21 1980-11-21 Preparation of synthetic intermediate of corticoids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16441980A JPS5788197A (en) 1980-11-21 1980-11-21 Preparation of synthetic intermediate of corticoids

Publications (2)

Publication Number Publication Date
JPS5788197A true JPS5788197A (en) 1982-06-01
JPS6352631B2 JPS6352631B2 (en) 1988-10-19

Family

ID=15792781

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16441980A Granted JPS5788197A (en) 1980-11-21 1980-11-21 Preparation of synthetic intermediate of corticoids

Country Status (1)

Country Link
JP (1) JPS5788197A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153001A2 (en) * 1984-02-03 1985-08-28 The Upjohn Company Steroids having an enamide or enimide group and their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153001A2 (en) * 1984-02-03 1985-08-28 The Upjohn Company Steroids having an enamide or enimide group and their preparation

Also Published As

Publication number Publication date
JPS6352631B2 (en) 1988-10-19

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