JPS5788197A - Preparation of synthetic intermediate of corticoids - Google Patents
Preparation of synthetic intermediate of corticoidsInfo
- Publication number
- JPS5788197A JPS5788197A JP16441980A JP16441980A JPS5788197A JP S5788197 A JPS5788197 A JP S5788197A JP 16441980 A JP16441980 A JP 16441980A JP 16441980 A JP16441980 A JP 16441980A JP S5788197 A JPS5788197 A JP S5788197A
- Authority
- JP
- Japan
- Prior art keywords
- hydrolyzed
- peroxide
- compound
- corticoids
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
PURPOSE: Acylaminopregnatriene-one is epoxidized with a peroxide and hydrolyzed to produce 17α-hydroxypregna-1,4-diene-3,20-dione used as an intermediate of adrenocortical hormones in high yield.
CONSTITUTION: The epoxidation of 20-acylaminopregna-1,4,17 or 20-triene-3-one of formulaI(R is alkyl of 5 or less carbon atoms; Wis either of E or Z steric configuration in methyl and acylamino groups on the 20-position carbon atom) is conducted using a peroxide, preferably a peracid such as peracetic acid in an amount of 1W1.3 times the molar quantity of the compound, preferably in a solvent of dichloromethane at -10W+30°C to form an epoxysteroid of formula II. Then, the product is hydrolyzed, preferably under alkaline conditions in an aqueous alcohol to give the objective compound. The starting steroid is obtained as a maxture of E and Z isomers by hydrolysis of the diacyl derivative.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16441980A JPS5788197A (en) | 1980-11-21 | 1980-11-21 | Preparation of synthetic intermediate of corticoids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16441980A JPS5788197A (en) | 1980-11-21 | 1980-11-21 | Preparation of synthetic intermediate of corticoids |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5788197A true JPS5788197A (en) | 1982-06-01 |
JPS6352631B2 JPS6352631B2 (en) | 1988-10-19 |
Family
ID=15792781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16441980A Granted JPS5788197A (en) | 1980-11-21 | 1980-11-21 | Preparation of synthetic intermediate of corticoids |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5788197A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0153001A2 (en) * | 1984-02-03 | 1985-08-28 | The Upjohn Company | Steroids having an enamide or enimide group and their preparation |
-
1980
- 1980-11-21 JP JP16441980A patent/JPS5788197A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0153001A2 (en) * | 1984-02-03 | 1985-08-28 | The Upjohn Company | Steroids having an enamide or enimide group and their preparation |
Also Published As
Publication number | Publication date |
---|---|
JPS6352631B2 (en) | 1988-10-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3260194D1 (en) | 2,3-dialkoxypropyl glyceryl ether and its preparation process as well as cosmetic composition containing same | |
JPS5788197A (en) | Preparation of synthetic intermediate of corticoids | |
JPS54144354A (en) | 8-exo-hydroxymethyl-endo-tricyclo5,2,1,02,6 decane ester and ether | |
JPS5466695A (en) | Azetidinone derivative and its preparation | |
JPS54130543A (en) | Prostagladin i2 analog, and its preparation | |
IE37347B1 (en) | Oxazolo (5,4-d) azepines | |
JPS5735599A (en) | 24,25-dihydroxycholestane and its preparation | |
ES8102149A1 (en) | Substituted-19-nor-pregn-4-ene-3,20-dione derivatives, process for their preparation and pharmaceutical compositions containing them. | |
GB1014890A (en) | Steroid 17ª-yi acetals and process for their preparation | |
IE800050L (en) | 21-alkylated steroids | |
JPS5236646A (en) | Process for preparation of prostaglandin derivatives and pharmceutical composition containing the compounds as effectual components | |
JPS56108731A (en) | Preparation of diterpene derivative | |
SE7909157L (en) | PROCEDURE FOR THE PREPARATION OF CYCLE-1,3,2-OXAZAPHOSPHORPHYL DERIVATIVES | |
JPS5566592A (en) | 7-alkoxythiazolo 3,2-a pyrimidine derivative, its preparation, and drug containing the same | |
AU5127579A (en) | 3 beta-amino-2beta-hydroxy steroid | |
JPS5531086A (en) | Prepartion of 5,6-epoxy-1,2,6-trimethyl-tricyclo 5.3.2.02,7 dodecane | |
JPS5551099A (en) | Preparation of estrone | |
JPS5788200A (en) | Synthetic intermediate of corticoids | |
GB1169073A (en) | 3-Cyanomethylene-Androstenes and -Oestrenes and process for their manufacture | |
GB777684A (en) | Polyhydrophenanthrene compounds | |
JPS5470493A (en) | Preparation of unsaturated alcohol | |
GB1196683A (en) | Improvements in or relating to 6,7-Dihalomethylene Steroids | |
JPS54151958A (en) | Preparation of pregnane steroid 17alpha-ester | |
GR74058B (en) | ||
JPS51128976A (en) | Process for preparing carbostyril derivatives |