JPS57212165A - Imidazole derivative and its preparation - Google Patents
Imidazole derivative and its preparationInfo
- Publication number
- JPS57212165A JPS57212165A JP56098936A JP9893681A JPS57212165A JP S57212165 A JPS57212165 A JP S57212165A JP 56098936 A JP56098936 A JP 56098936A JP 9893681 A JP9893681 A JP 9893681A JP S57212165 A JPS57212165 A JP S57212165A
- Authority
- JP
- Japan
- Prior art keywords
- imidazole
- preparation
- imidazole derivative
- formulai
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- -1 1-Benzyl-4-methyl-5-[(2-hydroxyethyl)thiomethyl]imidazole Chemical compound 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- AQIXAKUUQRKLND-UHFFFAOYSA-N cimetidine Chemical compound N#C/N=C(/NC)NCCSCC=1N=CNC=1C AQIXAKUUQRKLND-UHFFFAOYSA-N 0.000 abstract 1
- 229960001380 cimetidine Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 abstract 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 abstract 1
Abstract
NEW MATERIAL:An imidazole derivative of formulaI(Bz represents formula II, connected to 1- or 3-position.
EXAMPLE: 1-Benzyl-4-methyl-5-[(2-hydroxyethyl)thiomethyl]imidazole.
USE: It is used as a synthetic intermediate of cimetidine, an antiulcerative having an activity of blocking histamine H2 receptor.
PREPARATION: The reaction between 1-benzyl-4(5)-methyl-5(4)-chloromethyl- imidazole of formula III and mercaptoethanol is carried out in the presence of a base such as sodium ethylate or potassium methylate in a solvent such as methanol at a temperature lower than that room one, preferably below 0°C to give the compund of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56098936A JPS57212165A (en) | 1981-06-25 | 1981-06-25 | Imidazole derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56098936A JPS57212165A (en) | 1981-06-25 | 1981-06-25 | Imidazole derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57212165A true JPS57212165A (en) | 1982-12-27 |
Family
ID=14233002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56098936A Pending JPS57212165A (en) | 1981-06-25 | 1981-06-25 | Imidazole derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57212165A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51101976A (en) * | 1975-02-03 | 1976-09-08 | Smith Kline French Lab |
-
1981
- 1981-06-25 JP JP56098936A patent/JPS57212165A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51101976A (en) * | 1975-02-03 | 1976-09-08 | Smith Kline French Lab |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU528095B2 (en) | Heterocyclic derivatives of (4-phenyl-piperazin-1-yl aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1h-imidazoles and 1h-1,2,4-triazoles | |
AR241907A1 (en) | A procedure for the preparation of imidazole or triazole derivatives of arylphenylic ether, substitutes. | |
PL255311A1 (en) | Pesticide based on new derivatives of 1,2,4-triazole | |
DE3266532D1 (en) | Fungicidal 1,2,4-triazole and imidazole derivatives | |
AU2139083A (en) | Novel arylphenyl ether derivatives | |
AU575557B2 (en) | Bis-1,2,4-triazole antifungal derivatives | |
AU575800B2 (en) | 2-(imidazole(1,2,4-triazol)yl)-ethanol derivatives | |
AU563849B2 (en) | Imidazo(1,5-alpha)pyrimidine derivatives | |
JPS57212165A (en) | Imidazole derivative and its preparation | |
DK24079A (en) | PROCEDURE FOR THE PREPARATION OF 1,2,4-TRIAZOLE | |
PT75240B (en) | Process for the preparation of substituted thiazolo <3,2-a>pyrimidines | |
ZA825009B (en) | Process for the preparation of derivatives of 3,4-diphenyl 5-methyl pyrazole | |
FI824216A0 (en) | PROCEDURE FOR FRAMSTATION OF AV (-) - 2- / 1- (2,6-DICHLOROPHENOXY) -ETHYL- / 1,3-DIAZACYCLOPENT-2-EN | |
JPS57144269A (en) | Triazine derivative and its preparation | |
JPS57212163A (en) | Imidazole derivative and its preparation | |
DE3267240D1 (en) | Process for the preparation of substituted 3-hydroxy-1,2,4-triazoles | |
EP0198918A4 (en) | Bicyclic benzo-oxy heterocyclic ethers and thioethers as h 2?-receptors antagonists. | |
JPS57212166A (en) | Imidazole derivative and its preparation | |
JPS57212164A (en) | Imidazole derivative and its preparation | |
IT1190908B (en) | PROCEDURE FOR THE PREPARATION OF 6- (3,6-DIIDRO-1 (2H) -PYRIDYL) PIRIMIDIN-3-OXIDES | |
GB2130208B (en) | 1,1-disubstituted-2-heterocyclic ethanol derivatives useful as antifungal agents or plant-growth regulators | |
IE830256L (en) | Alkanediones and imidazoles. | |
JPS5764662A (en) | Alkylene disulfur derivative | |
JPS5553284A (en) | Pyridazinone derivative | |
YU44053B (en) | Process for obtaining 4(5)-methyl-5(4)-thiomethyl imidazole |