JPS57212174A - Thiazolidine compound - Google Patents

Thiazolidine compound

Info

Publication number
JPS57212174A
JPS57212174A JP56095661A JP9566181A JPS57212174A JP S57212174 A JPS57212174 A JP S57212174A JP 56095661 A JP56095661 A JP 56095661A JP 9566181 A JP9566181 A JP 9566181A JP S57212174 A JPS57212174 A JP S57212174A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
agent
reacted
expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56095661A
Other languages
Japanese (ja)
Other versions
JPH0136469B2 (en
Inventor
Junichi Iwao
Masayuki Ooya
Tadashi Iso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Priority to JP56095661A priority Critical patent/JPS57212174A/en
Publication of JPS57212174A publication Critical patent/JPS57212174A/en
Publication of JPH0136469B2 publication Critical patent/JPH0136469B2/ja
Granted legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A thiazolidine compound expressed by formulaI(A is phenylene or naphthylene; R1 is mesyl or 1W7C alkanoyl; R2 is 1W6C alkyl) and a salt thereof.
EXAMPLE: 2-[2-(e-tert-Butylamino-2-hydroxypropoxy)phenyl]-3-mesylthiazolidine hydrochloride.
USE: A sympathetic β-blocking agent and/or stimulant, inhibitor against blood platelet agglutination, calcium antagonistic agent, vasodilator and antispasmodic agent useful as a remedy for angina pectoris, arrhythmia and thrombosis.
PROCESS: A compound expressed by formula II is reacted with a reactive derivative of a compound expressed by the formula R1OH in the presence of a deacidifying agent to give a compound expressed by formula III, which is then reacted with epichlorohydrin in the presence of a deacidifying agent to afford compounds of formula IV and/or formula V. The resultant compound of formula IV or formula V or both are then reacted with an amine expressed by the formula R2NH2 to give the compound expressed by formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56095661A 1981-06-20 1981-06-20 Thiazolidine compound Granted JPS57212174A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56095661A JPS57212174A (en) 1981-06-20 1981-06-20 Thiazolidine compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56095661A JPS57212174A (en) 1981-06-20 1981-06-20 Thiazolidine compound

Publications (2)

Publication Number Publication Date
JPS57212174A true JPS57212174A (en) 1982-12-27
JPH0136469B2 JPH0136469B2 (en) 1989-07-31

Family

ID=14143671

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56095661A Granted JPS57212174A (en) 1981-06-20 1981-06-20 Thiazolidine compound

Country Status (1)

Country Link
JP (1) JPS57212174A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5841872A (en) * 1981-09-04 1983-03-11 Santen Pharmaceut Co Ltd Ether with thiazolidine ring
EP0167355A2 (en) * 1984-06-30 1986-01-08 Tanabe Seiyaku Co., Ltd. Thiazolidine derivative and processes for preparing the same
US4777178A (en) * 1985-06-15 1988-10-11 Tanabe Seiyaku Co., Ltd. Thiazolidine derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5841872A (en) * 1981-09-04 1983-03-11 Santen Pharmaceut Co Ltd Ether with thiazolidine ring
JPH026352B2 (en) * 1981-09-04 1990-02-08 Santen Pharma Co Ltd
EP0167355A2 (en) * 1984-06-30 1986-01-08 Tanabe Seiyaku Co., Ltd. Thiazolidine derivative and processes for preparing the same
US4689327A (en) * 1984-06-30 1987-08-25 Tanabe Seiyaku Co., Ltd. N-substituted-2-[2-[2-(4-phenylpiperazine-1-yl)ethoxy]phenyl]-thiazolidine-3-carboxamides useful as cardiotonic agent
US4777178A (en) * 1985-06-15 1988-10-11 Tanabe Seiyaku Co., Ltd. Thiazolidine derivatives

Also Published As

Publication number Publication date
JPH0136469B2 (en) 1989-07-31

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