JPS5726640A - Novel secoprostaglandin and its preparation - Google Patents

Novel secoprostaglandin and its preparation

Info

Publication number
JPS5726640A
JPS5726640A JP10045080A JP10045080A JPS5726640A JP S5726640 A JPS5726640 A JP S5726640A JP 10045080 A JP10045080 A JP 10045080A JP 10045080 A JP10045080 A JP 10045080A JP S5726640 A JPS5726640 A JP S5726640A
Authority
JP
Japan
Prior art keywords
formula
alkyl
hydroxyl group
protected hydroxyl
expected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10045080A
Other languages
Japanese (ja)
Other versions
JPH0159256B2 (en
Inventor
Toshio Tanaka
Takeshi Yu
Takeo Oba
Noriaki Okamura
Kenzo Watanabe
Kiyoshi Sakauchi
Seiji Kurozumi
Kenji Hoshina
Tatsuyuki Naritomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP10045080A priority Critical patent/JPS5726640A/en
Publication of JPS5726640A publication Critical patent/JPS5726640A/en
Publication of JPH0159256B2 publication Critical patent/JPH0159256B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The compound of formula I and formula II (A is O, H or OH; B is -CH=CH- or -C...C-; R1WR3 are H or 1W4C alkyl; R4 is H, OH or protected hydroxyl group; R5 is 1W10C (substituted) hydrocarbon group; R6 is H, 1W6C alkyl, or pharmacologically permissible cation; provided that when R4 is OH or protected hydroxyl group, at least one of R1WR3 is not H).
EXAMPLE: 14(RS)-Hydroxy-8-methyl-9-oxononadeca-5-cis-12-trans-dienoic acid.
USE: Expected as a drug. It is expected to be applied to the cardiac vessels, the kidney, the digestive tracts, and the genital organs, and to be effective to inflammation, blood coagulation, and cancer.
PROCESS: The compound of formula I is prepared by reacting the ketone of formula III (R41 is H or protected hydroxyl group) with a halide of formula IV (X is halogen; R61 is 1W6C alkyl) in the presence of a base.
COPYRIGHT: (C)1982,JPO&Japio
JP10045080A 1980-07-24 1980-07-24 Novel secoprostaglandin and its preparation Granted JPS5726640A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10045080A JPS5726640A (en) 1980-07-24 1980-07-24 Novel secoprostaglandin and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10045080A JPS5726640A (en) 1980-07-24 1980-07-24 Novel secoprostaglandin and its preparation

Publications (2)

Publication Number Publication Date
JPS5726640A true JPS5726640A (en) 1982-02-12
JPH0159256B2 JPH0159256B2 (en) 1989-12-15

Family

ID=14274244

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10045080A Granted JPS5726640A (en) 1980-07-24 1980-07-24 Novel secoprostaglandin and its preparation

Country Status (1)

Country Link
JP (1) JPS5726640A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49100032A (en) * 1972-10-30 1974-09-20

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49100032A (en) * 1972-10-30 1974-09-20

Also Published As

Publication number Publication date
JPH0159256B2 (en) 1989-12-15

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