JPS5747482A - Novel carcinostatic antibiotic, basidarin, and its preparation - Google Patents
Novel carcinostatic antibiotic, basidarin, and its preparationInfo
- Publication number
- JPS5747482A JPS5747482A JP12371080A JP12371080A JPS5747482A JP S5747482 A JPS5747482 A JP S5747482A JP 12371080 A JP12371080 A JP 12371080A JP 12371080 A JP12371080 A JP 12371080A JP S5747482 A JPS5747482 A JP S5747482A
- Authority
- JP
- Japan
- Prior art keywords
- basidarin
- antibiotic
- leucoagaricus
- mashroom
- crude product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: Basidarin, carcinostatic antibiotic, is collected from a kind of mashroom in Leucoagaricus.
CONSTITUTION: Leucoagaricus Naucina NZ157 (FERM-5615) is cultured by a usual method for a mashroom and the bodies are removed. The remaining culture mixture is brought into contact with an organic solvent under neutral to slightly acidic conditions to transfer the objective antibiotic into the solvent and the solvent is distilled off to collect the crude product. The crude product is recrystallized with warm ethyl acetate to give purified basidarin of formula A. The substance shows weak antibiotic activities against gram-positive and -negative bacteria and strong growth-inhibition activity against mice leukemia as well.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12371080A JPS5747482A (en) | 1980-09-05 | 1980-09-05 | Novel carcinostatic antibiotic, basidarin, and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12371080A JPS5747482A (en) | 1980-09-05 | 1980-09-05 | Novel carcinostatic antibiotic, basidarin, and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5747482A true JPS5747482A (en) | 1982-03-18 |
JPS6212793B2 JPS6212793B2 (en) | 1987-03-20 |
Family
ID=14867431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12371080A Granted JPS5747482A (en) | 1980-09-05 | 1980-09-05 | Novel carcinostatic antibiotic, basidarin, and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5747482A (en) |
-
1980
- 1980-09-05 JP JP12371080A patent/JPS5747482A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6212793B2 (en) | 1987-03-20 |
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