JPS5780395A - Nitrosourea derivative of sucrose - Google Patents

Nitrosourea derivative of sucrose

Info

Publication number
JPS5780395A
JPS5780395A JP15544380A JP15544380A JPS5780395A JP S5780395 A JPS5780395 A JP S5780395A JP 15544380 A JP15544380 A JP 15544380A JP 15544380 A JP15544380 A JP 15544380A JP S5780395 A JPS5780395 A JP S5780395A
Authority
JP
Japan
Prior art keywords
formula
expressed
deoxysucrose
chloroethyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15544380A
Other languages
Japanese (ja)
Other versions
JPS6139316B2 (en
Inventor
Tetsuo Suami
Yushi Ito
Shuichi Oki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NITSUSHIN SEITOU KK
Nisshin Seito KK
Nissin Sugar Manufacturing Co Ltd
Original Assignee
NITSUSHIN SEITOU KK
Nisshin Seito KK
Nissin Sugar Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NITSUSHIN SEITOU KK, Nisshin Seito KK, Nissin Sugar Manufacturing Co Ltd filed Critical NITSUSHIN SEITOU KK
Priority to JP15544380A priority Critical patent/JPS5780395A/en
Priority to US06/313,360 priority patent/US4387220A/en
Priority to DE8181109392T priority patent/DE3163319D1/en
Priority to EP81109392A priority patent/EP0051303B1/en
Publication of JPS5780395A publication Critical patent/JPS5780395A/en
Publication of JPS6139316B2 publication Critical patent/JPS6139316B2/ja
Granted legal-status Critical Current

Links

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I (R is H or acyl).
EXAMPLE: 6'-[{[(2-Chloroethyl)nitrosoamino]carbonyl}amino]-6'-deoxysucrose.
USE: An antileukemic agent and antitumor agent having very little side effects, e.g. pancreatic atrophy.
PROCESS: A 6'-amino-6'-deoxysucrose expressed by formula II is dissolved in water, and triethylamine is added thereto. The resultant mixture is then concentrated under reduced pressure to give a white crystal residue, which is then washed, suspended in methanol and reacted with a derivative of phenyl N- (2-chloroethyl)-N-nitrosocarbamate expressed by formula III (X is nitro or cyano). After the reaction is completed, the formed precipitate is filtered, and the filtrate is concentrated under reduced pressure to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP15544380A 1980-11-05 1980-11-05 Nitrosourea derivative of sucrose Granted JPS5780395A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP15544380A JPS5780395A (en) 1980-11-05 1980-11-05 Nitrosourea derivative of sucrose
US06/313,360 US4387220A (en) 1980-11-05 1981-10-20 Nitrosourea derivatives of sucrose
DE8181109392T DE3163319D1 (en) 1980-11-05 1981-10-30 Nitrosourea derivatives of sucrose, a method for their preparation, and pharmaceutical compositions containing them
EP81109392A EP0051303B1 (en) 1980-11-05 1981-10-30 Nitrosourea derivatives of sucrose, a method for their preparation, and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15544380A JPS5780395A (en) 1980-11-05 1980-11-05 Nitrosourea derivative of sucrose

Publications (2)

Publication Number Publication Date
JPS5780395A true JPS5780395A (en) 1982-05-19
JPS6139316B2 JPS6139316B2 (en) 1986-09-03

Family

ID=15606139

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15544380A Granted JPS5780395A (en) 1980-11-05 1980-11-05 Nitrosourea derivative of sucrose

Country Status (1)

Country Link
JP (1) JPS5780395A (en)

Also Published As

Publication number Publication date
JPS6139316B2 (en) 1986-09-03

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