JPS5732213A - Preparation of prolonged release composite material containing medicinal enzyme - Google Patents

Preparation of prolonged release composite material containing medicinal enzyme

Info

Publication number
JPS5732213A
JPS5732213A JP10803180A JP10803180A JPS5732213A JP S5732213 A JPS5732213 A JP S5732213A JP 10803180 A JP10803180 A JP 10803180A JP 10803180 A JP10803180 A JP 10803180A JP S5732213 A JPS5732213 A JP S5732213A
Authority
JP
Japan
Prior art keywords
composite material
enzyme
resultant
vital
medium fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10803180A
Other languages
Japanese (ja)
Inventor
Masaru Yoshida
Isao Kaetsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Atomic Energy Agency
Original Assignee
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Atomic Energy Research Institute filed Critical Japan Atomic Energy Research Institute
Priority to JP10803180A priority Critical patent/JPS5732213A/en
Publication of JPS5732213A publication Critical patent/JPS5732213A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: To obtain a composite material aiming at the prolonged release and protection of a medicinal enzyme, by mixing the medicinal enzyme and a vital medium fluid with a polymerizable vinyl monomer in various combinations, molding the resultant mixutre into a desired shape, and irradiating the resultant molded mterial with light or ionizing radiation.
CONSTITUTION: A medicinal enzyme, e.g. uricase, asparaginase or urokinase, and a vital medium fluid in a concentration of 0W70wt% are mixed with a vinyl monomer polymerizable with light or ionizing radiation in a low temperature region of room temperature to -120°C, and the resultant mixture is then polymerized and molded into various shapes, e.g. a film, particle, powder or rod, to give the aimed composite material. A suitable combination of various kinds of vinyl monomers with polyfunctional monomers provides the control of crosslinking degree, hydrophilic nature, etc. of the resultant composite material, and various porous structures can be imparted to the composite material by the presence of the vital medium fluid. The reaction of a substrate with the enzyme can be carried out on the outside or inside of the composite material according to the conditions.
COPYRIGHT: (C)1982,JPO&Japio
JP10803180A 1980-08-06 1980-08-06 Preparation of prolonged release composite material containing medicinal enzyme Pending JPS5732213A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10803180A JPS5732213A (en) 1980-08-06 1980-08-06 Preparation of prolonged release composite material containing medicinal enzyme

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10803180A JPS5732213A (en) 1980-08-06 1980-08-06 Preparation of prolonged release composite material containing medicinal enzyme

Publications (1)

Publication Number Publication Date
JPS5732213A true JPS5732213A (en) 1982-02-20

Family

ID=14474193

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10803180A Pending JPS5732213A (en) 1980-08-06 1980-08-06 Preparation of prolonged release composite material containing medicinal enzyme

Country Status (1)

Country Link
JP (1) JPS5732213A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0488139U (en) * 1990-12-17 1992-07-30

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5052274A (en) * 1973-09-12 1975-05-09
JPS5247982A (en) * 1975-10-08 1977-04-16 Japan Atom Energy Res Inst Method for low temperature immobilization of yeast or microbial cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5052274A (en) * 1973-09-12 1975-05-09
JPS5247982A (en) * 1975-10-08 1977-04-16 Japan Atom Energy Res Inst Method for low temperature immobilization of yeast or microbial cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0488139U (en) * 1990-12-17 1992-07-30

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