JPS57212174A - Thiazolidine compound - Google Patents
Thiazolidine compoundInfo
- Publication number
- JPS57212174A JPS57212174A JP56095661A JP9566181A JPS57212174A JP S57212174 A JPS57212174 A JP S57212174A JP 56095661 A JP56095661 A JP 56095661A JP 9566181 A JP9566181 A JP 9566181A JP S57212174 A JPS57212174 A JP S57212174A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound expressed
- agent
- reacted
- expressed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A thiazolidine compound expressed by formulaI(A is phenylene or naphthylene; R1 is mesyl or 1W7C alkanoyl; R2 is 1W6C alkyl) and a salt thereof.
EXAMPLE: 2-[2-(e-tert-Butylamino-2-hydroxypropoxy)phenyl]-3-mesylthiazolidine hydrochloride.
USE: A sympathetic β-blocking agent and/or stimulant, inhibitor against blood platelet agglutination, calcium antagonistic agent, vasodilator and antispasmodic agent useful as a remedy for angina pectoris, arrhythmia and thrombosis.
PROCESS: A compound expressed by formula II is reacted with a reactive derivative of a compound expressed by the formula R1OH in the presence of a deacidifying agent to give a compound expressed by formula III, which is then reacted with epichlorohydrin in the presence of a deacidifying agent to afford compounds of formula IV and/or formula V. The resultant compound of formula IV or formula V or both are then reacted with an amine expressed by the formula R2NH2 to give the compound expressed by formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56095661A JPS57212174A (en) | 1981-06-20 | 1981-06-20 | Thiazolidine compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56095661A JPS57212174A (en) | 1981-06-20 | 1981-06-20 | Thiazolidine compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57212174A true JPS57212174A (en) | 1982-12-27 |
JPH0136469B2 JPH0136469B2 (en) | 1989-07-31 |
Family
ID=14143671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56095661A Granted JPS57212174A (en) | 1981-06-20 | 1981-06-20 | Thiazolidine compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57212174A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5841872A (en) * | 1981-09-04 | 1983-03-11 | Santen Pharmaceut Co Ltd | Ether with thiazolidine ring |
EP0167355A2 (en) * | 1984-06-30 | 1986-01-08 | Tanabe Seiyaku Co., Ltd. | Thiazolidine derivative and processes for preparing the same |
US4777178A (en) * | 1985-06-15 | 1988-10-11 | Tanabe Seiyaku Co., Ltd. | Thiazolidine derivatives |
-
1981
- 1981-06-20 JP JP56095661A patent/JPS57212174A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5841872A (en) * | 1981-09-04 | 1983-03-11 | Santen Pharmaceut Co Ltd | Ether with thiazolidine ring |
JPH026352B2 (en) * | 1981-09-04 | 1990-02-08 | Santen Pharma Co Ltd | |
EP0167355A2 (en) * | 1984-06-30 | 1986-01-08 | Tanabe Seiyaku Co., Ltd. | Thiazolidine derivative and processes for preparing the same |
US4689327A (en) * | 1984-06-30 | 1987-08-25 | Tanabe Seiyaku Co., Ltd. | N-substituted-2-[2-[2-(4-phenylpiperazine-1-yl)ethoxy]phenyl]-thiazolidine-3-carboxamides useful as cardiotonic agent |
US4777178A (en) * | 1985-06-15 | 1988-10-11 | Tanabe Seiyaku Co., Ltd. | Thiazolidine derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPH0136469B2 (en) | 1989-07-31 |
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