JPS57212165A - Imidazole derivative and its preparation - Google Patents

Imidazole derivative and its preparation

Info

Publication number
JPS57212165A
JPS57212165A JP56098936A JP9893681A JPS57212165A JP S57212165 A JPS57212165 A JP S57212165A JP 56098936 A JP56098936 A JP 56098936A JP 9893681 A JP9893681 A JP 9893681A JP S57212165 A JPS57212165 A JP S57212165A
Authority
JP
Japan
Prior art keywords
imidazole
preparation
imidazole derivative
formulai
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56098936A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Giichi Funatsukuri
Ryuichi Fukui
Shuhei Takamatsu
Takeshi Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP56098936A priority Critical patent/JPS57212165A/en
Publication of JPS57212165A publication Critical patent/JPS57212165A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:An imidazole derivative of formulaI(Bz represents formula II, connected to 1- or 3-position.
EXAMPLE: 1-Benzyl-4-methyl-5-[(2-hydroxyethyl)thiomethyl]imidazole.
USE: It is used as a synthetic intermediate of cimetidine, an antiulcerative having an activity of blocking histamine H2 receptor.
PREPARATION: The reaction between 1-benzyl-4(5)-methyl-5(4)-chloromethyl- imidazole of formula III and mercaptoethanol is carried out in the presence of a base such as sodium ethylate or potassium methylate in a solvent such as methanol at a temperature lower than that room one, preferably below 0°C to give the compund of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56098936A 1981-06-25 1981-06-25 Imidazole derivative and its preparation Pending JPS57212165A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56098936A JPS57212165A (en) 1981-06-25 1981-06-25 Imidazole derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56098936A JPS57212165A (en) 1981-06-25 1981-06-25 Imidazole derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS57212165A true JPS57212165A (en) 1982-12-27

Family

ID=14233002

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56098936A Pending JPS57212165A (en) 1981-06-25 1981-06-25 Imidazole derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57212165A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51101976A (en) * 1975-02-03 1976-09-08 Smith Kline French Lab

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51101976A (en) * 1975-02-03 1976-09-08 Smith Kline French Lab

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