JPS5780395A - Nitrosourea derivative of sucrose - Google Patents
Nitrosourea derivative of sucroseInfo
- Publication number
- JPS5780395A JPS5780395A JP15544380A JP15544380A JPS5780395A JP S5780395 A JPS5780395 A JP S5780395A JP 15544380 A JP15544380 A JP 15544380A JP 15544380 A JP15544380 A JP 15544380A JP S5780395 A JPS5780395 A JP S5780395A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- deoxysucrose
- chloroethyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I (R is H or acyl).
EXAMPLE: 6'-[{[(2-Chloroethyl)nitrosoamino]carbonyl}amino]-6'-deoxysucrose.
USE: An antileukemic agent and antitumor agent having very little side effects, e.g. pancreatic atrophy.
PROCESS: A 6'-amino-6'-deoxysucrose expressed by formula II is dissolved in water, and triethylamine is added thereto. The resultant mixture is then concentrated under reduced pressure to give a white crystal residue, which is then washed, suspended in methanol and reacted with a derivative of phenyl N- (2-chloroethyl)-N-nitrosocarbamate expressed by formula III (X is nitro or cyano). After the reaction is completed, the formed precipitate is filtered, and the filtrate is concentrated under reduced pressure to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15544380A JPS5780395A (en) | 1980-11-05 | 1980-11-05 | Nitrosourea derivative of sucrose |
US06/313,360 US4387220A (en) | 1980-11-05 | 1981-10-20 | Nitrosourea derivatives of sucrose |
DE8181109392T DE3163319D1 (en) | 1980-11-05 | 1981-10-30 | Nitrosourea derivatives of sucrose, a method for their preparation, and pharmaceutical compositions containing them |
EP81109392A EP0051303B1 (en) | 1980-11-05 | 1981-10-30 | Nitrosourea derivatives of sucrose, a method for their preparation, and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15544380A JPS5780395A (en) | 1980-11-05 | 1980-11-05 | Nitrosourea derivative of sucrose |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5780395A true JPS5780395A (en) | 1982-05-19 |
JPS6139316B2 JPS6139316B2 (en) | 1986-09-03 |
Family
ID=15606139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15544380A Granted JPS5780395A (en) | 1980-11-05 | 1980-11-05 | Nitrosourea derivative of sucrose |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5780395A (en) |
-
1980
- 1980-11-05 JP JP15544380A patent/JPS5780395A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6139316B2 (en) | 1986-09-03 |
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