JPS5726640A - Novel secoprostaglandin and its preparation - Google Patents
Novel secoprostaglandin and its preparationInfo
- Publication number
- JPS5726640A JPS5726640A JP10045080A JP10045080A JPS5726640A JP S5726640 A JPS5726640 A JP S5726640A JP 10045080 A JP10045080 A JP 10045080A JP 10045080 A JP10045080 A JP 10045080A JP S5726640 A JPS5726640 A JP S5726640A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- hydroxyl group
- protected hydroxyl
- expected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 210000004392 genitalia Anatomy 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The compound of formula I and formula II (A is O, H or OH; B is -CH=CH- or -C...C-; R1WR3 are H or 1W4C alkyl; R4 is H, OH or protected hydroxyl group; R5 is 1W10C (substituted) hydrocarbon group; R6 is H, 1W6C alkyl, or pharmacologically permissible cation; provided that when R4 is OH or protected hydroxyl group, at least one of R1WR3 is not H).
EXAMPLE: 14(RS)-Hydroxy-8-methyl-9-oxononadeca-5-cis-12-trans-dienoic acid.
USE: Expected as a drug. It is expected to be applied to the cardiac vessels, the kidney, the digestive tracts, and the genital organs, and to be effective to inflammation, blood coagulation, and cancer.
PROCESS: The compound of formula I is prepared by reacting the ketone of formula III (R41 is H or protected hydroxyl group) with a halide of formula IV (X is halogen; R61 is 1W6C alkyl) in the presence of a base.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10045080A JPS5726640A (en) | 1980-07-24 | 1980-07-24 | Novel secoprostaglandin and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10045080A JPS5726640A (en) | 1980-07-24 | 1980-07-24 | Novel secoprostaglandin and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5726640A true JPS5726640A (en) | 1982-02-12 |
JPH0159256B2 JPH0159256B2 (en) | 1989-12-15 |
Family
ID=14274244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10045080A Granted JPS5726640A (en) | 1980-07-24 | 1980-07-24 | Novel secoprostaglandin and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5726640A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49100032A (en) * | 1972-10-30 | 1974-09-20 |
-
1980
- 1980-07-24 JP JP10045080A patent/JPS5726640A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49100032A (en) * | 1972-10-30 | 1974-09-20 |
Also Published As
Publication number | Publication date |
---|---|
JPH0159256B2 (en) | 1989-12-15 |
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