JPS5747482A - Novel carcinostatic antibiotic, basidarin, and its preparation - Google Patents

Novel carcinostatic antibiotic, basidarin, and its preparation

Info

Publication number
JPS5747482A
JPS5747482A JP12371080A JP12371080A JPS5747482A JP S5747482 A JPS5747482 A JP S5747482A JP 12371080 A JP12371080 A JP 12371080A JP 12371080 A JP12371080 A JP 12371080A JP S5747482 A JPS5747482 A JP S5747482A
Authority
JP
Japan
Prior art keywords
basidarin
antibiotic
leucoagaricus
mashroom
crude product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12371080A
Other languages
Japanese (ja)
Other versions
JPS6212793B2 (en
Inventor
Hamao Umezawa
Tomio Takeuchi
Osamu Tanabe
Hironobu Iinuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP12371080A priority Critical patent/JPS5747482A/en
Publication of JPS5747482A publication Critical patent/JPS5747482A/en
Publication of JPS6212793B2 publication Critical patent/JPS6212793B2/ja
Granted legal-status Critical Current

Links

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: Basidarin, carcinostatic antibiotic, is collected from a kind of mashroom in Leucoagaricus.
CONSTITUTION: Leucoagaricus Naucina NZ157 (FERM-5615) is cultured by a usual method for a mashroom and the bodies are removed. The remaining culture mixture is brought into contact with an organic solvent under neutral to slightly acidic conditions to transfer the objective antibiotic into the solvent and the solvent is distilled off to collect the crude product. The crude product is recrystallized with warm ethyl acetate to give purified basidarin of formula A. The substance shows weak antibiotic activities against gram-positive and -negative bacteria and strong growth-inhibition activity against mice leukemia as well.
COPYRIGHT: (C)1982,JPO&Japio
JP12371080A 1980-09-05 1980-09-05 Novel carcinostatic antibiotic, basidarin, and its preparation Granted JPS5747482A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12371080A JPS5747482A (en) 1980-09-05 1980-09-05 Novel carcinostatic antibiotic, basidarin, and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12371080A JPS5747482A (en) 1980-09-05 1980-09-05 Novel carcinostatic antibiotic, basidarin, and its preparation

Publications (2)

Publication Number Publication Date
JPS5747482A true JPS5747482A (en) 1982-03-18
JPS6212793B2 JPS6212793B2 (en) 1987-03-20

Family

ID=14867431

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12371080A Granted JPS5747482A (en) 1980-09-05 1980-09-05 Novel carcinostatic antibiotic, basidarin, and its preparation

Country Status (1)

Country Link
JP (1) JPS5747482A (en)

Also Published As

Publication number Publication date
JPS6212793B2 (en) 1987-03-20

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