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Sumitomo Chemical Co Ltd
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Sumitomo Chemical Co Ltd
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Application filed by Sumitomo Chemical Co LtdfiledCriticalSumitomo Chemical Co Ltd
Priority to JP12980280ApriorityCriticalpatent/JPS5753427A/en
Publication of JPS5753427ApublicationCriticalpatent/JPS5753427A/en
USE: Synthetic intermediate of antitumor anthracyclin antibiotics such as adriamycin or 4-desmethoxyadriamycin.
PREPARATION: For example, a carboxylic derivative of formula II (R4 is lower alkanoyl) is made to react with a halogenating agent to give a compound of formula III (X is halogen), which is made to react with diazomethane to prepare a compound of formula IV. Then, a hydrogen halide of HY (Y is halogen) is made to act on the compound of formula IV to give a compound of formula V, which is hydrolyzed to produce the compound of formula I.