JPS5746949A - Production of fluorine-containing alpha-aminoacid derivative having hydroxyl group - Google Patents

Production of fluorine-containing alpha-aminoacid derivative having hydroxyl group

Info

Publication number
JPS5746949A
JPS5746949A JP12287380A JP12287380A JPS5746949A JP S5746949 A JPS5746949 A JP S5746949A JP 12287380 A JP12287380 A JP 12287380A JP 12287380 A JP12287380 A JP 12287380A JP S5746949 A JPS5746949 A JP S5746949A
Authority
JP
Japan
Prior art keywords
compound
formula
fluorine
ethyl
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12287380A
Other languages
Japanese (ja)
Other versions
JPS5748143B2 (en
Inventor
Hiroshige Matsumura
Akio Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institute of Advanced Industrial Science and Technology AIST
Original Assignee
Agency of Industrial Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency of Industrial Science and Technology filed Critical Agency of Industrial Science and Technology
Priority to JP12287380A priority Critical patent/JPS5746949A/en
Publication of JPS5746949A publication Critical patent/JPS5746949A/en
Publication of JPS5748143B2 publication Critical patent/JPS5748143B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:Compounds of formula I (R is methyl, ethyl; R', R" are H, methyl, ethyl).
EXAMPLE: Ethyl 2-acetylamino-4,5,5,-trifluoro-6-hydroxyhexanoate.
USE: Synthetic intermediate of fluorine-containing aminoacids. Intermediate of medicines and agricultural chemicals.
PREPARATION: The radical addition reaction between a compound of formula II and an alcohol or R'R"CHOH is effected under irradiation of high energy rays to give the compound of formula I. The compound of formula II is dissolved in the alcohol in an excess amount of 5W50 times the weight of the compound and the solution is irradiated with high-energy rays such as γ-rays at room temperature. The irradiation time depends on the dose rate and the kind of alcohol, however, usually several tens hours to several days. The objective compound is readily produced by the one-step process. The hydrolysis of the compound of formula I gives a fluorine-containing α-aminoacid bearing hydroxyl groups.
COPYRIGHT: (C)1982,JPO&Japio
JP12287380A 1980-09-04 1980-09-04 Production of fluorine-containing alpha-aminoacid derivative having hydroxyl group Granted JPS5746949A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12287380A JPS5746949A (en) 1980-09-04 1980-09-04 Production of fluorine-containing alpha-aminoacid derivative having hydroxyl group

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12287380A JPS5746949A (en) 1980-09-04 1980-09-04 Production of fluorine-containing alpha-aminoacid derivative having hydroxyl group

Publications (2)

Publication Number Publication Date
JPS5746949A true JPS5746949A (en) 1982-03-17
JPS5748143B2 JPS5748143B2 (en) 1982-10-14

Family

ID=14846733

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12287380A Granted JPS5746949A (en) 1980-09-04 1980-09-04 Production of fluorine-containing alpha-aminoacid derivative having hydroxyl group

Country Status (1)

Country Link
JP (1) JPS5746949A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511733A (en) * 1981-12-25 1985-04-16 Daikin Kogyo Co., Ltd. Fluorine-containing aminocarboxylic acid compounds
JPH0259168A (en) * 1988-08-25 1990-02-28 Reiichi Okuda Precision casting method
JPH03193260A (en) * 1990-11-22 1991-08-23 Morita Mfg Co Ltd Casting machine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511733A (en) * 1981-12-25 1985-04-16 Daikin Kogyo Co., Ltd. Fluorine-containing aminocarboxylic acid compounds
JPH0259168A (en) * 1988-08-25 1990-02-28 Reiichi Okuda Precision casting method
JPH03193260A (en) * 1990-11-22 1991-08-23 Morita Mfg Co Ltd Casting machine

Also Published As

Publication number Publication date
JPS5748143B2 (en) 1982-10-14

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